crop-chem-docs/corpus/epa_ppls/264-825.md

PROLINE 480 SC FUNGICIDE

• EPA Reg No: 264-825
• Registrant: BAYER CROPSCIENCE, LLC
• Signal word: Caution
• Active ingredients: Prothioconazole (41%)
• Label accepted: 2026-04-30
• Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000264-00825-20260430.pdf

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April 30, 2026

Daljit Singh Senior Regulatory Affairs Manager Bayer CropScience LP 800 N. Lindbergh Blvd. St. Louis, MO 63167

Subject: Label Amendment – revise pests and environmental hazard statements Registration Review Label Amendment – Incorporating Mitigation Measures from the Registration Review Interim Decision for Prothioconazole Product Name: Proline 480 SC Fungicide EPA Registration Number: 264-825 Application Date(s): September 30, 2025 Case Number/Decision Number: 676344, 479583

Dear Daljit Singh:

The amended label referred to above, submitted in connection with registration under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended, is acceptable. This approval does not affect any conditions that were previously imposed on this registration. You continue to be subject to existing conditions on your registration and any deadlines connected with them.

The Agency, in accordance with FIFRA, as amended, has completed reviewing all the information submitted with your application to support the Registration Review of the above referenced product in connection with the Prothioconazole Interim Decision. The Agency has concluded that your submission is acceptable.

A stamped copy of your labeling is enclosed for your records. This labeling supersedes all previously accepted labeling. The next label printing of this product must use this labeling unless subsequent changes have been approved. You must submit one copy of the final printed labeling before you release the product for shipment with the new labeling. In accordance with 40 CFR 152.130(c), you may distribute or sell this product under the previously approved labeling for 12 months from the date of this letter. After 12 months, you may only distribute or sell this product if it bears this new revised labeling or subsequently approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its implementing regulation at 40 CFR 152.3.

Page 2 of 2 EPA Reg. No. 264-825 Case No./Decision No. 676344 S hould you wish to add/retain a reference to the company’s website on your label, then please be aware that the website becomes labeling under FIFRA and is subject to review by the Agency. If the website is false or misleading, the product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) lists examples of statements EPA may consider false or misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from those claims approved through the registration process. Therefore, should the Agency find or if it is brought to our attention that a website contains false or misleading statements or claims substantially differing from the EPA approved registration, the website will be referred to the EPA’s Office of Enforcement and Compliance. Y our release for shipment of the product constitutes acceptance of these conditions. If these conditions are not complied with, the registration will be subject to cancellation in accordance with FIFRA section 6. I f you have any questions, please contact Thomas Harty at 202-566-0394 or at harty.thomas@epa.gov. Sin cerely, T homas Harty, Risk Manager Product Team 22, Fungicide Branch Registration Division (7505T) E nclosure

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PROTHIOCONAZOLE GROUP 3 FUNGICIDE PROLINE® 480 SC Fungicide ABN: PTZ 480 ST; Redigo 480; Acceleron D-342 Fungicide Seed Treatment For control of specified diseases on listed crops. ACTIVE INGREDIENT: Prothioconazole, 2-[2-(1-Chlorocyclopropyl)-3- (2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione ..................................................................... 41.0% OTHER INGREDIENTS: .............................................................................................................................................. 59.0% TOTAL: 100.0% Contains 4 pounds Prothioconazole per gallon EPA Reg. No. 264-825 EPA Est.

KEEP OUT OF REACH OF CHILDREN CAUTION For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1-800-334-7577 For PRODUCT USE Information Call 1-866-99BAYER (1-866-992-2937) Please refer to [back panel] [booklet] for additional precautionary statements and directions for use. [Note to reviewer: Location of additional precautionary statements and directions for use will vary between those listed, depending on container type/size.] FIRST AID IF SWALLOWED: • Immediately call a poison control center or doctor for treatment advice. • Have person sip a glass of water if able to swallow. • Do not induce vomiting unless told to do so by a poison control center or doctor. • Do not give anything by mouth to an unconscious person. IF INHALED: • Move person to fresh air. • If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably mouth-to-mouth if possible. • Call a poison control center or doctor for further treatment advice. IF ON SKIN OR CLOTHING: • Take off contaminated clothing. • Rinse skin immediately with plenty of water for 15-20 minutes. • Call a poison control center or doctor for treatment advice. IF IN EYES: • Hold eye open and rinse slowly and gently with water for 15-20 minutes. • Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. • Call a poison control center or doctor for treatment advice. For MEDICAL Emergencies Call 24 Hours A Day 1-800-334-7577. Have the product container or label with you when calling a poison control center or doctor or going for treatment. NOTE TO PHYSICIAN: No specific antidote. Treat symptomatically. 04/30/2026 264-825

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PRECAUTIONARY STATEMENTS HAZARD (TO HUMANS AND DOMESTIC ANIMALS) CAUTION Harmful if swallowed or inhaled. Causes moderate eye irritation. Avoid contact with eyes and clothing. Avoid breathing vapor or spray mist. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacco. Remove and wash contaminated clothing before reuse. Personal Protective Equipment Applicators and other handlers must wear: • Long-sleeved shirt and long pants • Chemical resistant gloves made of any waterproof material • Shoes plus socks Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions exist for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. Engineering Control Statements When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.607(d-f)], the handler PPE requirements may be reduced or modified as specified in the WPS.

User Safety Recommendations Users should: • Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. • Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. • Remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

ENVIRONMENTAL HAZARDS This product is toxic to estuarine/marine invertebrates, and freshwater/estuarine/marine aquatic plants. DO NOT apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. DO NOT contaminate water when disposing of equipment washwater or rinsate. Surface Water Advisory This product may impact surface water quality due to runoff of rainwater. This is especially true for poorly draining soils and soils with shallow ground water. This product is classified as having high potential for reaching surface water via. runoff for several months or more after application. A level, well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the potential loading of prothioconazole and degradates from runoff water and sediment. Runoff of this product will be reduced by avoiding applications when rainfall or irrigation is expected to occur within 48 hours. Ground Water Advisory Degradates of prothioconazole are known to leach through soil into groundwater under certain conditions as a result of label use. These chemicals may leach into groundwater if used in areas where soils are permeable, particularly where the water table is shallow.

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DIRECTIONS FOR USE It is a violation of federal law to use this product in a manner inconsistent with its labeling. DO NOT apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. For any requirements specific to your State or Tribe, consult the agency responsible for pesticide regulation. DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment. AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE) and restricted-entry interval and notification to workers (as applicable). The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard. DO NOT enter or allow worker entry into treated areas during the restricted-entry interval (REI) of 12 hours. Some crops have longer crop-specific REIs. Crop-specific REIs are listed in the Directions for Use section associated with the crop. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water is: • Coveralls over long-sleeved shirt and pants • Chemical-resistant gloves made of any waterproof material. • Shoes plus socks

PRODUCT INFORMATION PROLINE® 480 SC Fungicide is a broad-spectrum systemic fungicide for the control of Ascomycetes, Basidiomycetes and Deuteromycetes diseases in a variety of crops including barley, buckwheat, bushberry subgroup, low growing berry subgroup (ex cept strawberry), corn, cotton, cucurbit vegetables, dry shelled pea and bean crop subgroup, millet, oats, peanuts, rapeseed subgroup 20A (including c anola and Brassica carinata), rice, rye, soybean, sugar beets, triticale, wheat; conifer and hardwood nursery seeds and seedlings. Under conditions conducive to extended infection periods or high disease pressure, additional fungicide applications beyond the number allowed by this label may be needed. Under these conditions use another fungicide registered for the crop/disease. Equipment must be properly calibrated before use.

FUNGICIDE RESISTANCE MANAGEMENT (FRAC) RECOMMENDATIONS For resistance management, PROLINE 480 SC Fungicide contains a Group 3 fungicide. Any fungal population may contain individuals naturally resistant to PROLINE 480 SC Fungicide and other Group 3 fungicides. A gradual or total loss of pest control may occur over time if these fungicides are used repeatedly in the same fields. Appropriate resistance-management strategies should be followed. To delay fungicide resistance, take one or more of the following steps: • Rotate the use of PROLINE 480 SC Fungicide or other Group 3 fungicides within a growing season sequence with different groups that control the same pathogens. • Use tank mixtures with fungicide from a different group that are equally effective on the target pest when such use is permitted. Use at least the minimum application rate as labeled by the manufacturer. • Adopt an integrated disease management program for fungicide use that includes scouting, uses historical information related to pesticide use, and crop rotation, and which considers host plant resistance, impact of environmental conditions on disease development, disease thresholds, as well as cultural, biological and other chemical control practices. • Where possible, make use of predictive disease models to effectively time fungicide applications. Note that using predictive models alone is not sufficient to manage resistance. • Monitor treated fungal/bacterial populations for resistance development. • Contact your local extension specialist or certified crop advisor for any additional pesticide resistance-management and/or IPM recommendations for specific crops and pathogens. • For further information or to report suspected resistance contact Bayer CropScience at 1-866-99BAYER (1-866-992-2937). You can also contact your pesticide distributor or university extension specialist to report resistance.

Spray Equipment/Volumes PROLINE 480 SC Fungicide may be applied by either ground, aerial and/or chemigation application equipment. Refer to the USE DIRECTIONS FOR SPECIFIC CROPS section of this label for approved applications for each crop. Apply in a minimum of 10 gallons of spray solution per acre by ground sprayer. Apply in a minimum of 5 gallons of spray solut ion per acre by aircraft spray equipment unless stated differently elsewhere in this label. Check equipment calibration frequently. C omplete coverage and uniform application are essential for the most effective results, especially when lower spray volumes are applied. If necessary, increase the spray volume per acre for complete crop coverage.

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Mixing Procedures It is the pesticide user’s responsibility to ensure that all products are registered for the intended use. Read and follow the applicable restrictions and limitations and directions for use on all product labels involved in tank mixing. Users must follow the most restrictive directions for use and precautionary statements of each product in the tank mixture. Prepare no more spray mixture than is necessary for the immediate operation. Thoroughly clean spray equipment before using this product. Maintain maximum agitation throughout the spray operation. DO NOT let the spray mixture stand overnight in the spray tank. Flush the spray equipment thoroughly following each use and apply the rinsate to the previously treated area or dispose of th e rinsate according to local regulations.

PROLINE 480 SC Fungicide Alone: Add ½ of the required amount of water to the mix tank. With the agitator running, add the PROLINE 480 SC Fungicide to the tank. Continue agitation while adding the remainder of the water. Begin application of the solution after the product has completely and uniformly dispersed into the mix water. Maintain agitation until all of the mixture has been applied.

PROLINE 480 SC Fungicide + Tank-Mix Partners: Add ½ of the required amount of water to the mix tank. Start the agitator running before adding any of the tank -mix partners. In general, tank -mix partners should be added in this order: products packaged in water - soluble packaging, wettable powders, wettable granules (dry flowables), liquid flowables, liquids, and emulsifiable concentrates. Always allow each tank -mix partner to become fully and uniformly dispersed before adding the next product. Provide sufficient agitation while adding the remainder of the water. Maintain agitation until all of the mixture has been applied. When using PROLINE 480 SC Fungicide in tank mixtures, all products in water -soluble packaging should be added to the tank before any other tank -mix partner, including PROLINE 480 SC Fungicide. Allow the water -soluble packaging to completely disperse before adding any other tank-mix partner to the tank. If using PROLINE 480 SC Fungicide in a tank mixture, observe all directions for use, crop/sites, use rates, dilution ratios, precautions, and limitations; which appear on the tank -mix product label. No label dosage rate must be exceeded, and the most restrictive label precautions and limitations must be followed. This product must not be mixed with any product that prohibits such mixing. Tan k mixtures or other applications of products are permitted only in those states in which the products are registered. PROLINE 480 SC Fungicide is compatible with most insecticide, fungicide, herbicide, and foliar nutrient products. However, the physical compatibility of PROLINE 480 SC Fungicide with tank-mix partners should be tested before use. To determine the physical compatibility of PROLINE 480 SC Fungicide with other products, use a jar test, as described below. Using a quart jar, add the proportionate amounts of the products to 1 qt. of water. Add wettable powders and water -dispersible granular products first, then liquids, and emulsifiable concentrates last. After thoroughly mixing, let stand for at least 5 minutes. If the combination remains mixed or can be remixed readily, it is physically compatible. Once compatibility has been proven, use the same procedure for adding required ingredients to the spray tank. For further information, contact your local Bayer CropScience representative. The crop safety of all potential tank mixes including additives and other pesticides on all crops has not been tested. Before applying any tank mixture not specifically recommended on this label, the safety to the target crop should be confirmed. To test for crop safety, apply PROLINE 480 SC Fungicide to the target crop in a small area and in accordance with label instructions for the target crop.

Soilborne/Seedling Disease Control PROLINE 480 SC Fungicide can provide control of certain soilborne/seedling diseases when applied as an in-furrow application at time of planting or as a banded application applied over the row at time of planting and up to row closure on certain crops. Refer to the USE DIRECTIONS FOR SPECIFIC CROPS section of the label to determine which crops contain recommendations for in-furrow and/or banded applications and for the optimal timings, rates and band widths of these applications.

In-Furrow Application • Apply PROLINE 480 SC Fungicide as an in-furrow application in 2.5 to 20 gallons of water at planting. • Mount the spray nozzle such that the spray is directed into the furrow just before the seeds are covered.

Banded Application • Apply PROLINE 480 SC Fungicide as a directed spray to the soil, using single or multiple nozzles which can be adjusted to provide uniform coverage of the lower stems and the soil surface surrounding the plants.

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Rate per 1000 Row Feet

RATE OF PROLINE 48O SC FUNGICIDE FOR IN-FURROW AND BANDED APPLICATIONS (fl oz per acre) fl oz product 15” rows 20” rows 22” rows 30” rows 32” rows 34” rows 36” rows 38” rows 40” rows 0.075 2.61 0.100 3.48 2.61 0.125 4.36 3.27 2.97 0.150 5.23 3.92 3.56 2.61 0.175 6.10 4.57 4.16 3.05 2.86 2.69 0.200 6.97 5.23 4.75 3.48 3.27 3.07 2.90 2.75 2.61 0.225 5.88 5.35 3.92 3.68 3.46 3.27 3.10 2.94 0.250 6.53 5.94 4.36 4.08 3.84 3.63 3.44 3.27 0.275 6.53 4.79 4.49 4.23 3.99 3.78 3.59 0.300 5.23 4.90 4.61 4.36 4.13 3.92 0.325 5.66 5.31 5.00 4.72 4.47 4.25 0.350 6.10 5.72 5.38 5.08 4.81 4.57 0.375 6.53 6.13 5.77 5.45 5.16 4.90 0.400 6.97 6.53 6.15 5.81 5.50 5.23 0.425 6.94 6.53 6.17 5.85 5.55 0.450 6.92 6.53 6.19 5.88 0.475 6.90 6.53 6.21 0.500 6.88 6.53 0.525 6.86 0.543 7.10

Aerial Application: Avoid application under conditions when uniform coverage cannot be obtained or when excessive spray drift may occur. DO NOT apply directly to humans or animals. Chemigation Application: Apply PROLINE 480 SC Fungicide through irrigation equipment only to crops for which chemigation is specified on this label. PROLINE 480 SC Fungicide alone or in combination with other pesticides, which are registered for application through irrigation systems, may be applied through irrigation systems. Apply this product only through center pivot, solid set, drip, linear, or moving wheel irrigation systems. DO NOT apply this product through any other type of irrigation system. Illegal pesticide residues in the crop can result from nonuniform distribution of treated water. If you have questions about calibration, you should contact State Extension Service specialists, equipment manufacturers, or other experts. DO NOT connect an irrigation system (including greenhouse systems) used for pesticide application to a public water system, unless the pesticide label -prescribed safety devices for public water systems are in place. A person knowledgeable of the chemigation system and responsible for its operation, or under the supervision of the re sponsible person, shall shut the system down and make necessary adjustments should the need arise. Operating Instructions

1. The system must contain a functional check-valve, vacuum relief valve, and low-pressure drain appropriately located on the irrigation pipeline to prevent water-source contamination from backflow.
2. The pesticide injection pipeline must contain a functional, automatic, quick -closing check -valve to prevent the flow of fluid back toward the injection pump.
3. The pesticide injection pipeline must also contain a functional, normally closed, solenoid- operated valve located on the intake side of the injection pump and connected to the system interlock to prevent fluid from being withdrawn from the supply tank when the irrigation system is either automatically or manually shut down.
4. The system must contain functional interlocking controls to automatically shut off the pesticide injection pump when the water pump motor stops.
5. The irrigation line or water pump must include a functional pressure switch, which will stop the water pump motor when the water pressure decreases to the point where pesticide distribution is adversely affected.
6. Systems must use a metering pump, such as a positive displacement injection pump (e.g., diaphragm pump), effectively desig ned, and constructed of materials that are compatible with pesticides and capable of being fitted with a system interlock.
7. DO NOT apply when wind speed favors drift beyond the area intended.

Center Pivot Irrigation Equipment Notes: (1) Use only with drive systems, which provide uniform water distribution. (2) DO NOT use end guns when chemigating PROLINE 480 SC Fungicide through center pivot systems because of non-uniform application. Determine the size of the area to be treated. Determine the time required to apply 1/8-1/2 inch of water over the area to be treated when the system and injection equipment are operated at normal pressures as recommended by the equipment manufacturer. When

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applying PROLINE 480 SC Fungicide through irrigation equipment use the lowest obtainable water volume while maintaining uniform distribution. Run the system at 80-95% of the manufacturer’s rated capacity. Using water, determine the injection pump output when operated at normal line pressure. Determine the amount of PROLINE 480 SC Fungicide required to treat the area covered by the irrigation system. Add the required amount of PROLINE 480 SC Fungicide and sufficient water to meet the injection time requirements to the solution tank. Make sure the system is fully charged with water before starting injection of the PROLINE 480 SC Fungicide solution. Time the injection to last at least as long as it takes to bring the system to full pressure. Maintain constant sol ution tank agitation during the injection period. Continue to operate the system until the PROLINE 480 SC Fungicide solution has cleared the sprinkler head. Solid Set and Moving Wheel Irrigation Equipment When applying PROLINE 480 SC Fungicide through irrigation equipment use the lowest obtainable water volume while maintaining uniform distribution. Determine the amount of PROLINE 480 SC Fungicide required to treat the area covered by the irrigation system. Add the required amount of PROLINE 480 SC Fungicide into the same quantity of water used to calibrate the injection period. Operate the system at the same pressure and time interval established during the calibration. Stop injection equipment after treatment is completed. Continue to operate the system until the PROLINE 480 SC Fungicide solution has cleared the last sprinkler head. Using Water from Public Water Systems Public water system means a system for the provision to the public of piped water for human consumption if such system has at least 15 service connections or regularly serves an average of at least 25 individuals daily at least 60 days out of the year. Chem igation systems connected to public water systems must contain a functional, reduced- pressure zone (RPZ), back flow preventer or the functional equivalent in the water supply line upstream from the point of pesticide introduction. As an option to the RPZ, the water from the public water system should be discharged into a reservoir tank prior to pesticide introduction. There shall be a complete physical break (air gap) between the flow outlet end of the fill pipe and the top or overflow rim of the reservoir tank of at least twice the inside diameter of the fill pipe. The pesticide injection pipeline must contain a functional, automatic, quick -closing check valve to prevent the flow of fluid back toward the injection. The pesticide injection pipeline must contain a functional, normally closed, solenoi d-operated valve located on the intake side of the injection pump and connected to the system interlock to prevent fluid from being withdrawn from the supply tank when the irrigation system is either automatically or manually shut down. The system must contain functional interlocking controls to automatically shut off the pesticide injection pump when the water pump motor stops or in cases wher e there is no water pump, when the water pressure decreases to the point where pesticide distribution is adversely affected. Systems mus t use a metering pump, such as a positive displacement injection pump (e.g., diaphragm pump) effectively designed and constructed of materials that are compatible with pesticides and capable of being fitted with a system interlock. Adjuvants: PROLINE 480 SC Fungicide is recommended to be used with a registered non-ionic surfactant at the lowest recommended labeled rate for most crops. Refer to the individual crop recommendations for those specific uses where a surfactant is not recommended.

SPRAY DRIFT ADVISORIES THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE SPRAY DRIFT. BE AWARE OF NEARBY NON-TARGET SITES AND ENVIRONMENTAL CONDITIONS.

Importance Of Droplet Size An effective way to reduce spray drift is to apply large droplets. Use the largest droplets that provide target pest control. While applying larger droplets will reduce spray drift, the potential for drift will be greater if applications are made improperly or under unfavorable environmental conditions.

Controlling Droplet Size – Ground Boom • Volume - Increasing the spray volume so that larger droplets are produced will reduce spray drift. Use the highest practical spray volume for the application. If a greater spray volume is needed, consider using a nozzle with a higher flow rate. • Pressure - Use the lowest spray pressure recommended for the nozzle to produce the target spray volume and droplet size. • Spray Nozzle - Use a spray nozzle that is designed for the intended application. Consider using nozzles designed to reduce drift.

Controlling Droplet Size – Aircraft • Adjust Nozzles - Follow nozzle manufacturer’s recommendations for setting up nozzles. Generally, to reduce fine droplets, nozzles should be oriented parallel with the airflow in flight.

Boom Height – Ground Boom For ground equipment, the boom should remain level with the crop and have minimal bounce.

Release Height – Aircraft Higher release heights increase the potential for spray drift.

Shielded Sprayers Shielding the boom or individual nozzles can reduce spray drift. Consider using shielded sprayers. Verify that the shields are not interfering with the uniform deposition of the spray on the target area.

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Temperature And Humidity When making applications in hot and dry conditions, use larger droplets to reduce effects of evaporation.

Temperature Inversions Drift potential is high during a temperature inversion. Temperature inversions are characterized by increasing temperature with altitude and are common on nights with limited cloud cover and light to no wind. The presence of an inversion can be indicated by ground fog or by the movement of smoke from a ground source or an aircraft smoke generator. Smoke that layers and moves laterally in a concentrated cloud (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates indicates good vertical air mixing. Avoid applications during temperature inversions.

Wind Drift potential generally increases with wind speed. AVOID APPLICATIONS DURING GUSTY WIND CONDITIONS. Applicators need to be familiar with local wind patterns and terrain that could affect spray drift.

ROTATIONAL RESTRICTIONS Treated areas may be replanted with any crop specified on this label as soon as practical after last application. For crops not listed on this label, DO NOT plant back within 30 days of last application.

FUNGICIDE RESISTANCE MANAGEMENT (FRAC) RECOMMENDATIONS For resistance management, PROLINE 480 SC Fungicide contains a Group 3 (prothioconazole) fungicide. Any fungal population may contain individuals naturally resistant to PROLINE 480 SC Fungicide and other Group 3 (prothioconazole) fungicides. A gradual or total loss of pest control may occur over time if these fungicides are used repeatedly in the same fields. Appropriate resistance-management strategies should be followed. To delay fungicide resistance, take one or more of the following steps: • Rotate the use of PROLINE 480 SC Fungicide or other Group 3 (prothioconazole) fungicides within a growing season sequence with different groups that control the same pathogens. • Use tank mixtures with fungicide from a different group that are equally effective on the target pest when such use is permitted. Use at least the minimum application rate as labeled by the manufacturer. • Adopt an integrated disease management program for fungicide use that includes scouting, uses historical information related to pesticide use, and crop rotation, and which considers host plant resistance, impact of environmental conditions on disease development, disease thresholds, as well as cultural, biological and other chemical control practices. • Where possible, make use of predictive disease models to effectively time fungicide applications. Note that using predictive models alone is not sufficient to manage resistance. • Monitor treated fungal/bacterial populations for resistance development. • Contact your local extension specialist or certified crop advisor for any additional pesticide resistance-management and/or IPM recommendations for specific crops and pathogens. • For further information or to report suspected resistance contact Bayer CropScience at 1-866-99BAYER (1-866-992-2937). You can also contact your pesticide distributor or university extension specialist to report resistance.

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USE DIRECTIONS FOR SPECIFIC CROPS PROLINE 480 SC Fungicide provides control or suppression of many important diseases of barley, buckwheat, bushberry subgroup, low growing berry subgroup (except strawberry), corn, cotton, cucurbit vegetables, dry shelled pea and bean crop subgroup, rice, millet, oats, peanuts, rapeseed subgroup 20A (including canola and Brassica carinata), rye, soybean, sugar beets, triticale, wheat; conifer and hardwood nursery seeds and seedlings. When reference is made to disease suppression, suppression can mean either erratic cont rol from good to fair or consistent control at a level below that obtained with the best commercial disease control products.

APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide Barley

Fusarium Head Blight (Fusarium spp.) (Suppression Only) 5.0 - 5.7 fl oz/A (0.156 - 0.178 lbs ai/A) Leaf and Stem Diseases Net Blotch (Pyrenophora teres) Powdery Mildew (Blumeria graminis f. sp. Hordei) Rusts (Puccinia spp.) Scald (Rhynchosporium secalis) Spot Blotch (Cochliobolus sativus) 2.8 - 4.3 fl oz/A (0.088 - 0.134 lbs ai/A) PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment. For aerial applications made prior to heading (prior to Feekes Growth Stage 10.5), apply a minimum of 2 gpa spray solution. For aerial applications made at the heading growth stage or later, apply in a minimum of 5 gpa spray solution. Chemigation use is allowed only for applications made prior to heading. Fusarium Head Blight (Suppression Only): The optimal time to apply PROLINE 480 SC Fungicide is as a preventative foliar spray when barley heads on the main stem are fully emerged (~ Feekes Growth Stages 10.5). Spray equipment must be set to provide good coverage to barley heads. For thorough coverage of barley head using ground application equipment, it is recommended to use forward and backward mounted nozzles or nozzles that have a two-directional spray. Nozzles should be operated within the spray pressure directions suggested by the manufacturer. Leaf and Stem Diseases: Apply PROLINE 480 SC Fungicide as a preventive foliar spray when the earliest disease symptoms appear on the leaves or stems. Barley fields should be observed closely for early disease symptoms, particularly when susceptible varieties are planted and/or under prolonged conditions favorable for disease development. Other Requirements: Apply up to two (2) applications of PROLINE 480 SC Fungicide per year. Repeat applications using a 14- day spray interval if conditions remain favorable for continued or increasing disease development. For optimum disease control, t he lowest labeled rate of a spray surfactant should be tank mixed with PROLINE 480 SC Fungicide. A maximum of 9.37 fl oz (0.293 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. DO NOT apply within 32 days of harvest. DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators.

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APPLICATION DIRECTIONS CROP DISEASES CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE

Bushberry subgroup (Subgroup 13- 07B): Aronia berry; blueberry (highbush and lowbush); Chilean guava; highbush cranberry; currant (black, buffalo, and red); elderberry; European barberry; gooseberry; edible honeysuckle; huckleberry; jostaberry; juneberry (Saskatoon berry); lingonberry; native currant; salal; sea buckthorn; and cultivars, varieties, and/or hybrids of these.

Septoria leaf spot (Septoria spp.)

Monilinia blight (Monilinia vaccinii-corymbosi)

Valdensinia leaf spot (Valdensinia heterodoxa)

Leaf rust (Thekopsora minima)

Anthracnose (Colletotrichum gloeosporioides)

Botrytis blight (Botrytis cinerea)

Phomopsis canker and twig blight [1] (Phomopsis vaccinii)

Alternaria fruit rot[1] (Alternaria spp.)

White pine blister rust[1] (Cronartium ribicola)

5.7 fl oz/A (0.178 lbs ai/A)

PROLINE 480 SC Fungicide may be applied by either ground or chemigation application equipment. Apply PROLINE 480 SC Fungicide at the first sign of disease.

Other Requirements: Apply up to two (2) applications of PROLINE 480 SC Fungicide per year. Repeat applications as needed using a 7- to 10-day spray interval if conditions remain favorable for continued or increasing disease development.

A maximum of 11.4 fl oz (0.356 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. DO NOT apply within 7 days of harvest.

DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment. [1 Not Registered for use in California.]

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APPLICATION DIRECTIONS CROP DISEASES CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE

Low growing berry subgroup, except strawberry[1]: Bearberry; bilberry; cloudberry; cranberry; muntries; partridgeberry; and cultivars, varieties, and/or hybrids of these

Fruit rot: Coleophoma empetri Glomerella cingulata Phyllosticta vaccinii Physalospora vaccinii Allantophomopsis lycopodina Allantophomopsis cytisporea Fusicoccum putrefaciens Penicillium spp. Phomopsis vaccinii Colletotrichum acutatum Botrytis spp. Monilinia spp.

Valdensinia leaf spot (Valdensinia heterodoxa)

5.0 fl oz/A (0.156 lbs ai/A)

PROLINE 480 SC Fungicide may be applied by either ground or chemigation application equipment. For best control of fruit rots begin applications at early bloom. Make a second application of PROLINE 480 SC Fungicide or another approved fungicide 7-10 days later.

Other Requirements: Apply up to two (2) applications of PROLINE 480 SC Fungicide per year. Repeat applications as needed using a 7- to 10-day spray interval if conditions remain favorable for continued or increasing disease development.

A maximum of 10.0 fl oz (0.313 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. DO NOT apply within 45 days of harvest.

DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment. [1 Not Registered for use in California.]

APPLICATION DIRECTIONS CROP DISEASES CONTROLLED RATE OF PROLINE 480 SC Fungicide Buckwheat Millet, pearl Millet, proso Oats Rye Rusts (Puccinia spp.) Glume Blotch (Stagonospora nodorum) Head Blight or Scab (Fusarium graminearum) – Suppression Powdery Mildew (Erysiphe graminis) Scald (Rynchosporium secalis) Speckled Blotch (Septoria avenae; Septoria tritici) Spot Blotch (Bipolaris sorokiniana) Tan Spot or Yellow leaf Spot (Pyrenophora tritici-repentis)

5 - 5.7 fl oz/A (0.156 to 0.178 lbs ai/A) Apply PROLINE 480 SC Fungicide as a preventive foliar spray when the earliest disease symptoms appear on the leaves or stems. Fields should be observed closely for early disease symptoms, particularly when susceptible varieties are planted and/or under prolonged conditions favorable for disease development. Other Requirements: Apply only one application per year. Applications may be made by ground or aerial spray equipment. A maximum of 5.7 fl oz (0.178 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. DO NOT apply within 30 days of harvest. DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators.

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APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide APPLICATION TIMING Corn (field corn, field corn grown for seed and popcorn)

Anthracnose Leaf Blight (Colletotrichum graminicola)

Eye spot (Aureobasidium zeae)

Gray leaf spot (Cercospora zeae-maydis)

Northern Corn Leaf Blight (Setosphaeria turcica) 1

Northern Corn Leaf Spot (Cochliobolus carbonum) 1

Rust (Puccinia spp.)

Southern Corn Leaf Blight (Cochliobolus heterostrophus) 1 5.7 fl oz/A (0.178 lbs ai/A) Apply PROLINE 480 SC Fungicide at the first sign of disease. Repeat applications as needed on a 7 – to 14-day interval if favorable conditions for disease development persist.

DO NOT use adjuvants in sprays made between V8 (8 leaf collar) and VT (lowest branch of the tassel is visible but the silks have not yet emerged). For the suppression of:

Fusarium[2] and Gibberella[2] ear rots (Fusarium spp and Gibberella spp.)

5.7 fl oz per acre (0.178 lbs ai/A) For optimum suppression of Fusarium and Gibberella ear rots, apply PROLINE 480 SC Fungicide from the R1 (initial silk emergence) to the R2 (brown silk) corn growth stages. PROLINE 480 SC Fungicide will reduce both disease symptoms and levels of mycotoxin in the grain. Soilborne/Seedling Diseases:

Rhizoctonia root[2] and stalk rot[2] (Rhizoctonia solani) 2.6 - 4.0 fl oz per acre (0.081 - 0.125 lbs ai/A) In furrow application for soilborne/seedling disease control, see use directions and rate chart for various row spacing under the SOILBORNE/SEEDLING DISEASE CONTROL Section. Other requirements: PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment.

For aerial applications, apply PROLINE 480 SC Fungicide using a minimum of 3 gpa spray solution. An adjuvant may be used to improve spray coverage. Refer to the adjuvant product label for specific use directions.

Application of PROLINE 480 SC Fungicide is not recommended at times when corn is under severe environmental stress conditions. DO NOT exceed 22.8 fl oz (0.713 lbs prothioconazole) total from all uses, including soil and foliar applications, per acre of PROLINE 480 SC Fungicide per year. DO NOT apply within 14 days of harvest for grain and fodder. Forage may be harvested the same day of application.

DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment. 1The above diseases are also known as Helminthosporium leaf blights [2Not registered for use in California.]

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APPLICATION DIRECTIONS CROP DISEASES SUPPRESSED RATE OF PROLINE 480 SC FUNGICIDE

Cotton

In furrow and Banded

Damping off (Rhizoctonia solani)

Fusarium Wilt [1] (Fusarium spp.)

5.7 - 7.1 fl oz/A (0.178 - 0.222 lbs ai/A) (0.4 - 0.5 fl oz per 1000 row feet)

Foliar

Target Spot (Corynespora cassiicola)

Rust (Puccinia spp.)

5.0 - 5.7 fl oz/A (0.156 - 0.178 lbs ai/A)

Application Directions: For foliar applications: PROLINE 480 SC Fungicide may be applied by ground, aerial, or chemigation application equipment. For in-furrow applications: Apply 5.7 to 7.1 fl oz per acre (0.393 to 0.489 fl oz per 1000 row feet if on 36 inch row spacing) in the furrow at planting. For banded applications: PROLINE 480 SC Fungicide may also be applied in a 4- to 6- inch band over the row at or near emergence.

General Comments: When used at 5.0 to 5.7 fl oz per acre, DO NOT apply more than three (3) applications of PROLINE 480 SC Fungicide per year including the in-furrow, banded and foliar applications. If any application is made at a rate above 5.7 fl oz per acre, DO NOT make more than two (2) total applications of PROLINE 480 SC Fungicide per year including in-furrow, banded, and foliar applications. Repeat applications as needed using a 14-day spray interval if conditions remain favorable for continued or increasing disease development. A maximum of 17.1 fl oz (0.534 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year including all soil and foliar applications. DO NOT apply within 30 days of harvest. [1Not registered for use in California.]

APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide Chickpea Ascochyta Blight (Ascochyta spp.) 5.0 - 5.7 fl oz/A (0.156 - 0.178 lb ai/A) PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment. Apply PROLINE 480 SC Fungicide at the first sign of disease. Use the higher use rate when conditions are favorable for severe disease pressure and/or when growing susceptible varieties. Other Requirements: Apply up to three (3) applications of PROLINE 480 SC Fungicide per year. Repeat applications as needed using a 10- to 14-day spray interval if conditions remain favorable for continued or increasing disease development. To optimize disease control, the lowest labeled rate of a spray surfactant should be tank-mixed with PROLINE 480 SC Fungicide. A maximum of 17.1 fl oz (0.534 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. Allow a minimum of 7 days from the last application until cutting or swathing the crop for harvest.

DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment.

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APPLICATION DIRECTIONS CROP DISEASES CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE

Cucurbit vegetables (Crop Group 9): Chayote (fruit); Chinese waxgourd (Chinese preserving melon); citron melon; cucumber; gherkin; edible gourd (includes hyotan, cucuzza, hechima, Chinese okra); Momordica spp (includes balsam apple, balsam pear, bittermelon, Chinese cucumber); muskmelon (includes true cantaloupe, cantaloupe, casaba, Crenshaw melon, golden pershaw melon, honeydew melon, honey balls, mango melon, Persian melon, pineapple melon, Santa Claus melon, and snake melon); pumpkin; squash (summer and winter, includes crookneck squash, scallop squash, straightneck squash, vegetable marrow, zucchini, butternut squash, calabaza, hubbard squash, acorn squash, spaghetti squash); watermelon

Fusarium wilt Fusarium blight (Fusarium oxysporum) (Fusarium spp.)

Gummy stem blight (Didymella spp.)

Southern blight[1] (Sclerotium roflsii)

Powdery mildew (Sphaerotheca fuliginea / Podosphaera xanthii) (Erysiphe cichoracearum)

5.7 fl oz/A (0.178 lbs ai/A) (soil)

5.7 fl oz/A (0.178 lbs ai/A) (foliar) PROLINE 480 SC Fungicide may be applied by either ground or chemigation application equipment (including drip irrigation). DO NOT use in water used for hand transplanting. Not for use in greenhouse/transplant house.

Other Requirements: Apply up to one (1) soil application and two (2) foliar applications of PROLINE 480 SC Fungicide per year. Repeat applications as needed using a 5- to 10-day spray interval if conditions remain favorable for continued or increasing disease development.

A maximum of 17.1 fl oz (0.534 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. DO NOT apply within 7 days of harvest.

DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment. [1Not registered for use in California.]

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APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide Dried Shelled Peas and Beans Subgroup (except soybeans) Lupinus spp. (Grain, Sweet, White and White Sweet lupins) Phaseolus spp .(Field, Kidney, Dry lima, Navy, Pinto and Tepary beans) Vigna spp. (Adzuki bean, Blackeyed pea, Catjang, Cowpea, Crowder pea, Moth bean, Mung bean, Rice bean, Southern pea and Urd bean) Dry broad bean Guar Lablab bean Pisum spp. [Pea (including Field pea) and Pigeon pea] Foliar 5.7 fl oz/A (0.178 lbs ai/A) Ascochyta Blight (Ascochyta pinodes) Rust (Uromyces appendiculatus) White Mold (Sclerotinia sclerotiorum) In Furrow 2.6 - 5.0 fl oz/A (0.081 - 0.156 lbs ai/A) Rhizoctonia rots[1] (Rhizoctonia spp.)

PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment. For ground applications, apply in a minimum of 20 gpa. In-furrow use: Apply up to 5.0 fl oz per acre (0.288 fl oz per 1000 row feet if on 30 inch row spacing; 0.192 fl oz per 1000 row feet if on a 20 inch row spacing) in the furrow at planting. See use directions and rate chart for various row spacing under the SOILBORNE/SEEDLING DISEASE CONTROL section. For rust control, apply PROLINE 480 SC Fungicide at the first sign of disease. For white mold control, apply PROLINE 480 SC Fungicide at 25% flower.

Other Requirements: Apply up to three (3) applications of PROLINE 480 SC Fungicide per year. Repeat applications as needed using a 5- to 14-day spray interval if conditions remain favorable for continued or increasing disease development. To optimize disease control, the lowest labeled rate of a spray surfactant should be tank-mixed with PROLINE 480 SC Fungicide. A maximum of 17.1 fl oz of PROLINE 480 SC Fungicide (0.534lbs prothioconazole) may be applied per acre per year. Allow a minimum of 7 days from the last application until cutting or swathing the crop for harvest. DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators. [1Not registered for use in California.]

APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide Lentils Ascochyta Blight (Ascochyta spp.) 4.3 - 5.7 fl oz/A (0.134 - 0.178 lbs ai/A) PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment. Apply PROLINE 480 SC Fungicide at early flower or at the first sign of disease. Use the higher use rate when conditions are favorable for severe disease pressure and/or when growing less disease resistant varieties. Other Requirements: Apply up to three (3) applications of PROLINE 480 SC Fungicide per year. Repeat applications as needed using a 10- to 14-day spray interval if conditions remain favorable for continued or increasing disease development. To optimize disease control, the lowest labeled rate of a spray surfactant should be tank-mixed with PROLINE 480 SC Fungicide. A maximum of 17.1 fl oz (0.534 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. Allow a minimum of 7 days from the last application until cutting or swathing the crop for harvest.

DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment.

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APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide Rapeseed Subgroup 20A (including canola and Brassica carinata[1]):

Borage, Brassica carinata, crambe, cuphea, echium, flax, gold of pleasure, hare’s ear mustard, lesquerella, lunaria, meadowfoam, milkweek, mustard seed, oil radish, poppy seed, rapeseed, sesame, sweet rocket, cultivars, varieties, and/or hybrids of these Sclerotinia Stem Rot White Mold (Sclerotinia sclerotiorum) 4.3 - 5.7 fl oz/A (0.134 - 0.178 lbs ai/A) PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment. Apply PROLINE 480 SC Fungicide when the crop is in the 20 - 50% bloom stage. Best protection will be achieved when the fungicide is applied prior to petals beginning to fall, and will allow for the maximum number of petals to be protected. Utilize the higher rate for fields with a history of heavy disease pressure or for dense crop stands. Good spray coverage of the plants is essential. The lowest labelled rate of a non-ionic surfactant may be tank-mixed with PROLINE 480 SC Fungicide. Other Requirements: Apply up to two (2) applications of PROLINE 480 SC Fungicide per year. A second application may be made after 14 days if conditions remain favorable for continued or increasing disease development. A m aximum of 11.4 fl oz (0.356 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. PROLINE 480 SC Fungicide may be applied until the 50% bloom stage. DO NOT apply within 36 days of harvest. DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators. [1Not registered for use in California.]

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APPLICATION DIRECTIONS CROP DISEASE SUPPRESSED RATE OF PROLINE 480 SC Fungicide Peanut[1]

In-furrow and banded Sclerotium Rot White Mold Southern Blight Southern Stem rot (Sclerotium rolfsii)

Rhizoctonia Limb Rot (Rhizoctonia solani)

Early Leaf Spot (Cercospora arachidicola)

Late Leaf Spot (Cercosporidium personatum)

Cylindrocladium Black Rot (CBR) (Cylindrocladium crotalariae) (Suppression with In furrow only) 0.4 fl oz per 1000 row feet (5.7 fl oz/A) (0.178 lbs ai/A) Soil-Borne Sclerotium Rot (Sclerotium rolfsii) (White Mold, Southern Blight, Southern Stem Rot) Rhizoctonia Limb Rot, Peg Rot, Pod Rot (Rhizoctonia solani) Cylindrolcadium Black Rot (Cylindrocladium crotalariae) (Suppression Only) 5.7 fl oz/A (0.178 lbs ai/A) Foliar Early Leaf Spot (Cercospora arachidicola) Late Leaf Spot (Cercosporidium personatum) Leaf Rust (Puccinia arachidis) Web Blotch (Phoma arachidicola) Leaf Scorch and Pepper Spot (Leptosphaerulina crassiasca) 5.0 - 5.7 fl oz/A (0.156 - 0.178 lbs ai/A) Proline 480 SC Fungicide may be applied by ground, chemigation, or aerial application equipment. In-furrow and Banded Spray Program: Apply 5.7 fl oz per acre (0.4 fl oz per 1000 row feet if on 36 inch row spacing) in the furrow at planting. PROLINE 480 SC Fungicide may also be applied in a 4- to 6- inch band over the row at or near emergence. Bayer CropScience recommends a minimum application volume of 20 gpa. Foliar Disease Spray Program: Apply the specified rate in a preventive spray schedule. Apply up to four (4) sprays using a 14-day interval. Use the higher use rate when conditions are favorable for severe disease pressure and/or when growing less disease resistant varieties. Soil-Borne Disease Spray Program: For optimum control of the specified soil -borne diseases, four consecutive applications of PROLINE 480 SC Fungicide must be made at 14-day intervals. In a typical 7 spray application program beginning 30-40 days after planting or as recommended by the local Extension Service, PROLINE 480 SC Fungicide should be applied for sprays 3, 4, 5 and 6. Applications of fungicides with a different mode of action should be made prior to and following applications of PROLINE 480 SC Fungicide to discourage development of resistant strains of fungi. Use PROLINE 480 SC Fungicide in conjunction with cultural practices that are known to reduce the severity of soil -borne diseases, such as proper crop rotation practices. For control of soil -borne diseases when using a Leaf Spot Advisory Program schedule, apply PROLINE 480 SC Fungicide in the first advisory spray in July and continue PROLINE 480 SC Fungicide applications at 14- day intervals. PROLINE 480 SC Fungicide must be carried by rainfall or irrigation into the root and pod zone for control of root and pod rots caused by Sclerotium rolfsii and Rhizoctonia solani . Drought conditions will decrease the effectiveness of PROLINE 480 SC Fungicide against the root and pod rots.

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Other Requirements: Apply up to four (4) applications of PROLINE 480 SC Fungicide per year, including the in -furrow and banded applications. When planting varieties with good to excellent levels of resistance to foliar diseases, the application interval may be extended up to 21 days in the absence of soil borne diseases. A maximum of 22.8 fl oz (0.713 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. PROLINE 480 SC Fungicide may be applied up to 14 days before harvest. DO NOT feed hay or threshings or allow livestock to graze in treated areas. DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators. [1Not registered for use in California.]

APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE® 480 SC FUNGICIDE Rice[1]

Sheath/Stem Diseases Sheath Blight (Rhizoctonia solani) 4.5 fl oz/A (0.141 lbs ai/A) Foliar Diseases Brown Spot (Cochliobolus miyabeanus) Narrow Brown Leafspot (Cercospora oryzae) Leaf Smut (Entyloma oryzae) False smut (Ustilaginoidea virens)

Apply PROLINE® 480 SC Fungicide at initial sign of disease. Exact timing for rice disease control is dependent on rice growth stage, rice variety, the type of disease to be controlled and disease severity. Applications typically will occur from panicle differentiation to late boot. Consult with your local extension personnel or Bayer Crop Science representative to determine if treatment is needed. Other Requirements: Apply only one application of PROLINE® 480 SC Fungicide per year. Application may be made by ground or aerial spray equipment. A maximum of 4.5 fl oz (0.141 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. DO NOT apply PROLINE 480 SC Fungicide later than 70% panicle emergence from the boot. DO NOT apply within 40 days of harvest. Not for use in California. DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators. [1Not registered for use in California.]

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APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide Soybean Asian Soybean Rust (Phakopsora pachyrhizi)

Frog Eye Leaf Spot (Cercospora sojina)

Powdery Mildew (Microsphaera diffusa)

Brown Spot [1] (Septoria glycines)

2.5 - 3.0 fl oz/A (0.078 - 0.094 lbs ai/A) Alternaria Leaf Spot[1] (Alternaria spp.)

Anthracnose[1] (Colletotrichum truncatum)

Asian Soybean Rust[1] (Phakopsora pachyrhizi)

Brown Spot[1] (Septoria glycines)

Cercospora Blight [1] (Cercospora kikuchii)

Frogeye Leaf Spot [1] (Cercospora sojina)

Pod & Stem Blight[1] (Diaporthe phaseolorum)

Powdery Mildew[1] (Microsphaera diffusa)

Rhizoctonia Aerial Blight[1] (Rhizoctonia solani)

Sclerotinia Stem Rot also known as White Mold (Sclerotinia sclerotiorum) (Suppression Only) 3.0 - 5.0 fl oz/A (0.094 to 0.156 lbs ai/A) In Furrow 2.6 - 5.0 fl oz/A (0.081 - 0.156 lbs ai/A) Rhizoctonia rots[1] (Rhizoctonia spp.) PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment. For aerial application, apply in a minimum spray volume of 2 gpa. Apply PROLINE 480 SC Fungicide as a broadcast, preventative foliar spray or at first visible symptoms of the disease. Repeat applications on a 10- to 21-day spray interval if environmental conditions are favorable for continued disease development. Use of the higher rate and shorter spray intervals are recommended when disease pressure is severe.

In-furrow use: Apply up to 5.0 fl oz per acre (0.288 fl oz per 1000 row feet if on 30 inch row spacing; 0.192 fl oz per 1000 row feet if on a 20 inch row spacing) in the furrow at planting. See use directions and rate chart for various row spacing under the SOILBORNE/SEEDLING DISEASE CONTROL section.

Sclerotinia Stem Rot (Suppression Only): Apply PROLINE 480 SC Fungicide as a broadcast foliar spray at R1 (beginning bloom) when conditions are favorable for disease development. A sequential treatment of PROLINE 480 SC Fungicide or Stratego YLD Fungicide may be made at R3 – R4 (beginning to full pod). PROLINE 480 SC Fungicide may be applied by ground or air. Apply in a minimum of 10 gallons of spray solution per acre by ground sprayer or in a minimum of 5 gallons of spray solution per acre by aircraft spray equipment. Other Requirements: Applications may not be made within 21 days of harvest. DO NOT apply more than 3 applications per year including all soil and foliar applications. DO NOT apply more than 12.9 fl oz (0.403 lbs prothioconazole) of PROLINE 480 SC Fungicide per acre per year.

DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators.

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[1Not registered for use in California.]

APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide

Sugar beets

Foliar Diseases

Cercospora Leaf Spot (Cercospora beticola)

Powdery Mildew (Erysiphe polygoni)

5.0 - 5.7 fl oz/A (0.156 - 0.178 lbs ai/A)

In furrow and banded 5.7 fl oz/A (0.178 lbs ai/A) Rhizoctonia Stem Canker, Root Rot, Crown Rot (Rhizoctonia solani) PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment.

Foliar disease control: Apply PROLINE 480 SC Fungicide at the first sign of disease. Use the higher use rate and shorter intervals when conditions are favorable for severe disease pressure and/or when growing less disease resistant varieties.

Soil-borne disease control: Apply PROLINE 480 SC Fungicide in a seven-inch band at the 4-leaf to row closure growth stage.

For in-furrow use: apply up to 5.7 fl oz per acre (0.4 fl oz per 1000 row feet if on 36 inch row spacing) in the furrow at planting. See use directions and rate chart for various row spacing under the SOILBORNE/SEEDLING DISEASE CONTROL section.

Other Requirements: Apply up to 3 applications of PROLINE 480 SC Fungicide per year including all soil and foliar applications. Repeat applications as needed using a 14- to 21-day spray interval depending on disease pressure. Use a 14-day spray interval under normal to heavy disease pressure and a 21-day spray interval under light disease pressure.

To optimize disease control, the lowest labeled rate of a spray surfactant may be tank-mixed with PROLINE 480 SC Fungicide.

A maximum of 17.1 fl oz of PROLINE 480 SC Fungicide (0.534 lbs prothioconazole) may be applied per acre per year. Allow a minimum of 7 days from the last application before harvesting.

PROLINE 480 SC Fungicide is a Group 3 fungicide. To limit the potential for development of disease resistance: • Alternate every application of PROLINE 480 SC Fungicide with a non-Group 3 fungicide.

DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators.

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APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC Fungicide Wheat (spring, durum and winter) Triticale

Fusarium Head Blight (Fusarium spp.) (Suppression Only) 5.0 - 5.7 fl oz/A (0.156 - 0.178 lbs ai/A) Leaf and Stem Diseases Powdery Mildew (Blumeria graminis f. sp. tritici) Rusts (Puccinia spp.) Septoria Leaf and Glume Blotch (Septoria tritici) Stagonospora Blotch (Stagonospora nodorum) Tan Spot (Pyrenophora tritici-repentis) 4.3 - 5.0 fl oz/A (0.134 - 0.156 lbs ai/A) PROLINE 480 SC Fungicide may be applied by either ground, aerial or chemigation application equipment. For aerial application made prior to early flower (prior to Feekes Growth Stage 10.51, apply a minimum of 2 gpa spray solution. For aerial applications made at the early flower growth stage or later, apply in a minimum of 5 gpa spray solution. Chemigation use is allowed only for applications made prior to early flower. Fusarium Head Blight (Suppression Only): The optimal time to apply PROLINE 480 SC Fungicide is as a preventative foliar spray at early flower (Feekes Growth Stage 10.51). Spray equipment must be set to provide good coverage to wheat heads. For thorough coverage of the wheat head using ground application equipment, use forward and backward mounted nozzles or nozzles that have a two -directional spray. Operate nozzles within the spray pressure directions suggested by the manufacturer. Leaf and Stem Diseases: Apply PROLINE 480 SC Fungicide as a preventive foliar spray when the earliest disease symptoms appear on the leaves or stems. Wheat fields should be observed closely for early disease symptoms, particularly when susceptible varieties are planted and/or under prolonged conditions favorable for disease development. Other Requirements: Apply up to two (2) applications of PROLINE 480 SC Fungicide per year. Repeat applications using a 14-day spray interval if conditions remain favorable for continued or increasing disease development. For optimum disease control, t he lowest labeled rate of a spray surfactant should be tank mixed with PROLINE 480 SC Fungicide. A maximum of 9.37 fl oz (0.293 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per year. DO NOT apply within 30 days of harvest. DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators.

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APPLICATION DIRECTIONS CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE Nursery seedlings of Shortleaf, Loblolly, Slash, Longleaf and other pines and other Conifers and Hardwoods

Fusiform rust (Cronartium quercum f.sp. fusiforme)

Pitch canker (Fusarium spp.)

Rhizoctonia foliar blight (Rhizoctonia spp.) 5.0 fl oz/A (0.156 lbs ai/A)

Nursery seeds of Shortleaf, Loblolly, Slash, Longleaf and other pines and other Conifers and Hardwoods Fusiform rust (Cronartium quercum f.sp. fusiforme)

Pitch canker (Fusarium spp.) 10 fl oz per 50 lbs seed

DO NOT use in forest planting or established woodlands. The crop safety and mix compatibility on all tree species and in tank-mixes with other products (spray surfactants, fertilizers, insecticides, etc.) has not been confirmed. Bayer CropScience recommends small scale testing with your planned use pattern. The user assumes all risks with the use of this product on trees.

DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment.

Tree Seedling Application Directions: Foliar disease control: Apply PROLINE 480 SC Fungicide preventatively or at the first sign of disease using ground equipment only. Repeat applications as needed using a 14- to 21-day spray interval depending on your region. Consult your local extension agent on locally recommended spray intervals. Use shorter intervals when conditions are favorable for severe disease pressure and/or when growing less disease resistant varieties. To optimize disease control, the lowest labeled rate of a spray surfactant may be tank-mixed with PROLINE 480 SC Fungicide. A maximum off 25 fl oz (0.781 lbs prothioconazole) of PROLINE 480 SC Fungicide may be applied per acre per crop year.

Tree Seed Treatment Directions: Apply specified dosage to seed in a commercial treater or other suitable tumbler apparatus. Allow to mix for at least 10 minutes. Thoroughly air dry before sowing. DO NOT use treated seed for food or feed purposes. Seed that has been treated with this product that is then packaged or bagged for future use must contain the following labeling on the outside of the seed package or bag: “This seed has been treated with prothioconazole. Treated Seed – DO NOT Use for Food, Feed, or Oil Purposes. When opening this bag or loading/pouring the treated seed, wear a long sleeved shirt, long pants, shoes, socks, and chemical resistant gloves. After the seeds have been planted, do not enter or allow worker entry into treated areas during the restricted-entry interval (REI) of 12 hours. Exception: Once the seeds are planted in soil or other planting media, the Worker Protection Standard allows workers to enter the treated area without restriction if there will be no worker contact with the treated seeds in the soil or planting media.

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STORAGE AND DISPOSAL DO NOT contaminate water, food, or feed by storage or disposal. Pesticide Storage: Store in a cool, dry place and in such a manner as to prevent cross contamination with other pesticides, fertilizers, food, and feed. Store in original container and out of the reach of children, preferably in a locked storage area. Handle and open container in a manner as to prevent spillage. If container is leaking, invert to prevent leakage. If the cont ainer is leaking or material is spilled for any reason or cause, carefully dam up spilled material to prevent runoff. Refer to Precaut ionary Statements on label for hazards associated with the handling of this material. DO NOT walk through spilled material. Absorb spilled material with absorbing type compounds and dispose of as directed for pesticides below. In spill or leak incidents, keep unauthorized people away. You may contact the Bayer CropScience Emergency Response Team for decontamination procedures or any other assistance that may be necessary. The Bayer CropScience Emergency Response Telephone No. is 1-800-334-7577. Pesticide Disposal: Wastes resulting from the use of this product must be disposed of on- site or at an approved waste disposal facility. Container Disposal: Non-refillable container. DO NOT reuse or refill this container. Triple rinse or pressure rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Pressure rinse as follows: Empty the remaining contents into application equipment or a mix tank and continue to drain for 10 seconds after the flow begins to drip. Hold container upside down over application equipment or mix tank or collect rinsate for later use or disposal. Insert pressure-rinsing nozzle in the side of the container, and rinse at about 40 PSI for at least 30 seconds. Drain for 10 seconds after the flow begins to drip. Offer for recycling, if available. If not recycled, then puncture and dispose of in a sanitary landfill, or by incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke.

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IMPORTANT: READ BEFORE USE Read the entire Directions for Use, Conditions, Disclaimer of Warranties and Limitations of Liability before using this product. If terms are not acceptable, return the unopened product container at once. By using this product, user or buyer accepts the following Conditions, Disclaimer of Warranties and Limitations of Liability. CONDITIONS: The directions for use of this product are believed to be adequate and must be followed carefully. However, it is impossible to eliminate all risks associated with the use of this product. Crop injury, ineffectiveness or other unintended c onsequences may result because of such factors as weather conditions, presence of other materials, or the manner of use or application, all of which are beyond the control of Bayer CropScience. To the extent consistent with applicable law, all such risks shall be assumed by the user or buyer. DISCLAIMER OF WARRANTIES: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THIS LABEL. No agent of Bayer CropScience is authorized to make any warranties beyond those contained herein or to modify the warranties contained herein. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BAYER CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER FOR SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. LIMITATIONS OF LIABILITY: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES, INJURIES OR DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHALL NOT EXCEED THE PURCHASE PRICE PAID, OR AT BAYER CROPSCIENCE’S ELECTION, THE REPLACEMENT OF PRODUCT.

NET CONTENTS:

Proline is a registered trademark of Bayer Group.

PRODUCED FOR

Bayer CropScience LP 800 N. Lindbergh Blvd. St. Louis, MO 63167 1-866-99BAYER (1-866-992-2937)

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PROLINE® 480 SC Fungicide ABN: PTZ 480 ST; Redigo 480; Acceleron D-342 Fungicide Seed Treatment

Section B: Seed Treatment Uses

PROTHIOCONAZOLE GROUP 3 FUNGICIDE

25

PROTHIOCONAZOLE GROUP 3 FUNGICIDE PROLINE® 480 SC Fungicide [ABN: PTZ 480 ST; Redigo 480; Acceleron D-342 Fungicide Seed Treatment] For: control of specified diseases on listed crops. ACTIVE INGREDIENT: Prothioconazole, 2-[2-(1-Chlorocyclopropyl)-3- (2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione: ...................................................................................... 41.00% OTHER INGREDIENTS: ................................................................................................................................................................. 59.00% TOTAL: 100.00%

Contains 4.00 pounds Prothioconazole per U.S. gallon

EPA Reg. No. 264-825 EPA Est.

KEEP OUT OF REACH OF CHILDREN CAUTION For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1 -800-334-7577 For PRODUCT USE Information Call 1-866-99BAYER (1-866-992-2937)

Please refer to [back panel] [booklet] for additional precautionary statements and directions for use. [Note to reviewer: Location of additional precautionary statements and directions for use will vary between those listed, depending on container type/size.]

Net Contents:

PRODUCED FOR

Bayer CropScience LP 800 N. Lindbergh Blvd. St. Louis, MO 63167 1-866-99BAYER (1-866-992-2937)

26

FIRST AID If Swallowed: • Immediately call a poison control center or doctor for treatment advice. • Have person sip a glass of water if able to swallow. • Do not induce vomiting unless told to do so by a poison control center or doctor. • Do not give anything by mouth to an unconscious person. If Inhaled: • Move person to fresh air. • If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably mouth-to - mouth if possible. • Call a poison control center or doctor for further treatment advice. If on Skin or Clothing: • Take off contaminated clothing. • Rinse skin immediately with plenty of water for 15-20 minutes. • Call a poison control center or doctor for treatment advice. If in eyes: • Hold eye open and rinse slowly and gently with water for 15-20 minutes. • Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. • Call a poison control center or doctor for treatment advice. In case of emergency call toll free the Bayer CropScience Emergency Response Telephone No. 1-800-334-7577. Have the product container or label with you when calling a poison control center or doctor, or going for treatment. Note to Physician: No specific antidote. Treat symptomatically.

PRECAUTIONARY STATEMENTS

HAZARDS TO HUMANS AND DOMESTIC ANIMALS CAUTION • Harmful if swallowed or inhaled. • Causes moderate eye irritation. • Avoid contact with eyes and clothing. Avoid breathing vapor or spray mist. • Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacco. • Remove and wash contaminated clothing before reuse.

PERSONAL PROTECTIVE EQUIPMENT (PPE)

Applicators and other handlers must wear: • Long-sleeved shirt and long pants • Chemical resistant gloves made of any waterproof material • Shoes plus socks

ENGINEERING CONTROLS When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.670(d-f)], the handler PPE requirements may be reduced or modified as specified in the WPS.

USER SAFETY RECOMMENDATIONS • Users should wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. • Users should remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. • Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

USER SAFETY REQUIREMENTS Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.

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ENVIRONMENTAL HAZARDS

This product is toxic to estuarine/marine invertebrates, and freshwater/estuarine/marine aquatic plants. DO NOT apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. DO NOT contaminate water when disposing of equipment washwater or rinsate. Surface Water Advisory This product may impact surface water quality due to runoff of rainwater. This is especially true for poorly draining soils and soils with shallow ground water. This product is classified as having high potential for reaching surface water via. runoff for several months or more after application. A level, well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the potential loading of prothioconazole and degradates from runoff water and sediment. Runoff of this product will be reduced by avoiding applications when rainfall or irrigation is expected to occur within 48 hours. Ground Water Advisory Degradates of prothioconazole are known to leach through soil into groundwater under certain conditions as a result of label use. These chemicals may leach into groundwater if used in areas where soils are permeable, particularly where the water table is shallow.

CONDITIONS OF SALE AND LIMITATIONS OF WARRANTY AND LIABILITY Read the entire Directions for Use, Conditions, Disclaimer of Warranties and Limitations of Liability before using this product. If terms are not acceptable, return the unopened product container at once. By using this product, user or buyer accepts the following Conditions, Disclaimer of Warranties and Limitations of Liability. Treatment of highly mechanically damaged seed, or seed of known low vigor and poor quality, may result in reduced germination and/or reduction of seed and seedling vigor. Treat and conduct germination tests on a small portion of seed before committing the total seed lot to a selected chemical treatment. Due to seed quality conditions beyond the control of Bayer CropScience, no claims are made to guarantee germination of carry-over seed. CONDITIONS: The directions for use of this product are believed to be adequate and must be followed carefully. However, it is impossible to eliminate all risks associated with the use of this product. Crop injury, ineffectiveness or other unintended consequences may result because of such factors as weather conditions, presence of other materials, or the manner of use or application, all of which are beyond the control of Bayer CropScience. To the extent consistent with applicable law, all such risks shall be assumed b y the user or buyer. DISCLAIMER OF WARRANTIES: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THIS LABEL. No agent of Bayer CropScience is authorized to make any warranties beyond those contained herein or to modify the warranties contained herein. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, B AYER CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER FOR SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. LIMITATIONS OF LIABILITY: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES, INJURIES OR DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHALL NOT EXCEED THE PURCHASE PRICE PAID, OR AT BAYER CROPSCIENCE’S ELECTION, THE REPLACEMENT OF PRODUCT.

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DIRECTIONS FOR USE

It is a violation of Federal law to use this product in a manner inconsistent with its labeling. Read the entire label before using this product.

For use only in commercial seed treatment equipment. DO NOT use in hopper box, planter box, slurry box, or other on-farm seed treatment applications.

PRODUCT INFORMATION PROLINE® 480 SC Fungicide: • is a broad-spectrum systemic seed treatment fungicide for the control of Ascomycetes, Basidiomycetes and Deuteromycetes diseases in a variety of crops including alfalfa, barley, buckwheat, cotton, dried shelled pea and bean (except for soybean) subgroup, millet (Pearl & Proso), oats, rice, rye, sorghum, soybeans, triticale, and wheat.

APPLICATION INSTRUCTIONS • PROLINE 480 SC Fungicide provides control or suppression of many important diseases of alfalfa, barley, buckwheat, cotton, dried shelled pea and bean (except for soybean) subgroup, millet (Pearl & Proso), oats, rice, rye, sorghum, soybeans, triticale, and wheat. • Apply using standard slurry or mist-type seed treatment equipment. Uniform application of seed is necessary to ensure seed safety and best disease protection. Product should be diluted with sufficient water to ensure complete seed coverage. Consult a seed treatment specialist regarding slurry rates recommended for the crop to be treated with Proline 480 SC Fungicide. For best results, apply to high quality, properly cleaned seed. • When reference is made to disease suppression, suppression can mean either erratic control from good to fair or consistent control at a level below that obtained with the best commercial disease control products. • Under conditions conducive to extended infection periods or high disease pressure, additional fungicide applications beyond the number allowed by this label may be needed. Under these conditions use another fungicide registered for the crop/disease. • Equipment must be properly calibrated before use.

USE RESTRICTIONS • DO NOT use in hopper box, planter box, slurry box, or other on-farm seed treatment applications. • This product does not contain colorant. The purchaser of this product is responsible for ensuring that all seed treated with this product are adequately dyed with a suitable color to prevent its accidental use as food for man or feed for animals. Refer to 21CFR, part 2.25. Any colorant added to treated seed must be cleared for use under 40CFR, Part 153.155(c). • In California – Registered only for use in commercial seed treating establishments. DO NOT use for “on-farm” use. • Store treated seeds away from food and feedstuffs. • DO NOT allow children, pets, or livestock to have access to treated seed. • Wear long-sleeved shirt, long pants, shoes, socks, and chemical-resistant gloves when handling treated seed. • Excess treated seed may be used for ethanol production only if (1) by-products are not used for livestock feed and (2) no measurable residues of pesticide remain in ethanol by-products that are used in agronomic practice. • Treated seeds exposed on soil surface may be hazardous to wildlife. Cover or collect treated seeds spilled during loading and planting (such as in row). • Dispose of all excess treated seed. • DO NOT contaminate water bodies when disposing of planting equipment wash waters. • Plant treated seed into the soil at a minimum depth of 1/2 inch or greater to minimize exposure. • DO NOT plant treated seed by broadcasting to the soil surface. Ensure that all planted seeds are thoroughly incorporated by the planter during planting, additional incorporation may be required to thoroughly cover exposed seeds. • Dispose of seed packaging or containers in accordance with local requirements. DO NOT use empty seed bags for any other purpose. • To reduce seed dust which can drift onto blooming crops or weeds, ensure that planting equipment is functioning properly in accordance with manufacturer’s recommendations. Surplus seed or empty seed containers must be stored or disposed according to local federal regulations. • After the seeds have been planted, DO NOT enter or allow worker entry into the treated areas during the restricted-entry interval (REI) of 12 hours. Exception: Once the seeds are planted in soil or other planting media, the Worker Protection Standard allows workers to enter the treated area without restriction if there will be no worker contact with the treated seeds in the soil or with the planting media. • DO NOT use with handheld application equipment, including backpack or mechanically/manually pressurized hand equipment. Refer to the specific use directions and restrictions in each Crop, Crop Group or Crop Subgroup table.

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ROTATIONAL RESTRICTIONS Treated areas may be replanted with any crop specified on this label as soon as practical after last application. For crops not listed on this label. DO NOT plant back within 30 days of last application.

FUNGICIDE RESISTANCE MANAGEMENT (FRAC) RECOMMENDATIONS For resistance management, PROLINE 480 SC Fungicide contains a Group 3 (prothioconazole) fungicide. Any fungal population may contain individuals naturally resistant to PROLINE 480 SC Fungicide and other Group 3 (prothioconazole) fungicides. A gradual or total loss of pest control may occur over time if these fungicides are used repeatedly in the same fields. Appropriate resistance-management strategies should be followed. To delay fungicide resistance, take one or more of the following steps: • Rotate the use of PROLINE 480 SC Fungicide or other Group 3 (prothioconazole) fungicides within a growing season sequence with different groups that control the same pathogens. • Use tank mixtures with fungicide from a different group that are equally effective on the target pest when such use is permitted. Use at least the minimum application rate as labeled by the manufacturer. • Adopt an integrated disease management program for fungicide use that includes scouting, uses historical information related to pesticide use, and crop rotation, and which considers host plant resistance, impact of environmental conditions on disease development, disease thresholds, as well as cultural, biological and other chemical control practices. • Where possible, make use of predictive disease models to effectively time fungicide applications. Note that using predictive models alone is not sufficient to manage resistance. • Monitor treated fungal/bacterial populations for resistance development. • Contact your local extension specialist or certified crop advisor for any additional pesticide resistance-management and/or IPM recommendations for specific crops and pathogens. • For further information or to report suspected resistance contact Bayer CropScience at 1-866-99BAYER (1-866-992-2937). You can also contact your pesticide distributor or university extension specialist to report resistance.

SPECIFIC CROP DIRECTIONS

CROP USE DIRECTIONS

APPLICATION DIRECTIONS FOR SEED TREATMENT

APPLICATION DIRECTIONS FOR SEED TREATMENT CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE Alfalfa[1]

Seed rot and damping-off caused by Rhizoctonia 0.48 fl oz per 100 lbs seed (15 g ai per 100 kg seed) [1Not registered for use in California.]

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CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE Beans and Peas (dried) including Soybean (Crop Group 6C) [1]

Soybean, Adzuki Bean, Blackeyed Pea, Broad Bean, Catjang, Chickpea, Cowpea, Crowder Pea, Field Bean, Field Pea, Guar, Kidney Bean, Lablab Bean, Lentil, Lima Bean, Moth Bean, Mung Bean, Navy Bean, Pigeon Pea, Pinto Bean, Rice Bean, Southern Pea, Tepary Bean, Urd Bean Seed rot and damping-off caused by Rhizoctonia, Fusarium Seed decay APPLICATION RATE PER 100 LBS: 0.16 - 0.32 fl oz per 100 lbs seed (5 - 10 g ai per 100 kg seed)

APPLICATION RATE PER SEED (based on 3000 seed per lbs; soybean only): 0.0075 - 0.015 mg ai per seed

[1Not registered for use in California.]

CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE Cereal grains [1] Barley

Buckwheat

Millet (Pearl and Proso)

Oats

Rye

Triticale

Wheat

Corn and Rice (see corn and rice sections in this table)

Common bunt Covered smut False loose smut Flag smut Leaf stripe Loose smut Stinking smut Stem smut True loose smut Seed rot, pre-emergence damping-off and seedling blight caused by soilborne Rhizoctonia solani, Fusarium, Cochliobolus Seed decay Common root rot, foot rot, and crown rot (early season suppression) Rust, Septoria and powdery mildew (early season suppression)

Note - For environments with Pythium pressure, combine Proline 480 with Allegiance Flowable Seed Treatment Fungicide at rates recommended on label.

0.16 - 0.8 fl oz per 100 lbs seed (5 - 25 g ai per 100 kg seed)

[1Not registered for use in California.]

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CORN (Field Corn, Field Corn Grown For Seed, Popcorn, and Sweet Corn)[1] Disease(s) Controlled/Suppressed Seedborn disease and early season seedling disease caused by: Fusarium spp. Rhizoctonia solani Rate of Proline 480 SC Fungicide Crop seeds/lb2 fl oz/100 lbs seed fl oz/80,000 seed unit mg ai/seed Field Corn, Field Corn Grown For Seed 1681 0.08 - 0.2 0.038 - 0.381 0.0068 - 0.0676 Popcorn 3061 0.08 - 0.2 0.021 - 0.210 0.0037 - 0.0371 Sweet Corn 3150 0.08 - 0.2 0.020 - 0.203 0.0036 - 0.0361

Crop Specific Directions and Restrictions: • Maximum application rate is 2.0 fl oz a.i./100 lbs seed. 2Seeds/lb values based on averages for Field Corn (1681 seeds/lb), Popcorn (3061 seeds/lb), and Sweet Corn (3150 seeds/lb). [1Not registered for use in California.]

CROP DISEASE CONTROLLED RATE OF PROLINE 480 SC FUNGICIDE Rice[1] Seed rot and damping-off caused by Rhizoctonia and Fusarium Seed decay

0.16 - 0.32 fl oz per 100 lbs seed (5 - 10 g ai per 100 kg seed)

Notes and Restrictions • DO NOT plant treated rice seed directly into a flooded field. DO NOT soak treated rice seed. [1Not registered for use in California.]

COTTON[1] Disease(s) Controlled Seedborne decay caused by Fusarium spp. Cladosporium spp., Penicillium spp. Alternaria spp. Soilborne seedling disease caused by Fusarium spp. Rhizoctonia solani Rate of Proline 480 SC Fungicide seeds/lb fl oz/100 lbs seed fl oz/100,000 seeds mg ai/seed 4500 0.15 - 0.40 0.035 - 0.090 0.005 - 0.013 Disease(s) Controlled Seedling disease caused by heavy infestations of Fusarium spp. and Rhizoctonia solani Rate of Proline 480 SC Fungicide seeds/lb fl oz/100 lbs seed fl oz/100,000 seeds mg ai/seed 4500 0.40 - 0.81 0.090 - 0.18 0.013 - 0.026 Crop Specific Directions and Restrictions: • Application rate specified for planting rate range of 29,000 - 85,000 cotton seed per acre DO NOT use with handheld application equipment, including mechanically pressurized spray gun, backpack or tank pressurized spray gun, or handheld boom applicators. [1Not registered for use in California.]

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Sorghum[1] Disease(s) Controlled Seedborne and soilborne fungi which cause seed decay, damping-off and seedling blight including the following: Fusarium spp. Alternaria spp. Cladosporium spp. Penicillium spp. Rate of Proline 480 SC Fungicide seeds/lb2 fl oz/100 lbs seed fl oz/100,000 seeds mg ai/seed 11,000 - 25,000 0.08 - 0.32 0.0032 - 0.0291 0.00045 - 0.0041 Crop Specific Directions and Restrictions: • Plant treated sorghum seed at a minimum depth of ½ inch. • 2Application rate specified for planting rate range of 25,000 to 100,000 sorghum seed per acre. [1Not registered for use in California.]

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SEED TAG LABELING The Federal Seed Act requires that the container of seed treated with Proline 480 SC Fungicide must be labeled with the following statements: • This seed has been treated with: o Proline 480 SC Fungicide, which contains 41% Prothioconazole. • DO NOT use treated seed for food, feed, or oil production. In addition, the following statements are required on the container of seed treated with Proline 480 SC Fungicide: • Treated areas may be replanted with any crop specified on this label as soon as practical after last application. For crops n ot listed on this label, DO NOT plant back within 30 days of last application. • Store treated seeds away from food and feedstuffs. • DO NOT allow children, pets, or livestock to have access to treated seed. • When opening this bag or loading/pouring the treated seed/seed-pieces, wear long-sleeved shirt, long pants, shoes, socks, and chemical-resistant gloves when handling treated seed. • Excess treated seed may be used for ethanol production only if (1) by-products are not used for livestock feed and (2) no measurable residues of pesticide remain in ethanol by-products that are used in agronomic practice. • Treated seeds exposed on soil surface may be hazardous to wildlife. Cover or collect treated seeds spilled during loading. • Dispose of all excess treated seed. • DO NOT contaminate water bodies when disposing of planting equipment wash waters. • Treated at manufacturer’s recommended rate • Plant treated seed into the soil to the recommended minimum depth or greater to minimize exposure. • Dispose of seed packaging or containers in accordance with local requirements. DO NOT use empty seed bags for any other purpose. • DO NOT plant treated seed by broadcasting to the soil surface. Ensure that all planted seeds are thoroughly incorporated by the planter during planting, additional incorporation may be required to thoroughly cover exposed seeds. • Excess treated seed may be used for ethanol production if (1) by-products are not used for livestock feed and (2) no measurable residues of pesticide remain in ethanol by-products that are used in agronomic practice. • To reduce seed dust which can drift onto blooming crops or weeds, ensure that planting equipment is functioning properly in accordance with manufacturer’s recommendations. Surplus seed or empty seed containers must be stored or disposed according to local federal regulations. • After the seeds have been planted, DO NOT enter or allow worker entry into the treated areas during the restricted-entry interval (REI) of 12 hours. Exception: Once the seeds are planted in soil or other planting media, the Worker Protection Standard allows workers to enter the treated area without restriction if there will be no worker contact with the treated seeds in the soil or with the planting media.

For PRODUCT USE Information Call 1-866-99BAYER (1-866-992-2937) For MEDICAL, TRANSPORTATION or OTHER Emergencies ONLY Call 24 Hours A Day 1-800-334-7577

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STORAGE AND DISPOSAL DO NOT contaminate water, food or feed by storage, disposal or cleaning of equipment.

Pesticide Storage Store in a cool, dry place and in such a manner as to prevent cross contamination with other pesticides, fertilizers, food, and feed. Store in original container and out of the reach of children, preferably in a locked storage area. Handle and open container in a manner as to prevent spillage. If container is leaking, invert to prevent leakage. If the container is leaking or material is spilled for any reason or cause, carefully dam up spilled material to prevent runoff. Refer to Precautionary Statements on label for hazards associated with the handling of this material. DO NOT walk through spilled material. Absorb spilled material with absorbing type compounds and dispose of as directed for pesticides below. In spill or leak incidents, keep unauthorized people away. You may contact the Bayer CropScience Emergency Response Team for decontamination procedures or any other assistance that may be necessary. The Bayer CropScience Emergency Response Telephone No. is 1-800-334-7577.

Pesticide Disposal Wastes resulting from the use of this product must be disposed of on-site or at an approved waste disposal facility.

Container Handling

[Dilutable Seed Treatment Products in Non-Refillable Plastic Containers]

Rigid, Non-refillable containers (equal to or less than 5 gallons) Non-refillable container. DO NOT reuse or refill this container. Triple rinse or pressure rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container 1/4 full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times.

Pressure rinse as follows: Empty the remaining contents into application equipment or a mix tank and continue to drain for 10 seconds after the flow begins to drip. Hold container upside down over application equipment or mix tank or collect rinsate for later use or disposal. Insert pressure rinsing nozzle in the side of the container, and rinse at about 40 PSI for at least 30 seconds. Drain for 10 seconds after the flow begins to drip.

Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill or by incineration.

Rigid Non-refillable containers that are too large to shake (i.e., with capacities greater than 5 gallons or 50 lbs) Non-refillable container. DO NOT reuse or refill this container. After emptying product from container, either return container to Bayer CropScience per instructions from Bayer CropScience Customer Service Center (1-800-527-4781), or rinse and either recycle or dispose of the container as follows:

Bottom Discharge IBC (e.g. – Schuetz Caged IBC or Snyder Square Stackable) Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. To pressure rinse the container before final disposal, empty the remaining contents from the IBC into application equipment or mix tank. Raise the bottom of the IBC by 1.5 inches on the side which is opposite of the bottom discharge valve to promote more complete product removal. Completely remove the top lid of the IBC. Use water pressurized to at least 40 PSI to rinse all interior portions. Continuously pump or drain rinsate into application equipment or rinsate collection system while pressure rinsing. Continue pressure rinsing for 2 minutes or until rinsate becomes clear. Replace the lid and close bottom valve.

Top Discharge IBC, Drums, Kegs (e.g.– Snyder 120 Next Gen, Bonar B120, Drums, and Kegs) Triple rinsing the container before final disposal is the responsibility of the person disposing of the container. To triple rinse the container before final disposal, empty the remaining contents from this container into application equipment or mix tank. Fill the container at least 10 percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Rinse all interior surfaces. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this procedure two more times.

Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration.

[Dilutable Seed Treatment Products in Non-Refillable Metal Containers]

Nonrefillable container. DO NOT reuse or refill this container. After emptying product from container, either return container to Bayer CropScience per instructions from Bayer CropScience Customer Service Center (1-800-527-4781), or rinse and either recycle or dispose of the container as follows:

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Liquid dilutables in containers small enough to shake (5 gallons or less) Triple Rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times.

Solid dilutables in containers small enough to shake (5 gallons or 50 pounds or less) Triple Rinse as follows: Empty the remaining contents into application equipment or a mix tank. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times.

Any dilutable pesticides in containers too large to shake (larger than 5 gallons or 50 pounds) Triple Rinse as follows: Empty remaining contents into application equipment or a mix tank. Fill the container ¼ full with water. Replace and tighten closures. Tip container on its side and roll it back and forth, ensuring at least one complete revolution, for 30 seconds. Stand the container on its end and tip it back and forth several times. Turn the container over onto its other end and tip it back and forth several times. Empty the rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Repeat this procedure two more times.

Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration.

[Non-Dilutable Seed-Treatment Products in Non-Refillable Containers]

Seed-Treatment Products in Non-Refillable Fiber Drums with Liners Non-refillable container. DO NOT reuse or refill this container. Completely empty liner by shaking and tapping sides and bottom to loosen clinging particles. Empty residue into application equipment, then offer for recycling if available or dispose of in a sanitary landfill or by incineration. If drum is contaminated and cannot be reused, dispose of it in the manner required for its liner.

Seed-Treatment Products in Non-rigid, Non-Refillable Containers Nonrefillable container. DO NOT reuse or refill this container. Completely empty container into application equipment. Then offer for recycling if available or dispose of in a sanitary landfill or by other procedures approved by state and local authorities.

[Seed Treatment Products in Refillable Containers]

Refillable container. Refill this container with pesticide only. DO NOT reuse this container for any other purpose. After emptying product from container, either return container to Bayer CropScience per instructions from Bayer CropScience Customer Service Center (1-800-527-4781) or rinse and either recycle or dispose of the container as follows:

Bottom Discharge IBC (e.g. – Schuetz Caged IBC or Snyder Square Stackable) Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling is the responsibility of the refiller. To pressure rinse the container before final disposal, empty the remaining contents from the IBC into application equipment or mix tank. Raise the bottom of the IBC by 1.5 inches on the side which is opposite of the bottom discharge valve to promote more complete product removal. Completely remove the top lid of the IBC. Use water pressurized to at least 40 PSI to rinse all interior portions. Continuously pump or drain rinsate into application equipment or rinsate collection system while pressure rinsing. Continue pressure rinsing for 2 minutes or until rinsate becomes clear. Replace the lid and close bottom valve.

Top Discharge IBC, Drums, Kegs (e.g. – Snyder 120 Next Gen, Bonar B120, Drums, and Kegs) Triple rinsing the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling is the responsibility of the refiller. To triple rinse the containers before final disposal, empty the remaining contents from this container into application equipment or mix tank. Fill the container at least 10 percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Rinse all interior surfaces. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this procedure two more times.

Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill or by incineration.

End users are authorized to remove tamper evident cables as required to remove the product from the container unless the container is equipped with one way valves and refilling or returning is planned. If this is the case, end users are not authorized to remove tamper evident cables, remove one way valves or clean container.

Proline is a registered trademark of Bayer Group PROLINE 480 SC Fungicide (PENDING) 07/15/2025, 7/16/2025, 07/23/2025, 04/01/2026