# DFZ / MFX FS

- EPA Reg No: **100-1428**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Metalaxyl-M (1.93%); Difenoconazole (7.73%)
- Label accepted: 2025-12-19
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01428-20251219.pdf

---
December 19, 2025 
 
Nestor Algarin 
Regulatory Product Manager 
Syngenta Crop Protection, LLC 
P.O. Box 18300 
Greensboro, NC 27419 
 
Subject: Label Amendment - Registration Review Mitigation for Metalaxyl-M/Mefenoxam 
 Product Name: DFZ/MFX FS 
 EP A Registration Number: 100-1428 
Case Number: 671128 
Application Date: November 21, 2022 
 
Dear Nestor Algarin: 
 
The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), 
as amended, has completed reviewing all the information submitted with your application to 
support the Registration Review of the above referenced product in connection with the 
Metalaxyl-M/Mefenoxam Interim Decision, and has concluded that your submission is 
acceptable. The label referred to above, submitted in connection with registration under FIFRA, 
as amended, is acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please 
be aware that the website becomes labeling under the Federal Insecticide, Fungicide, and 
Rodenticide Act and is subject to review by the Agency. If the website is false or misleading, the 
product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 
40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In 
addition, regardless of whether a website is referenced on your product’s label, claims made on 
the website may not substantially differ from those claims approved through the registration 
process. Therefore, should the Agency find or if it is brought to our attention that a website 
contains false or misleading statements or claims substantially differing from the EPA approved 
registration, the website will be referred to the EPA’s Office of Enforcement and Compliance 
Assurance. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes 
all previously accepted labeling and must be used at your next label printing. You must 
submit one copy of the final printed labeling before you release the product for

Page 2 of 2 
EPA Reg. No. 100-1428 
Case No. 671128 
 
shipment with the new labeling. In accordance with 40 CFR 152.130(c), you may 
distribute or sell this product under the previously approved labeling for 12 months 
from the date of this letter. After 12 months, you may only distribute or sell this 
product if it bears this new revised labeling or subsequently approved labeling. “To 
distribute or sell” is defined under FIFRA section 2(gg) and its implementing regulation 
at 40 CFR 152.3. 
 
If you have any questions about this letter, please contact Concepción Rodríguez by phone at 
202-566-0820, or via email at rodriguez.concepcion@epa.gov. 
 
 S i n c e r e l y , 
 
 
Julie Javier, Team Leader 
Risk Mitigation and Implementation Branch 4 
Pesticide Re-Evaluation Division 
Office of Pesticide Programs 
 
ENCLOSURE: Stamped label

Dec 19, 2025
100-1428

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