crop-chem-docs/corpus/epa_ppls/100-1283.md

# THX/MXM/FDL CZ

- EPA Reg No: **100-1283**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Thiamethoxam (21.5%); Fludioxonil (1.07%); Metalaxyl-M (3.21%)
- Label accepted: 2019-07-11
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01283-20190711.pdf

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
Fast Track Label Acceptable v.20150320 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
July 11, 2019 
 
Matthew Flanery 
Regulatory Specialist 
Syngenta Crop Protection, LLC. 
P.O. Box 18300 
Greensboro, NC 27419 
 
Subject: Label Amendment – Revised Resistance Management Language 
 Product Name: THX/MXM/FDL CZ 
 EPA Registration Number: 100-1283 
 Application Date: February 14, 2018 
 Decision Number: 541649 
 
Dear Mr. Flanery: 
 
The amended label referred to above, submitted in connection with registration under the Federal Insecticide, Fungicide and 
Rodenticide Act, as amended, is acceptable. This approval does not affect any conditions that were previously imposed on 
this registration. You continue to be subject to existing conditions on your registration and any deadlines connected with 
them. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes all previously accepted labeling. You 
must submit one copy of the final printed labeling before you release the product for shipment with the new labeling. In 
accordance with 40 CFR 152.130(c), you may distribute or sell this product under the previously approved labeling for 18 
months from the date of this letter. After 18 months, you may only distribute or sell this product if it bears this new revised 
labeling or subsequently approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its 
implementing regulation at 40 CFR 152.3. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be aware that the website 
becomes labeling under the Federal Insecticide Fungicide and Rodenticide Act and is subject to review by the Agency. If the 
website is false or misleading, the product would be misbranded and unlawful to sell or distribute under FIFRA section 
12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, regardless 
of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from 
those claims approved through the registration process. Therefore, should the Agency find or if it is brought to our attention 
that a website contains false or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance. 
 
Your release for shipment of the product constitutes acceptance of these conditions. If these conditions are not complied with, 
the registration will be subject to cancellation in accordance with FIFRA section 6. If you have any questions, please contact 
Kevin Ulrich by phone at 703-347-0464, or via email at ulrich.kevin@epa.gov. 
 
 
Sincerely, 
 
Venus Eagle, Product Manager 01 
Invertebrate and Vertebrate Branch 3 
Registration Division (7505P) 
Office of Pesticide Programs 
 
Enclosure: Stamped label

[Master Label] 
THIAMETHOXAM GROUP 4A INSECTICIDE
MEFENOXAM GROUP 4 FUNGICIDE 
FLUDIOXONIL GROUP 12 FUNGICIDE 
THX/MXM/FDL CZ 
[Alternate Brand Name: Adage™ ST] 
Insecticide with Fungicides 
A seed treatment product for protection against damage from listed insects, seed-borne 
diseases, and seedling diseases on soybean 
Active Ingredients: 
Thiamethoxam* ............................................................................. 21.50 % 
Mefenoxam** ................................................................................... 3.21 % 
Fludioxonil*** ................................................................................... 1.07 % 
Other Ingredients: 74.22 % 
Total: 100.00 % 
*CAS No. 153719-23-4 
**CAS No. 70630-17-0 and CAS No. 69516-34-3 
***CAS No. 131341-86-1 
One gallon of THX/MXM/FDL CZ [Adage™ ST] contains 2.06 lb thiamethoxam, 0.31 lb 
mefenoxam and 0.10 lb fludioxonil. 
KEEP OUT OF REACH OF CHILDREN. 
CAUTION 
See additional precautionary statements and directions for use in booklet [on label]. 
 
EPA Reg. No. 100-1283 
 
EPA Est. XXXXX 
 
 
__________ 
Net Contents 
 
[Batch Code: _____ ] (For non-refillables only) 
 
07/11/2019
100-1283

2
FIRST AID 
If swallowed x Call a poison control center or doctor immediately for 
treatment advice. 
x Have person sip a glass of water if able to swallow. 
x Do not induce vomiting unless told to do so by the poison 
control center or doctor. 
x Do not give anything by mouth to an unconscious 
person. 
If in eyes x Hold eye open and rinse slowly and gently with water for 
15-20 minutes. 
x Remove contact lenses, if present, after the first 5 
minutes, then continue rinsing eye. 
x Call a poison control center or doctor for treatment 
advice. 
If on skin or 
clothing 
x Take off contaminated clothing. 
x Rinse skin immediately with plenty of water for 15-20 
minutes. 
x Call a poison control center or doctor for treatment 
advice. 
If inhaled x Move person to fresh air. 
x If person is not breathing, call 911 or an ambulance, then 
give artificial respiration, preferably by mouth-to-mouth, if 
possible. 
x Call a poison control center or doctor for further 
treatment advice. 
Have the product container or label with you when calling a poison control center 
or doctor or going for treatment. 
HOT LINE NUMBER 
For 24-Hour Medical Emergency Assistance (Human or Animal) 
Or Chemical Emergency Assistance (Spill, Leak, Fire or Accident) 
Call 
1-800-888-8372

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PRECAUTIONARY STATEMENTS 
 
Hazards to Humans and Domestic Animals 
 
CAUTION 
 
Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes, skin, or 
clothing. Wash thoroughly with soap and water after handling, and before eating, 
drinking, chewing gum, using tobacco, or using the toilet. 
 
Personal Protective Equipment (PPE) 
 
 
Applicators and other handlers must wear: 
 
x Long-sleeved shirt and long pants 
 
x Chemical-resistant gloves made of barrier laminate, butyl rubber > 14 mils, nitrile 
rubber > 14 mils, neoprene rubber > 14 mils, polyvinyl chloride (PVC) > 14 mils, or 
Viton® > 14 mils 
 
x Shoes plus socks 
 
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions 
exist for washables, use detergent and hot water. Keep and wash PPE separately from 
other laundry. 
 
Engineering Control Statements 
 
When handlers use closed systems in a manner that meets the requirements listed in 
the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-
6)], the handler PPE requirements may be reduced or modified as specified in the WPS.

4
 
User Safety Recommendations 
 
Users should: 
 
x Wash hands before eating, drinking, chewing gum, using tobacco, or using the 
toilet. 
x Remove clothing immediately if pesticide gets inside. Then wash thoroughly 
and put on clean clothing. 
 
 
 
Environmental Hazards 
 
This product is toxic to wildlife, freshwater and estuarine/marine fish and highly toxic to 
aquatic invertebrates. Runoff may be hazardous to aquatic organisms in neighboring 
areas. Exposed treated seed may be hazardous to wildlife. Cover seed spilled during 
loading. Do not contaminate water when disposing of equipment washwater or rinsate. 
 
Pollinator Precautions 
Thiamethoxam is highly toxic to bees exposed to direct treatment, and effects may be 
possible as a result of exposure to translocated residues in blooming crops. 
 
Groundwater Advisory 
Thiamethoxam has properties and characteristics associated with chemicals detected in 
groundwater. This chemical may leach into the ground water if used in areas where 
soils are permeable, particularly where the water table is shallow. Fludioxonil has 
properties and characteristics associated with chemicals detected in groundwater. This 
chemical may leach into groundwater if used in areas where soils are permeable, 
particularly where the water table is shallow. Mefenoxam is known to leach through soil 
into ground water under certain conditions as a result of label use. This chemical may 
leach into the ground water if used in areas where soils are permeable, particularly 
where the water table is shallow. 
 
Physical and Chemical Hazards 
 
Do not use, pour, spill or store near heat or open flame.

5
CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY 
 
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not 
acceptable, return the product at once, unopened, and the purchase price will be 
refunded. 
 
The Directions for Use of this product must be followed carefully. It is impossible to 
eliminate all risks inherently associated with the use of this product. Crop injury, 
ineffectiveness or other unintended consequences may result because of such factors 
as manner of use or application, weather or crop conditions, presence of other materials 
or other influencing factors in the use of the product, which are beyond the control of 
SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by 
applicable law, Buyer and User agree to hold SYNGENTA and Seller harmless for any 
claims relating to such factors. 
 
SYNGENTA warrants that this product conforms to the chemical description on the label 
and is reasonably fit for the purposes stated in the Directions for Use, subject to the 
inherent risks referred to above, when used in accordance with directions under normal 
use conditions. To the extent permitted by applicable law: (1) this warranty does not 
extend to the use of the product contrary to label instructions, or under conditions not 
reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer 
and User assume the risk of any such use. TO THE EXTENT PERMITTED BY 
APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY 
OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR 
IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL. 
 
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for 
any incidental, consequential or special damages resulting from the use or handling of 
this product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE 
EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY 
OF SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES 
OR DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, 
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) 
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE 
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION 
OF SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT. 
 
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

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DIRECTIONS FOR USE 
 
It is a violation of Federal law to use this product in a manner inconsistent with its 
labeling. 
 
Maximum usage when applying metalaxyl- and mefenoxam-containing products 
to the same crop within the same season: Do not apply more than the maximum 
yearly total application rate for the active ingredient as stated on the label of the product 
containing the lowest yearly total on that crop. 
 
 
AGRICULTURAL USE REQUIREMENTS 
 
Use this product only in accordance with its labeling and with the Worker 
Protection Standard, 40 CFR part 170. This Standard contains requirements for 
the protection of agricultural workers on farms, forests, nurseries, and 
greenhouses, and handlers of agricultural pesticides. It contains requirements 
for training, decontamination, notification, and emergency assistance. It also 
contains specific instructions and exceptions pertaining to the statements on this 
label about personal protective equipment (PPE) and restricted-entry interval. 
The requirements in this box only apply to uses of this product that are covered 
by the Worker Protection Standard. 
 
Do not enter or allow worker entry into treated areas during the restricted-
entry interval (REI) of 48 hours. Exception: If the seed is treated with the 
product and the treated seed is soil-injected or soil-incorporated, the Worker 
Protection Standard, under certain circumstances, allows workers to enter the 
treated area if there will be no contact with anything that has been treated. 
 
PPE required for early entry to treated areas that is permitted under the Worker 
Protection Standard and that involves contact with anything that has been 
treated, such as plants, soil, or water is: 
 
x Coveralls 
x Chemical-resistant gloves made of barrier laminate, butyl rubber > 14 mils, 
nitrile rubber > 14 mils, neoprene rubber > 14 mils, polyvinyl chloride 
(PVC) > 14 mils, or Viton® > 14 mils 
x Shoes plus socks

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FAILURE TO FOLLOW THE DIRECTIONS FOR USE AND PRECAUTIONS ON THIS 
LABEL MAY RESULT IN CROP INJURY, POOR INSECT AND/OR DISEASE 
CONTROL, AND/OR ILLEGAL RESIDUES. 
 
Treatment of highly mechanically scarred or damaged seed or seed known to be of low 
vigor and poor quality may result in reduced germination and/or reduction of seed and 
seedling vigor. Treat a quantity of seed using equipment similar to that planned for 
treating the total seed lot. Prior to treatment, conduct germination tests on a portion of 
seed before committing the total seed lot to a selected seed treatment. 
 
Due to seed quality, crop or variety sensitivity, and seed storage conditions beyond the 
control of Syngenta, no claims are made to guarantee the germination of seed or 
propagating material for all crop seed when treated with THX/MXM/FDL CZ [Adage ST]. 
 
 
USE INFORMATION 
 
THX/MXM/FDL CZ [Adage ST] is a seed treatment product containing the active 
ingredients: thiamethoxam (insecticide) and fludioxonil and mefenoxam (fungicides). 
THX/MXM/FDL CZ [Adage ST] protects against damage from listed early season 
insects, soil-borne and seed-borne diseases of soybeans. 
 
Thiamethoxam is a systemic seed treatment insecticide belonging to the neonicotinoid 
class of chemistry. Thiamethoxam protects against certain chewing and sucking insects 
through contact and ingestion. 
 
Mefenoxam fungicide is active against Pythium, Phytophthora and systemic downy 
mildew. 
 
Fludioxonil fungicide is active against Fusarium, Rhizoctonia, and suppresses seed-
borne Sclerotinia and Phomopsis species. 
 
 
MIXING PROCEDURES 
 
Important: Always re-circulate THX/MXM/FDL CZ [Adage ST] thoroughly before using. 
 
The typical density of THX/MXM/FDL CZ [Adage ST] is 9.6 pounds per gallon. Consult 
the manufacturer of the application equipment you plan to use for suitability for this 
application and for instructions on operation and calibration of the equipment. Follow 
the manufacturer application instructions for the seed treatment equipment being used. 
 
Apply THX/MXM/FDL CZ [Adage ST] as a water-based slurry utilizing standard slurry 
seed treatment equipment which provides uniform seed coverage. Uneven or 
incomplete seed coverage may not give the desired level of disease control.

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Thoroughly mix the specified amount of THX/MXM/FDL CZ [Adage ST] into the required 
amount of water or liquid inoculant for the slurry treater and dilution rate to be used. 
 
Certain crops require addition of inoculants when the seed is treated or planted. 
THX/MXM/FDL CZ [Adage ST] is compatible with several liquid inoculant products. 
Consult the maker of the inoculant product and a Syngenta Crop Protection 
representative for directions before applying THX/MXM/FDL CZ [Adage ST] with 
inoculants. 
 
Under certain disease conditions, additional amounts of fungicides may be required. 
When needed, apply additional Apron XL® or similar fungicide. Other tank mix partners 
may be used with THX/MXM/FDL CZ [Adage ST]; however, the user must consider the 
use rate, formulation, seed and crop safety factors and compatibility of each product to 
be mixed when determining the total application volume. 
 
The total application volume must be sufficient to provide desired level of coverage. 
Dilution is typically done with water or liquid inoculants. The minimum slurry volume to 
achieve adequate coverage is 4.0 fluid ounces per 100 pounds of seed. More diluent 
may be required to obtain complete coverage. 
 
Continuous agitation or mixing of the slurry mixture is necessary to prevent settling out 
of the solution. 
 
Allow seed to dry before bagging. 
 
Follow planter manufacturer recommendations for use of seed lubricant/fluency agent, 
or other hopper box additives at planting. Seed should be completely dry before adding 
to planter. 
 
Seed treated with this product must be visually identifiable from untreated seed by the 
use of an approved colorant or dye to prevent accidental use of treated seed as food for 
humans or feed for animals. Refer to 21 CFR, Part 2.25. Any colorant or dye added to 
treated seed must be cleared for use in accordance with 40 CFR 153.155(c). 
 
 
ROTATIONAL CROP RESTRICTIONS 
 
In the event of a crop failure or harvest of a crop grown from THX/MXM/FDL CZ [Adage 
ST] treated seed, the field may be replanted immediately to alfalfa, Brassica (cole) leafy 
vegetables, cereal grains (including barley, buckwheat, corn, pearl millet, proso millet, 
oats, popcorn, rice (dry-seeded), rye, sorghum, teosinte, triticale, wheat and wild rice), 
canola, cotton, cucurbit vegetables, dry bulb onions, fruiting vegetables, leafy 
vegetables, legume vegetables (including soybeans), mint (peppermint and spearmint), 
oil seed crops (rapeseed, Indian rapeseed, Indian mustard seed, field mustard seed, 
black mustard seed, flax seed, safflower seed, crambe seed and borage seed),

9
peanuts, root vegetables, strawberry, sunflowers, tobacco, and tuberous and corm 
vegetables. 
 
For any other crop, the minimum plant-back interval is 120 days from the date 
THX/MXM/FDL CZ [Adage ST] treated seed was planted. A cover crop other than the 
crops listed above that is planted for erosion control or soil improvement may be planted 
sooner than the 120 day interval; however, the crop may not be grazed or harvested for 
food or feed. 
 
 
SEED BAG LABEL REQUIREMENTS 
 
The Federal Seed Act requires that bags containing treated seeds shall be labeled with 
the following statements: 
x This seed has been treated with thiamethoxam insecticide and fludioxonil and 
mefenoxam fungicides. 
x Do not use for feed, food, or oil purposes. 
x User is responsible for ensuring that the seed bag meets all requirements under 
the Federal Seed Act. 
 
In addition, the U.S. Environmental Protection Agency requires the following statements 
on bags containing seeds treated with THX/MXM/FDL CZ [Adage ST]: 
x Groundwater Advisory: Mefenoxam is known to leach through soil into 
groundwater under certain conditions as a result of label use. Fludioxonil and 
Thiamethoxam have properties and characteristics associated with chemicals 
detected in groundwater. These chemicals may leach into groundwater if used in 
areas where soils are permeable, particularly where the water table is shallow. 
x Pollinator Precautions: Thiamethoxam is highly toxic to bees, and effects are 
possible as a result of exposure to translocated residues in blooming crops. 
x Store away from feeds and foodstuffs. 
x Wear long-sleeved shirt, long pants and chemical resistant gloves when handling 
treated seed. 
x Treated seeds exposed on soil surface may be hazardous to wildlife. Cover or 
collect treated seeds spilled during loading. 
x Treated seed must be planted into the soil at a depth greater than 1 inch. 
x Dispose of all excess treated seed. Leftover treated seed may be doublesown 
around the headland or buried away from water sources in accordance with local 
requirements. 
x Do not contaminate water bodies when disposing of planting equipment wash 
waters. 
x Dispose of seed packaging in accordance with local requirements. 
x In the event of a crop failure or harvest of a crop grown from THX/MXM/FDL CZ 
[Adage ST] treated seed, the field may be replanted immediately to alfalfa, 
Brassica (cole) leafy vegetables, cereal grains (including barley, buckwheat, 
corn, pearl millet, proso millet, oats, popcorn, rice (dry-seeded), rye, sorghum,

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teosinte, triticale, wheat and wild rice), canola, cotton, cucurbit vegetables, dry 
bulb onions, fruiting vegetables, leafy vegetables, legume vegetables (including 
soybeans), mint (peppermint and spearmint), oil seed crops (rapeseed, Indian 
rapeseed, Indian mustard seed, field mustard seed, black mustard seed, flax 
seed, safflower seed, crambe seed and borage seed), peanuts, root vegetables, 
strawberry, sunflowers, tobacco, and tuberous and corm vegetables. For any 
other crop, the minimum plant-back interval is 120 days from the date 
THX/MXM/FDL CZ [Adage ST] treated seed was planted. A cover crop other 
than the crops listed above that is planted for erosion control or soil improvement 
may be planted sooner than the 120 day interval; however, the crop may not be 
grazed or harvested for food or feed. 
x Do not allow children, pets, or livestock to have access to treated seed. 
x Do not apply more than 0.083 lb thiamethoxam/Acre (37.8 grams ai/A), 0.026 lb 
mefenoxam/Acre (12 grams ai/A), and 0.0085 lb fludioxonil/A (3.9 grams ai/A) as 
a seed treatment application. This seed has been treated with thiamethoxam at 
0.0756 mg ai/seed, mefenoxam at 0.0113 mg ai/seed and fludioxonil 0.0038 mg 
ai/seed. 
x Do not apply a neonicotinoid insecticide within 45 days of planting soybean seed 
treated with THX/MXM/FDL CZ [Adage ST]. 
x Excess treated seed may be used for ethanol production only if (1) by-products 
are not used for livestock feed and (2) no measurable residues of pesticide 
remain in the ethanol by- products that are used in agronomic practice. 
 
 
CROP USE RESTRICTIONS 
x Do not use for feed, food, or oil purposes. 
x Do not contaminate water bodies when disposing of planting equipment wash 
waters. 
x Do not allow children, pets, or livestock to have access to treated seed. 
x Do not apply more than 0.083 lb thiamethoxam/Acre (37.8 grams ai/A), 0.026 lb 
mefenoxam/Acre (12 grams ai/A), and 0.0085 lb fludioxonil/A (3.9 grams ai/A) as 
a seed treatment application. This seed has been treated with thiamethoxam at 
0.0756 mg ai/seed, mefenoxam at 0.0113 mg ai/seed and fludioxonil 0.0038 mg 
ai/seed. 
x Do not apply a neonicotinoid insecticide within 45 days of planting soybean seed 
treated with THX/MXM/FDL CZ [Adage ST].

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CROP USE PRECAUTIONS 
 
Resistance Management 
 
MEFENOXAM GROUP 4 FUNGICIDE 
FLUDIOXONIL GROUP 12 FUNGICIDE 
 
For resistance management, please note that THX/MXM/FDL CZ [Adage ST] contains 
Group 4/mefenoxam and Group 12/fludioxonil fungicides. Any fungal population may 
contain individuals naturally resistant to THX/MXM/FDL CZ [Adage ST] and other Group 
4 or Group 12 fungicides. A gradual or total loss of pest control may occur over time if 
these fungicides are used repeatedly in the same fields. Appropriate resistance-
management strategies should be followed. 
 
Mefenoxam belongs to the phenylamide class of chemistry which interferes with fungal 
RNA synthesis. Fludioxonil belongs to the phenylpyrrole class of chemistry which 
interferes with osmotic signal transduction. 
 
To delay fungicide resistance, take one or more of the following steps: 
x Rotate the use of THX/MXM/FDL CZ [Adage ST] or other Group 4 or Group 12 
fungicides within a growing season sequence with different groups that control the 
same pathogens. 
x Use tank mixtures with fungicide from a different group that are equally effective on 
the target pest when such use is permitted. Use at least the minimum application 
rate as labeled by the manufacturer. 
x Adopt an integrated disease management program for fungicide use that includes 
scouting, uses historical information related to pesticide use, and crop rotation, and 
which considers host plant resistance, impact of environmental conditions on 
disease development, disease thresholds, as well as cultural, biological and other 
chemical control practices. 
x Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage 
resistance. 
x Monitor treated fungal populations for resistance development. 
x Contact your local extension specialist or certified crop advisor for any additional 
pesticide resistance-management and/or IPM recommendations for specific crop 
and pathogens. 
x For further information or to report suspected resistance contact Syngenta at 1-866-
Syngent(a) (866-796-4368). You can also contact your pesticide distributor or 
university extension specialist to report resistance. 
 
Syngenta encourages responsible product stewardship to ensure effective long term 
control of the fungal diseases on this label.

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THIAMETHOXAM GROUP 4A INSECTICIDE
 
For resistance management, THX/MXM/FDL CZ [Adage ST] contains a Group 
4A/thiamethoxam insecticide. Any insect population may contain individuals naturally 
resistant to THX/MXM/FDL CZ [Adage ST] and other Group 4A insecticides. The 
resistant individuals may dominate the insect population if this group of insecticides are 
used repeatedly in the same fields. Appropriate resistance-management strategies 
should be followed. 
 
Thiamethoxam is a systemic insecticide belonging to the neonicotinoid class of 
chemistry which includes nicotinic acetylcholine receptor (nAChR) agonists. 
 
To delay insecticide resistance, take the following steps: 
 
x Rotate the use of THX/MXM/FDL CZ [Adage ST] or other Group 4A insecticides 
within a growing season, or among growing seasons, with different groups that 
control the same pests. 
x Use tank mixtures with insecticides from a different group that are equally effective 
on the target pest when such use is permitted. Do not rely on the same mixture 
repeatedly for the same pest population. Consider any known cross-resistance 
issues (for the targeted pests) between the individual components of a mixture. In 
addition, consider the following recommendations provided by the Insecticide 
Resistance Action Committee (IRAC): 
o Individual insecticides selected for use in mixtures should be highly effective and 
be applied at the rates at which they are individually registered for use against 
the target species. 
o Mixtures with components having the same IRAC mode of action classification 
are not recommended for insect resistance management. 
o When using mixtures, consider any known cross-resistance issues between the 
individual components for the targeted pest(s). 
o Mixtures become less effective if resistance is already developing to one or both 
active ingredients, but they may still provide pest management benefits. 
o The insect resistance management benefits of an insecticide mixture are greatest 
if the two components have similar periods of residual insecticidal activity. 
Mixtures of insecticides with unequal periods of residual insecticide activity may 
offer an insect resistance management benefit only for the period where both 
insecticides are active. 
x Adopt an integrated pest management program for insecticide use that includes 
scouting, uses historical information related to pesticide use, crop rotation, record 
keeping, and which considers cultural, biological and other chemical control 
practices. 
x Monitor after application for unexpected target pest survival. If the level of survival 
suggests the presence of resistance, consult with your local university specialist or 
certified pest control advisor.

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x Contact your local extension specialist or certified crop advisors for any additional 
pesticide resistance-management and/or IPM recommendations for the specific site 
and pest problems in your area. 
 
For additional information on Insecticide Resistance Management: 
x Contact Syngenta representatives at 1-800-334-9481 
x Visit the Insecticide Resistance Action Committee (IRAC) on the web at: 
http://www.irac-online.org 
 
Syngenta encourages responsible product stewardship to ensure effective long-term 
control of the insect pests on this label. 
 
 
CROP USE DIRECTIONS 
 
When applied according to the THX/MXM/FDL CZ [Adage ST] RATE TABLE, 
THX/MXM/FDL CZ [Adage ST] provides early season protection against injury by 
aphids, bean leaf beetle, grape colaspis, leaf miners, leaf hoppers, Mexican bean 
beetle, seed corn maggot, three cornered alfalfa hopper, thrips, white grubs, and 
wireworm. 
 
THX/MXM/FDL CZ [Adage ST] provides protection against damping-off and seed borne 
rots due to Pythium, Phytophthora, Fusarium, Rhizoctonia species and early season 
Phytophthora root rot. THX/MXM/FDL CZ [Adage ST] also suppresses seed-borne 
Sclerotinia and Phomopsis species. 
 
THX/MXM/FDL CZ [Adage ST] Rate table
1 
 
Crop 
 
 
Rate of THX/MXM/FDL CZ [Adage ST] 
 
Soybean, 
including 
soybean, 
vegetable 
(edamame) 
fl oz per 
100 lb seed 
or 
fl oz per 140,000 seeds 
 
grams ai per 
100 kg seed 
 
mg ai 
per seed 
 
3.1 fl oz per 100 lb seed 
 
or 
 
1.45 fl oz per 140,000 seeds 
 
Thiamethoxam 
50 gm 
 
Mefenoxam 
7.50 gm 
 
Fludioxonil 
2.5 gm 
 
 
Thiamethoxam 
0.0756 mg 
 
Mefenoxam 
0.0113 mg 
 
Fludioxonil 
0.0038 mg 
 
Total= 
0.0907 mg 
 
1The mg ai per seed, fl oz per 100 lb seed and fl oz THX/MXM/FDL CZ [Adage ST] per 140,000 seeds 
rates are based on 3,000 seeds per pound.

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When to Add Additional Apron XL or similar fungicide: 
 
If target fields have a history of high Phytophthora pressure, add additional Apron XL (or 
similar fungicide) as directed in the product label. The additional Apron XL may reduce 
compatibility with some rhizobia inoculants. Consult with the maker of rhizobia 
inoculants before adding the additional Apron XL. 
 
Stored Grain Protection 
When treated according to the directions for post-planting protection against listed 
pests, THX/MXM/FDL CZ [Adage ST] will also provide protection during post treatment 
storage of the soybean seed against damage from the following stored grain insects: 
Indian Meal Moth (Plodia interpunctella), Rice Weevil (Sitophilus oryza), Red Flour 
Beetle (Tribolium castaneum), and Lesser Grain Borer (Rhizopertha dominica). 
 
If the soybean seed to be treated has existing infestations of stored grain insects, it is 
recommended that the seed be fumigated prior to treating with THX/MXM/FDL CZ 
[Adage ST] and bagging. 
 
STORAGE AND DISPOSAL 
 
Do not contaminate water, food, or feed by storage or disposal. 
 
Pesticide Storage 
Store in a cool, dry place. Storage for extended periods above 90°F is not 
recommended. 
 
For minor spills, leaks, etc., follow all precautions indicated on this label and clean up 
immediately. Take special care to avoid contamination of equipment and facilities 
during cleanup procedures and disposal of wastes. 
 
Pesticide Disposal 
Wastes resulting from the use of this product may be disposed of on site or at an 
approved waste disposal facility. If these wastes cannot be disposed of by use 
according to label instructions, contact your State Pesticide or Environmental Control 
Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for 
guidance. 
 
Container Handling [less than or equal to 5 gallons] 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank and drain for 10 seconds after the flow 
begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. 
Pour rinsate into application equipment or a mix tank or store rinsate for later use or 
disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two 
more times. Then offer for recycling if available or puncture and dispose of in a sanitary

15
landfill, or by incineration, or by other procedures approved by state and local 
authorities. 
 
Container Handling [greater than 5 gallons] 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank. Fill the container ¼ full with water. 
Replace and tighten closures. Tip container on its side and roll it back and forth, 
ensuring at least one complete revolution, for 30 seconds. Stand the container on its 
end and tip it back and forth several times. Turn the container over onto its other end 
and tip it back and forth several times. Empty the rinsate into application equipment or 
a mix tank or store rinsate for later use or disposal. Repeat this procedure two more 
times. Then offer for recycling if available or puncture and dispose of in a sanitary 
landfill, or by incineration, or by other procedures approved by state and local 
authorities. 
 
Container Handling [greater than 5 gallons] 
Refillable container. Refill this container with pesticide only. Do not reuse this 
container for any other purpose. Cleaning the container before final disposal is the 
responsibility of the person disposing of the container. Cleaning before refilling is the 
responsibility of the person refilling. 
 
To clean container before final disposal, empty the remaining contents from this 
container into application equipment or mix tank. Fill the container about 10 percent full 
with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Pour or 
pump rinsate into application equipment or rinsate collection system. Repeat this 
rinsing procedure two more times. Then offer for recycling if available or puncture and 
dispose of in a sanitary landfill, or by incineration, or by other procedures approved by 
state and local authorities. 
 
CONTAINER IS NOT SAFE FOR FOOD, FEED, OR DRINKING WATER! 
 
Adage™, Apron XL®, and SYNGENTA are Trademarks of a Syngenta Group Company 
Viton® is a registered trademark of E.I. DuPont de Nemours and Company 
 
©20XX Syngenta 
 
For non-emergency (e.g., current product information), call 
Syngenta Crop Protection at 1-800-334-9481. 
 
Manufactured for: 
Syngenta Crop Protection, LLC 
P. O. Box 18300 
Greensboro, North Carolina 27419-8300 
 
THX-MXM-FDL CZ 1283 MAS 0717 NOTIF DEC2017-Ver A– mar – 3/5/2019

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THX-MXM-FDL CZ 1283 MAS 0717 NOTIF DEC2017-HI-Ver A– mar – 3/5/2019 
000100-01283.20171211A.THX-MXM-FDL_CZ.NOTIF.DEC2017-HI.pdf 
 
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