crop-chem-docs/corpus/epa_ppls/228-728.md

AZURE XTRA FUNGICIDE

• EPA Reg No: 228-728
• Registrant: NUFARM AMERICAS, INC.
• Signal word: Caution
• Active ingredients: Azoxystrobin (18.2%); Cyproconazole (7.3%)
• Label accepted: 2022-02-02
• Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000228-00728-20220202.pdf

---

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, DC 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION February 2, 2022

Danielle A. Larochelle Regulatory Manager Nufarm Americas, Inc. 11901 S. Austin Avenue Alsip, IL 60803

Subject: Registration Review Label Mitigation for Azoxystrobin and Cyproconazole Product Name: Azure Xtra Fungicide EPA Registration Number: 228-728 Application Dates: 7/5/2019; 1/6/2021 Decision Numbers: 552860; 569426

Dear Ms. Larochelle:

The Agency, in accordance with the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), as amended, has completed reviewing all the information submitted with your application to support the Registration Review of the above referenced product in connection with the Azoxystrobin and Cyproconazole Interim Decisions, and has concluded that your submission is acceptable. The label referred to above, submitted in connection with registration under FIFRA, as amended, is acceptable.

Should you wish to add/retain a reference to the company’s website on your label, then please be aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide Act and is subject to review by the Agency. If the website is false or misleading, the product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from those claims approved through the registration process. Therefore, should the Agency find or if it is brought to our attention that a website contains false or misleading statements or claims substantially differing from the EPA approved registration, the website will be referred to the EPA’s Office of Enforcement and Compliance.

A stamped copy of your labeling is enclosed for your records. This labeling supersedes all previously accepted labeling. You must submit one copy of the final printed labeling before you release the product for shipment with the new labeling. In accordance with 40 CFR 152.130(c), you may distribute or sell this product under the previously approved labeling for 12 months from the date of this letter. After 12 months, you may only distribute or sell this product if it bears this new revised labeling or subsequently approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its implementing regulation at 40 CFR 152.3.

Page 2 of 2 EPA Reg. No. 228-728 Decision No. 552860; 569426

If you have any questions about this letter, please contact Jaclyn Pyne by phone at 202-566- 2326, or via email at pyne.jaclyn@epa.gov .

Sincerely,

Linda Arrington, Branch Chief Risk Management and Implementation Branch 4 Pesticide Re-Evaluation Division Office of Pesticide Programs

Enclosure

000228-00728.20210427.Reg Review Label CYPROCONAZOLE GROUP 3 FUNGICIDE AZOXYSTROBIN GROUP 11 FUNGICIDE AZURE¥¥Xtra Fungicide Broad-spectrum fungicide for control of plant diseases [ Alternate Brand Name: NUP-14035 Fungicide ] ACTIVE INGREDIENTS Azoxystrobin (CAS No. 131860-33-8)............................................................................................... 18.2% Cyproconazole (CAS No. 94361-06-5) ............................................................................................... 7.3% OTHER INGREDIENTS .................................................................................................................... 74.5% TOTAL ........................................................................................................................................... 100.0% Azure Xtra Fungicide is a 280SC formulation that contains 0.67 lb cyproconazole and 1.67 lb azoxystrobin per gallon KEEP OUT OF REACH OF CHILDREN CAUTION See Label Booklet for [First Aid and] Precautionary Statements For Chemical Spill, Leak, Fire, or Exposure, Call CHEMTREC (800) 424-9300 For Medical Emergencies Only, Call (877) 325-1840 EPA Reg. No. 228-728 EPA Est. No. ___________ MANUFACTURED FOR NUFARM AMERICAS INC. 11901 S. AUSTIN AVENUE ALSIP, IL 60803 NET CONTENTS: Gallons ( Liters) [Designation as “NONREFILLABLE” or “REFILLABLE” for containers > 5 GAL] [Grow a Better Tomorrow] [Nufarm Grow a Better Tomorrow] Feb 02, 2022 228-728

Page 2 of 14

FIRST AID IF SWALLOWED x Call a poison control center or doctor immediately for treatment advice. x Have person sip a glass of water if able to swallow. x Do not induce vomiting unless told to do so by the poison control center or doctor. x Do not give anything by mouth to an unconscious person. IF IN EYES x Hold eye open and rinse slowly and gently with water for 15-20 minutes. x Remove contact lenses, if present, after th e first 5 minutes, then continue rinsing eye. x Call a poison control center or doctor for treatment advice. IF ON SKIN OR CLOTHING x Take off contaminated clothing. x Rinse skin immediately with plenty of water for 15-20 minutes. x Call a poison control center or doctor for treatment advice. IF INHALED x Move person to fresh air x If person is not breathing, call 911 or an am bulance, then give artificial respiration, preferably mouth to mouth, if possible. x Call a poison control center or doctor for future treatment advice. HOTLINE NUMBER Have the product container or label with you when calling a poison control center or doctor, or going for treatment. You may also contact (877) 325-1840 for emergency medical treatment information.

PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS CAUTION Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. PERSONAL PROTECTIVE EQUIPMENT (PPE) All handlers must wear: x Long-sleeved shirt and long pants x Waterproof gloves x Shoes plus socks In addition, mixers/loaders/applicators using mechanically pressurized handwands must wear: x A minimum of a NIOSH-approved particulate filtering fa cepiece respirator with any N, R or P filter; OR a NIOSH-approved elastomeric partic ulate respirator with any N, R or P filter; OR a NIOSH-approved powered air purifying respirator with HE filters. Human flagging is prohibited. Follow the manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. Engineering Controls When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for ag ricultural pesticides [40 CFR 170.240(d)(4-6)], the handler PPE requirements may be reduced or modified as specified in the WPS. Respirator fit testing, medical qualification, and training Using a program that conforms to OSHA's requirements (see 29 CFR Part 1910.134), employers must verify that any handler who uses a respirator is: • Fit-tested and fit-checked, • Trained, and • Examined by a qualified medical practitioner to ensure physical ability to safely wear the style of respirator to be worn. A qualified medical practitioner is a physi cian or other licensed health care professional who will evaluate the ability of a worker to wear a respirat or. The initial evaluation consists of a questionnaire that asks about medical conditions (such as a heart co ndition) that would be problematic for respirator use. If concerns are identified, then additional evaluations, such as a physical exam, might be necessary. The initial evaluation must be done before respir ator use begins. Handlers must be reexamined by a qualified medical practitioner if their health status or respirator style or use conditions change.

Page 3 of 14 Upon request by local/state/federal /tribal enforcement personnel, employers must provide documentation demonstrating how they have complied with these requirements.

USER SAFETY RECOMMENDATIONS Users should: x Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. x Remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. ENVIRONMENTAL HAZARDS Azoxystrobin is toxic to freshwater, estuarine/marine fi sh and aquatic invertebrates. Azoxystrobin can be persistent for several months or longer. For terrestrial uses: do not apply directly to water, or to areas where surface water is present, or to intertidal areas below the mean high water ma rk. Drift and runoff may be hazardous to aquatic organisms in water adjacent to treated areas. Do not contaminate water when disposing of equipment wash-water or rinsate. Ground Water Advisory Azoxystrobin, a degradate of azoxyst robin, and cyproconazole are known to leach through soil to ground water under certain conditions as a result of label use. This chemical may leach into ground water if used in areas where soils are permeable, particularly where the water table is shallow. Surface Water Advisory This product may impact surface water quality due to runoff of rain water. This is especially true for poorly draining soils and soils with shallow ground water. Th is product is classified as having a high potential for reaching surface water via runoff for several months or more after application. A level, well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the pote ntial loading of azoxystrobin and a degradate of azoxystrobin from runoff water and sediment. Runo ff of this product will be reduced by avoiding applications when rainfall or irrigation is expected to occur within 48 hours. Notify state and/or federal authorit ies and Nufarm immediately if you observe any adverse environmental effects due to use of this product. DIRECTIONS FOR USE It is a violation of federal law to use this product in a manner inconsistent with its labeling. FAILURE TO FOLLOW THE USE DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY RESULT IN PLANT INJURY OR POOR DISEASE CONTROL. Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. For any requirements specific to your state or tribe, consult the agency responsible for pesticide regulation. AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Prot ection Standard, 40 CFR Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and em ergency assistance. It also contains specific instructions and exceptions pertaining to the stat ements on this label about personal protective equipment ( PPE), notification to workers, and restricted-entry interval. The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard. Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil or water is: x Coveralls x Waterproof gloves x Shoes plus socks

Page 4 of 14 PRODUCT INFORMATION This product is a broad spectrum, preventative fu ngicide with systemic and curative properties recommended for the control of many important plant diseases. Applications may be made as foliar sprays in alternating spray programs or in tank mixes with ot her crop protection products. All applications must be made according to the use directions that follow. USE PRECAUTIONS Under certain conditions conducive to extended infect ion periods, use another registered fungicide for additional applications if the maximum amount of product has been applied. The active ingredients in this product may have ef fects on federally listed threatened and endangered species or critical habitat in some counties. Wh en using this product, you must follow the measures contained in the County Bulletin for the county in which you are applying the pesticide. To determine whether your County has a Bulletin consult http://128.104.224.199/espp_front/view.jsp. Bulletins also may be available from local pesticide dealers, extension offices, or state pesticide agencies. RESTRICTIONS Do not use in nurseries, greenhouses or landscape plantings. Rotational Crop Restrictions The following crops may be planted at the specified interval following application of this product.

Crop Plantback Interval Soybean Corn Wheat 0 Days Cereal grains other than wheat Cotton 180 Days All other crops (including leafy vegetables 270 Days

PHYTOTOXICITY This product is extremely phytotoxic to certain apple and crabapple varieties. AVOID SPRAY DRIFT. Extreme care must be used to prevent injury to apple and crabapple trees (and fruit). Refer to SPRAY DRIFT MANAGEMENT information below. Do not spray this product where spray drift may reach apple and crabapple trees. Do not spray apple and crabapple trees with spray equipment previously used to apply this product. Even trace amounts of this product may cause unacceptab le phytotoxicity to certain apple and crabapple varieties. This product demonstrates some phytotoxic effects when mixed with products that are formulated as ECs. These effects are enhanced if applications are made under cool, cloudy conditions and these conditions remain for several days following application. In addition, adjuvants that contain some form of silicone can contribute to phytotoxicity. Under certain environmental conditions, tank mixes of this product plus herbicides and/or fertilizers may cause crop injury.

Page 5 of 14 SPRAY DRIFT MANAGEMENT

SPRAY DRIFT Aerial Applications x Do not release spray at a height greater than 10 feet above the ground or crop canopy, unless a greater application height is necessary for pilot safety. x Applicators are required to select nozzles that deliver medium to coarse spray droplets in accordance with ASABE Standard S-572.1. x Do not apply when wind speed exceeds 15 mph at the application site. If the windspeed is greater than 10 mph, the boom length must be 65% or less of the wingspan for fixed wing aircraft and 75% or less of the rotor diameter for helicopters. Otherwise, the boom length must be 75% or less of the wingspan for fixed-wing aircraft and 90% or less of the rotor diameter for helicopters. x Applicators must use ½ swath displacement upwind at the downwind edge of the field. x Do not apply during temperature inversions. Ground Boom Applications x User must only apply with the release height recommended by the manufacturer, but no more than 4 feet above the ground or crop canopy. x Applicators are required to use a medium or coarser droplet size (ASABE S572.1). x Do not apply when wind speeds exceed 15 mph at the application site. x Do not apply during temperature inversions. SPRAY DRIFT ADVISORIES THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE SPRAY DRIFT. BE AWARE OF NEARBY NON-TARGET SITES AND ENVIRONMENTAL CONDITIONS. IMPORTANCE OF DROPLET SIZE An effective way to reduce spray drift is to apply large droplets. Use the largest droplets that provide target pest control. While applying larger droplets will redu ce spray drift, the potential for drift will be greater if applications are made improperly or under unfavorable environmental conditions. Controlling Droplet Size – Ground Boom x Volume - Increasing the spray volume so that larger droplets are produced will reduce spray drift. Use the highest practical spray volume for the application. If a greater spray volume is needed, consider using a nozzle with a higher flow rate. x Pressure - Use the lowest spray pressure recommended for the nozzle to produce the target spray volume and droplet size. x Spray Nozzle - Use a spray nozzle that is designed for the intended application. Consider using nozzles designed to reduce drift. Controlling Droplet Size – Aircraft x Adjust Nozzles - Follow nozzle manufacturers ’ recommendations for settin g up nozzles. Generally, to reduce fine droplets, nozzles should be oriented parallel with the airflow in flight. BOOM HEIGHT – Ground Boom For ground equipment, the boom should remain level with the crop and have minimal bounce. RELEASE HEIGHT – Aircraft Higher release heights increase the potential for spray drift. SHIELDED SPRAYERS Shielding the boom or individual nozzles can reduce spray drift. Consider using shielded sprayers. Verify that the shields are not interfering with the uniform deposition of the spray on the target area. TEMPERATURE AND HUMIDITY When making applications in hot and dry conditions, use larger droplets to reduce effects of evaporation. TEMPERATURE INVERSIONS Drift potential is high during a temperature invers ion. Temperature inversions are characterized by increasing temperature with altitude and are common on nights with limited cloud cover and light to no wind. The presence of an inversion can be indicated by ground fog or by the movement of smoke from a ground source or an aircraft smoke generator. Smoke that layers and moves laterally in a concentrated cloud

Page 6 of 14 (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates indicates good vertical air mixing. Avoid applications during temperature inversions. WIND Drift potential generally increases with wind speed. AVOID APPLICATIONS DURING GUSTY WIND CONDITIONS. Applicators need to be familiar with local wind patterns and terrain that could affect spray drift. RESISTANCE MANAGEMENT

For resistance management, please note that AZURE ¥ XTRA Fungicide contains both a Group 3 (cyproconazole) and Group 11 (azoxystrobin) fungicid e. Any fungal population may contain individuals naturally resistant to AZURE ¥ XTRA Fungicide and other Group 3 or Group 11 fungicides. A gradual or total loss of pest control may occur over time if th ese fungicides are used repe atedly in the same fields . Appropriate resistance-management strategies should be followed. The following steps may delay the development of fungicide resistance:  Rotate the use of this product or other Group 3 and 11 fungicides within a growing season sequence with different groups that control the same pathogens.  Use tank mixtures with fungicides from a different group that are effective on the target pest when such use is permitted. Use at least the minimum application rate as labeled by the manufacturer.  Adopt an integrated disease management program for fungicide use that includes scouting, uses historical information related to pesticide use , and crop rotation, and which considers host plant resistance, impact of environmental conditions on disease development, disease thresholds , as well as cultural, biological and other chemical control practices.  Where possible, make use of predictive disease models to effectively time fungicide applications . Note that using predictive models alone is not sufficient to manage resistance.  Monitor treated fungal populations for resistance development.  Contact your local extension specialist or certified crop advisor for any additi onal pesticide resistance management and/or IPM recommendations for specific crops and pathogens.  For further information or to report suspected resistance, contact Nufarm Americas Inc. at (855) 280- 6609. You can also contact your pesticide distribu tor or university extension specialist to report resistance. Follow crop specific recommendations that limit the total number of sprays on a crop and the required rotation with fungicides from other resistance management groups. In situations requiring multiple sprays (more than two), develop season long spray programs for Group 11 (QoI) fungicides. The program should meet the goal of no more than 1/3 of the total sprays per season, when a Group 11 fungicide is used as a solo product, or 1/2 the total sprays when a Group 11 fungicide is used in a mixture. Programs that include both solo Group 11 products and/or mixes containing Group 11 products should be no more than 1/2 the total sprays. Avoid rotating or tank mixing this product with any fungicide to which resistance has already developed. PRODUCT USE INSTRUCTIONS INTEGRATED PEST (DISEASE) MANAGEMENT Use this product as part of an integrated disease and pest management strategy whenever the use of a fungicide is needed. Follow cultural practices known to help reduce disease development. The CROP SPECIFIC USE DIRECTIONS section in this label identifies specif ic IPM recommendations for each crop. Consult your local agricultural authorities for additiona l IPM strategies established for your area. This product may be used in State Agricultural Extensio n advisory (disease forecasting) programs which recommend application timing based on environmental factors favorable for disease development. SPRAY EQUIPMENT Equip sprayers with nozzles that provide accurate and uniform application. Be certain that nozzles are the same size and uniformly spaced across the boom. Calibrate sprayer before use.

Page 7 of 14 Use a pump with capacity to: (1) maintain at least 35 -40 psi at nozzles, and (2) provide sufficient agitation in tank to keep mixture in suspension - this requires recirculation of 10% of tank volume per minute. Use a jet agitator or liquid sparge tube for agitation. Do not air sparge. This product is a suspoemulsion concentrate. It is suggested that screens be used to protect the pump and to prevent nozzles from clogging. Screens placed on suction side of pump should be 16-mesh or coarser. Do not place a screen in the recirculation line. Us e 50-mesh or coarser screens between the pump and boom, and where required, at the nozzles. Check nozzle manufacturer’s recommendations. For more information on spray equipment and cali bration, consult sprayer manufacturers and state recommendations. For specific local directions and spray schedules, consult the current state and local agricultural recommendations. SPRAYING/MIXING This product may be applied with all types of spra y equipment commonly used for ground and aerial applications. Do not apply this product through any type of ultra low volume (ULV) spray system. Proper adjustments and calibration of spraying equipment to give good canopy penetration and coverage is essential for good disease control. Higher rates in the rate range and/or shorter spray intervals may be required under conditions of heavy infection pressure, highly susceptible varieties, or when environmental conditions conducive to disease exist. For ground applications, apply this product in a mi nimum of 10 gallons of water volume for adequate coverage and canopy penetration. For aerial applications, follow local recommendations. Prepare no more spray mixture than is required for immediate use. Thoroughly clean spray equipment before using this product. Agitate the spray soluti on before and during application. Rinse spray tank thoroughly with clean water after each day’s use and dispose of pest icide rinsate by appli cation to an already treated area. AZURE XTRA Alone Add 1/2 - 2/3 of the required amount of water to a spra y or mixing tank. With the agitator running, add this product to the tank and continue agitation while adding the remainder of the water. Begin application of the spray solution after complete dispersion of the product into the mix water and maintain agitation until all of the mixture has been sprayed. Tank Mixtures of AZURE XTRA and Other Products Do not tank mix this product with pesticides, surfactants, or fertilizers, unless compatibility charts or your own prior use has shown that the combination is physical ly compatible, effective, and non-injurious to the crop under your conditions of use. Compatibility To determine physical compatibility of this product and other products, conduct a jar test. Using a quart jar, add proportionate amounts of the tank mix partners to 1 qt. of water. Add wettable powders and water- dispersible granular products first, then liquid flow ables (suspoemulsions), and emulsifiable concentrates last. After thoroughly mixing, let stand for at least 5 minutes. If the combination remains mixed or can be remixed readily, it is physically compatible. Once compatibility has been proven, use the same procedure for adding required ingredients to the spray tank. Spray Solution Preparation Add 1/2 - 2/3 of the required amount of water to a spray or mixing tank. With the agitator running, add the tank mix partner into the tank. Allow the material to completely dissolve and disperse into the mix water. Continue agitation while adding the remainder of the wat er and this product to the spray tank. Allow the product to completely disperse. Spray the mixture with the agitator running. Observe the most restrictive of the labeling limitations and precautions of all products used in tank mixtures. APPLICATION INSTRUCTIONS Apply this product at rates and timings as described in this label. Apply by ground, by air, or via chemigation. Refer toCrop Specific Use Direction section of this label. Apply this product in a minimum of 10 GPA via ground application equipment and 2 GPA via aerial application equipment. Directions for Use Through Sprinkler Chemigation Systems (apply this product only to crops for which chemigation is specified on this label):

Page 8 of 14 Spray Preparation: Chemical tank and injector system should be thoroughly cleaned. Flush system with clean water. Use Precautions for Sprinkler Irrigation Applications Apply this product through sprinkler irrigation systems including center pivot, lateral move, end tow, side [wheel] roll, traveler, big gun, solid set, drip (trickle) , or hand move irrigation systems. Do not apply this product through any other type of irrigation system except as specified on this label. Apply with center pivot or continuous-move equipment di stributing 1/2 acre-inch or less during treatment. In general, use the least amount of water required for proper distribution and coverage. If stationary systems (solid set, handlines or wheel lines other than continuous-move) are used, this product should be injected into no more than the last 20-30 minutes of the set. Do not apply when winds are greater than 10- 15 mph to avoid drift or wind skips. Do not apply whe n wind speed favors drift beyond the area intended for treatment. Plant injury, lack of effectiveness, or illegal pesticide residues in the crop can result from non-uniform treated water. Thorough coverage of foliage is required for good control. Good agitation should be maintained during the entire application period. If you have questions about calibration you should co ntact State Extension Service specialist, equipment manufacturers or other experts. The system must contain a functional check valve, vacuum relief valve, and low-pressure drain appropriately located on the irrigation pipeline to prevent water-source contamination from backflow. The pesticide injection pipeline must contain a functional, automatic, quick-closing check valve to prevent the flow of fluid back toward the injection pump. The pesticide injection pipeline must also contain a functional, normally closed, solenoid-operated valve located on the intake side of the injection pump and connected to the system interlock to prevent fluid from being withdrawn from the supply tank when the irrigati on system is either automatically or manually shut down. The system must contain functional interlocking contro ls to automatically shut off the pesticide injection pump when the water pump motor stops. The irrigation line or water pump must include a functional pressure switch which will stop the water pump motor when the water pressure decreases to the point where pesticide distribution is adversely affected. Systems must use a metering pump, such as a positive displacement injection pump (e.g., diaphragm pump) effectively designed and constructed of materials that are compatible with pesticides and capable of being fitted with a system interlock. Allow sufficient time for pesticide to be flushed through all lines and all nozzles before turning off irrigation water. A person knowledgeable of the chemigation syst em and responsible for its operation, or under the supervision of the responsible person, shall shut the system down and make necessary adjustments should the need arise. Do not connect an irrigation system (including green house systems) used for pesticide application to a public water system unless the pesticide label-prescribed safety devices for public water systems are in place.

Specific Instructions for Public Water Systems

1. Public water system means a system for the provision to the public of piped water for human consumption if such system has at least 15 service connections or regularly serves an average of at least 25 individuals daily at least 60 days out of the year.
2. Chemigation systems connected to public water syst ems must contain a functional, reduced-pressure zone, back-flow preventer (RPZ) or the functional eq uivalent in the water supply line upstream from the point of pesticide introduction. As an option to the RPZ, the water from the public water system should be discharged into a reservoir tank prior to pesticide introduction. There shall be a complete physical break (air gap) between the outlet end of the fill pipe and the top or overflow rim of the reservoir tank of at least twice the inside diameter of the fill pipe.
3. The pesticide injection pipeline must contain a functional, automatic, quick-closing check valve to prevent the flow of fluid back toward the injection pump.
4. The pesticide injection pipeline must contain a functional, normally closed, solenoid-operated valve located on the intake side of the injection pump and connected to the system interlock to prevent fluid

Page 9 of 14 from being withdrawn from the supply tank when the irrigation system is either automatically or manually shut down. 5. The system must contain functional interlocking cont rols to automatically shut off the pesticide injection pump when the water pump motor stops or in ca ses where there is no water pump, when the water pressure decreases to the point where pesticide distribution is adversely affected. 6. Systems must use a metering pump , such as a positive displacement injection pump (e.g., diaphragm pump) effectively designed and co nstructed of materials that are compatible with pesticides and capable of being fitted with a system interlock. 7. Do not apply when wind speed favors dri ft beyond the area intended for treatment.

Page 10 of 14 CROP SPECIFIC USE DIRECTIONS

Crop Target Diseases Use Rate fl oz product/A (ai/A) Remarks CEREALS WHEAT TRITICALE

Early season suppression of: Glume blotch (Stagonospora nordorum) Leaf blight (Septoria tritici) Powdery mildew (Blumeria spp., Erysiphe spp.) Tan spot (Pyrenophora tritici- repentis) 3.5 (0.018 lb cyproconazole) (0.046 lb azoxystrobin) Apply this product in the spring at approximately Feekes Stage 5. The minimum retreatment interval is 14 days. Apply by ground, air, or chemigation. If applying by chemigation, use a maximum of 0.25 inch of water. Control of Leaf Diseases: Glume blotch (Stagonospora nordorum) Helminthosporium leaf blight (Drechslera tritici- repentis) Leaf blight (Septoria tritici) Powdery mildew (Blumeria spp., Erysiphe spp.) Rust (stripe, leaf, and stem) (Puccinia spp.) Spot blotch (Bipolaris sorokiniana) Tan spot (Pyrenophora tritici- repentis) 5–6.8 (0.026-0.036 lb cyproconazole) (0.065-0.089 lb azoxystrobin)

Apply this product between Feekes Stage 8 and 10.5.1. Protecting the flag leaf is important for maximizing the potential yield.

The minimum retreatment interval is 14 days. Treat up to 30 days prior to harvest. Apply by ground, air, or chemigation. Resistance Management : Make no more than two foliar applications of this product or other Grpi[ 11 fungicides per growing season. Do not alternate or tank mix with fungicides to which resistance has developed in the pathogen population.

Specific Use Restrictions: (1) Do not apply more than 6.8 fl oz/A of this product per year. (2) Do not exceed the equivalent of 0.036 lb cyproconazole/A/year from any cyproconazole-containing products. (3) Do not exceed the equivalent of 0.4 lb azoxystrobin/A/year fr om any azoxystrobin- containing products. (4) Do not harvest wheat within 30 days of application. (5) Do not harvest forage or hay within 21 days of application.

Page 11 of 14 Crop Target Diseases Use Rate fl oz product/A (ai/A) Remarks CORN FIELD SEED

Eye spot (Aureobasidium zeae) Gray leafspot (Cercospora zeae- maydis) Northern corn leaf blight (Setosphaeria turcica) Northern corn leaf spot (Cochliobolus carbonum) Rusts (common and Southern) (Puccinia spp.) Southern corn leaf blight (Cochliobolus heterostrophus) [also known as Helminthosporium leaf blights (H. maydis, H. turcicum, H. carbonum)] 3.5–6.8 (0.018-0.036 lb cyproconazole) (0.046-0.089 lb azoxystrobin) Apply this product when disease first appears. Use the low er rate when disease pressure is low. Under heavy disease pressure or if conditions are favorable for disease development, apply the high er rate. A sec ond application may be made 7 –14 days later. Application Directions : Apply by ground, air, or chemigation. Resistance Management : Make no more than two foliar applications of this product or other strobilurin Group 11 fungicides per year. Do not alternate or tank mix with fungicides to which resistance has developed in the pathogen population.

Specific Use Restrictions: (1) Do not apply within 30 days of harvest. (2) Do not harvest silage within 21 days of an application. (3) Do not apply more than 6.8 fl oz/A/year of this product. (4) Do not exceed the equivalent of 0.036 lb cyproconazole/A/year from any cyproconazole-containing products. (5) Do not exceed the equivalent of 2.0 lb azoxystrobin/A/year fr om any azoxystrobin- containing products.

Page 12 of 14 Crop Target Diseases Use Rate fl oz product/A (ai/A) Remarks SOYBEAN

Rust (Phakopsora spp.)

4.0–6.8 (0.02-0.036 lb cyproconazole) (0.052-0.089 lb azoxystrobin)

For soybean rust: Repeat applications at 14 - to 28-day intervals if conditions favorable for rust development persist. Lower use rates may require a shorter spray interval. Depending on the conditions, application timing should be at R1 (beginning flowering, approximately 50 days after planting) up to the R6 stage (seed development), but could be earlier. Aerial blight (Rhizoctonia solani) Alternaria leaf spot (Alternaria spp.) Anthracnose (Colletotrichum truncatum) Brown spot (Septoria glycines) Cercospora blight and leaf spot (Cercospora kikuchii) Frogeye leafspot (Cercospora sojina) Pod and Stem blight (Diaporthe phaseolorum 5.0–6.8 (0.026-0.036 lb cyproconazole) (0.065-0.089 lb azoxystrobin)

For diseases other than soybean rust: Begin applications prior to disease development. Use the higher rates under conditions favorable for severe disease pressure, dense plant canopies, or when disease is present. Contact extension personnel for local economic thresholds and timings for specific diseases in your area. An adjuvant may be added at recommended rates to improve coverage.

Application Directions: Coverage and penetration are important for best results. Use sufficient water volume to provide thorough and uniform plant coverage. Appl y by ground, air or chemigation. Addition of an additive with spreading and penetrating qualities will enhance coverage and efficacy. Resistance Management: Make no more than two foliar applications of this product or other Group 11 fungicides per year. Do not alternate or tank mix with fungicides to which resistance has developed in the pathogen population. Specific Use Restrictions: (1) Do not apply more than 13.6 fl oz of this product/A/year. (2) Do not exceed the equivalent of 0.072 lb cyproconazole/A/year from any cyproconazole-containing products. (3) Do not exceed the equivalent of 1.5 lb azoxystrobin/A/year fr om any azoxystrobin- containing products. (4) Do not apply within 30 days of harvest of soybeans (bean). (5) Do not graze forage within 14 days of an application. (6) Do not use soybean forage or hay as livestock fe ed if making more than one application at 6.8 fl oz product/A.

Page 13 of 14 RATE CONVERSION TABLE Product (fl oz/A) Cyproconazole (lb a.i./A) Azoxystrobin (lb a.i./A) Treated acres per gallon product 3.5 0.018 0.046 36.6 4.0 0.021 0.052 32.0 5.0 0.026 0.065 25.6 6.5 0.034 0.085 19.7 6.8 0.036 0.089 18.8 13.7 0.072 0.178 N/A

STORAGE AND DISPOSAL Do not contaminate water, food, or feed by storage or disposal. STORAGE: Store in original container only. Keep container closed when not in use. Do not store near food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical waste storage area until proper disposal can be made if product cannot be used according to the label. PESTICIDE DISP OSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of federal law. If these wastes cannot be disposed of by use according to label instructions, contact yo ur State Pesticide or Environmental Control Agency, or the Hazardous Waste representative of the nearest EPA Regional Office for guidance. CONTAINER HANDLING: [Note to Reviewer: The following statement will be included on all Final Printed Labels bearing multiple Container Handling statements] “NOTE: This product is available in multiple containers. Refer to the Net Contents section of this product's labeling fo r the applicable “Nonrefillable” or “Refillable” designation. Follow the container handling instructions below that apply to your container type/size.” [Nonrefillable Containers 5 Gallons or Less] Nonrefillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container 1/4 full with water and recap. Shake for 10 seconds. Pour ri nsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for recycling or reconditioning, or puncture and dispose of in a sanitary landfill, or by other procedures approved by state and local authorities. Plastic containers are also disposable by incineration, or, if allowed by state and local authorities, by burning. If burned stay out of smoke. [Nonrefillable containers larger than 5 gallons] Nonrefillable container. Do not reuse or refill this container. Triple rinse or pressure rinse container (or equivalent) promptly af ter emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank. Fill the container 1/4 full with water. Replace and tighten closures. Tip container on its side and roll it back and forth, ensuring at least one complete revolution, for 30 seconds. Stand the container on its end and tip it back and forth several times. Turn the container over onto its other end and tip it back and forth several times. Empty the rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Repeat this procedure two more times. Pressure rinse as follows: Empty the remaining contents into application equipment or a mix tank and continue to drain for 10 seconds after the flow begins to drip. Hold container upside down over application equipment or mix tank or collect rinsate for later use or disposal. Insert pressure -rinsing nozzle in the side of the container, and rinse at about 40 psi for at least 30 seconds. Drain for 10 seconds after the flow begins to drip. Then offer for recycling if available, or puncture and dispose of in a sanitary landfill, or by other procedures approved by state and local authorities. Plastic containers are also disposable by incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke.

Page 14 of 14 [Refillable containers larger than 5 gallons] Refillable container. Refill this container with pest icide only. Do not reuse this container for any other purpose. Cleaning the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling is the responsibility of the refiller. To clean the container before final disposal, empty the remaining contents from this co ntainer into application equipment or a mix tank. Fill the container about 10% full with water. Agitat e vigorously or recirculate water with the pump for two minutes. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this rinsing procedure two more times

WARRANTY DISCLAIMER The directions for use of this product must be followed carefully. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, (1) THE GOODS DELIVERED TO YOU ARE FURNISHED “AS IS” BY MANUFACTURER OR SELLER AND (2) MANUFACTURER AND SELLER MAKE NO WARRANTIES, GUARANTEES, OR REPRESENTATIONS OF ANY KIND TO BUYER OR USER, EITHER EXPRESS OR IMPLIED, OR BY USAGE OF TRADE, STATUTORY OR OTHERWISE, WITH REGARD TO THE PRODUCT SOLD, INCLUDING, BUT NOT LIMI TED TO MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, USE, OR ELIGIBILITY OF THE PRODUCT FOR ANY PARTICULAR TRADE USAGE. UNINTENDED CONSEQUENCES, INCLUDING BUT NOT LIMITED TO INEFFECTIVENESS, MAY RESULT BECAUSE OF SUCH FACTORS AS THE PRESENCE OR ABSENCE OF OTHER MATERIALS USED IN COMBINATION WITH THE GOODS, OR THE MANNER OF USE OR APPLICATION, INCLUDING WEATHER, ALL OF WHICH ARE BEYOND THE CONTROL OF MANUFACTURER OR SELLER AND ASSUMED BY BUYER OR USER. THIS WRITING CONTAINS ALL OF THE REPRESENTATIONS AND AGREEMENTS BETWEEN BUYER, MANUFACTURER AND SELLER, AND NO PERSON OR AGENT OF MANUFACTURER OR SELLER HAS ANY AUTHORITY TO MAKE ANY REPRESENTATION OR WARRANTY OR AGREEMENT RELATING IN ANY WAY TO THESE GOODS. LIMITATION OF LIABILITY TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INCIDENT AL, OR CONSEQUENTIAL DAMAGES, OR FOR DAMAGES IN THEIR NATURE OF PENALTIES RE LATING TO THE GOODS SOLD, INCLUDING USE, APPLICATION, HANDLING, AND DISPOSAL. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, MANUFACTURER OR SELLER SHALL NOT BE LIABLE TO BUYER OR USER BY WAY OF INDEMNIFICATION TO BUYER OR TO CUSTOMERS OF BUYER, IF ANY, OR FOR ANY DAMAGES OR SUMS OF MONEY, CLAIMS OR DEMANDS WHATSOEVER, RESULTING FROM OR BY REASON OF, OR RISING OUT OF THE MISUSE, OR FAILURE TO FOLLOW LABEL WARNINGS OR INSTRUCTIONS FOR USE, OF THE GOODS SOLD BY MANUFACTURER OR SELLER TO BUYER. ALL SUCH RISKS SHALL BE ASSUMED BY THE BUYER, USER, OR ITS CUSTOMERS. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BUYER'S OR USER'S EXCLUSIVE REMEDY, AND MANUFACTURER'S OR SELLER'S TOTAL LIABILITY SHALL BE FOR DAMAGES NOT EXCEEDING THE COST OF THE PRODUCT. If you do not agree with or do not accept any of the directions for use, the warranty disclaimers, or limitations of liability, do not use the product and return it unopened to the Seller, and the purchase price will be refunded. (RV042721) Azure is a trademark of Nufarm Americas Inc. All other trademarks that appear on this label which are not owned by Nufarm Americas Inc. or its subsidiaries are the property of their respective owners.