crop-chem-docs/corpus/bayer/prosaro-421-sc.md

# Prosaro 421 SC Fungicide

- **Product class:** fungicide
- **EPA Reg No:** 264-862
- **Active ingredients:** Prothioconazole, Tebuconazole
- **Source:** https://www.cropscience.bayer.us/crop-protection/fungicide/prosaro-421-sc-fungicide
- **Label PDF:** https://cs-assets.bayer.com/is/content/bayer/Prosaro_421_SC_Fungicide_Label7pdf

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Net
Contents:
2.5 Gallons
US85424726B (181019B) LABMC PROSARO SC 2.5GAL US   colors: cmyk  05/15/19
Fungicide421 SC
®
GROUP 3 FUNGICIDE
For control of specified diseases on various crops.
ACTIVE INGREDIENTS: Prothioconazole,
 2-[2-(1-Chlorocyclopropyl)-3-(2-chlorophenyl)-
 2-hydroxypropyl]-1,2-dihydro-3H-1, 2, 4-triazole-3-thione ................ 19.0%
Tebuconazole, alpha-[2-(4-chlorophenyl) ethyl]-alpha-(1, 1-dimethylethyl)-
 1H-1, 2, 4-triazole-1-ethanol ....................................... 19.0%
OTHER INGREDIENTS: .......................................... 62.0%
  TOTAL:   100.0%
Contains 1.76 lbs/gal of prothioconazole plus 1.76 lbs/gal of tebuconazole
EPA Reg. No. 264-862
STOP - Read the label before use
KEEP OUT OF REACH OF CHILDREN
CAUTION
For MEDICAL and TRANSPORTATION Emergencies ONLY
Call 24 Hours A Day 1-800-334-7577
For PRODUCT USE Information Call 1-866-99BAYER (1-866-992-2937)
Please refer to booklet for additional precautionary statements
and directions for use.
Produced for:
Bayer CropScience LP
800 N. Lindbergh Blvd.
St. Louis, MO 63167
PROSARO is a registered trademark of Bayer.
©2019 Bayer CropScience
US85424726B             181019B 05/19

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FIRST AID
IF SWALLOWED: • Call a poison control center or doctor immediately for treatment advice.
• Do not induce vomiting unless told to do so by a poison control center
or doctor.
• Have person sip a glass of water if able to swallow.
• Do not give anything to an unconscious person.
IF INHALED: • Move person to fresh air.
• If person is not breathing, call 911 or an ambulance, and then give
artificial respiration, preferably mouth-to-mouth if possible.
• Call a poison control center or doctor for treatment advice.
IF ON SKIN
OR CLOTHING:
• Take off contaminated clothing.
• Rinse skin immediately with plenty of water for 15-20 minutes.
• Call a poison control center or doctor for treatment advice.
IF IN EYES: • Hold eye open and rinse slowly and gently with water for 15-20 minutes.
• Remove contact lenses, if present, after the first 5 minutes, then
continue rinsing eye.
• Call a poison control center or doctor for treatment advice.
For MEDICAL Emergencies Call 24 Hours A Day 1-800-334-7577.
Have the product container or label with you when calling a poison control center
or doctor or going for treatment.
NOTE TO PHYSICIAN:  No specific antidote.  Treat symptomatically.
PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS AND DOMESTIC ANIMALS
CAUTION
Harmful if swallowed, inhaled, or absorbed through the skin. Causes moderate eye irritation.
Avoid contact with skin, eyes, and clothing. Avoid breathing vapor or spray mist. Wash
thoroughly with soap and water after handling and before eating, drinking, chewing gum, or
using tobacco. Remove and wash contaminated clothing before reuse.
Personal Protective Equipment (PPE)
Applicators and other handlers must wear:
• Long-sleeved shirt and long pants
• Chemical resistant gloves made of any waterproof material
• Shoes plus socks
Follow manufacturer’s instructions for cleaning/maintaining PPE.  If no such instructions exist for
washables, use detergent and hot water.  Keep and wash PPE separately from other laundry.
Engineering Control Statements
When handlers use closed systems, enclosed cabs, or aircraft in a  manner that meets the
requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides
[40 CFR 170.240(d)(4-6)], the handler PPE requirements may be reduced or modified as
specified in the WPS.
User Safety Recommendations
Users should:
• Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet.
• Remove clothing/PPE  immediately if pesticide gets inside. Then wash thoroughly and put
on clean clothing.
• Wash the outside of gloves before removing.
ENVIRONMENTAL HAZARDS
This product is toxic to mammals, fish, aquatic invertebrates, and freshwater/estuarines/
marine aquatic plants. Do not apply directly to water, or to areas where surface water is
present or to intertidal areas below the mean high water mark. Runoff may be hazardous
to aquatic organisms in neighboring areas. Do not contaminate water when disposing of
equipment washwater or rinsate. (continued)

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Groundwater Advisory: Prothioconazole-desthio (a degradate of prothioconazole) and
tebuconazole are known to leach through soil into ground water under certain conditions as
a result of label use. Use of this chemical in areas where soils are permeable, particularly
where the water table is shallow, may result in ground-water contamination.
Surface Water Advisory: This product may contaminate water through drift of spray in wind.
Drift and runoff are hazardous to aquatic organisms in water adjacent to treated areas. This
product has a high potential for runoff for several months or more after application. Poorly
draining soils and soils with shallow water tables are more prone to produce runoff that
contains this product. A level, well maintained vegetative buffer strip between areas to which
this product is applied and surface water features such as ponds, streams, and springs will
reduce the potential for contamination of water from rainfall-runoff. Runoff of this product
will be reduced by avoiding applications when rainfall is forecasted to occur within 48 hours.
DIRECTIONS FOR USE
It is a violation of federal law to use this product in a manner inconsistent with its labeling.
Do not apply this product in a way that will contact workers or other  persons, either directly
or through drift.  Only protected handlers may be in the area during application.  For any
requirements specific to your State or Tribe, consult the agency responsible for pesticide
regulation.
AGRICULTURAL USE REQUIREMENTS
Use this product only in accordance with its labeling and with the Worker Protection
Standard, 40 CFR part 170.  This Standard contains requirements for the protection
of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers
of agricultural pesticides.  It contains requirements for training, decontamination,
notification, and emergency assistance.  It also contains specific instructions and
exceptions pertaining to the statements on this label about personal protective equipment
(PPE) and restricted-entry interval (REI).  The requirements in this box only apply to uses
of this product that are covered by the Worker Protection Standard.
Do not enter or allow worker entry into treated areas during the REI of 12 hours.
PPE required for early entry to treated areas that is permitted under the Worker
Protection Standard and that involves contact with anything that has been treated, such
as plants, soil, or water is:
• Coveralls
• Chemical-resistant gloves made of any waterproof material.
• Shoes plus socks
PRODUCT INFORMATION
PROSARO® 421 SC Fungicide is a broad-spectrum systemic fungicide for the control of
Ascomycetes, Basidiomycetes and Deuteromycetes diseases in barley, corn (field corn, field
corn grown for seed, popcorn, and sweet corn), and wheat. Under conditions conducive to
extended infection periods or high disease pressure, another registered fungicide may be
needed once this product’s maximum application rates have been reached.  Under these
conditions use another fungicide registered for the crop/disease.
Resistance Management Statement
PROSARO 421 SC Fungicide is a Group 3 fungicide, which exhibits no known cross-resistance
to other fungicide groups.  However, fungal pathogens are known to develop resistance to
products with the same mode of action when used repeatedly.  Any fungal population may
contain or develop individuals that are resistant to PROSARO 421 SC and other Group 3
fungicides.  If Group 3 fungicides are used repeatedly in the same field or in successive years
as the primary method of control for targeted diseases, the resistant isolates may eventually
dominate the fungal population.  Because resistance development cannot be predicted, the use
of this product should conform to resistance management strategies established for the crop
and use area.  Such strategies may include rotation and /or tank mixing with products having
different modes of action or limiting the total number of applications per season.  Contact your
local extension specialist, certified crop advisor, and/or manufacturer for fungicide resistance
management and/or integrated disease management directions for specific crops and
pathogen populations.  Bayer CropScience encourages responsible resistance management to
ensure effective long-term control of the fungal diseases on this label.

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Spray Equipment/Volumes
PROSARO 421 SC FUNGICIDE may be applied by either ground, aerial and/or chemigation
application equipment. Equipment must be properly calibrated before use.
For ground application, apply in a minimum of 10 gallons of spray solution per acre.  For aerial
application, apply in a minimum of 2 gallons of spray solution per acre unless stated differently
in the USE DIRECTIONS FOR SPECIFIC CROPS section.  Check equipment calibration
frequently.  Complete coverage and uniform application are essential for the most effective
results, especially when lower spray volumes are applied.  If necessary, increase the spray
volume per acre for complete crop coverage.
Mixing Procedures
Prepare no more spray mixture than is necessary for the immediate operation.  Thoroughly
clean spray equipment before using this product. Maintain maximum agitation throughout the
spray operation.  Do not let the spray mixture stand overnight in the spray tank.  Flush the
spray equipment thoroughly following each use and apply the rinsate to the previously treated
area or dispose of the rinsate according to local regulations. Do not tank mix with products
containing a prohibition against tank mixing.  Follow the most restrictive labeling requirements
of any tank mix product.
PROSARO 421 SC FUNGICIDE Alone: Add 1/2 of the required amount of water to the
mix tank.  With the agitator running, add the PROSARO 421 SC FUNGICIDE to the tank.
Continue agitation while adding the remainder of the water.  Begin application of the solution
after the product has completely and uniformly dispersed into the mix water.  Maintain
agitation until all of the mixture has been applied.
PROSARO 421 SC FUNGICIDE + Tank-Mix Partners:  Add 1/2 of the required amount of
water to the mix tank.  Start the agitator running before adding any of the tank-mix partners.  In
general, tank-mix partners should be added in this order: products packaged in water-soluble
packaging*, wettable powders, wettable granules (dry flowables), liquid flowables, liquids, and
emulsifiable concentrates. Always allow each tank-mix partner to become fully and uniformly
dispersed before adding the next product.  Provide sufficient agitation while adding the
remainder of the water.  Maintain agitation until all of the mixture has been applied.
* Note:  When using PROSARO 421 SC FUNGICIDE in tank mixtures, all products in
water-soluble packaging should be added to the tank before any other tank-mix partner,
including PROSARO 421 SC FUNGICIDE.  Allow the water-soluble packaging to completely
disperse before adding any other tank-mix partner to the tank.
If using PROSARO 421 SC FUNGICIDE in a tank mixture, observe all directions for use,
crop/sites, use rates, dilution ratios, precautions, and limitations; which appear on the
tank-mix product label.  No label dosage rate must be exceeded, and the most restrictive
label precautions and limitations must be followed.  This product must not be mixed with
any product that prohibits such mixing.  Tank mixtures or other applications of products
referenced on this label are permitted only in those states in which the referenced products
are registered.
PROSARO 421 SC FUNGICIDE is compatible with most insecticide, fungicide, herbicide,
and foliar nutrient products.  However, the physical compatibility of PROSARO 421 SC
FUNGICIDE with tank-mix partners should be tested before use.  To determine the physical
compatibility of PROSARO 421 SC FUNGICIDE with other products, use a jar test, as
described below.
Using a quart jar, add the proportionate amounts of the products to 1 qt. of water.  Add
wettable powders and water-dispersible granular products first, then liquids and emulsifiable
concentrates last.  After thoroughly mixing, let stand for at least 5 minutes.  If the combination
remains mixed or can be remixed readily, it is physically compatible.  Once compatibility has
been proven, use the same procedure for adding required ingredients to the spray tank. For
further information, contact your local Bayer CropScience representative.
The crop safety of all potential tank mixes including additives and other pesticides on all
crops has not been tested.  Before applying any tank mixture not specified on this label, the
safety to the target crop should be confirmed.  To test for crop safety, apply PROSARO 421
SC FUNGICIDE to the target crop in a small area and in accordance with label instructions
for the target crop.
Aerial Application: Avoid application under conditions when uniform coverage cannot be
obtained or when excessive spray drift may occur. Aerial application is prohibited in New
Y ork State.

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Chemigation Application: Apply PROSARO 421 SC FUNGICIDE through irrigation
equipment only to crops for which chemigation is specified on this label.
PROSARO 421 SC FUNGICIDE alone or in combination with other pesticides, which are
registered for application through irrigation systems, may be applied through irrigation
systems. Apply this product only through center pivot, solid set, hand move, or moving wheel
irrigation systems. Do not apply this product through any other type of irrigation system. Illegal
pesticide residues in the crop can result from nonuniform distribution of treated water. If you
have questions about calibration, you should contact State Extension Service specialists,
equipment manufacturers, or other experts. Do not connect an irrigation system (including
greenhouse systems) used for pesticide application to a public water system, unless the
pesticide label-prescribed safety devices for public water systems are in place. A person
knowledgeable of the chemigation system and responsible for its operation, or under the
supervision of the responsible person, shall shut the system down and make necessary
adjustments should the need arise.
Operating Instructions
1. The system must contain a functional check-valve, vacuum relief valve, and low-pressure
drain appropriately located on the irrigation pipeline to prevent water-source contamination
from backflow.
2. The pesticide injection pipeline must contain a functional, automatic, quick-closing
check-valve to prevent the flow of fluid back toward the injection pump.
3. The pesticide injection pipeline must also contain a functional, normally closed, solenoid-
operated valve located on the intake side of the injection pump and connected to the
system interlock to prevent fluid from being withdrawn from the supply tank when the
irrigation system is either automatically or manually shut down.
4. The system must contain functional interlocking controls to automatically shut off the
pesticide injection pump when the water pump motor stops.
5. The irrigation line or water pump must include a functional pressure switch, which will stop
the water pump motor when the water pressure decreases to the point where pesticide
distribution is adversely affected.
6. Systems must use a metering pump, such as a positive displacement injection pump (e.g.,
diaphragm pump), effectively designed, and constructed of materials that are compatible
with pesticides and capable of being fitted with a system interlock.
7. Do not apply when wind speed favors drift beyond the area intended for treatment.
Center Pivot Irrigation Equipment
Notes: (1) Use only with drive systems, which provide uniform water distribution. (2) Do
not use end guns when chemigating PROSARO 421 SC FUNGICIDE through center pivot
systems because of non-uniform application.
Determine the size of the area to be treated. Determine the time required to apply 1/8-1/2
inch of water over the area to be treated when the system and injection equipment are
operated at normal pressures as recommended by the equipment manufacturer. When
applying PROSARO 421 SC FUNGICIDE through irrigation equipment use the lowest
obtainable water volume while maintaining uniform distribution. Run the system at 80-95%
of the manufacturer’s rated capacity. Using water, determine the injection pump output when
operated at normal line pressure. Determine the amount of PROSARO 421 SC FUNGICIDE
required to treat the area covered by the irrigation system. Add the required amount of
PROSARO 421 SC FUNGICIDE and sufficient water to meet the injection time requirements
to the solution tank. Make sure the system is fully charged with water before starting injection
of the PROSARO 421 SC FUNGICIDE solution. Time the injection to last at least as long as
it takes to bring the system to full pressure. Maintain constant solution tank agitation during
the injection period. Continue to operate the system until the PROSARO 421 SC FUNGICIDE
Fungicide solution has cleared the sprinkler head.

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Solid Set, Hand Move, and Moving Wheel Irrigation Equipment
When applying PROSARO 421 SC FUNGICIDE through irrigation equipment use the lowest
obtainable water volume while maintaining uniform distribution. Determine the amount of
PROSARO 421 SC FUNGICIDE required to treat the area covered by the irrigation system.
Add the required amount of PROSARO 421 SC FUNGICIDE into the same quantity of
water used to calibrate the injection period. Operate the system at the same pressure and
time interval established during the calibration. Stop injection equipment after treatment is
completed. Continue to operate the system until the PROSARO 421 SC FUNGICIDE solution
has cleared the last sprinkler head.
Adjuvants: PROSARO 421 SC FUNGICIDE is recommended to be used with a registered
non-ionic surfactant at the lowest specified labeled rate for most uses. Refer to the USE
DIRECTIONS FOR SPECIFIC CROPS for adjuvant recommendations on corn.
Spray Drift Directions
Do not make applications when conditions favor drift beyond the target application area.
When drift may be a problem, take measures to reduce drift, including:
1. Do not spray if wind speeds are or become excessive.  Do not spray if wind speed is 15
mph or greater.  If non-target crops are located downwind, use caution when spraying if
wind is present.  Do not spray if winds are gusty.
2. Use caution when conditions are favorable for drift (high temperatures, drought, and low
relative humidity).
3. Do not apply when temperature inversion exists.  If inversion conditions are suspected,
consult with local weather services before making an application.
ROTATIONAL RESTRICTIONS
Treated areas may be replanted with dry beans, peanuts  and soybeans as well as any crop
specified on this label as soon as practical after last application.  For additional crops, do not
plant back within 120 days of last application.

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USE DIRECTIONS FOR SPECIFIC CROPS
PROSARO 421 SC FUNGICIDE provides control or suppression of many important diseases
of barley, corn (field corn, field corn grown for seed, popcorn, and sweet corn), and wheat.
When reference is made to disease suppression, suppression can mean either erratic control
from good to fair or consistent control at a level below that obtained with the best commercial
disease control products.
APPLICATION DIRECTIONS
CROP DISEASE CONTROLLED RATE OF PROSARO 421 SC FUNGICIDE
Barley Fusarium Head Blight (Suppression)
  (Fusarium spp.)
Leaf and Stem Diseases
Net Blotch (Pyrenophora teres)
Powdery Mildew
  (Blumeria graminis f. sp. hordei)
Scald (Rhynchosporium secalis)
Spot Blotch (Bipolaris sorokiniana)
Rusts (Puccinia spp.)
6.5 - 8.2 fl oz per acre
Application Directions: Straw cut after harvest may be fed or used for bedding.
Spray Equipment/Volumes:  PROSARO 421 SC FUNGICIDE may be applied by either
ground, aerial or chemigation application equipment.  For ground applications, apply
a minimum of 10 gpa spray solution.  For aerial applications, apply a minimum of 2
gpa spray solution.  When applied through chemigation, large carrier volumes may
result in reduced activity against Fusarium head blight.
Disease Control:
Fusarium Head Blight (Suppression Only):
The optimal time to apply PROSARO 421 SC FUNGICIDE is as a preventative foliar spray
when barley heads on the main stem are fully emerged (~ Feekes Growth Stage 10.5).
Spray equipment must be set to provide good coverage of barley heads. For thorough
coverage of the barley head using ground application equipment, use forward, forward
and backward mounted nozzles, or nozzles that have a two-directional spray. Nozzles
should be operated within the spray pressure directions suggested by the manufacturer.
For aerial applications, apply a minimum of 5 gpa spray solution.
Leaf and Stem Diseases:
Apply PROSARO 421 SC FUNGICIDE as a preventive foliar spray when the earliest disease
symptoms appear on the leaves and stems.  Barley fields should be observed closely for
early disease symptoms, particularly when susceptible varieties are planted and/or under
prolonged conditions favorable for disease development.
For optimum disease control, the lowest specified rate of a spray surfactant should be
tank-mixed with PROSARO 421 SC FUNGICIDE.
Restrictions:  Do not apply more than 8.2 fl oz of Prosaro 421 SC Fungicide per acre per crop year.  Do
not apply within 30 days of harvest. Grazing livestock or feeding of green forage is only permitted 6 or
more days after the last application of PROSARO 421 SC FUNGICIDE.

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APPLICATION DIRECTIONS
CROP DISEASE
RATE OF PROSARO 421 SC
FUNGICIDE
Corn1
(field corn, field
corn grown for
seed, popcorn and
sweet corn)
Anthracnose
(Colletotrichum graminicola)
Eye spot
(Aureobasidium zeae)
Gray leaf spot
(Cercospora zeae-maydis)
Northern corn leaf blight
(Setosphaeria  turcica)*
Northern corn leaf spot
(Cochliobolus carbonum)*
Rust
(Puccinia spp.)
Southern corn leaf blight
(Cochliobolus heterostrophus)*
*The above diseases are also known as
Helminthosporium leaf blights
6.5 fl oz per acre
Application Directions:
Spray Equipment/Volumes:  PROSARO 421 SC FUNGICIDE may be applied
by either ground, aerial or chemigation application equipment. For ground
applications, apply a minimum of 10 gpa spray solution. For aerial applications,
apply a minimum of 2 gpa spray solution.
Adjuvants: Under some conditions, the lowest specified labeled rate of a spray
adjuvant may be tank-mixed with PROSARO 421 SC FUNGICIDE to improve
performance.
Disease Control: Apply PROSARO 421 SC FUNGICIDE when disease first appears.
In sweet corn, continue applications on a 5- to 14-day interval if favorable
conditions for disease development persist. In all other corn, continue applications
on a 7- to 14-day interval if favorable conditions for disease development persist.
Application of PROSARO 421 SC FUNGICIDE is not recommended at times when
corn is under severe environmental stress conditions.
Restrictions: Do not apply more than 26 fl oz of PROSARO 421 SC FUNGICIDE per acre per crop
season. For field corn, field corn grown for seed and popcorn, do not apply within 21 days before the
harvest of forage and 36 days before the harvest of grain or fodder. For sweet corn, do not apply within
7 days before harvest of ears or forage and 49 days before the harvest of fodder.
Do not use adjuvants if PROSARO 421 SC FUNGICIDE is applied between corn growth stages V8 (8 leaf
collar) and VT (lowest branch of the tassel is visible but silks have not emerged).
1 Not for use on corn in New York.

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APPLICATION DIRECTIONS
CROP DISEASE CONTROLLED
RATE OF PROSARO 421 SC
FUNGICIDE
Wheat
(spring, durum,
and winter)
Fusarium Head Blight
  (Fusarium spp.)
Leaf and Stem Diseases
Powdery Mildew
  (Blumeria graminis f. sp. tritici)
Rusts
  (Puccinia spp.)
Septoria Leaf and Glume Blotch
  (Septoria tritici)
Stagonospora Blotch
 (Stagonospora nodorum)
Tan Spot
  (Pyrenophora tritici-repentis)
6.5 - 8.2 fl oz per acre
Application Directions: Straw may be fed or used for bedding.
Spray Equipment/Volumes: PROSARO 421 SC FUNGICIDE may be applied by either
ground, aerial or chemigation application equipment.  For ground applications, apply a
minimum of 10 gpa spray solution. For aerial applications, apply a minimum of 2 gpa
spray solution.  When applied through chemigation, large carrier volumes may result
in reduced activity against Fusarium head blight.
Disease Control:
Fusarium Head Blight:
The optimal time to apply PROSARO 421 SC FUNGICIDE is as a preventative foliar
spray at early flower (Feekes Growth Stage 10.51). Spray equipment must be set to
provide good coverage to wheat heads.  For thorough coverage of the wheat head
using ground application equipment, use forward, forward and backward mounted
nozzles, or nozzles that have a two-directional spray.  Operate nozzles within the spray
pressure directions suggested by the manufacturer. For aerial applications, apply a
minimum of 5 gpa spray solution.
Leaf and Stem Diseases:
Apply PROSARO 421 SC FUNGICIDE as a preventive foliar spray when the earliest
disease symptoms appear on the leaves and stems. Wheat fields should be observed
closely for early disease symptoms, particularly when susceptible varieties are planted
and/or under prolonged conditions favorable for disease development.
For optimum disease control, the lowest specified rate of a spray surfactant should be
tank-mixed with PROSARO 421 SC FUNGICIDE.
Restrictions: Do not apply more than 8.2 fl oz of PROSARO 421 SC FUNGICIDE applied per acre per
crop year. Do not apply within 30 days of harvest. Do not allow livestock to graze or feed green forage
to livestock prior to 6 days after treatment with PROSARO 421 SC FUNGICIDE.
OBSERVE THE FOLLOWING RESTRICTIONS WHEN SPRAYING IN THE VICINITY OF
AQUATIC AREAS SUCH AS LAKES, RESERVOIRS, RIVERS, PERMANENT STREAMS,
MARSHES OR NATURAL PONDS, AND ESTUARIES.
Apply only during alternate years in fields adjacent to aquatic areas listed above.
Do not apply by ground or air within 100 feet of aquatic areas listed above.
Do not cultivate within 10 feet of an aquatic area to allow growth of a vegetative filter strip.
Spray Drift Management:  For aerial applications, the spray boom should be mounted on
the aircraft so as to minimize drift caused by wing tip vortices.  The minimum practical boom
length should be used, and must not exceed 75% of the wingspan or rotor diameter.
Use the largest droplet size consistent with pest control.  Formation of very small droplets may
be minimized by appropriate nozzle selection, by orienting nozzles away from the air stream
as much as possible and by avoiding excessive spray boom pressure.  Apply in a minimum
of 5 gallons of spray solution per acre by aircraft spray equipment.
(continued)

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Spray should be released at the lowest possible height consistent with good pest control
and flight safety.  Applications more than 10 feet above the crop canopy should be avoided.
Make aerial or ground applications when wind velocity favors on-target product deposition
(approximately 3 to 10 mph).  Do not apply when wind velocity exceeds 15 mph.  Avoid
applications when wind gusts approach 15 mph.
Risk of exposure to sensitive aquatic areas can be reduced by avoiding applications when wind
direction is toward the aquatic area.
Low humidity and high temperatures increase the evaporation rate of spray droplets and
therefore the likelihood of spray drift to aquatic areas.  Avoid spraying during conditions of
low humidity and/or high temperature.
Do not make aerial or ground applications during temperature inversions.  Inversions are
characterized by stable air and increasing temperatures with height above the ground.  Mist
or fog may indicate the presence of an inversion in humid areas.  The applicator may detect
the presence of an inversion by producing smoke and observing a smoke layer near the
ground surface.
STORAGE AND DISPOSAL
Do not contaminate water, food, or feed by storage or disposal.
Pesticide Storage: Store in a cool, dry place and in such a manner as to prevent cross
contamination with other pesticides, fertilizers, food, and feed.  Store in original container and
out of the reach of children, preferably in a locked storage area.
Handle and open container in a manner as to prevent spillage. If container is leaking, invert
to prevent leakage. If the container is leaking or material is spilled for any reason or cause,
carefully dam up spilled material to prevent runoff. Refer to Precautionary Statements on
label for hazards associated with the handling of this material. Do not walk through spilled
material. Absorb spilled material with absorbing type compounds and dispose of as directed
for pesticides below. In spill or leak incidents, keep unauthorized people away.
Pesticide Disposal:  Wastes resulting from the use of this product may be disposed of on site or
at an approved waste disposal facility.
Container Handling:
Non-Seed Treatment Products in Non-Refillable Containers
Rigid, Non-refillable containers (equal to or less than 5 gallons)
Non-refillable container. Do not reuse or refill this container. Offer for recycling, if available.
Triple rinse or pressure rinse container (or equivalent) promptly after emptying. Triple rinse as
follows:  Empty the remaining contents into application equipment or a mix tank and drain for
10 seconds after the flow begins to drip. Fill the container 1/4 full with water and recap. Shake
for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later
use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two
more times.
Pressure rinse as follows: Empty the remaining contents into application equipment or a mix
tank and continue to drain for 10 seconds after the flow begins to drip. Hold container upside
down over application equipment or mix tank or collect rinsate for later use or disposal. Insert
pressure rinsing nozzle in the side of the container, and rinse at about 40 PSI for at least 30
seconds. Drain for 10 seconds after the flow begins to drip.
Once container is rinsed, offer for recycling if available or puncture and dispose of in a
sanitary landfill.
Rigid Non-refillable Containers that are too large to shake (i.e., with capacities greater
than 5 gallons or 50 lbs)
Non-refillable container. Do not reuse or refill this container. Refer to Bottom Discharge IBC
information as follows.
Bottom Discharge IBC (e.g. – Schuetz Caged IBC or Snyder Square Stackable)
Pressure rinsing the container before final disposal is the responsibility of the person disposing
of the container. To pressure rinse the container before final disposal, empty the remaining
contents from the IBC into application equipment or mix tank. Raise the bottom of the IBC
by 1.5 inches on the side which is opposite of the bottom discharge valve to promote more
complete product removal. Completely remove the top lid of the IBC. Use water pressurized to
at least 40 PSI to rinse all interior portions. Continuously pump or drain rinsate into application
equipment or rinsate collection system while pressure rinsing. Continue pressure rinsing for 2
minutes or until rinsate becomes clear. Replace the lid and close bottom valve.
(continued)

10
4.50”
4.0625”
7.75”
7.375”
COPY AREA
COPY AREA
Y ou may contact the Bayer CropScience Emergency Response Team for decontamination
procedures or any other assistance that may be necessary. The Bayer CropScience
Emergency Response Telephone No. is 1-800-334-7577.
IMPORTANT: READ BEFORE USE
Read the entire Directions for Use, Conditions, Disclaimer of Warranties and Limitations of
Liability before using this product.  If terms are not acceptable, return the unopened product
container at once.
By using this product, user or buyer accepts the following Conditions, Disclaimer of Warranties
and Limitations of Liability.
CONDITIONS: The directions for use of this product are believed to be adequate and must be
followed carefully. However, it is impossible to eliminate all risks associated with the use of this
product.  Crop injury, ineffectiveness or other unintended consequences may result because
of such factors as weather conditions, presence of other materials, or the manner of use or
application, all of which are beyond the control of Bayer CropScience.  To the extent consistent
with applicable law, all such risks shall be assumed by the user or buyer.
DISCLAIMER OF WARRANTIES: TO THE EXTENT CONSISTENT WITH APPLICABLE
LAW, BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR
IMPLIED, OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR
OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THIS LABEL. No
agent of Bayer CropScience is authorized to make any warranties beyond those contained
herein or to modify the warranties contained herein. TO THE EXTENT CONSISTENT WITH
APPLICABLE LAW, BAYER CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER
FOR SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE
USE OR HANDLING OF THIS PRODUCT.
LIMITATIONS OF LIABILITY: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW,
THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES,
INJURIES OR DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS
PRODUCT, WHETHER IN CONTRACT, WARRANTY , TORT, NEGLIGENCE, STRICT
LIABILITY OR OTHERWISE, SHALL NOT EXCEED THE PURCHASE PRICE PAID, OR AT
BAYER CROPSCIENCE’S ELECTION, THE REPLACEMENT OF PRODUCT.

11
4.50”
4.0625”
7.75”
7.375”
COPY AREA
COPY AREA

(01)  0 0785740 55278  0
PLACE BAR CODE HERE
5.50”
BASE LABEL
4.125”0.875” 0.50”
7.75”
7.50”
COPY AREA
COPY AREA
NET CONTENTS: 2 1/2 GALLONS
STORAGE AND DISPOSAL
Do not contaminate water, food, or feed by storage or
disposal.
Pesticide Storage: Store in a cool, dry place and in such
a manner as to prevent cross contamination with other
pesticides, fertilizers, food, and feed.  Store in original
container and out of the reach of children, preferably in a
locked storage area.
Handle and open container in a manner as to prevent
spillage. If container is leaking, invert to prevent leakage.
If the container is leaking or material is spilled for any
reason or cause, carefully dam up spilled material to
prevent runoff. Refer to Precautionary Statements on label
for hazards associated with the handling of this material.
Do not walk through spilled material. Absorb spilled
material with absorbing type compounds and dispose of
as directed for pesticides below. In spill or leak incidents,
keep unauthorized people away.
Pesticide Disposal: Wastes resulting from the use of
this product may be disposed of on site or at an approved
waste disposal facility.
Container Handling:
Non-Seed Treatment Products in Non-Refillable
Containers
Rigid, Non-refillable containers (equal to or less than
5 gallons)
Non-refillable container. Do not reuse or refill this
container. Offer for recycling, if available. Triple rinse or
pressure rinse container (or equivalent) promptly after
emptying. Triple rinse as follows:  Empty the remaining
contents into application equipment or a mix tank and
drain for 10 seconds after the flow begins to drip. Fill
the container 1/4 full with water and recap. Shake for
10 seconds. Pour rinsate into application equipment or
a mix tank or store rinsate for later use or disposal. Drain
for 10 seconds after the flow begins to drip. Repeat this
procedure two more times.
Pressure rinse as follows: Empty the remaining contents
into application equipment or a mix tank and continue to
drain for 10 seconds after the flow begins to drip. Hold
container upside down over application equipment or
mix tank or collect rinsate for later use or disposal. Insert
pressure rinsing nozzle in the side of the container, and
rinse at about 40 PSI for at least 30 seconds. Drain for 10
seconds after the flow begins to drip.
Once container is rinsed, offer for recycling if available or
puncture and dispose of in a sanitary landfill.
Bayer CropScience LP
800 N. Lindbergh Blvd.
St. Louis, MO 63167
PROSARO is a registered trademark of Bayer.
©2019 Bayer CropScience
US85424726B             181019B  05/19
FIRST AID
IF
SWALLOWED:
• Call a poison control center or
doctor immediately for treatment
advice.
• Do not induce vomiting unless told
to do so by a poison control center
or doctor.
• Have person sip a glass of water if
able to swallow.
• Do not give anything to an
unconscious person.
IF INHALED: • Move person to fresh air.
• If person is not breathing, call 911
or an ambulance, and then give
artificial respiration, preferably
mouth-to-mouth if possible.
• Call a poison control center or
doctor for treatment advice.
IF ON SKIN
OR
CLOTHING:
• Take off contaminated clothing.
• Rinse skin immediately with plenty
of water for 15 - 20 minutes.
• Call a poison control center or
doctor for treatment advice.
IF IN EYES: • Hold eye open and rinse slowly
and gently with water for 15 - 20
minutes.
• Remove contact lenses, if present,
after the first 5 minutes, then
continue rinsing eye.
• Call a poison control center or
doctor for treatment advice.
For MEDICAL Emergencies Call 24 Hours A Day
1-800-334-7577.
Have the product container or label with you
when calling a poison control center or doctor
or going for treatment.
NOTE TO PHYSICIAN: No specific antidote. Treat
symptomatically.
PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS AND DOMESTIC ANIMALS
CAUTION
Harmful if swallowed, inhaled, or absorbed through the
skin. Causes moderate eye irritation. Avoid contact with
skin, eyes, and clothing. Avoid breathing vapor or spray
mist. Wash thoroughly with soap and water after handling
and before eating, drinking, chewing gum, or using
tobacco. Remove and wash contaminated clothing
before reuse.
DIRECTIONS FOR USE
It is a violation of federal law to use this product
in a manner inconsistent with its labeling.
PROSARO® 421 SC Fungicide
For control of specified diseases on various crops.
ACTIVE INGREDIENTS: Prothioconazole, 2-[2-(1-Chlorocyclopropyl)-3-
 (2-chlorophenyl) -2-hydroxypropyl]-1, 2-dihydro-3H-1, 2, 4-triazole-3-thione ..................... 19.0%
Tebuconazole, alpha-[2-(4-chlorophenyl) ethyl]-alpha-(1, 1-dimethylethyl)-
 1H-1, 2, 4-triazole-1-ethanol .......................................................... 19.0%
OTHER INGREDIENTS: ............................................................. 62.0%
Contains 1.76 lbs/gal of prothioconazole plus 1.76 lbs/gal of tebuconazole  TOTAL:  100.0%
EPA Reg. No. 264-862
STOP - Read the label before use
KEEP OUT OF REACH OF CHILDREN
CAUTION
For MEDICAL and TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1-800-334-7577
For PRODUCT USE Information Call 1-866-99BAYER (1-866-992-2937)
Please refer to booklet for additional precautionary statements and directions for use.
GROUP 3 FUNGICIDE