crop-chem-docs/corpus/epa_ppls/100-1647.md

A22388B

• EPA Reg No: 100-1647
• Registrant: SYNGENTA CROP PROTECTION, LLC
• Signal word: Caution
• Active ingredients: Thiabendazole (1.51%); Thiamethoxam (10.9%); Metalaxyl-M (1.25%); Difenoconazole (3.34%); Sedaxane (0.7%)
• Label accepted: 2025-12-03
• Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01647-20251203.pdf

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December 3, 2025

Ricky Kyaw Regulatory Product Manager Syngenta Crop Protection, Inc. P.O Box 18300 Greensboro, NC 27419

Subject: Label Amendment - Registration Review Mitigation for Thiabendazole Product Name: A22388B EPA Registration Number: 100-1647 Case Number: 475649 Application Dates: 12/14/2020

Dear Ricky Kyaw:

The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended, has completed reviewing all the information submitted with your application to support the Registration Review of the above referenced product in connection with the Thiabendazole Interim Decision, and has concluded that your submission is acceptable. The label referred to above, submitted in connection with registration under FIFRA, as amended, is acceptable.

Should you wish to add/retain a reference to the company’s website on your label, then please be aware that the website becomes labeling under the Federal Insecticide, Fungicide, and Rodenticide Act and is subject to review by the Agency. If the website is false or misleading, the product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from those claims approved through the registration process. Therefore, should the Agency find or if it is brought to our attention that a website contains false or misleading statements or claims substantially differing from the EPA approved registration, the website will be referred to the EPA’s Office of Enforcement and Compliance Assurance.

Page 2 of 2 EPA Reg. No. 100-1647 Case No. 475649

A stamped copy of your labeling is enclosed for your records. This labeling supersedes all previously accepted labeling and must be used at your next label printing. You must submit one copy of the final printed labeling before you release the product for shipment with the new labeling. In accordance with 40 CFR 152.130(c), you may distribute or sell this product under the previously approved labeling for 12 months from the date of this letter. After 12 months, you may only distribute or sell this product if it bears this new revised labeling or subsequently approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its implementing regulation at 40 CFR 152.3.

If you have any questions about this letter, please contact Nicholas Barnett by phone at 513- 569-7643, or via email at barnett.nicholas@epa.gov.

Sincerely,

Maryam K. Muhammad-Perch, Team Lead Risk Management and Implementation Branch 4 Pesticide Re-Evaluation Division Office of Pesticide Programs

ENCLOSURE: Stamped Label

A22388B Page 1 [MASTER] THIAMETHOXAM GROUP 4A INSECTICIDE THIABENDAZOLE GROUP 1 FUNGICIDE DIFENOCONAZOLE GROUP 3 FUNGICIDE MEFENOXAM GROUP 4 FUNGICIDE SEDAXANE GROUP 7 FUNGICIDE A22388B Insecticide with Fungicides A seed treatment product for protection against damage from listed insect pests and diseases of cereals. Active Ingredients: Sedaxane1 .................................................................................................................0.70% Mefenoxam2 ..............................................................................................................1.25% Thiabendazole3..........................................................................................................1.51% Difenoconazole4 ........................................................................................................3.34% Thiamethoxam5 .......................................................................................................10.90% Other Ingredients: 82.30% Total: 100.00% 1CAS No. 874967-67-6 2CAS No. 70630-17-0 and 69516-34-3 3CAS No. 148-79-8 4CAS No. 119446-68-3 5CAS No. 153719-23-4 A22388B is a flowable concentrate for seed treatment containing 0.064 lb sedaxane, 0.115 lb mefenoxam, 0.139 lb thiabendazole, 0.307 lb difenoconazole, and 1.00 lb thiamethoxam per gallon. KEEP OUT OF REACH OF CHILDREN. CAUTION See additional precautionary statements and directions for use in booklet. EPA Reg. No. 100-1647 EPA Est. No. XXXX

Net Contents [Batch Code: _____ ] (For nonrefillables only.) 12/03/2025 100-1647

A22388B Page 2 TABLE OF CONTENTS 1.0 FIRST AID 2.0 PRECAUTIONARY STATEMENTS 2.1 Hazards to Humans and Domestic Animals 2.2 Personal Protective Equipment (PPE) 2.2.1 User Safety Requirements 2.2.2 Engineering Controls 2.2.3 User Safety Recommendations 2.3 Environmental Hazards 2.3.1 Pollinator Precautions 2.3.2 Non-Target Organism Advisory Statement 2.3.3 Groundwater Advisory 2.3.4 Surface Water Advisory 3.0 PRODUCT INFORMATION 3.1 Insecticide Resistance Management 3.2 Fungicide Resistance Management 4.0 APPLICATION DIRECTIONS 4.1 Tank Mixtures 5.0 USE RESTRICTIONS 6.0 SEED CONTAINER LABEL REQUIREMENTS 7.0 SEED TREATMENT DIRECTIONS 7.1 Cereals 8.0 STORAGE AND DISPOSAL 9.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY

A22388B Page 3 1.0 FIRST AID FIRST AID If swallowed xCall a poison control center or doctor immediately for treatment advice. xHave a person sip a glass of water if able to swallow. xDo not induce vomiting unless told to by a poison control center or doctor. xDo not give anything by mouth to an unconscious person. If on skin or clothing xTake off contaminated clothing. xRinse skin immediately with plenty of water for 15-20 minutes. xCall a poison control center or doctor for treatment advice. Have the product container or label with you when calling a poison control center or doctor, or going for treatment. HOT LINE NUMBER For 24-Hour Medical Emergency Assistance (Human or Animal) Or Chemical Emergency Assistance (Spill, Leak, Fire or Accident), Call 1-800-888-8372 2.0 PRECAUTIONARY STATEMENTS 2.1 Hazards to Humans and Domestic Animals CAUTION Harmful if swallowed or absorbed through skin. Avoid contact with skin, eyes or clothing. 2.2 Personal Protective Equipment (PPE) Applicators and other handlers must wear: x Long-sleeved shirt and long pants x Chemical-resistant gloves: EDUULHUODPLQDWHEXW\OUXEEHU•PLOVQHRSUHQHUXEEHU •PLOVQLWULOHUXEEHU•PLOVSRO\YLQ\OFKORULGH39&•PLOV, or 9LWRQŠ•PLOV x Shoes plus socks

A22388B Page 4 2.2.1 User Safety Requirements Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. 2.2.2 Engineering Controls When handlers use closed systems, enclosed cabs , or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-6)], the handler PPE requirements may be reduced or modified as specified in the WPS. 2.2.3 User Safety Recommendations Users should: x Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. x Remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing. 2.3 Environmental Hazards This pesticide is toxic to wildlife, freshwater and estuarine/marine fish, and highly toxic to aquatic invertebrates. Do not contaminate water when disposing of equipment washwater or rinsate. Do not apply when weather conditions favor drift from the target area. Runoff may be hazardous to aquatic organisms in neighboring areas. Do not apply directly to water, to areas where surface water is present, or to intertidal areas below the mean high water mark. 2.3.1 Pollinator Precautions Thiamethoxam is highly toxic to bees exposed to direct treatment, and effects may be possible as a result of exposure to translocated residues in blooming crops. 2.3.2 Non-Target Organism Advisory Statement This product may adversely impact non-target organisms feeding on treated seeds. Protect the non-target organisms by following label directions intended to minimize availability of treated seed to non-target organisms.

A22388B Page 5 x Cover or collect treated seeds spilled during loading and planting in areas (such as in row ends). x Dispose of all excess treated seed by burying seed away from bodies of water. 2.3.3 Groundwater Advisory Mefenoxam is known to leach through soil into groundwater under certain conditions as a result of label use. This chemical may leach into groundwater if used in areas where soils are permeable, particularly where the water table is shallow, and may result in groundwater contamination. Thiamethoxam has properties and characteristics associated with chemicals detected in groundwater. This chemical may leach into groundwater if used in areas where soils are permeable, particularly where the water table is shallow, and may result in groundwater contamination. 2.3.4 Surface Water Advisory Mefenoxam may impact surface water quality due to runoff of rain water. This is especially true for poorly draining soils and soils with shallow groundwater. This product is classified as having high potential for reaching surface water via runoff for several months or more after application. A level, well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the potential loading of mefenoxam from runoff water and sediment. Runoff of this product will be reduced by avoiding applications when rainfall or irrigation is expected to occur within 48 hours. DIRECTIONS FOR USE It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Use is permitted on-farm and in commercial seed treatment facilities. Do not use for at-plant applications (e.g. hopper box, planter box, etc.). This product is to be applied as a water- based slurry through standard liquid-type seed treatment equipment. Seed treaters with atomizers or spinning discs are highly recommended for better product coverage on the seed. Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. For any requirements specific to your State or Tribe, consult the agency responsible for pesticide regulation. Maximum usage when applying metalaxyl- and mefenoxam- containing products to the same crop within the same season: Do not apply more than the maximum yearly total

A22388B Page 6 application rate for the active ingredient as stated on the label of the product containing the lowest yearly total on that crop. FAILURE TO FOLLOW DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY RESULT IN CROP INJURY; POOR INSECT AND/OR DISEASE CONTROL; AND/OR ILLEGAL RESIDUES. AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE) and restricted-entry interval. The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard. Do not enter or allow worker entry into treated areas during the restricted- entry interval (REI) of 48 hours. Exception: If the seed is treated with the product and the treated seed is soil-injected or soil-incorporated, the Worker Protection Standard, under certain circumstances, allows workers to enter the treated area if there will be no contact with anything that has been treated. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water is: x Coveralls x Chemical-resistant gloves made RI EDUULHU ODPLQDWH EXW\O UXEEHU • PLOV QHRSUHQHUXEEHU•PLOVQLWULOHUXEEHU•PLOVSRO\YLQ\OFKORULGH39&• PLOVRU9LWRQŠ•PLOV x Shoes plus socks Treatment of highly mechanically scarred or damaged seed or seed known to be of low vigor and poor quality may result in reduced germination and/or reduction of seed and seedling vigor. Treat a quantity of seed using equipment similar to that planned for treating the total seed lot. Then conduct germination tests with a portion of this treated seed before committing the total seed lot to a selected seed treatment. Due to seed quality, crop or variety sensitivity, and seed storage conditions beyond the control of Syngenta, no claims are made to guarantee the germination of seed or propagating material for any crop seed treated with A22388B.

A22388B Page 7 3.0 PRODUCT INFORMATION A22388B is a broad-spectrum seed treatment that consists of four fungicide active ingredients: difenoconazole, mefenoxam, sedaxane, and thiabendazole, as well as one insecticide active ingredient: thiamethoxam. Each active ingredient has a different mode of action. This seed treatment is recommended for protection against many listed important fungal plant diseases as well as listed early-season insect pests. Refer to the directions for use for a complete list of diseases and insects. 3.1 Insecticide Resistance Management For resistance management, A22388B contains a Group 4A/thiamethoxam insecticide. Any insect population may contain individuals naturally resistant to A22388B and other Group 4A insecticides. The resistant individuals may dominate the insect population if this group of insecticides are used repeatedly in the same fields. Appropriate resistance-management strategies should be followed. Thiamethoxam is a systemic insecticide belonging to the neonicotinoid class of chemistry which includes nicotinic acetylcholine receptor (nAChR) agonists. To delay insecticide resistance, take the following steps: x Rotate the use of A22388B or other Group 4A insecticides within a growing season, or among growing seasons, with different groups that control the same pests. x Use tank mixtures with insecticides from a different group that are equally effective on the target pest when such use is permitted. Do not rely on the same mixture repeatedly for the same pest population. Consider any known cross-resistance issues (for the targeted pests) between the individual components of a mixture. In addition, consider the following recommendations provided by the Insecticide Resistance Action Committee (IRAC): o Individual insecticides selected for use in mixtures should be highly effective and be applied at the rates at which they are individually registered for use against the target species. o Mixtures with components having the same IRAC mode of action classification are not recommended for insect resistance management. o When using mixtures, consider any known cross-resistance issues between the individual components for the targeted pest(s). o Mixtures become less effective if resistance is already developing to one or both active ingredients, but they may still provide pest management benefits. o The insect resistance management benefits of an insecticide mixture are greatest if the two components have similar periods of residual insecticidal activity. Mixtures of insecticides with unequal periods of residual insecticide THIAMETHOXAM GROUP 4A INSECTICIDE

A22388B Page 8 activity may offer an insect resistance management benefit only for the period where both insecticides are active. x Adopt an integrated pest management program for insecticide use that includes scouting, uses historical information related to pesticide use, crop rotation, record keeping, and which considers cultural, biological and other chemical control practices. x Monitor after application for unexpected target pest survival. If the level of survival suggests the presence of resistance, consult with your local university specialist or certified pest control advisor. x Contact your local extension specialist or certified crop advisors for any additional pesticide resistance-management and/or IPM recommendations for the specific site and pest problems in your area. For additional information on Insecticide Resistance Management: x Contact Syngenta representatives at 1-800-334-9481 x Visit the Insecticide Resistance Action Committee (IRAC) on the web at: http://www.irac-online.org Syngenta encourages responsible product stewardship to ensure effective long term control of the insect pests on this label. 3.2 Fungicide Resistance Management THIABENDAZOLE GROUP 1 FUNGICIDE DIFENOCONAZOLE GROUP 3 FUNGICIDE MEFENOXAM GROUP 4 FUNGICIDE SEDAXANE GROUP 7 FUNGICIDE For resistance management, please note that A22388B contains Group 1/thiabendazole, Group 3/difenoconazole, Group 4/mefenoxam, and Group 7/sedaxane fungicides. Any fungal population may contain individuals naturally resistant to A22388B and other Group 1, Group 3, Group 4, or Group 7 fungicides. A gradual or total loss of pest control may occur over time if these fungicides are used repeatedly in the same fields. Appropriate resistance- management strategies should be followed. Thiabendazole belongs to the methyl-benzimidazole carbamate class of chemistry which disrupts ß-tubulin assembly in mitosis. Difenoconazole belongs to the triazole class of chemistry and is a demethylation inhibitor of sterol biosynthesis (DMI) which disrupts membrane synthesis of the fungal cell. Mefenoxam belongs to the phenylamide class of chemistry which interferes with fungal RNA synthesis. Sedaxane is a succinate dehydrogenase inhibitor (SDHI) and belongs to the carboxamide class of chemistry which disrupts cellular respiration and energy generation. To delay fungicide resistance, take one or more of the following steps: x Rotate the use of A22388B or other Group 1, Group 3, Group 4, or Group 7 fungicides within a growing season sequence with different groups that control the same pathogens.

A22388B Page 9 x Use tank mixtures with fungicides from a different group that are equally effective on the target pest when such use is permitted. Use at least the minimum application rate as labeled by the manufacturer. x Adopt an integrated disease management program for fungicide use that includes scouting, uses historical information related to pesticide use, and crop rotation, and which considers host plant resistance, impact of environmental conditions on disease development, disease thresholds, as well as cultural, biological and other chemical control practices. x Where possible, make use of predictive disease models to effectively time fungicide application. Note that using predictive models alone is not sufficient to manage resistance. x Monitor treated fungal populations for resistance development. x Contact your local extension specialist or certified crop advisor for any additional pesticide resistance-management and/or IPM recommendations for specific crops and pathogens. x For further information or to report suspected resistance contact Syngenta at 1-866- SYNGENT(A) (866-796-4368). You can also contact your pesticide distributor or university extension specialist to report resistance. 4.0 APPLICATION DIRECTIONS Important: Recirculate A22388B thoroughly before using. Follow the manufacturer’s application instructions for the seed treatment equipment being used. Apply A22388B as a water-based slurry through standard liquid-type seed treatment equipment that provides uniform seed coverage. Seed treaters with atomizers or spinning discs are highly recommended for better product coverage on the seed. Uneven or incomplete seed coverage may not give the desired level of insect or disease control. Thoroughly mix the specified amount of A22388B into the required amount of water for the slurry treater and dilution rate to be used. Continuous agitation or mixing of the slurry mixture is necessary to prevent settling out of the solution. Clean out any unused product from the treater after treating or maintain constant agitation if the leftover slurry will be maintained overnight. x Allow seed to dry before bagging. x A22388B contains an EPA-approved dye/colorant that imparts an unnatural color to the seed as required by the Federal Seed Act.

A22388B Page 10 4.1 Tank Mixtures A22388B mixes easily with water and other water-based seed treatments. When mixing with products from other manufacturers, test the compatibility prior to use by conducting a jar test: mix all intended seed treatments with a proportional amount of water in a clear glass container. Mix well and allow mixture to sit for one hour. Remix and observe for incompatibility. Mixing A22388B with tank-mix partners: Add ½ of the required water to the mix tank and turn on the agitation. Mechanical agitation is preferred. If using wettable powders, add them first to clean water allowing them to completely disperse prior to adding A22388B or other products. Allow each tank-mix partner to completely disperse before adding the next product. Add the remaining amount of water and agitate. Maintain agitation until the entire slurry mixture has been used. It is the pesticide user’s responsibility to ensure that all products are registered for the intended use. Read and follow the applicable restrictions and limitations and directions for use on all product labels involved in tank mixing. Users must follow the most restrictive directions for use and precautionary statements of each product in the tank mixture. When using A22388B in tank mixtures, all products in water-soluble packaging should be added to the tank before any other tank mix partner, including A22388B. Allow the water- soluble packaging to completely dissolve and the product(s) to completely disperse before adding any other tank mix partner to the tank. If using A22388B in a tank mixture with other seed treatment products, observe all directions for use, crops/sites, use rates, dilution ratios, precautions, and limitations which appear on the tank mix partner label. No label dosage may be exceeded and the most restrictive label precautions and limitations must be follower. This product may not be mixed with any product which prohibits such mixing.

A22388B Page 11 5.0 USE RESTRICTIONS x Do not allow children, pets, or livestock to have access to treated seed. x Store treated seed away from feeds and foodstuffs. x Wear long-sleeved shirt, long pants and chemical resistant gloves when handling treated seed. x Do not apply more than 0.08 lb thiamethoxam per acre (36 g ai/A) per season as a seed treatment application. Do not apply more than 0.075 lb thiabendazole per acre (34 g ai/A) per season as a seed treatment application. Do not apply more than 0.038 lb difenoconazole per acre (17 g ai/A) per season as a seed treatment application. Do not apply more than 0.024 lb mefenoxam per acre (10.9 g ai/A) per season as a seed treatment application. Do not apply more than 0.079 lb sedaxane per acre (3.6 g ai/A) per season as a seed treatment application. x For barley (based upon an average seed weight of 12,500 seeds/lb): This seed has been treated with at 0.014 mg thiamethoxam/seed, 0.002 mg thiabendazole/seed, 0.004 mg difenoconazole/seed, 0.0016 mg mefenoxam/seed, and 0.0009 mg sedaxane/seed. x For oats (based upon an average seed weight of 16,400 seeds/lb): This seed has been treated with at 0.011 mg thiamethoxam/seed, 0.0015 mg thiabendazole/seed, 0.003 mg difenoconazole/seed, 0.0012 mg mefenoxam/seed, and 0.0007 mg sedaxane/seed. x For rye (based upon an average seed weight of 15,600 seeds/lb): This seed has been treated with at 0.011 mg thiamethoxam/seed, 0.0016 mg thiabendazole/seed, 0.003 mg difenoconazole/seed, 0.0013 mg mefenoxam/seed, and 0.0007 mg sedaxane/seed. x For triticale (based upon an average seed weight of 12,750 seeds/lb): This seed has been treated with at 0.014 mg thiamethoxam/seed, 0.0019 mg thiabendazole/seed, 0.004 mg difenoconazole/seed, 0.0016 mg mefenoxam/seed, and 0.0009 mg sedaxane/seed. x For winter and spring wheat (based upon an average seed weight of 15,000 seeds/lb): This seed has been treated with at 0.012 mg thiamethoxam/seed, 0.0016 mg thiabendazole/seed, 0.004 mg difenoconazole/seed, 0.0014 mg mefenoxam/seed, and 0.0008 mg sedaxane/seed. x Do not make any soil or foliar application of products containing thiamethoxam to crops grown from seed treated with A22388B. x Treated seed must be planted into the soil at a depth greater than 0.5 inch. x Cover or collect treated seeds spilled during loading and planting in areas (such as in row ends). x Dispose of all excess treated seed by burying seed away from bodies of water. x Do not contaminate water bodies when disposing of planting equipment wash waters. x Dispose of seed packaging in accordance with local requirements. x For seed treated with A22388B, do not graze or feed livestock on treated areas for 45 days after planting.

A22388B Page 12 x Excess treated seed may be used for ethanol production only if (1) by-products are not used for livestock feed and (2) no measurable residues of pesticide remain in the ethanol by-products that are used in agronomic practice. ROTATIONAL CROP RESTRICTIONS x In the event of a crop failure or harvest of a crop grown from seed treated with A22388B, the field may be replanted according to the following schedule: Plantback Interval Table Immediate Plantback Interval Minimum 30-Day Plantback Interval Cereal Grains: Barley, Oats, Rye, Sweet Corn, Triticale, and Wheat Soybean Alfalfa All other Cereal Grains Crop Group 15 Cotton Cucurbit Vegetables Crop Group 9 Fruiting Vegetables Crop Group 8 Head and Stem Brassica Crop Subgroup 5A Leafy Brassica Greens Crop Subgroup 5B Leafy Vegetables Crop Group 4 Legume Vegetables (Succulent or Dried) Crop Group 6 Mint: Peppermint and Spearmint Oilseeds: Borage, Canola, Crambe, Flax Seed, and Mustard Seed Onion, Dry Bulb Peanut Root and Tuber Vegetables Crop Group 1 Strawberry Sugarbeet Sunflower Tobacco x For all other crops, the minimum plantback interval is 120 days from the date of planting seeds treated with A22388B. A cover crop, other than the crops listed above, planted for erosion control or soil improvement may be planted sooner than the 120 day interval; however, the crop may not be grazed or harvested for food or feed. x The maximum number of seasons per year is 2.

A22388B Page 13 6.0 SEED CONTAINER LABEL REQUIREMENTS The Federal Seed Act requires that containers of treated seeds must be labeled with the following statements: x This seed has been treated with thiabendazole, difenoconazole, mefenoxam, and sedaxane fungicides and thiamethoxam insecticide. x Do not use for feed, food, or oil purposes. x User is responsible for ensuring that the seed bag meets all requirements under the Federal Seed Act. In addition, the following statements are required on containers of seeds treated with A22388B: x Non-Target Organism Advisory Statement: This product may adversely impact non-target organisms feeding on treated seeds. Protect the non-target organisms by following label directions intended to minimize availability of treated seed to non-target organisms. o Cover or collect treated seeds spilled during loading and planting in areas (such as in row ends). o Dispose of all excess treated seed by burying seed away from bodies of water. x Groundwater Advisory: Mefenoxam is known to leach through soil into groundwater under certain conditions as a result of label use. Thiamethoxam has properties and characteristics associated with chemicals detected in groundwater. These chemicals may leach into groundwater if used in areas where soils are permeable, particularly where the water table is shallow. x Pollinator Precautions: Thiamethoxam is highly toxic to bees exposed to direct treatment, and effects may be possible as a result of exposure to translocated residues in blooming crops. x Do not allow children, pets, or livestock to have access to treated seed. x Store treated seed away from feeds and foodstuffs. x Wear long-sleeved shirt, long pants and chemical resistant gloves when handling treated seed. x Do not apply more than 0.08 lb thiamethoxam per acre (36 g ai/A) per season as a seed treatment application. Do not apply more than 0.075 lb thiabendazole per acre (34 g ai/A) per season as a seed treatment application. Do not apply more than 0.038 lb difenoconazole per acre (17 g ai/A) per season as a seed treatment application. Do not apply more than 0.024 lb mefenoxam per acre (10.9 g ai/A) per season as a seed treatment application. Do not apply more than 0.0079 lb sedaxane per acre (3.6 g ai/A) per season as a seed treatment application. x For barley (based upon an average seed weight of 12,500 seeds/lb): This seed has been treated with at 0.014 mg thiamethoxam/seed, 0.002 mg thiabendazole/seed, 0.004 mg difenoconazole/seed, 0.0016 mg mefenoxam/seed, and 0.0009 mg sedaxane/seed.

A22388B Page 14 x For oats (based upon an average seed weight of 16,400 seeds/lb): This seed has been treated with at 0.011 mg thiamethoxam/seed, 0.0015 mg thiabendazole/seed, 0.003 mg difenoconazole/seed, 0.0012 mg mefenoxam/seed, and 0.0007 mg sedaxane/seed. x For rye (based upon an average seed weight of 15,600 seeds/lb): This seed has been treated with at 0.011 mg thiamethoxam/seed, 0.0016 mg thiabendazole/seed, 0.003 mg difenoconazole/seed, 0.0013 mg mefenoxam/seed, and 0.0007 mg sedaxane/seed. x For triticale (based upon an average seed weight of 12,750 seeds/lb): This seed has been treated with at 0.014 mg thiamethoxam/seed, 0.0019 mg thiabendazole/seed, 0.004 mg difenoconazole/seed, 0.0016 mg mefenoxam/seed, and 0.0009 mg sedaxane/seed. x For winter and spring wheat (based upon an average seed weight of 15,000 seeds/lb): This seed has been treated with at 0.012 mg thiamethoxam/seed, 0.0016 mg thiabendazole/seed, 0.004 mg difenoconazole/seed, 0.0014 mg mefenoxam/seed, and 0.0008 mg sedaxane/seed. x Do not make any soil or foliar application of products containing thiamethoxam to crops grown from seed treated with A22388B. x Treated seed must be planted into the soil at a depth greater than 0.5 inch. x Do not contaminate water bodies when disposing of planting equipment wash waters. x Dispose of seed packaging in accordance with local requirements. x For seed treated with A22388B, do not graze or feed livestock on treated areas for 45 days after planting. x Excess treated seed may be used for ethanol production only if (1) by-products are not used for livestock feed and (2) no measurable residues of pesticide remain in the ethanol by-products that are used in agronomic practice. x In the event of a crop failure or harvest of a crop grown from seed treated with A22388B, the field may be replanted according to the following schedule:

A22388B Page 15 Plantback Interval Table Immediate Plantback Interval Minimum 30-Day Plantback Interval Cereal Grains: Barley, Oats, Rye, Sweet Corn, Triticale, and Wheat Soybean Alfalfa All other Cereal Grains Crop Group 15 Cotton Cucurbit Vegetables Crop Group 9 Fruiting Vegetables Crop Group 8 Head and Stem Brassica Crop Subgroup 5A Leafy Brassica Greens Crop Subgroup 5B Leafy Vegetables Crop Group 4 Legume Vegetables (Succulent or Dried) Crop Group 6 Mint: Peppermint and Spearmint Oilseeds: Borage, Canola, Crambe, Flax Seed, and Mustard Seed Onion, Dry Bulb Peanut Root and Tuber Vegetables Crop Group 1 Strawberry Sugarbeet Sunflower Tobacco x For all other crops, the minimum plantback interval is 120 days from the date of planting seeds treated with A22388B. A cover crop, other than the crops listed above, planted for erosion control or soil improvement may be planted sooner than the 120 day interval; however, the crop may not be grazed or harvested for food or feed. x The maximum number of seasons per year is 2.

A22388B Page 16 7.0 SEED TREATMENT DIRECTIONS 7.1 Cereals Crop Target Pests / Diseases Use Rate (fl oz/100 lb seeds) Use Rate (mg ai/1000 seeds) Barley Insects: Aphids1 Greenbug European Chafer Wireworms Hessian fly2 5.0 fl oz /100 lb seeds Total: 23.03* Sedaxane: 0.907 Mefenoxam: 1.630 Thiabendazole: 1.970 Difenoconazole: 4.352 Thiamethoxam: 14.175 based upon an average seed weight of 12,500 seeds/lb Diseases: General Seed Rots3 Seedling Blight, Root Rot, and Damping-Off caused by seed- and soil-borne Fusarium or Rhizoctonia Seedling Blight, Root Rot, and Damping-Off caused by soil-borne Pythium Seed-borne Septoria Covered Smut False Loose Smut True Loose Smut Diseases Suppressed Only4: Common Root Rot (Cochliobolus ) Fusarium Crown and Foot Rot Take-All Oats Insects: Aphids1 Greenbug European Chafer Wireworms Hessian fly2 5.0 fl oz /100 lb seeds Total: 17.56 Sedaxane: 0.691 Mefenoxam: 1.242 Thiabendazole: 1.502 Difenoconazole: 3.317 Thiamethoxam: 10.804 based upon an average seed weight of 16,400 seeds/lb Diseases: General Seed Rots3 Seedling Blight, Root Rot, and Damping-Off caused by seed- and soil-borne Fusarium or Rhizoctonia Seedling Blight, Root Rot, and Damping-Off caused by soil-borne Pythium Seed-borne Septoria Covered Smut Loose Smut Diseases Suppressed Only4: Common Root Rot (Cochliobolus) Rye Insects: Aphids1 Greenbug European Chafer Wireworms Hessian fly2 5.0 fl oz /100 lb seeds Total: 18.46

A22388B Page 17 Diseases: General Seed Rots3 Seedling Blight, Root Rot, and Damping-Off caused by seed- and soil-borne Fusarium or Rhizoctonia Seedling Blight, Root Rot, and Damping-Off caused by soil-borne Pythium Seed-borne Septoria Common Bunt5 Dwarf Bunt5 Sedaxane: 0.727 Mefenoxam: 1.306 Thiabendazole: 1.579 Difenoconazole: 3.487 Thiamethoxam: 11.358 based upon an average seed weight of 15,600 seeds/lb Diseases Suppressed Only4: Common Root Rot (Cochliobolus) Fusarium Crown and Foot Rot Take-All Triticale Insects: Aphids1 Greenbug European Chafer Wireworms Hessian fly2 5.0 fl oz /100 lb seeds Total: 22.58 Sedaxane: 0.889 Mefenoxam: 1.598 Thiabendazole: 1.932 Difenoconazole: 4.266 Thiamethoxam: 13.897 based upon an average seed weight of 12,750 seeds/lb Diseases: General Seed Rots3 Seedling Blight, Root Rot, and Damping-Off caused by seed- and soil-borne Fusarium or Rhizoctonia Seedling Blight, Root Rot, and Damping-Off caused by soil-borne Pythium Seed-borne Septoria Septoria Leaf Blotch6 Common Bunt5 Flag Smut Fusarium Seed Scab Dwarf Bunt5 Karnal Bunt Loose Smut Pythium Damping Off Diseases Suppressed Only4: Common Root Rot (Cochliobolus) Fusarium Crown, Foot, and Root Rot Take-All Winter Wheat Insects: Aphids1 Greenbug European Chafer Wireworms Hessian fly2 5.0 fl oz /100 lb seeds Total: 19.19 Sedaxane: 0.756 Mefenoxam: 1.358 Thiabendazole: 1.642 Difenoconazole: 3.626 Diseases: General Seed Rots3 Seedling Blight, Root Rot, and Damping-Off caused by seed- and soil-borne Fusarium or Rhizoctonia

A22388B Page 18 Seedling Blight, Root Rot, and Damping-Off caused by soil-borne Pythium Seed-borne Septoria Septoria Leaf Blotch6 Common Bunt5 Flag Smut Fusarium Seed Scab Dwarf Bunt5 Karnal Bunt Loose Smut Pythium Damping Off Thiamethoxam: 11.812 based upon an average seed weight of 15,000 seeds/lb Spring Wheat Insects: Aphids1 Greenbug European Chafer Wireworms Hessian fly2 5.0 fl oz /100 lb seeds Total: 19.19 Sedaxane: 0.756 Mefenoxam: 1.358 Thiabendazole: 1.642 Difenoconazole: 3.626 Thiamethoxam: 11.812 *based upon an average seed weight of 15,000 seeds/lb Diseases: General Seed Rots3 Seedling Blight, Root Rot, and Damping-Off caused by seed- and soil-borne Fusarium or Rhizoctonia Seedling Blight, Root Rot, and Damping-Off caused by soil-borne Pythium Seed-borne Septoria Fusarium Seed Scab Common Bunt5 Karnal Bunt Loose Smut Pythium Damping Off Diseases Suppressed Only4: Common Root Rot (Cochliobolus) Fusarium Crown, Foot, and Root Rot Take-All 1The 5 fluid oz/100 lbs rate of A22388B provides early season protection of seedlings against injury by aphids and reduces the potential spread of barley yellow dwarf virus due to aphid vectors. If pressure is high, apply up to 0.3 fl. oz. additional Cruiser 5FS. 2The 5 fluid oz/100 lbs rate of A22388B provides suppression of Hessian fly. For maximum protection, add 0.3 fl. oz of additional Cruiser 5FS or utilize a foliar spray program. 3Protection against general seed rots. This includes rots caused by Fusarium, Pythium, and Rhizoctonia. 4Suppression means consistent protection at a level which is not optimal but is still of commercial benefit. 5Protects against both seed- and soil-borne bunts (common, dwarf). 6Early season foliar disease protection for first 4 weeks after planting. For full season protection, apply a foliar fungicide according to label directions.

A22388B Page 19 8.0 STORAGE AND DISPOSAL STORAGE AND DISPOSAL Do not contaminate water, food or feed by storage or disposal. Pesticide Storage Store in a cool, dry place. Storage for extended periods above 90°F is not recommended. Store in original containers only. Keep container closed when not in use. Do not store near food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical waste storage area until proper disposal can be made if product cannot be used according to the label. Pesticide Disposal Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal Law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste Representative at the nearest EPA Regional Office for guidance. Container Handling (less than or equal to 5 gallons) Non-refillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures approved by state and local authorities. Container Handling (greater than 5 gallons) Non-refillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank. Fill the container ¼ full with water. Replace and tighten closures. Tip container on its side and roll it back and forth, ensuring at least one complete revolution, for 30 seconds. Stand the container on its end and tip it back and forth several times. Turn the container over onto its other end and tip it back and forth several times. Empty the rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Repeat this procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures approved by state and local authorities. Container Handling (greater than 5 gallons) Refillable container. Refill this container with pesticide only. Do not reuse this container for any other purpose. Cleaning the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling is the responsibility of the person refilling. To clean container before final disposal, empty the remaining contents from this container into application equipment or mix tank. Fill the container about 10 percent full with

A22388B Page 20 water. Agitate vigorously or recirculate water with the pump for 2 minutes. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this rinsing procedure two more times. Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures approved by state and local authorities. CONTAINER IS NOT SAFE FOR FOOD, FEED, OR DRINKING WATER.

A22388B Page 21 9.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of Warranty and Liability before buying or using this product. If the terms are not acceptable, return the product at once, unopened, and the purchase price will be refunded. The Directions for Use of this product must be followed carefully. It is impossible to eliminate all risks inherently associated with the use of this product. Crop injury, ineffectiveness or other unintended consequences may result because of such factors as manner of use or application, weather or crop conditions, presence of other materials or other influencing factors in the use of the product, which are beyond the control of SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by applicable law, Buyer and User agree to hold SYNGENTA and Seller harmless for any claims relating to such factors. SYNGENTA warrants that this product conforms to the chemical description on the label and is reasonably fit for the purposes stated in the Directions for Use, subject to the inherent risks referred to above, when used in accordance with directions under normal use conditions. To the extent permitted by applicable law: (1) this warranty does not extend to the use of the product contrary to label instructions, or under conditions not reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer and User assume the risk of any such use. TO THE EXTENT PERMITTED BY APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL. To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any incidental, consequential or special damages resulting from the use or handling of this product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION OF SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT. SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be modified except by written agreement signed by a duly authorized representative of SYNGENTA.

A22388B Page 22 The ALLIANCE FRAME the SYNGENTA Logo, and the PURPOSE ICON are Trademarks of a Syngenta Group Company Viton® is a registered trademark of E.I. DuPont de Nemours & Company, Inc. ©20XX Syngenta For non-emergency (e.g. current product information), call Syngenta Crop Protection at 1-800-334-9481. Manufactured for: Syngenta Crop Protection, LLC P.O. Box 18300 Greensboro, North Carolina 27419-8300 A22388B 1647 MAS 0919 AMEND 1220-CL – jeb – 12/04/2020 000100-01647.20201211.A22388B_AMEND_1220-CL.pdf