crop-chem-docs/corpus/epa_ppls/100-1428.md

DFZ / MFX FS

• EPA Reg No: 100-1428
• Registrant: SYNGENTA CROP PROTECTION, LLC
• Signal word: Caution
• Active ingredients: Metalaxyl-M (1.93%); Difenoconazole (7.73%)
• Label accepted: 2025-12-19
• Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01428-20251219.pdf

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December 19, 2025

Nestor Algarin Regulatory Product Manager Syngenta Crop Protection, LLC P.O. Box 18300 Greensboro, NC 27419

Subject: Label Amendment - Registration Review Mitigation for Metalaxyl-M/Mefenoxam Product Name: DFZ/MFX FS EP A Registration Number: 100-1428 Case Number: 671128 Application Date: November 21, 2022

Dear Nestor Algarin:

The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended, has completed reviewing all the information submitted with your application to support the Registration Review of the above referenced product in connection with the Metalaxyl-M/Mefenoxam Interim Decision, and has concluded that your submission is acceptable. The label referred to above, submitted in connection with registration under FIFRA, as amended, is acceptable.

Should you wish to add/retain a reference to the company’s website on your label, then please be aware that the website becomes labeling under the Federal Insecticide, Fungicide, and Rodenticide Act and is subject to review by the Agency. If the website is false or misleading, the product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from those claims approved through the registration process. Therefore, should the Agency find or if it is brought to our attention that a website contains false or misleading statements or claims substantially differing from the EPA approved registration, the website will be referred to the EPA’s Office of Enforcement and Compliance Assurance.

A stamped copy of your labeling is enclosed for your records. This labeling supersedes all previously accepted labeling and must be used at your next label printing. You must submit one copy of the final printed labeling before you release the product for

Page 2 of 2 EPA Reg. No. 100-1428 Case No. 671128

shipment with the new labeling. In accordance with 40 CFR 152.130(c), you may distribute or sell this product under the previously approved labeling for 12 months from the date of this letter. After 12 months, you may only distribute or sell this product if it bears this new revised labeling or subsequently approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its implementing regulation at 40 CFR 152.3.

If you have any questions about this letter, please contact Concepción Rodríguez by phone at 202-566-0820, or via email at rodriguez.concepcion@epa.gov.

S i n c e r e l y ,

Julie Javier, Team Leader Risk Mitigation and Implementation Branch 4 Pesticide Re-Evaluation Division Office of Pesticide Programs

ENCLOSURE: Stamped label

Dec 19, 2025 100-1428

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