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- Registrant: BAYER CROPSCIENCE, LLC
- Signal word: Caution
- Active ingredients: Bacillus thuringiensis Cry1A.105 protein and genetic material necessary (vector PV-ZMIR245) for its production in corn (0.0059%); Bacillus thuringiensis Cry2Ab2 protein and the genetic material necessary (vector PV-ZMIR245) for its production in corn (0.0043%); Bacillus thuringiensis Vip3Aa20 protein encoded by vector pNOV1300 in event MIR162 corn (SYN-IR162-4), % dw (0.015%)
- Label accepted: 2018-07-05
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000524-00625-20180705.pdf
- Label accepted: 2026-08-17
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000524-00625-20260817.pdf
---
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20460
OFFICE OF CHEMICAL SAFETY
AND POLLUTION PREVENTION
July 5, 2018
David Chi
Regulatory Affairs Manager
Monsanto Company
800 North Lindbergh Blvd.
St. Louis, Missouri 63167
Subject: Non-PRIA (Pesticide Registration Improvement Act) Labeling Amendment to:
 Correct the common name of P. nebris as a target pest;
 Remove “TreceptaTM corn” as an alternate brand name;
 Modify the designations for the active and inactive ingredients;
 Replace the registration number “524-AEL” with “524-625;”
 Make minor changes to the Directions for Use.
Product Name: MON 89034 x MIR162
EPA Registration Number: 524-625
Application Dates: March 29, 2018
OPP Decision Numbers: 542188
Dear Mr. Chi:
In an application dated March 29, 2018, you notified the U.S. Environmental Protection Agency (EPA)
that you requested to modify the designations for the active and inactive ingredients, correct the
common name of P. nebris as a target pest, remove “TreceptaTM corn” as an alternate brand name,
replace the registration number “524-AEL” with “524-625,” and make minor changes to the Directions
for Use section. Subsequently, the EPA determined that the actions requested do not fall under the scope
of Pesticide Registration Notice 98-10 and therefore converted the notification to a non-PRIA
amendment (OPP Decision Number 542188). The amended labeling referred to above, submitted in
connection with registration under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as
amended, is acceptable.
The alternate brand name “TriceptaTM Corn” has been removed from the registration, and our records
have been updated accordingly. This approval does not affect any terms or conditions that were
previously imposed on this registration. You continue to be subject to existing terms or conditions on
your registration and any deadlines connected with them.
A stamped copy of your labeling is enclosed for your records. This labeling supersedes all previously
accepted labeling. You must submit one (1) copy of the final printed labeling before you release this
August 17, 2026
Edwards Allen, Ph.D.
Global Regulatory Manager
Bayer CropScience LLC
700 Chesterfield Parkway West
Chesterfield, MO 63017
Subject:
PRIA (Pesticide Registration Improvement Act) B900 Amendments – Addition of
time-limited refuge requirement for southwestern corn borer management in
specified areas of New Mexico and Arizona and associated label updates.
Product Names: See Table 1 below.
EPA Registration Numbers: See Table 1 below.
EPA Receipt Date: July 07, 2026
OPP Case Numbers: See Table 1 below.
Dear Dr. Allen:
The amendments referenced above and described below, submitted in connection with
registration under Section 3(c)(5) of the Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA), are acceptable. The following products are subject to these amendments:
Table 1. List of Amended Products
Product Name EPA
Registration
No.
OPP Action Case
No.
Lepidopteran Active Toxins
MON 89034 x MIR162 524-625 00702260 Cry1A.105, Cry2Ab2,
Vip3Aa20
MON 89034 x MIR162
x MON 87411
524-635 00702259 Cry1A.105, Cry2Ab2,
Vip3Aa20, Cry3Bb1, DvSnf7
For each of the products listed in Table 1, the refuge requirements are modified as follows:
x Growers in Hidalgo Co., NM (near Antelope Wells and Animas) and Cochise Valley in
Arizona (Cochise Co. south of Graham Co., AZ) are not required to plant a non-Bt refuge
for the 2027 and 2028 growing seasons.
This approval does not affect any of the other terms or conditions that were previously
imposed on these registrations. You continue to be subject to existing terms or conditions on
your registrations and any deadlines connected with them, as described in EPA’s Registration
Page 2 of 2
EPA Reg. No. 524-625
OPP Decision Nos. 542188
product for shipm
ent with the new labeling. In accordance with 40 CFR § 152.130(c), you may
distribute or sell this product under the previously approved labeling for 18 months from the date of this
letter. After 18 months, you may only distribute or sell this product if it bears this new revised labeling
or subsequently approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its
implementing regulation at 40 CFR § 152.3.
Should you wish to add/retain a reference to your company’s website on your label, then please be
aware that the website becomes labeling under FIFRA and is subject to review by the EPA. If the
website is false or misleading, the product will be considered to be misbranded and sale or distribution
of the product is unlawful under FIFRA section 12(a)(1)(E). 40 CFR § 156.10(a)(5) lists examples of
statements the EPA may consider false or misleading. In addition, regardless of whether a website is
referenced on your product’s label, claims made on the website may not substantially differ from those
claims approved through the registration process. Therefore, should the EPA find or if it is brought to
our attention that a website contains false or misleading statements or claims substantially differing from
the EPA-approved registration, the website will be referred to the EPA’s Office of Enforcement and
Compliance Assurance.
Your release for shipment of this product constitutes acceptance of these terms. If these terms are not
complied with, this registration will be subject to cancellation in accordance with FIFRA section 6.
If you have any questions, please contact Matt Weiner by phone at 703-347-0333 or via email at
weiner.matthew@epa.gov
EPA Registration Nos. 524-625 and 524-635
Action Case Nos. 00702260 and 00702259
Notices for these products.
Should you wish to add/retain a reference to your company’s website on your label(s), then
please be aware that the website becomes labeling under FIFRA and is subject to review by the
U.S. Environmental Protection Agency (EPA). If the website is false or misleading, the product(s)
will be considered to be misbranded and sale or distribution of the product is unlawful under
FIFRA section 12(a)(1)(E). 40 CFR § 156.10(a)(5) lists examples of statements EPA may consider
false or misleading. In addition, regardless of whether a website is referenced on your product’s
label, claims made on the website may not substantially differ from those claims approved
through the registration process. Therefore, should EPA find or if it is brought to our attention
that a website contains statements or claims substantially differing from statements or claims
made in connection with obtaining a FIFRA section 3 registration, the website will be referred
to EPA’s Office of Enforcement and Compliance Assurance.
Stamped copies of your labels are enclosed for your records. This labeling supersedes all
previously accepted labeling. In accordance with 40 CFR § 152.130(c), you may distribute or sell
this product under the previously approved labeling for 18 months from the date of this letter.
After 18 months, you may only distribute or sell this product if it bears this new revised labeling
or subsequently approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg)
and its implementing regulation at 40 § CFR 152.3.
Your release for shipment of these products constitutes acceptance of these terms. If these
terms are not complied with, these registrations will be subject to cancellation in accordance
with FIFRA section 6.
The following approved Confidential Statements of Formula (CSF) are on file for your products:
x 524-625: Basic CSF Dated April 1, 2020
x 524-635: Basic CSF Dated May 10, 2016
If you have any questions, please contact David Linz by email at linz.david@epa.gov or by
phone at (513) 569-7538.
Sincerely,
A
l a n R eynolds, Team Leader
E
m e r g i n g T e chnologies Branch
Alan Reynolds, Product Manager 94
Emerging Technologies Branch
Biopesticides and Pollution
Prevention Division (7511P)
Prevention Division (7511M)
Office of Pesticide Programs
Enclosure
Enclosures: Product Label Stamped “Acceptable”
Digitally signed by
ALAN REYNOLDS
Date: 2026.08.17
13:43:45 -04'00'
Plant-Incorporated Protectant Label
MON 89034 × MIR162
Lepidopteran-Protected Corn
(OECD Unique Identifier: MON-89Ø34-3 × SYN-IR162-4)
This product is effective in controlling leaf, stalk, and ear damage cause d by corn borers
a n dc o r ne a r w o r m .
Active Ingredients:
Bacillus thuringiensis Cry1A.105 and the genetic material (vector PV-ZMIR245)
necessary for its production in MON 89034 × MIR162 corn (OECD Unique Identi fier:
021‘î6<1,5  ”
Bacillus thuringiensis Cry2Ab2 and the genetic material (vector PV-ZMIR245) necessary
for its production in MON 89034 × MIR162 corn (OECD Unique Identifier:
021‘î6<1,5  ”
Bacillus thuringiensis Vip3Aa20 and the genetic material (vector pNOV1300) necessary
for its production in MON 89034 × MIR162 corn (OECD Unique Identifier:
021‘î6<1,5  ”
Other Ingredients:
Phosphomannose isomerase (PMI) marke r protein and the genetic material ( vector
pNOV1300) necessary for its production in MON 89034 × MIR162 corn (OECD Uni que
,GHQWLILHU021‘î6<1,5  ”
*Percentage (wt/wt) on a dry weight basis for whole plant (forage) of MON 89 034
× MIR162 plants.
KEEP OUT OF REACH OF CHILDREN
CAUTION
NET CONTENTS__________
EPA Registration No. 524-625
EPA Establishment No. 524-MO-002
07/05/2018
Plant-Incorporated Protectant Label
MON 89034 × MIR162
(OECD Unique Identifier: MON-89Ø34-3 × SYN-IR162-4)
Active Ingredients:
Bacillus thuringiensis Cry1A.105 protein and the genetic material (vector PV-ZMIR245)
necessary for its production in event MON 89034 × MIR162 corn (OECD Unique
,GHQWLILHU 021‘ î 6<1,5  ”
Bacillus thuringiensis Cry2Ab2 protein and the genetic material (vector PV-ZMIR245)
necessary for its production in MON 89034 × MIR162 corn (OECD Unique Identifier:
021‘ î 6<1,5  ”
Bacillus thuringiensis Vip3Aa20 protein and the gene tic material (vector pNOV1300)
necessary for its production in MON 89034 × MIR162 corn (OECD Unique Identifier:
021‘ î 6<1,5   ”
Other Ingredients:
Phosphomannose isomerase (PMI) marker protein and the genetic material (vector
pNOV1300) necessary for its production in MON 89034 × MIR162 corn (OECD Unique
,GHQWLILHU 021‘ î 6<1,5   ”
*Percentage (wt/wt) on a dry weight basis for whole plant (forage).
KEEP OUT OF REACH OF CHILDREN
CAUTION
NET CONTENTS__________
EPA Registration No. 524-625
EPA Establishment No. 524-MO-002
Bayer CropScience LLC
800 North Lindbergh Blvd.
St Louis, MO 63167
08/17/2026
524-625
Monsanto Company
800 North Lindbergh Blvd.
St. Louis, MO 63167
DIRECTIONS FOR USE
It is a violation of Federal law to use this product in any manner inconsiste nt with its
labeling. Information regarding co mmercial production as specified in t he terms and
conditions of this registration must b e included in the Technology Use Gui de and/or
Insect Resistance Management (IRM) Grower Guide.
MON 89034 × MIR162 can be used to protect corn plants from leaf, stalk, and ea r
damage caused by corn borers and corn earworm.
This plant-incorporated protectant (PIP) may be combined through conven tional breeding
with other registered plant-incorporated protectants that are similarl y approved for use in
combination, through conventional br eeding, with other registered plan t-incorporated
protectants to produce inbred corn lines and hybrid corn varieties with co mbined
pesticidal traits.
Refuge Requirements for MON 89034 × MIR162 Field Corn
In order to minimize the risk of corn borers and corn earworm developing res istance to
MON 89034 × MIR162 field corn, an insect resistance management plan must be
implemented which includes planting of a structured refuge.
For the sole purpose of manufacturing and small scale research trials for o bservation,
these refuge requirements do not apply to seed increase/propagation of in bred and hybrid
seed corn up to a total of 20,000 acres per county and up to a combined United S tates
(U.S.) total of 250,000 acres per plant -incorporated protectant (PIP) ac tive ingredient per
registrant per year.
a) Corn-Belt/Non-Cotton-Growing Area Refuge Requirements
For MON 89034 × MIR162 field corn grown outside cotton-growing areas (e.g. ,t h eC o r n
Belt), grower guides must specify that growers must adhere to the followin gr e f u g e
requirements.
Growers must plant a structured refuge of at least 5% corn, which is not a Lep idopteran-
protected B.t. corn hybrid. The refuge may be treated with insecticides, as detailed
below, to control Lepidopteran s talk-boring and other pests.
DIRECTIONS FOR USE
It is a violation of Federal law to use this product in any manner inconsistent with its
labeling. Information regarding co mmercial production reflected here and, in the terms,
and conditions of this registration must be included in the Technology Use Guide.
MON 89034 × MIR162 protects corn crops from leaf, stalk, and ear damage caused by
lepidopteran corn pests listed on this label. In order to minimize the risk of these pests
developing resistance to MON 89034 × MIR162, an insect resistance management (IRM)
plan must be implemented which includes planting of a structured refuge.
This plant-incorporated protectant (PIP ) may be combined or produced through
conventional breeding with other registered PIPs that are si milarly approved for use in
combination, through conventional breeding, with other registered PIPs.
These refuge requirements do not apply to planting of inbred/hybrid corn seed
productions, breeding, and small-sc ale research trials on up to a total of 20,000 acres per
county and up to a combined United States (U.S.) total of 250,000 ac res per PIP active
ingredient per registrant per year.
Growers in Hidalgo Co, NM (near Antelope Wells and Animas) and Cochise Valley in
Arizona (Cochise Co. South of Graham Co, AZ) are not required to plant a non-Bt refuge
for the 2027 and 2028 growing seasons.
Several options for deployment of the re fuge for MON 89034 × MIR162 are available to
growers. These options are based on the planting of MON 89034 × MIR162 in cotton or
non-cotton growing regions and the insect pres sure present in those locations. The refuge
sizes for these regions are ei ther 5% (i.e., 5 acres of non-PIP corn for every 95 acres
MON 89034 × MIR162 corn planted) or 20% (20 acres of non-PIP corn for every 80
acres of MON 89034 × MIR162 corn planted).
a) Corn-Belt/Non-Cotton-Growing Area Refuge Requirements
For MON 89034 × MIR162 field corn grown outside cotton-growing areas (e.g., the Corn
Belt), grower guides must sp ecify that growers must adhe re to the following refuge
requirements.
Growers must plant a structured refuge of at least 5% corn, which is not a lepidopteran-
protected Bt corn hybrid. The refu ge may be treated with inse cticides, as detailed below,
to control lepidopteran stalk-boring and other pests.
Insecticide treatments for pest s listed on this label may be applied only if economic
thresholds are reached for one or more of th ese target pests. Economic thresholds will be
determined using methods recommended by local or re gional professionals (e.g.,
Insecticide treatments for pests listed on this label may be applied only i f economic
thresholds are reached for one or more of these target pests. Economic thre sholds will be
determined using methods recommende d by local or regional professionals (e.g.,
Extension Service agents or crop cons ultants). Instructions to growers w ill specify that
microbial B.t. insecticides must not be applied to non- B.t. corn refuges.
Refuge planting options include: separate fields, blocks within fields ( e.g., along the
edges or headlands), perimeter str ips, and strips across the field.
External refuges must be planted within ½ mile.
When planting the refuge in strips across the field, refuges must be at leas t four (4)
consecutive rows wide.
b) Cotton-Growing Area Refuge Requirements
Cotton-growing areas include the following states: Alabama, Arkansas, G eorgia, Florida,
Louisiana, North Carolina, Missis sippi, South Carolina, Oklahoma (only the counties of
Beckham, Caddo, Comanche, Custer, Greer, Harmon, Jackson, Kay, Kiowa, Ti llman, and
Washita), Tennessee (only the coun ties of Carroll, Chester, Crockett, Dy er, Fayette,
Franklin, Gibson, Hardeman, Hardin, Haywood, Lake, Lauderdale, Lincoln , Madison,
Obion, Rutherford, Shelby, and Tipton), Texas (except the counties of Car son, Dallam,
Hansford, Hartley, Hutchinson, Lipscomb, Moore, Ochiltree, Roberts, an d Sherman),
Virginia (only the counties of Dinwiddie, Franklin City, Greensville, Is le of Wight,
Northampton, Southampton, Suffolk City, Surrey, Sussex), and Missouri ( only the
counties of Dunklin, New Madrid , Pemiscot, Scott, Stoddard).
MON 89034 × MIR162
Extension Service agents or crop consultants ). Instructions to growers will specify that
microbial Bt insecticides must not be applied to non-B.t. corn refuges.
Refuge planting options include: separate fields, blocks within fields (e.g., along the
edges or headlands), perimeter strips, and strips across the field.
External refuges must be planted within ½ mile.
When planting the refuge in stri ps across the field, refuges mu st be at least 4 consecutive
rows wide.
b) Cotton-Growing Area Refuge Requirements
Cotton-growing areas include the following stat es: Alabama, Arkansas, Georgia, Florida,
Louisiana, North Carolina, Mississippi, Sout h Carolina, Oklahoma (only the counties of
Beckham, Caddo, Comanche, Custer, Greer, Harmon, Jackson, Kay, Kiowa, Tillman, and
Washita), Tennessee (only the counties of Carroll, Chester, Crockett, Dyer, Fayette,
Franklin, Gibson, Hardeman, Hardin, Hayw ood, Lake, Lauderdale, Lincoln, Madison,
Obion, Rutherford, Shelby, and Tipton), Texas (except the counties of Carson, Dallam,
Hansford, Hartley, Hutchinson, Lipscomb, Moor e, Ochiltree, Roberts, and Sherman),
Virginia (only the counties of Dinwiddie, F ranklin City, Greensville, Isle of Wight,
Northampton, Southampton, Suffolk City, Surrey, Sussex) and Missouri (only the
counties of Dunklin, New Madrid, Pemiscot, Scott, Stoddard).
For MON 89034 × MIR162 field corn grown in cotton-growing areas, grower guides
must specify that growers must adhere to the following refuge requirements.
MON 89034 x MIR162
(95 acres) ”½ mile
Refuge
Non-B.t. lepidopteran-
protected corn
Refuge
Non-Bt Lepidopteran-
protected corn
(5 acres)
MON 89034 × MIR162
(95 acres)
Refuge
Non-B.t. lepidopteran-
protected corn
MON 89034 x MIR162
(95 acres)
Refuge
Non-Bt Lepidopteran-
protected corn
(5 acres)
For MON 89034 × MIR162 field corn grown in cotton-growing areas, grower gui des
must specify that growers must adhere to the following refuge requirement s.
Growers must plant a structured refuge of at least 20% corn, which is not a le pidopteran-
protected B.t. corn hybrid. The refuge may be treated with insecticides, as detailed
below, to control lepidopteran stalk-boring and other pests.
Insecticide treatments for pests listed on this label may be applied only i f economic
thresholds are reached for one or more of these target pests. Economic thre sholds will be
determined using methods recommende d by local or regional professionals (e.g.,
Extension Service agents, crop consul tants). Instructions to growers wi ll specify that
microbial B.t. insecticides must not be applied to non- B.t. corn refuges.
Refuge planting options include: separate fields, blocks within fields ( e.g., along the
edges or headlands), perimeter str ips, and strips across the field.
External refuges must be planted within ½ mile.
When planting the refuge in strips across the field, refuges must be at leas t four (4)
consecutive rows wide.
MON 89034 × MIR162
Growers must plant a structured refuge of at least 20% cor n, which is not a lepidopteran-
protected Bt corn hybrid. The refu ge may be treated with insect icides, as detailed below,
to control lepidopteran stalk-boring and other pests.
Insecticide treatments for pest s listed on this label may be applied only if economic
thresholds are reached for one or more of thes e target pests. Economic thresholds will be
determined using methods recommended by local or re gional professionals (e.g.,
Extension Service agents, crop consultants). Instructions to growers will specify that
microbial Bt insecticides must not be applied to non-Bt corn refuges.
Refuge planting options include : separate fields, blocks within fields (e.g., along the
edges or headlands), perimeter strips, and strips across the field.
External refuges must be planted within ½ mile.
When planting the refuge in stri ps across the field, refuges mu st be at least 4 consecutive
rows wide.
MON 89034 x MIR162
(80 acres) ”½ mile
Refuge
Non-B.t. lepidopteran-
protected corn
Refuge
Non-Bt lepidopteran-
protected corn
(20 acres)
MON 89034 × MIR162
(80 acres)
Refuge
Non- B.t. lepidopteran -
protected corn
MON 89034 x MIR162
(80 acres)
Refuge
Non-Bt lepidopteran-
protected corn
(20 acres)
Corn Insects Controlled or Suppressed
Corn Insects Controlled or Suppressed
European corn borer Ostrinia nubilalis
Southwestern corn borer Diatraea grandiosella
Southern cornstalk borer Diatraea crambidoides
Corn earworm Helicoverpa zea
Fall armyworm Spodoptera frugiperda
Stalk borer Papaipema nebris
Sugarcane borer Diatraea saccharalis
Stalk borer Papaipema nebris
Sugarcane borer Diatraea saccharalis
Beet armyworm Spodoptera exigua
True armyworm Pseudelatia unipuncta
Black cutworm Agrotis ipsilon
Western bean cutworm Striacosta albicosta
Lesser cornstalk borer Elasmopalpus lignosellus
Dingy Cutworm Feltia jaculifera
Sales of corn hybrids that contain Monsanto’s B.t. corn plant-incorporated protectant
must be accompanied by a Grower Guide which includes information on planti ng,
production, and insect resistance management and notes that routine appl ications of
insecticides to control these insects are usually unnecessary when corn c ontaining the B.t.
proteins is planted.
__________________________
MON 89034 × MIR162 is a product of Monsanto’s research program offering uni que genetic
characteristics for specific grower needs and may be protected by one or mo re of the following U.S. patents
that can be found at http://www.monsantotechnology.com
Sales of corn hybrids that contain Bayer’s Bt corn plant incorporated protectant must be
accompanied by a Grower Guide which includes information on planting, production and
insect resistance management and notes that routine applications of insecticides to control
these insects are usually unnecessary when corn containing the Bt proteins is planted.
__________________________
MON 89034 × MIR162 is a product of Bayer’s research program offering unique genetic characteristics for
specific grower needs and may be protected by one or mo re of the following U.S. patents that can be found
at http://cs.bayerpatents.bayer.com