crop-chem-docs/corpus/epa_ppls/100-1742.md

Miravis Era

• EPA Reg No: 100-1742
• Registrant: SYNGENTA CROP PROTECTION, LLC
• Signal word: Caution
• Active ingredients: Pydiflumetofen (17.5%); Prothioconazole (17.5%)
• Label accepted: 2025-09-23
• Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01742-20250923.pdf

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U.S. ENVIRONMENTAL PROTECTION AGENCY Office of Pesticide Programs Registration Division (7505T) 1200 Pennsylvania Ave., N.W. Washington, D.C. 20460

EPA Reg. Number:

100-1742

Date of Issuance:

9/23/25 NOTICE OF PESTICIDE: X Registration Reregistration

Term of Issuance: Unconditional (under FIFRA, as amended) Name of Pesticide Product: Miravis Era

Name and Address of Registrant (include ZIP Code): Syngenta Crop Protection, LLC P. O. Box 18300 Greensboro, NC 27419

Note: Changes in labeling differing in substance from that accepted in connection with this registration must be submitted to and a ccepted by the Registration Division prior to use of the label in commerce. In any correspondence on this product always refer to the above EPA registration number.

On the basis of information furnished by the registrant, the above named pesticide is hereby registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA).

Registration is in no way to be construed as an endorsement or recommendation of this product by the Agency. In order to protect health and the environment, the Administrator, on his motion, may at any time suspend or cancel the registration of a pesticide in accordance with the Act. The acceptance of any name in connection with the registration of a product under this Act is not to be construed as giving the registrant a right to exclusive use of the name or to its use if it has been covered by others.

This product is unconditionally registered in accordance with FIFRA section 3(c)(5) provided that you:

1. Submit and/or cite all data required for registration/reregistration/registration review of your product when the Agency requires all registrants of similar products to submit such data.

Continues page 2

Signature of Approving Official:

Stephanie Suarez, Ph.D., Acting Product Manager 22 Fungicide Branch, Registration Division (7505T)

Date:

9/23/25 EPA Form 8570-6

Page 2 of 2 EPA Reg. No. 100-1742 Case No. 491758

2. Make the following label changes before you release the product for shipment:

• Revise the EPA Registration Number to read, “EPA Reg. No. 100-1742.”

3. Submit one copy of the final printed label for the record before you release the product for shipment.

Should you wish to add/retain a reference to the company’s website on your label, then please be aware that the website becomes labeling under FIFRA and is subject to review by the Agency. If the website is false or misleading, the product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) lists examples of statements EPA may consider false or misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from those claims approved through the registration process. Therefore, should the Agency find or if it is brought to our attention that a website contains false or misleading statements or claims substantially differing from the EPA approved registration, the website will be referred to the EPA’s Office of Enforcement and Compliance.

If these conditions are not complied with, the registration will be subject to cancellation in accordance with FIFRA section 6. Your release for shipment of the product constitutes acceptance of these conditions. A stamped copy of the label is enclosed for your records.

The record for this product currently contains the following CSF:

• Basic CSF dated 10/09/2024

If you have any questions, please contact James Orrock by phone at 202-566-2862 or by email at orrock.james@epa.gov.

Enclosure

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[MASTER]

PROTHIOCONAZOLE GROUP 3 FUNGICIDE PYDIFLUMETOFEN GROUP 7 FUNGICIDE

Miravis® Era

FUNGICIDE

ADEPIDYN® Technology*

Active Ingredients: Pydiflumetofen**: ..................................................................................................... 17.5% Prothioconazole***: .................................................................................................. 17.5% Other Ingredients: 65.0% Total: 100.0%

*Technology denotes the active ingredient Pydiflumetofen **CAS No. 1228284-64-7 ***CAS No. 178928-70-6

Miravis Era is a suspension concentrate (SC) formulation and contains 1.67 lb of active ingredient pydiflumetofen and 1.67 lb ai active ingredient prothioconazole per gallon.

KEEP OUT OF REACH OF CHILDREN.

CAUTION/PRECAUCIÓN

Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. (If you do not understand the label, find someone to explain it to you in detail.) See additional Precautionary Statements and Directions for Use inside booklet.

EPA Reg. No. 100-XXXX

EPA Est.

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Net Contents

[Batch Code: _____ ] (For nonrefillables only.) 09/23/2025 100-1742

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TABLE OF CONTENTS

1.0 FIRST AID 2.0 PRECAUTIONARY STATEMENTS 2.1 Hazards to Humans and Domestic Animals 2.2 Personal Protective Equipment (PPE) 2.2.1 Engineering Controls 2.3 Environmental Hazards 2.3.1 Groundwater Advisory 2.3.2 Surface Water Advisory 2.4 Physical or Chemical Hazards DIRECTIONS FOR USE 3.0 PRODUCT INFORMATION 3.1 Integrated Pest (Disease) Management (IPM) 3.2 Resistance Management 4.0 APPLICATION DIRECTIONS 4.1 Methods of Application 4.2 Application Equipment 4.2.1 Nozzles 4.2.2 Pumps 4.3 Application Volume and Spray Coverage 4.4 Mixing Directions 4.4.1 Miravis Era Alone 4.4.2 Tank-Mix Precautions 4.4.3 Tank-Mix Compatibility Test 4.4.4 Miravis Era in Tank Mixtures 4.4.5 Spray Additives 4.5 Application through Irrigation Systems (Chemigation) 4.5.1 Application Directions for Overhead Irrigation Systems 4.5.2 Center-Pivot Irrigation 4.5.3 Solid-Set, Hand-Move, and Moving-Wheel Irrigation 4.5.4 Operating Instructions for Chemigation 4.5.5 Specific Instructions for Public Water Systems 5.0 ROTATIONAL CROP RESTRICTIONS 6.0 RESTRICTIONS AND PRECAUTIONS 6.1 Use Restrictions 6.2 Use Precautions 6.3 Spray Drift Management 6.4 Spray Drift Advisories 6.4.1 Importance of Droplet Size 6.4.2 Controlling Droplet Size – Ground Application 6.4.3 Controlling Droplet Size – Aerial Application 6.4.4 Boom Height – Ground Application 6.4.5 Release Height – Aerial Application

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6.4.6 Shielded Sprayers 6.4.7 Temperature and Humidity 6.4.8 Temperature Inversions 6.4.9 Wind and Rain 6.4.10 Handheld Technology Applications 6.4.11 Non-Target Areas 7.0 CROP USE DIRECTIONS 7.1 Cereals Grains 8.0 STORAGE AND DISPOSAL 9.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY 10.0 APPENDIX 10.1 Miravis Era Rate Conversion Chart (for use with Section 7.0) 10.2 [Optional Table] Miravis Era Use Summary Table

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1.0 FIRST AID FIRST AID If swallowed:  Call a poison control center or doctor immediately for treatment advice.  Have person sip a glass of water if able to swallow.  DO NOT induce vomiting unless told to do so by a poison control center or doctor.  DO NOT give anything by mouth to an unconscious person. If on skin or clothing:  Take off contaminated clothing.  Rinse skin immediately with plent y of water for 15-20 minutes.  Call a poison control center or doctor for treatment advise. If in eyes:  Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.  Call a poison control center or doctor for treatment advice. Have the product container or label with y ou when calling a poison control center, or doctor, or going for treatment. SYNGENTA HOTLINE NUMBER For 24-Hour Medical Emergency Assistance (Human or Animal) Or Chemical Emergency Assistance (Spill, Leak, Fire or Accident) Call 1-800-888-8372

2.0 PRECAUTIONARY STATEMENTS 2.1 Hazards to Humans and Domestic Animals CAUTION

Harmful if swallowed or absorbed through skin. Causes moderate eye irritation. Avoid contact with skin, eyes or clothing. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet. Remove and wash contaminated clothing before reuse.

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2.2 Personal Protective Equipment (PPE)

Applicators and other handlers must wear:

 Long-sleeved shirt and long pants  Chemical-resistant gloves made o f: Barrier laminate, butyl rubber ≥ 14 mils, nitrile rubber ≥ 14 mils, neoprene rubber ≥ 14 mils, natural rubber ≥ 14 mils, polyethylene, polyvinyl chloride (PVC) ≥ 14 mils, or Viton™ ≥ 14 mils  Shoes plus socks

User Safety Requirements

Follow the manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.

User Safety Recommendations Users should:  Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet.  Remove clothing/PPE immediately if pes ticide gets inside. Then wash thoroughly and put on clean clothing.  Remove PPE immediately after handling th is product. Wash the outside of gloves before removing. As soon as possibl e, wash thoroughly and change into clean clothing.

2.2.1 Engineering Controls When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides (40 CFR 170.240 (d)(4-6)), the handler PPE requirements may be reduced or modified as specified in the WPS.

IMPORTANT: When reduced PPE is worn because a closed system is being used, handlers must be provided all PPE specified above for “applicators and other handlers” and have such PPE immediately available for use in an emergency, such as a spill or equipment breakdown.

2.3 Environmental Hazards Prothioconazole is toxic to estuarine/marine invertebrates, and freshwater/estuaries/marine aquatic plants. Pydiflumetofen is toxic to fish, aquatic invertebrates, and oysters and shrimp. Drift and runoff may be hazardous to aquatic organisms in water adjacent to treated area.

For terrestrial uses: DO NOT apply directly to water, or to areas where surface water is present, or to intertidal areas below the mean high-water mark. Drift and runoff may be

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hazardous to aquatic organisms in water adjacent to treated areas. DO NOT contaminate water when disposing of equipment washwater or rinsate.

2.3.1 Groundwater Advisory Pydiflumetofen has properties and characteristics associated with chemicals detected in groundwater. Degradates of prothioconazole are known to leach through soil into groundwater under certain conditions as a result of label use. These chemicals may leach into groundwater if used in areas where soils are permeable, particularly where the water table is shallow.

2.3.2 Surface Water Advisory This product may impact surface water quality due to runoff of rain water. This is especially true for poorly draining soils and soils with shallow groundwater. This product is classified as having a high potential for reaching surface water and for reaching aquatic sediment via runoff for several months or more after application.

A level, well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the potential loading of pydiflumetofen and prothioconazole from runoff water and sediment. Runoff of this product will be reduced by avoiding applications when rainfall or irrigation is expected to occur within 48 hours. Sound erosion control practices will reduce this product’s potential to reach aquatic sediment via runoff.

2.4 Physical or Chemical Hazards DO NOT use or store near heat or open flame.

DIRECTIONS FOR USE

It is a violation of federal law to use this product in a manner inconsistent with its labeling.

DO NOT apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. For any requirements specific to your state or tribe, consult the agency responsible for pesticide regulation.

Notify state and/or f ederal authorities and Syngenta immediat ely if you observe any adverse environmental effects due to use of this product.

FAILURE TO FOLLOW THE USE DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY RESULT IN PLANT INJURY, POOR DISEASE CONTROL AND/OR ILLEGAL RESIDUES.

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AGRICULTURAL USE REQUIREMENTS

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE), notification to workers, and restricted-entry interval. The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard.

DO NOT enter or allow worker entry into treated areas during the restricted-entry interval (REI) of 12 hours.

For early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil or water, wear:  Coveralls  Chemical-resistant gloves made of: Barrier laminate, butyl rubber ≥ 14 mils, nitrile rubber ≥ 14 mils, neoprene rubber ≥ 14 mils, natural rubber ≥ 14 mils, polyethylene, polyvinyl chloride (PVC) ≥ 14 mils, or Viton ≥ 14 mils  Shoes plus socks

3.0 PRODUCT INFORMATION  Miravis Era is not for residential use.  Read all label directions befor e use. All applications must be made according to the use directions that follow.  Miravis Era is a broad-spectr um, preventative fungicide for use in the control of many important plant diseases, formulated as a suspension concentrate (SC).  Miravis Era is a member of Syngenta’s Plant Health product line and may also improve the yield and/or quality of the crop. These additional benefits are due to positive effects on plant physiology. The effects may vary according to factors such as the crop, crop hybrid, application timing, or environment.

CROP TOLERANCE Plant tolerance has been found to be acceptable for all crops on the label; however, not all possible tank-mix combinations have been tested under all conditions. When possible, test your tank-mix combination(s) on a small portion of the crop to ensure that a phytotoxic response will not occur as a result of application.

DISEASE SUPPRESSION If a use indicates suppression it refers to control which can range from fair to good, or consistent control at a level below that obtained with products registered for control.

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3.1 Integrated Pest (Disease) Management (IPM) Miravis Era should be integrated into an overall disease and pest management strategy whenever the use of a fungicide is required. Cultural practices known to reduce disease development should be followed. This should include selection of varieties with disease tolerance, removal of plant debris in which inoculum overwinters, and proper timing and placement of irrigation. Consult your local agricultural authorities for additional IPM strategies established for your area. Miravis Era may be used in state agricultural extension advisory (disease forecasting) programs which advise application timing based on environmental factors favorable for disease development. 3.2 Resistance Management

For resistance management, please note that Miravis Era contains both a Group 7 (pydiflumetofen), and group 3 (prothioconazole) fungicide. Any fungal population may contain individuals naturally resistant to either or both of the active ingredients in Miravis Era and other Group 7 or Group 3 fungicides. A gradual or total loss of pest control may occur over time if these fungicides are used repeatedly in the same fields. Appropriate resistance- management strategies should be followed.

To delay fungicide resistance, take one or more of the following steps:

 Rotate the use of Miravis Era or other Group 7 and Group 3 fungicides within a growing season sequence with different groups that control the same pathogens.  Use tank mixtures with fungi cides from a different group that are equally effective on the target pest when such use is permitted. Use at least the minimum application rate as labeled by the manufacturer.  Adopt an integrated diseas e management program for fungicide use that includes scouting, uses historical information related to pesticide use, and crop rotation, and which considers host plant resistance, impact of environmental conditions on disease development, disease thresholds, as well as cultural, biological and other chemical control practices.  Where possible, make use of predictive di sease models to effectively time fungicide applications. Note that using predictive models alone is not sufficient to manage resistance.  Monitor treated fungal populati ons for resistance development.  Contact your local extension specialist or certified crop advisor for any additional pesticide resistance-management and/or IPM directions for specific crops and pathogens.  For further information or to report suspected resistance contact Syngenta Crop Protection at 1-866-796-4368. You can also contact your university extension specialist to report resistance.

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As part of a resistance management strategy:

 Apply no more than 2 sequent ial applications unless otherwise stated in the crop section.  Follow the crop-specific resist ance management directions in Section 7.0.

4.0 APPLICATION DIRECTIONS

4.1 Methods of Application Apply Miravis Era at rates specified in the crop tables (Section 7.0). Thorough coverage will provide best results. Where permitted, applications can be made by ground, by air, and via chemigation as specified in Section 7.0. Refer to Section 4.5 for details of application by chemigation. 4.2 Application Equipment Miravis Era may be applied with all types of spray equipment commonly used for making aerial and ground applications. Proper adjustments and calibration of spray equipment are needed to provide penetration and coverage essential for good disease control. To ensure accuracy, calibrate sprayer before each use. 4.2.1 Nozzles

 Equip sprayers with nozzles that provide uniform application and desired spray quality.  Screens should be used to protect the pum p and to prevent nozzles from clogging.

4.2.2 Pumps  Use a pump with capacity to:

1. Maintain 35-40 psi at nozzles
2. Provide sufficient agitation in the tank to keep tank-mixture in suspension - this requires recirculation of 10% of tank volume per minute.  Use a jet agitator or liquid sparge tube for agitation.  DO NOT air sparge.  Screens placed on suction side of pum p should be 16-mesh or coarser.  DO NOT place a screen in the recirculation line.  Use 50-mesh or coarser screens between t he pump and boom, and where required, at the nozzles.

For more information on spray equipment and calibration, consult sprayer manufacturers and state directions. For specific local directions and spray schedules, consult the current state agricultural directions.

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4.3 Application Volume and Spray Coverage  Thorough coverage is necessary to provide good disease control.  Avoid spray overlap, as crop injury may occur.  For aerial application, apply in a minimum of 2 gallons of water per acre unless specified otherwise on this label.  For ground application, apply in a minimum of 10 gallons of water per acre unless specified otherwise on this label.  Avoid application under conditions when uniform coverage cannot be obtained or when excessive spray drift may occur.

4.4 Mixing Directions  Prepare no more spray mixture than is required for the immediate operation.  Thoroughly clean spray application equipment before using this product.  Thoroughly agitate the spray solu tion before and during application.  Rinse spray tank thoroughly with clean wa ter after each day’s use and dispose of pesticide rinsate by application to an already treated area.

4.4.1 Miravis Era Alone  Add ½- ⅔ of the required amount of water to the spray or mixing tank.  With the agitator running, add Miravis Era to the tank.  Continue agitation while adding the remainder of the water.  Begin application of the spray solution after Miravis Era has completely dispersed into the mix water.  Maintain agitation until all of the mixture has been sprayed.  [Add tank-mix defoamer if needed.]  [Add a tank-mix compatibility agent and buffering agents when using with fertilizer suspensions.]

4.4.2 Tank-Mix Precautions It is the pesticide user’s responsibility to ensure that all products are registered for the intended use. Read and follow the applicable restrictions, limitations, and directions for use on all product labels involved in tank mixing. Users must follow the most restrictive directions for use and precautionary statements of each product in the tank mixture.

 Miravis Era can be tank-mixed with other fu ngicides, herbicides, insecticides, liquid fertilizers, adjuvants, and additives; however, not all combinations or environmental conditions have been tested.  To ensure against incompatibility and crop injury , it is advised to test the combinations on a small portion of the crop to be treated.  DO NOT mix Miravis Era with dodine containing products or crop injury may occur.

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4.4.3 Tank-Mix Compatibility Test A jar compatibility test is advised prior to tank mixing with other pesticides and/or adjuvants/additives, in order to ensure the compatibility of Miravis Era with other products, adjuvants or fertilizers. The advised procedure for conducting jar tank-mix compatibility tests is as follows:

Compatibility Test: Always perform a tank-mix compatibility test when mixing with new or unknown tank-mix partners before use. Use compatibility agents or buffering agents as per manufacturer label directions when using fertilizer suspensions as carrier. The following test assumes a spray volume of 25 gal/A. For other spray volumes, make appropriate changes in the components. Perform tank-mix compatibility test as follows:

1. Add 1 pt of carrier (either t he water or liquid fertilizer to be used in the spray operation) to each of two clear 1-qt jars with tight lids.

2. To one of the jars, add ¼ tsp or 1.2 ml of a commercially available tank-mix compatibility agent approved for this use (¼ tsp is equivalent to 2 pt/100 gallons of spray solution). Close the lid, invert the jar, shake or stir gently to ensure thorough mixing of the compatibility agent.

3. To both jars, add the appropriate amount of each tank-mix partner. If more than one tank-mix partner is to be used, follow the mixing order, add dry formulations (wettable powders or water dispersible granules) first, followed by liquid flowables, capsule suspensions, emulsifiable concentrates, and finally add adjuvants. After each addition, invert the jar, shake or stir gently to thoroughly mix. The appropriate amount of each tank-mix partner for this test, is as follows:

Dry formulations: For each pound to be applied per acre, add 1.5 level teaspoons to each jar.

Liquid formulations: For each pint to be applied per acre, add 0.5 teaspoon or 2.5 milliliters to each jar.

4. After adding all ingredients, cl ose the jars and tighten, then invert each jar 10 times to fully mix. Let the mixtures stand for 15-30 minutes and then assess by looking for separation, large flakes, precipitates, gels, heavy oily film on the jar, or other signs of incompatibility. Determine if a compatibility agent is needed in the spray mixture by comparing the two jars. If either mixture separates, but can be remixed readily, the mixture can be sprayed as long as good agitation is used. If the mixtures are incompatible, test the following methods of improving compatibility: (A) Pre-slurry dry formulations in water before addition to the jar, or (B) add the compatibility agent directly into liquid formulations, before addition to the jar. If these procedures are followed but incompatibility is still observed, DO NOT prepare the tank-mix in the spray tank.

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4.4.4 Miravis Era in Tank Mixtures  Add ½- ⅔ of the required amount of water to the spray or mixing tank.  Start the agitator before adding any tank-mix partners  When using in a tank-mix, add different fo rmulation types in the sequence indicated below.

1. products packaged in water-soluble packaging
2. wettable powders
3. wettable granules (dry flowables)
4. liquid flowables including Miravis Era
5. capsule suspensions
6. soluble liquids
7. emulsifiable concentrates
8. surfactants / adjuvants.  Allow each product to completely dissolve and disperse into the mix water before adding the next product. Continue agitation while the next product is added.  Continue agitation while adding the remainder of the water.  Begin application of the spray solution a fter all products have completely dispersed into the mix water.  Maintain agitation until all of the mixture has been sprayed.  [Add tank-mix defoamer if needed.]

4.4.5 Spray Additives  For some uses on this label, a spreading/penetrating type adjuvant such as a non- ionic surfactant, crop oil concentrate, silicone based, or blend must be added at the manufacturer’s advised rates.  For other crop uses, an adjuvant is advis ed. When an adjuvant is to be used with this product, the use of an adjuvant that meets the standards of the Council of Producers and Distributors of Agrotechnology (CPDA) certification program is advised.

4.5 Application through Irrigation Systems (Chemigation)

4.5.1 Application Directions for Overhead Irrigation Systems  Use only on crops for which chemi gation is specified on this label.  Use only with drive systems which pr ovide uniform water distribution.  DO NOT use end guns because of non-uniform application  Apply this product only through center-piv ot, solid-set, hand-move, or moving-wheel irrigation systems. DO NOT apply this product through any other type of irrigation system.  Crop injury, lack of effectiveness, or illegal pesticide residues in the crop can result from non-uniform distribution of treated water. If you have questions about calibration, contact state extension service specialists, equipment manufacturers, or chemigation experts.  DO NOT connect an irrigation system (including greenhouse systems) used for pesticide application to a public water system unless the pesticide label-prescribed

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safety devices for public water systems are in place.  A person knowledgeable of t he chemigation system and responsible for its operation, or under the supervision of the responsible person, shall shut the system down and make necessary adjustments should the need arise.  Chemical tank and injector system should be thoroughly cleaned and flushed with clean water prior to use.  DO NOT apply when winds are greater than 10 mph to avoid drift or wind skips.  DO NOT apply when wind speed favors drift beyond the area intended for treatment.  Thorough coverage of foliage is required for good control.  Good agitation should be maintained in the t ank during the entire application period.  Miravis Era has not been sufficiently tested via irrigation systems to determine product efficacy.  In general, best performance via irrigation is 0.1 to 0.25 inches of water per acre.

4.5.2 Center-Pivot Irrigation  Determine the size of the area to be treated.  Determine the time required to apply ⅛-½ inch of water over the area to be treated when the system and injection equipment are operated at normal pressures as specified by the equipment manufacturer. When applying Miravis Era through irrigation equipment, use the lowest obtainable water volume while maintaining uniform distribution. Run the system at 80-95% of the manufacturer’s rated capacity.  Using water, determine the injecti on pump output when operated at normal line pressure.  Determine the amount of Miravis Era requi red to treat the area covered by the irrigation system.  Add the required amount of Miravis Era and sufficient water to meet the injection time requirements for the solution tank.  Make sure the system is fully charged with wa ter before starting injection of the Miravis Era solution. Time the injection to last at least as long as it takes to bring the system to full pressure.  Maintain constant solution tank agitation during the injection period.  Continue to operate the system until the Miravis Era solution has cleared the last sprinkler head.

4.5.3 Solid-Set, Hand-Move, and Moving-Wheel Irrigation

 Determine the acreage covered by the sprinklers.  Fill injector solution tank with water and adjus t flow rate to use the contents over a 20 to 30-minute interval. When applying Miravis Era through irrigation equipment use the lowest obtainable water volume while maintaining uniform distribution.  Determine the amount of Miravis Era needed to treat the area covered by the irrigation system.  Add the required amount of Miravis Era into the same quantity of water used to calibrate the injection period.  Operate the system at the same pressure and time interval established during the calibration.  Stop injection equipment after treatment is completed. Continue to operate the system

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until the Miravis Era solution has cleared the last sprinkler head.

4.5.4 Operating Instructions for Chemigation

1. The system must contain a functional check va lve, vacuum relief valve, and low pressure drain appropriately located on the irrigation pipeline to prevent water-source contamination from backflow.
2. The pesticide injection pipeline must contai n a functional, automatic, quick-closing check valve to prevent the flow of fluid back toward the injection pump.
3. The pesticide injection pipeline must also contain a functional, normally closed, solenoid- operated valve located on the intake side of the injection pump and connected to the system interlock to prevent fluid from being withdrawn from the supply tank when the irrigation system is either automatically or manually shut down.
4. The system must contain functional interlo cking controls to automatically shut off the pesticide injection pump when the water pump motor stops.
5. The irrigation line or water pump must include a functional pressure switch which will stop the water pump motor when the water pressure decreases to the point where pesticide distribution is adversely affected.
6. Systems must use a metering pump, such as a positive displacement injection pump (e.g., diaphragm pump) effectively designed and constructed of materials that are compatible with pesticides and capable of being fitted with a system interlock.
7. DO NOT apply when wind speed favors drift beyond the area intended for treatment.

Allow sufficient time for pesticide to be flushed through all lines and all nozzles before turning off irrigation water.

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4.5.5 Specific Instructions for Public Water Systems

1. Public water system means a system for t he provision to the public of piped water for human consumption if such system has at least 15 service connections or regularly serves an average of at least 25 individuals daily at least 60 days out of the year.
2. Chemigation systems connec ted to public water systems must contain a functional, reduced-pressure zone (RPZ), back-flow preventer or the functional equivalent in the water supply line upstream from the point of pesticide introduction. As an option to the RPZ, the water from the public water system should be discharged into a reservoir tank prior to pesticide introduction. There shall be a complete physical break (air gap) between the flow outlet end of the fill pipe and the top or overflow rim of the reservoir tank of at least twice the inside diameter of the fill pipe.
3. The pesticide injection pipeline must contai n a functional, automatic, quick-closing check valve to prevent the flow of fluid back toward the injection pump.
4. The pesticide injection pipeline must c ontain a functional, normally closed, solenoid- operated valve located on the intake side of the injection pump and connected to the system interlock to prevent fluid from being withdrawn from the supply tank when the irrigation system is either automatically or manually shut down.
5. The system must contain functional interlo cking controls to automatically shut off the pesticide injection pump when the water pump motor stops, or in cases where there is no water pump, when the water pressure decreases to the point where pesticide distribution is adversely affected.
6. Systems must use a metering pump, such as a positive displacement injection pump (e.g., diaphragm pump) effectively designed and constructed of materials that are compatible with pesticides and capable of being fitted with a system interlock.
7. DO NOT apply when wind speed favors drift beyond the area intended for treatment

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5.0 ROTATIONAL CROP RESTRICTIONS The following crops may be planted at the specified interval following application of Miravis Era: Crop, Crop Group, or Crop Subgroup Plant-Back Interval Beans – Specified Dry and Succulent Beans as follows; Lupinus spp. (Grain Lupin, Sweet Lupin, White Lupin, White Sweet Lupin); Phaseolus spp. (Kidney Bean, Lima Bean (dry and succulent), Navy Bean, Pinto Bean, Tepary beans); Vigna spp. (Blackeyed Pea, Cowpea (except for cowpea grown for animal feed), Crowder Pea, Moth Bean, Mung Bean, Rice Bean, Southern Pea, Urd Bean, Dry Broad Bean); Chickpea (Garbanzo Bean); Lentils, Guar, Lalab Bean, Pisum spp. (Pea, including field pea and Pidgeon pea) Berry, Low growing Crop subgroup 13-07G (except cranberry and strawberry) Bushberry Crop Subgroup 13-07B Cereals (barley, oats, wheat, triticale, rye) Corn (field, pop, and grown for seed) Corn, sweet Cotton Cucurbit Vegetables (Crop Group 9) Peanut Rapeseed (Crop Subgroup 20A (canola)) Soybean Sugar Beet 0 days Alfalfa (Crop Group 18) Brassica Leafy Greens (Crop Subgroup 4-16B) Bulb Vegetables (Crop Group 3-07) Fruiting Vegetables (Crop Group 8-10) Garden beets Grasses Grown for Seed (Cool season grasses only) Leaf Petiole Vegetables (Crop Subgroup 22B) Leafy Greens (Crop Subgroup 4-16A) Mustard Greens Leaves of Root and Tuber Vegetables Peppers Pome Fruit (Crop Group 11-10) Potato Quinoa Rice Root Vegetables (Crop Subgroup 1B) Sorghum Stone Fruit (Crop Group 12-12) 30 days

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Strawberry Succulent or dry peas not listed above Sunflower (Crop Subgroup 20B) Root & Tuberous Vegetables (Crop Group 1) not listed above Tobacco Tomatoes Tree Nuts (Crop Group 14-12) All other crops Intended for Food and Feed 365 days

6.0 RESTRICTIONS AND PRECAUTIONS

6.1 Use Restrictions  DO NOT apply through any ultra-low volume (ULV) spray system.  DO NOT apply to plants grown for transplanting purposes.  DO NOT use in greenhouses.  DO NOT use as a tree injection.  DO NOT apply in a manner that will result in exposure to humans or animals.

6.2 Use Precautions  Under certain conditions conducive to extended infection periods, use another registered fungicide for additional applications if maximum amount of Miravis Era has been used.  If isolates resistant to Gr oup 7 or 3 fungicides are present, efficacy can be reduced for certain diseases.  The higher rates in the rate range and/or shorter spray intervals may be required under conditions of heavy infection pressure, with highly susceptible varieties, or when environmental conditions are conducive to disease.

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6.3 Spray Drift Management SPRAY DRIFT MANAGEMENT

 DO NOT apply when conditions favor drift beyond the target area.  Applicators must follow all state and local pe sticide drift requirements regarding application of this product. Where states have more stringent regulations, they must be observed.  The interaction of many equipment- and weat her-related factors determines the potential for spray drift.  DO NOT apply when the wind speed is greater than 10 mph or during periods of temperature inversions.  DO NOT apply when weather conditions favor drift from treated areas to non-target aquatic habitat.  Avoid spray overlap, as crop injury may occur.

Aerial Applications  DO NOT release spray at a height greater than 10 ft above the vegetative canopy unless a greater application height is necessary for pilot safety.  The boom length must not exceed 75% of the wingspan for airplanes or 75% of the rotor blade diameter for helicopters.  Applicators must use ½ swath displacement upwind at the downwind edge of the field.  Nozzles must be oriented so the spray is directed toward the back of the aircraft.

Ground Applications  Apply with the nozzle height advised by the manufacturer, but no more than 3 feet above the ground or crop canopy unless making a pasture or rangeland application, in which case applicators may apply with a nozzle height no more than 4 feet above the ground.  For all other applications, applic ators are required to use a medium or coarser droplet size (ASABE S572.1).

6.4 Spray Drift Advisories THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE SPRAY DRIFT. BE AWARE OF NEARBY NON-TARGET SITES AND ENVIRONMENTAL CONDITIONS.

6.4.1 Importance of Droplet Size  An effective way to reduce spray drift is to apply large droplets. Use the largest droplets that provide target pest control. While applying larger droplets will reduce spray drift, the potential for drift will be greater if applications are made improperly or under unfavorable environmental conditions.

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6.4.2 Controlling Droplet Size – Ground Application

 Volume – Increasing the spray volume so that larger droplets are produced will reduce spray drift. Use the highest practical spray volume for the application. If a greater spray volume is needed, consider using a nozzle with a higher flow rate.  Pressure – Use the lowest spray pressure recommended for the nozzle to produce the target spray volume and droplet size.  Spray Nozzle – Use a spray nozzle that is designed for the intended application. Consider using nozzles designed to reduce drift.

6.4.3 Controlling Droplet Size – Aerial Application  Adjust Nozzles – Follow nozzle manufacturers’ recommendations for setting up nozzles. Generally, to reduce fine droplets, nozzles should be oriented parallel with the airflow in flight.

6.4.4 Boom Height – Ground Application

 For ground equipment, the boom should remain level with the crop and have minimal bounce.

6.4.5 Release Height – Aerial Application  Higher release heights increase the potential for spray drift. 6.4.6 Shielded Sprayers

 Shielding the boom or indi vidual nozzles can reduce spray drift. Consider using shielded sprayers. Verify that the shields are not interfering with the uniform deposition of the spray on the target area.

6.4.7 Temperature and Humidity

 When making applications in hot and dry condi tions, use larger droplets to reduce effects of evaporation.

6.4.8 Temperature Inversions

 Drift potential is high during a temperature inversion.  Temperature inversions are characterized by increasing temperatures with altitude and are common on nights with limited cloud cover and light to no wind.  The presence of an inversion can be indica ted by ground fog or by the movement of smoke from a ground source or an aircraft smoke generator. Smoke that layers and moves laterally in a concentrated cloud (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates, indicates good vertical air mixing.

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6.4.9 Wind and Rain

 Drift potential generally increases with win d speed and is lowest when wind speeds are 10 mph or less. However, many factors, including droplet size, pressure, and equipment type determine drift potential at any given wind speed. Note: Local terrain can influence wind patterns. Leave a 25-foot buffer downwind of the application to avoid drift to non-target areas.  AVOID APPLICATIONS DURING GUSTY WIND CONDITIONS.  Applicators need to be familiar with local wi nd patterns and terrain that could affect spray drift.  DO NOT apply less than an hour prior to a rainfall event.

6.4.10 Handheld Technology Applications  Take precautions to mi nimize spray drift.

6.4.11 Non-Target Areas

DO NOT apply this pesticide when the product may drift to non-target areas (i.e. residential areas, bodies of water, known habitat for threatened or endangered species, non-target crops).

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7.0 CROP USE DIRECTIONS 7.1 Cereals Grains Crops (Including cultivars, varieties, and/or hybrids of these) (Not registered for use in California) Barley Oats Rye Triticale Wheat Target Disease Rate (fl oz/A) Application Timing Use Directions Control of Diseases: Barley scald (Rhynchosporium secalis) Black point (C. sativus, Alternaria spp.) Ergot (Claviceps purpurea) Fusarium head blight (Fusarium spp.) Helminthosporium leafspot (Dreschlera avenae) Powdery mildew (Blumeria graminis) Leaf and glume blotch (Stagonospora nodorum) Net blotch (Pyrenophora teres) Rust (Puccinia spp.) Septoria blotch (S. tritici) Spot blotch (Cochliobolus sativus) Tan spot (Pyrenophora tritici- repentis) 8.3 – 10.2*

Apply between Feekes growth stage 10.3 (50% head emergence from the boot, BBCH 55) and 10.5.2 (mid anthesis to full flowering, BBCH 65) for optimal disease control and plant health benefits.

For best results apply when all or most heads are fully emerged, (feekes 10.5) and use spray nozzles configured to provide thorough coverage of the head.

(See growth stage descriptions below). Apply by ground, air, or chemigation.

An adjuvant may be added at labeled rates.

Use spray nozzles configured to provide thorough coverage of the head.

[Optional language if label has a rate range: If disease pressure is high, use the highest rate.]

[Optional language if label has a single rate and interval range: If disease pressure is high, use the shortest interval.]

[Optional language if label has a rate range and interval range: If disease pressure is high, use the shortest interval and highest rate.]

[Optional language: If conditions persist for heavy disease pressure after application, make a second application 14 days later.] Control of Leaf Diseases: Barley scald (Rhynchosporium secalis) Black point (C. sativus, Alternaria spp.) Helminthosporium leafspot (Dreschlera avenae) Powdery mildew (Blumeria graminis) Leaf and glume blotch (Stagonospora nodorum) Net blotch (Pyrenophora teres) Ramularia leaf spot 8.3 – 10.2* Protecting the flag leaf is important for optimal disease control and plant health benefits.

For control of diseases on the flag leaf, apply from Feekes 8 (BBCH 37) through feekes 10.3 (BB55).

(See growth stage descriptions below).

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(Ramularia collo-cygni) Rust (Puccinia spp.) Septoria blotch (S. tritici) Spot blotch (Cochliobolus sativus) Tan spot (Pyrenophora tritici- repentis) Early-season diseases: Leaf blotch (Stagnospora nodorum) Powdery mildew (Blumeria graminis) Septoria blotch (S. tritici) Tan spot (Pyrenophora tritici- repentis) Rusts (Puccinia spp.) Eye spot (Tapsia spp.) 8.3 – 10.2* Apply prior to disease development.

Apply after first tiller visible to just prior to flag leaf emergence (Feekes 2 to 7, BBCH 21 – 36) for suppression of early season diseases and plant health benefits.

(See growth stage descriptions below). *8.3 fl oz product/A is equivalent to 0.112 lb ai pydiflumetofen/A and 0.112 lb ai prothioconazole/A. 10.2 fl oz product/A is equivalent to 0.134 lb ai pydiflumetofen/A and 0.134 lb ai prothioconazole/A.

Feekes Growth Stage and BBCH description: Feekes 2 to 5 / BBCH 21 to 30 – tillering. Feekes 6 to 7 / BBCH 31 to 36 – 1st node to just prior to visible flag leaf. Feekes 8 to 10 / BBCH 37 to 45 – flag leaf emerging to swollen boot. Feekes 10.3 / BBCH 55 – head 50% emerged from boot. Feekes 10.5 to 10.52 / BBCH 61 to 65 – full head emergence, to mid-anthesis, full flowering. Feekes 10.5.4 / BBCH 71 – post flowering (kernel watery ripe). Precaution:  Under certain environmental conditions, tank mixes of Miravis Era plus herbicides and/or fertilizers may cause crop injury. Resistance Management:  Refer to Section 3.2.  DO NOT make more than two applications of Miravis Era or other Group 7 and 3 fungicides before alternation with a fungicide that is not in Group 7 or 3. USE RESTRICTIONS

1. Refer to Section 6.1 for additional product use restrictions.
2. Maximum Single Application Rate: a. Forage and Hay: DO NOT exceed the maximum rate listed in the table. b. Grain: DO NOT exceed the maximum rate listed in the table.
3. Maximum Number of Applications per Year: a. Forage and Hay: DO NOT make more than 1 application per year. b. Grain: DO NOT make more than 1 application at the maximum rate per year
4. Minimum Application Interval: 14 days
5. Maximum Annual Rate: a. Forage and Hay: 10.2 fl oz/A (equivalent to 0.134 lb ai pydiflumetofen and 0.134 lb ai prothioconazole). b. DO NOT apply more than 0.134 lb ai/A/year of pydiflumetofen-containing products. c. DO NOT apply more than 0.293 lb ai/A/year of prothioconazole-containing products. d. Grain: 20.4 fl oz/A/year (equivalent to 0.268 lb ai pydiflumetofen and 0.268 lb ai

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prothioconazole). e. DO NOT apply more than 0.31 lb ai/A/year of pydiflumetofen-containing products. f. DO NOT apply more than 0.293 lb ai/A/year of prothioconazole-containing products. 6) Pre-harvest Interval (PHI): a. Forage and Hay: 14 days b. Grain: DO NOT apply after Feekes 10.5.4 (kernel watery ripe), or 32 days prior to harvest.

8.0 STORAGE AND DISPOSAL

STORAGE AND DISPOSAL

DO NOT contaminate water, food or feed by storage or disposal.

Pesticide Storage Keep this product in its tightly closed original container, when not in use. Store in a cool, dry (preferably locked) area that is inaccessible to children and animals.

Pesticide Disposal Pesticide wastes may be hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of federal law. If these wastes cannot be disposed of by use according to label instructions, contact your state pesticide or environmental control agency, or the hazardous waste representative of the nearest EPA regional office for guidance.

Container Handling (less than or equal to 5 gallons) Non-refillable container. DO NOT reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures approved by state and local authorities.

Container Handling (greater than 5 gallons) Non-refillable container. DO NOT reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank. Fill the container ¼ full with water. Replace and tighten closures. Tip container on its side and roll it back and forth, ensuring at least one complete revolution, for 30 seconds. Stand the container on its end and tip it back and forth several times. Turn the container over onto its other end and tip it back and forth several times. Empty the rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Repeat this procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures approved by state and local authorities.

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Container Handling (greater than 5 gallons) Refillable container. Refill this container with pesticide only. DO NOT reuse this container for any other purpose. Cleaning the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling is the responsibility of the person refilling. To clean container before final disposal, empty the remaining contents from this container into application equipment or mix tank. Fill the container about 10 percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this rinsing procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures approved by state and local authorities.

CONTAINER IS NOT SAFE FOR FOOD, FEED OR DRINKING WATER.

9.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY

NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of Warranty and Liability before buying or using this product. If the terms are not acceptable, return the product at once, unopened, and the purchase price will be refunded.

The Directions for Use of this product must be followed carefully. It is impossible to eliminate all risks inherently associated with the use of this product. Crop injury, ineffectiveness or other unintended consequences may result because of such factors as manner of use or application, weather or crop conditions, presence of other materials or other influencing factors in the use of the product, which are beyond the control of SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by applicable law, Buyer and User agree to hold SYNGENTA and Seller harmless for any claims relating to such factors.

SYNGENTA warrants that this product conforms to the chemical description on the label and is reasonably fit for the purposes stated in the Directions for Use, subject to the inherent risks referred to above, when used in accordance with directions under normal use conditions. To the extent permitted by applicable law: (1) this warranty does not extend to the use of the product contrary to label instructions, or under conditions not reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer and User assume the risk of any such use. TO THE EXTENT PERMITTED BY APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL.

To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any incidental, consequential or special damages resulting from the use or handling of this product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF SYNGENTA

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AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION OF SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT.

SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be modified except by written agreement signed by a duly authorized representative of SYNGENTA.

10.0 APPENDIX 10.1 Miravis Era Rate Conversion Chart (for use with Section 7.0) Fl oz Product/A Pydiflumetofen Lb ai/A Prothioconazole Lb ai/A Acres Treated per gallon 8.3 0.112 0.112 15.4 10.2 0.134 0.134 12.6

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10.2 [Optional Table] Miravis Era Use Summary Table IMPORTANT: The table below is a summary of the Crop Use Directions for Miravis Era. However, it is important for the user to read and follow the complete instructions contained within this label.

Crop or Crop Group or Subgroup, with examples Maximum Rate per Application (fl oz/A) Minimum Application Interval (days) Pre-Harvest Interval (PHI) Maximum Rate per Year (fl oz/A) Cereal Grains (grain): barley, wheat, oats, rye 10.2 14 32 days 20.4 Cereal Grains (forage/hay): barley, wheat, oats 10.2 14 14 days 10.2

ADEPIDYN®, Miravis®, the ALLIANCE FRAME the SYNGENTA Logo and the PURPOSE ICON are Trademarks of a Syngenta Group Company

Viton™ is a trademark of The Chemours Company FC, LLC

©20XX Syngenta For non-emergency (e.g. current product information), call Syngenta Crop Protection at 1-866-796-4368.

Manufactured for: Syngenta Crop Protection, LLC P.O. Box 18300 Greensboro, North Carolina 27419-8300

Miravis Era XXXX MAS NEW-E 0923-CL – ep – 9-9-25 000100-0XXXX.20230928E.MIRAVIS_ERA-NEW-0923-CL