crop-chem-docs/corpus/epa_ppls/100-1564.md

# A21185B

- EPA Reg No: **100-1564**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Gibberellic acid (0.018%); Indole-3-butyric acid (0.027%); Thiamethoxam (5.79%); Metalaxyl-M (0.87%); Cytokinin (as kinetin) (0.054%); Difenoconazole (3.47%); Sedaxane (0.87%)
- Label accepted: 2025-11-19
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01564-20251119.pdf

---
November 19, 2025 
 
Nestor Algarin 
Regulatory Product Manager 
Syngenta Crop Protection, LLC 
P.O. Box 18300 
Greensboro, NC 27419 
 
Subject: Label Amendment - Registration Review Mitigation for Metalaxyl-M/Mefenoxam 
 Product Name: A21185B 
 EPA Registration Number: 100-1564 
Case Number: 671135 
Application Date: November 21, 2022 
 
Dear Nestor Algarin: 
 
The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), 
as amended, has completed reviewing all the information submitted with your application to 
support the Registration Review of the above referenced product in connection with the 
Metalaxyl/Mefenoxam Interim Decision, and has concluded that your submission is acceptable. 
The label referred to above, submitted in connection with registration under FIFRA, as 
amended, is acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please 
be aware that the website becomes labeling under the Federal Insecticide, Fungicide, and 
Rodenticide Act and is subject to review by the Agency. If the website is false or misleading, the 
product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 
40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In 
addition, regardless of whether a website is referenced on your product’s label, claims made on 
the website may not substantially differ from those claims approved through the registration 
process. Therefore, should the Agency find or if it is brought to our attention that a website 
contains false or misleading statements or claims substantially differing from the EPA approved 
registration, the website will be referred to the EPA’s Office of Enforcement and Compliance 
Assurance. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes 
all previously accepted labeling and must be used at your next label printing. You must 
submit one copy of the final printed labeling before you release the product for

Page 2 of 2 
EPA Reg. No. 100-1564 
Case No. 671135 
 
shipment with the new labeling. In accordance with 40 CFR 152.130(c), you may 
distribute or sell this product under the previously approved labeling for 12 months 
from the date of this letter. After 12 months, you may only distribute or sell this 
product if it bears this new revised labeling or subsequently approved labeling. “To 
distribute or sell” is defined under FIFRA section 2(gg) and its implementing regulation 
at 40 CFR 152.3. 
 
If you have any questions about this letter, please contact Concepción Rodríguez by phone at 
202-566-0820, or via email at rodriguez.concepcion@epa.gov. 
 
 Sincerely, 
 
 
 
 
Maryam K. Muhammad-Perch, Team Lead 
Risk Management and Implementation Branch 4 
Pesticide Re-Evaluation Division 
Office of Pesticide Programs 
 
 
 
 
ENCLOSURE: Stamped label

A21185B 
Page 2 
FIRST AID 
Have the product container with you when calling a poison control center or doctor, or 
going for treatment. 
HOT LINE NUMBER 
For 24-Hour Medical Emergency Assistance (Human or Animal) or 
Chemical Emergency Assistance (Spill, Leak, Fire, or Accident), 
Call 
1-800-888-8372 
 
 
PRECAUTIONARY STATEMENTS 
 
Hazards to Humans and Domestic Animals 
 
CAUTION 
 
Wash thoroughly with soap and water after handling and before eating, drinking, 
chewing gum, using tobacco, or using the toilet. Remove and wash contaminated 
clothing before reuse. 
 
Personal Protective Equipment (PPE) 
 
Mixers, loaders, applicators and other handlers must wear: 
 
x Long-sleeved shirt and long pants 
x Shoes plus socks 
x Chemical-resistant gloves made of polyvinyl chloride [PVC]
 ≥14 mils, nitrile rubber 
≥14 mils , butyl rubber ≥14 mils, barrier laminate, neoprene rubber ≥14 mils, or 
Viton® ≥14 mils 
 
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions 
for washables exist, use detergent and hot water. Keep and wash PPE separately from 
other laundry. 
 
Engineering Controls 
 
When handlers use closed systems in a manner that meets the requirements listed in 
the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-
6)], the handler PPE requirements may be reduced or modified as specified in the WPS.

A21185B 
Page 3 
 
 
User Safety Recommendations 
 
Users should: 
 
x Wash hands before eating, drinking, chewing gum, using tobacco, or using the 
toilet. 
x Remove clothing/PPE immediately if pestic ides get inside. Then wash thoroughly 
and put on clean clothing. 
x Remove PPE immediately after handling this product. Wash the outside of gloves 
before removing. As soon as possible, wash thoroughly and change into clean 
clothing. 
 
 
 
Environmental Hazards 
This product is toxic to wildlife, freshwater and estuarine/marine fish and highly toxic to 
aquatic invertebrates. Runoff may be hazardous to aquatic organisms in neighboring 
areas. Do not contaminate water when disposing of equipment washwater or rinsate. 
Exposed treated seed may be hazardous to wildlife. 
 
 
Pollinator Precautions 
Thiamethoxam is highly toxic to bees, and effects are possible as a result of exposure 
to translocated residues in blooming crops. 
 
If treated seed is spilled outdoors or in areas accessible to birds, promptly clean up or 
bury to prevent ingestion. 
 
 
Groundwater Advisory 
Mefenoxam is known to leach through soil into ground water under certain conditions as 
a result of agricultural use. Use of this chemical in areas where soils are permeable, 
particularly where the water ta ble is shallow, may lead to groundwater contamination.
 
Thiamethoxam has properties and characteristics associated with chemicals detected in 
ground water. Mefenoxam and Thiamethoxam may leach into the ground water if used 
in areas where soils are permeable, particularly where the water table is shallow.

A21185B 
Page 4 
CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY 
 
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not acceptable, 
return the product at once, unopened, and the purchase price will be refunded. 
 
The Directions for Use of this product must be followed carefully. It is impossible to 
eliminate all risks inherently associated with the use of this product. Crop injury, 
ineffectiveness or other unintended consequences may result because of such factors 
as manner of use or application, weather or crop conditions, presence of other materials 
or other influencing factors in the use of the product, which are beyond the control of 
SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by 
applicable law, Buyer and User agree to hold SYNGENTA and Seller harmless for any 
claims relating to such factors. 
 
SYNGENTA warrants that this product conforms to the chemical description on the label 
and is reasonably fit for the purposes stated in the Directions for Use, subject to the 
inherent risks referred to above, when used in accordance with directions under normal 
use conditions. To the extent permitted by applicable law: (1) this warranty does not 
extend to the use of the product contrary to label instructions or under conditions not 
reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer 
and User assume the risk of any such use. To the extent permitted by applicable law, 
SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY OR OF FITNESS 
FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED 
WARRANTY EXCEPT AS WARRANTED BY THIS LABEL. 
 
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any 
incidental, consequential or special damages resulting from the use or handling of this 
product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE 
REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF 
SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR 
DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, 
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) 
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE 
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION OF 
SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT. 
 
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

A21185B 
Page 5 
DIRECTIONS FOR USE 
 
It is a violation of Federal law to use this product in a manner inconsistent with its labeling. 
 
For use in commercial seed treatment facilities. Use is also permitted as an end-use seed 
treatment on agricultural establishments at pl anting, or immediately before planting, as 
specified in the specific Crop Use Directions. This product is to be used in liquid or slurry 
treaters only. 
 
Do not make any soil or foliar application of products containing a neonicotinoid to crops 
grown from seed treated with A21185B. 
 
Do not apply this product in a way that will contact workers or other persons, either 
directly or through drift. Only protected handlers may be in the area during application. 
For any requirements specific to your State or Tribe, consult the agency responsible for 
pesticide regulation. 
FAILURE TO FOLLOW DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY 
RESULT IN CROP INJURY, POOR DISEASE CONTROL, AND/OR ILLEGAL 
RESIDUES. 
 
Treatment of highly mechanically scarred or damaged seed, or seed known to be of low 
vigor and poor quality, except for the purpose of curative control of existing disease 
pests, may result in reduced germination and/or reduction of seed and seedling vigor. 
Conduct germination tests on a small portion of seed before committing the total seed 
lot to a selected seed treatment. Treat using equipment similar to that planned for 
treating the total seed lot. Due to seed quality and seed storage conditions beyond the 
control of Syngenta, no claims are made to guarantee the germination of carry-over 
treated seed. 
 
Maximum usage when applying both metalaxyl- and mefenoxam-containing 
products to the same crop within the same season: Do not apply more than the 
maximum yearly total application rate for the active ingredient as stated on the label of 
the product containing the lowest yearly total on that crop. 
 
AGRICULTURAL USE REQUIREMENTS 
Use this product only in accordance with it s labeling and with the Worker Protection 
Standard, 40 CFR part 170. This Standard cont ains requirements for the protection of 
agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 
agricultural pesticides. It contains requirements for training, decontamination, 
notification, and emergency assistance. It also contains specific instructions and 
exceptions pertaining to the statements on this label about personal protective 
equipment (PPE
), notifications to workers, and restricted- entry interval. The 
requirements in this box only apply to uses of this product that are covered by the 
Worker Protection Standard. 
 
Do not enter or allow worker entry into treated areas during the res tricted-entry 
interval (REI) of 48 hours. Exception: If the seed is treated with the product and the 
treated seed is soil-injected or soil-incorporated, the Worker Protection Standard, under

A21185B 
Page 6 
certain circumstances, allows workers to en ter the treated area if there will be no 
contact with anything that has been treated. 
 
PPE required for early entry to treated area s that is permitted under the Worker 
Protection Standard and that involves contact with anything that has been treated, such 
as plants, soil, or water is: 
x Coveralls 
x Chemical-resistant gloves made of polyvinyl chloride [PVC] ≥14 mils, nitrile 
rubber ≥14 mils , butyl rubber ≥14 mils, barrier laminate, neoprene rubber ≥14 
mils, or Viton® ≥14 mils 
x Shoes plus socks 
 
 
 
PRODUCT INFORMATION 
 
A21185B is a seed treatment product containing one insecticide active 
ingredient (thiamethoxam), three fungicide active ingredients (difenoconazole, 
mefenoxam, and sedaxane) and three plant-growth regulators (cytokinin, indole butyric 
acid and giberellic acid). A21185B seed treatment protects against damage from 
certain early-season insects and certain seed- and soil-borne diseases of cereal crops. 
 
Difenoconazole provides protection against several seed, seedling and certain foliar 
disease including bunts and smuts. Mefenoxam protects against damping-off caused by 
Pythium spp. 
 Sedaxane protects against Rhizoctonia spp. and loose smuts (Ustilago 
spp.). 
 
Thiamethoxam is a systemic seed treatment insecticide belonging to the neoticotinoid 
class of chemistry. Thiamethoxam in A211 85B protects against aphids, wireworm and 
European chafer. 
 
A21185B contains the plant-growth regulators cytokinin, gibberellic acid and indolebutyric 
acid to aid in enhanced germination and early season root and top growth. 
 
Resistance Management 
 
For resistance management, A21185B contains a Group 4A/thiamethoxam insecticide. 
Any insect population may contain individuals naturally resistant to A21185B and other 
Group 4A insecticides. The resistant individuals may dominate the insect population if 
this group of insecticides are used repeatedly in the same fields. Appropriate 
resistance-management strategies should be followed 
 
Thiamethoxam is a systemic insecticide belonging to the neonicotinoid class of 
chemistry which includes nicotinic acetylcholine receptor (nAChR) agonists. 
 
If resistance to this product develops in your area, this product, or other products with a 
similar mode of action, may not provide adequate control. If poor performance cannot 
be attributed to improper application or weather conditions, a resistant strain of insect or

A21185B 
Page 7 
pathogen may be present. If you experience difficulty with control and resistance is a 
reasonable cause, immediately consult your local company representative or 
agricultural advisor for the best alternative method of control for your area. 
 
 
In order to maintain susceptibility to this class of chemistry: 
x Avoid using Group 4A insecticides exclusively for season long control of insect 
species with more than one generation per crop season. 
x For insect species with successive or overlapping generations, apply A21185B and 
other Group 4A insecticides using a “treatment window” approach. A treatment 
window is a period of time as defined by the stage of crop development and/or the 
biology of the pests of concern. Within the treatment window, depending on the 
length of residual activity, there may either be single or consecutive applications 
(seed treatment, soil, foliar, unless otherwise stated) of the Group 4A insecticides. 
Do not exceed the maximum A21185B allowed per calendar year. 
x Following a treatment window of Group 4A insecticides, rotate to a treatment window 
of effective products with a different mode of action before making additional 
applications of Group 4A insecticides. 
x A treatment window rotation, along with other IPM practices for the crop and use 
area, is considered an effective strategy for preventing or delaying a pest’s ability to 
develop resistance to this class of chemistry. 
x If resistance is suspected, do not reapply A21185B or any other Group 4A 
insecticides. 
 
Other Insect Resistance Management (IRM) practices include: 
ƒ Incorporating IPM techniques into your insect control program. 
ƒ Monitoring treated insect populations for loss of field efficacy. 
ƒ Using tank-mixtures or premixes with inse cticides from a different target site of 
action group as long as the involved products are all registered for the same crop 
and effective rates are applied. 
 
For additional information on Insect Resistance Management: 
ƒ Contact your local extension specialist, certified crop advisor and/or product 
manufacturer for additional insect resistance management recommendations. 
ƒ Visit the Insecticide Resistance Action Committee (IRAC) on the web at: 
http://www.irac-online.org 
 
Syngenta encourages responsible product stewardship to ensure effective long-term 
control of the insects on this label. 
 
 
For resistance management, please note that A21185B contains a Group 
3/difenoconazole, Group 4/mefenoxam, and Group 7/sedaxane fungicide. Any fungal 
population may contain individuals naturally resistant to A21185B and other Group 3, 
Group 4, or Group 7 fungicides. A gradual or total loss of pest control may occur over 
time if these fungicides are used repeatedly in the same fields. Appropriate resistance-
management strategies should be followed.

A21185B 
Page 8 
Difenoconazole belongs to the triazole class of chemistry and is a demethylation 
inhibitor of sterol biosynthesis (DMI). DMI’s disrupt membrane synthesis by blocking 
demethylation. Mefenoxam is a systemic fungicide belonging to the phenylamide class 
of chemistry which adversely affects fungal RNA synthesis. Sedaxane belongs to the 
carboxamide class of chemistry and is a succinate dehydrogenase inhibitor (SDHI). 
SDHI’s inhibit fungal metabolism by binding to the succinate dehydrogenase enzyme 
thereby disrupting cellular respiration and energy generation. 
 
To delay fungicide resistance, take one or more of the following steps: 
 
x Rotate the use of A21185B or other Grou p 3, Group 4, or Group 7 fungicides 
within a growing season sequence with different groups that control the same 
pathogens. 
 
x Use tank mixtures with fung icides from a different group that are equally effective 
on the target pest when such use is permitted. Use at least the minimum 
application rate as labeled by the manufacturer. 
 
x Adopt an integrated disease management program for fungicide use that 
includes scouting, uses historical information related to pesticide use, and crop 
rotation, and which considers host plant resistance, impact of environmental 
conditions on disease development, disease thresholds, as well as cultural, 
biological and other chemical control practices. 
 
x Where possible, make use of predicti ve disease models to effectively time 
fungicide application. Note that using predictive models alone is not sufficient to 
manage resistance. 
 
x Monitor treated fungal populations for resistance development. 
 
x Contact your local extension specialist or certified crop advisor for any additional 
pesticide resistance-management and/or IPM recommendations for specific 
crops and pathogens. 
 
x For further information or to report suspected resistance contact Syngenta at 1-
866-SYNGENT(A) (866-796-4368). You can also contact your pesticide 
distributor or university extension specialist to report resistance. 
 
Syngenta encourages responsible product stewardship to ensure effective long term 
control of the fungal diseases on this label. 
ROTATIONAL CROP RESTRICTIONS 
 
In the event of crop failure or harvest of a crop grown from seed treated with A21185B, 
crops may be replanted according to the following schedule: 
 
Plantback Interval Table

A21185B 
Page 9 
Immediate Plantback Minimum 30-Day 
Plantback Interval 
Cereal Grains: Barley, Oats, 
Rye, Triticale, and Wheat 
 
Alfalfa 
 
Cereal Grains 
Crop Group 15 
 
Cotton 
 
Cucurbit Vegetables 
Crop Group 9 
 
Fruiting Vegetables 
Crop Group 8 
 
Head and Stem Brassica 
Crop Subgroup 5A 
 
Leafy Brassica Greens 
Crop Subgroup 5B 
 
Leafy Vegetable 
(Except Brassica Vegetables) 
Crop Group 4 
 
Legume Vegetables 
(Succulent or Dried) 
Crop Group 6 
 
Mint: Peppermint and Spearmint 
 
Oilseeds: Borage, Canola 
(Rapeseed), Crambe, Flax Seed, 
Mustard Seed, and Safflower 
 
Onion, Bulb 
 
Peanut 
 
Root Vegetables (including 
sugarbeet) 
Crop Subgroup 1A 
 
Tuberous and Corm Vegetables 
(including potato) 
Crop Subgroup 1C 
 
Strawberry 
 
Sunflower 
 
Tobacco 
 
For any other crops the minimum plantback interval is 120 days from the date the seeds 
treated with A21185B were planted. A cover crop other than the crops listed above that 
is planted for erosion control or soil improvement may be planted sooner than the 120 
day interval; however, the crop may not be grazed or harvested for food or feed.

A21185B 
Page 10 
 
 
MIXING INSTRUCTIONS 
 
 
Important: Always re-circulate A21185B thoroughly before using. 
 
Apply A21185B as a water-based slurry utilizing standard slurry seed treatment 
equipment which provides uniform seed coverage. Uneven or incomplete seed coverage 
may not give the desired level of insect and disease control. 
 
A21185B may be applied in tank mixes or sequentially with other EPA-registered seed 
treatment pesticide products. If using A21185B in a tank mixture with other seed 
treatment products, observe all directions for use, crops/sites, use rates, dilution ratios, 
precautions, and limitations which appear on the tank-mix partner label(s). 
 
It is the pesticide user's responsibility to ensure that all products in the listed mixtures are 
registered for the intended use. Users must follow the most restrictive directions are 
precautionary language of the products of the mixture (for example, first aid from one 
product, spray drift management from another).
 
 
Consult the manufacturer of the application e quipment you plan to employ for suitability 
for this application and for instructions on operation and calibration of the equipment. 
Follow the manufacturer application instructions for the seed treatment equipment being 
used. 
 
Continuous agitation or mixing of the slurry mixture is necessary to prevent settling out of 
the solution. 
 
Allow seed to dry before bagging. 
 
Follow planter manufacturer specifications for use of talc or other hopper box additives at 
planting. Seed must be completely dry before adding to planter. 
 
A21185B contains an EPA-approved dye/colorant that imparts an unnatural color to the 
seed as required by the Federal Seed Act.

A21185B 
Page 11 
 
SEED BAG LABEL REQUIREMENTS 
 
The Federal Seed Act requires that bags containing treated seeds shall be labeled with 
the following statements: 
x This seed has been treated with difenoconazole, mefenoxam and sedaxane 
fungicides, thiamethoxam insecticide, and cytokinin, indole butyric acid and 
gibberellic acid plant growth regulators. 
x Do not use for feed, food, or oil purposes. 
 
In addition, the U.S. Environmental Protection Agency requires the following statements 
on bags containing seeds treated with A21185B: 
x Pollinator Precaution: Thiamethoxam is highly toxic to bees, and effects are 
possible as a result of exposure to translocated residues in blooming crops. 
x Groundwater Advisory: 
Mefenoxam is known to leach through soil into ground water under certain 
conditions as a result of agricultural use. Use of this chemical in areas where 
soils are permeable, particularly where the water table is shallow, may lead to 
groundwater contamination.
 Thiamethoxam has properties and characteristics 
associated with chemicals detected in ground water. These chemicals may 
leach into the ground water if used in areas where soils are permeable, 
particularly where the water table is shallow. 
x Store away from feeds and foodstuffs. 
x Wear long-sleeved shirt, shoes, long pants and chemical resistant gloves when 
handling treated seed. 
x Treated seeds exposed on soil surface may be hazardous to wildlife. Cover or 
collect treated seeds spilled during loading. 
x Do not allow children, pets, or livest ock to have access to treated seed. 
x Dispose of all excess treated seed. Leftover treated seed may be doublesown 
around the headland or buried away from water sources in accordance with local 
requirements. 
x Do not contaminate water bodies when disposing of planting equipment wash 
waters. 
x Dispose of seed packaging in accordance with local requirements. 
x Treated seed must be planted into the soil at a depth greater than 0.5 inch. 
x In the event of crop failure or harvest of a crop grown from seed treated with 
A21185B, crops may be replanted according to the following schedule:

A21185B 
Page 12 
Plantback Interval Table 
Immediate Plantback Minimum 30-Day 
Plantback Interval 
Cereal Grains: Barley, Oats, 
Rye, Triticale, and Wheat 
 
Alfalfa 
 
Cereal Grains 
Crop Group 15 
 
Cotton 
 
Cucurbit Vegetables 
Crop Group 9 
 
Fruiting Vegetables 
Crop Group 8 
 
Head and Stem Brassica 
Crop Subgroup 5A 
 
Leafy Brassica Greens 
Crop Subgroup 5B 
 
Leafy Vegetable 
(Except Brassica Vegetables) 
Crop Group 4 
 
Legume Vegetables 
(Succulent or Dried) 
Crop Group 6 
 
Mint: Peppermint and Spearmint 
 
Oilseeds: Borage, Canola 
(Rapeseed), Crambe, Flax Seed, 
Mustard Seed, and Safflower 
 
Onion, Bulb 
 
Peanut 
 
Root Vegetables (including 
sugarbeet) 
Crop Subgroup 1A 
 
Tuberous and Corm Vegetables 
(including potato) 
Crop Subgroup 1C 
 
Strawberry 
 
Sunflower 
 
Tobacco 
x For any other crop, the minimum plant back interval is 120 days from the date the 
A21185B treated seed was planted. A cover crop other than the crops listed 
above that is planted for erosion control or soil improvement may be planted 
sooner than the 120-day interval; however, the crop may not be grazed or 
harvested for food or feed.

A21185B 
Page 13 
x Do not make any soil or foliar applicat ion of products containing a neonicotinoid 
to crops grown from seed treated with A21185B. 
x Do not apply any product containing cytokinin, gibberellic acid, or indole butyric 
acid as an in-furrow, band, side dress or mark out application. 
x Do not use at a rate that will result in more than 0.05 lb thiamethoxam per acre 
(22.7 grams ai/A) per calendar year as a seed treatment application. 
x This seed has been treated with 0.008 mg ai thiamethoxam per seed assuming 
an average seed size of 12,000 seeds per pound. 
x Excess treated seed may be used for ethanol production only if (1) by-products 
are not used for livestock feed, and (2) no measurable residues of pesticide 
remain in the ethanol byproducts that are used in agronomic practice. 
 
CROP USE DIRECTIONS 
 
Crop Effect 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Use rate 
for all crops 
(5 fl oz per 
100 lb seed)
 
Barley 
Oats 
Rye 
Triticale 
Wheat 
Growth Regulation: Enhanced germination and early-
season root and top growth 
Barley 
Oats 
Rye 
Spring 
Wheat 
Winter 
Wheat 
Insect Protection against: 
Aphids1 
European Chafer 
Wireworms1 
Barley Disease Protection against: 
General Seed Rots2 
Seedling Blight, Root Rot, and Damping-Off caused by 
seed- and soil-borne Fusarium or Rhizoctonia spp. 
Seedling Blight, Root Rot, and Damping-Off caused by 
soil-borne Pythium spp. 
Seed-borne Septoria 
Covered Smut 
False Loose Smut 
True Loose Smut 
 
Diseases Suppressed3: 
Common Root Rot (Cochliobolus spp.) 
Fusarium Crown and Foot Rot 
Take-All 
Oats Disease Protection against: 
General Seed Rots2 
Seedling Blight, Root Rot, and Damping-Off caused by 
seed- and soil-borne Fusarium or Rhizoctonia spp. 
Seedling Blight, Root Rot, and Damping-Off caused by 
soil-borne Pythium spp. 
Seed-borne Septoria 
Covered Smut 
Loose Smut

A21185B 
Page 14 
Diseases Suppressed3: 
Common Root Rot (Cochliobolus spp.) 
Rye Disease Protection against: 
General Seed Rots2 
Seedling Blight, Root Rot, and Damping-Off caused by 
seed- and soil-borne Fusarium or Rhizoctonia spp. 
Seedling Blight, Root Rot, and Damping-Off caused by 
soil-borne Pythium spp. 
Seed-borne Septoria 
Common Bunt4 
Dwarf Bunt4 
 
Diseases Suppressed3: 
Common Root Rot (Cochliobolus spp.) 
Fusarium Crown and Foot Rot 
Take-All 
Spring 
Wheat 
Disease Protection against: 
General Seed Rots2 
Seedling Blight, Root Rot, and Damping-Off caused by 
seed- and soil-borne Fusarium or Rhizoctonia spp. 
Seedling Blight, Root Rot, and Damping-Off caused by 
soil-borne Pythium spp. 
Seed-borne Septoria 
Fusarium Seed Scab 
Common Bunt4 
Karnal Bunt 
Loose Smut 
Pythium Damping-Off 
 
Diseases Suppressed3: 
Common Root Rot (Cochliobolus spp.) 
Fusarium Crown and Foot and Root Rot 
Take-All 
 
 
 
 
 
 
 
 
Use rate 
for all crops 
(5 fl oz per 
100 lb seed)
 
Triticale 
Winter 
Wheat 
Disease Protection against: 
General Seed Rots2 
Seedling Blight, Root Rot, and Damping-Off caused by 
seed- and soil-borne Fusarium or Rhizoctonia spp. 
Seedling Blight, Root Rot, and Damping-Off caused by 
soil-borne Pythium spp. 
Seed-borne Septoria 
Septoria Leaf Blotch5 
Common Bunt4 
Flag Smut 
Fusarium Seed Scab 
Dwarf Bunt4 
Karnal Bunt 
Loose Smut 
Pythium Damping-Off 
 
Diseases Suppressed3: 
Common Root Rot (Cochliobolus spp.) 
Fusarium Crown and Foot and Root Rot 
Take-All 
1The 5 fluid oz/100 lb rate of A2118 5B provides suppression of wireworm activity, aphids and aphid vectored 
barley yellow dwarf virus. If pressure is moderate or high or control is required, apply up to 0.8 fl oz additional 
Cruiser 5FS.

A21185B 
Page 15 
2This includes rots caused by Fusarium, Pythium, Rhizoctonia, Penicillium and Aspergillus spp. 
3Suppression means consistent protection at a level which is not optimal but is still of commercial benefit. 
4Protects against both seed- and soil-borne bunts. 
5Provides early-season foliar disease protection for first 4 weeks after planting. For full-season protection, apply 
a foliar fungicide according to label directions. 
 
Restrictions: If seed has been treated with A21185A, do not apply any product 
containing cytokinin, gibberellic acid, or indol e butyric acid as an in-furrow, band, side 
dress or mark out application. Do not apply more than 0.05 lbs of thiamethoxam per acre 
per calendar year. 
 
 
STORAGE AND DISPOSAL 
 
Do not contaminate water, food or feed by storage or disposal. 
 
Pesticide Storage 
Store in original containers only. Keep container closed when not in use. Do not store 
near food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical 
waste storage area until proper disposal can be made if product cannot be used according 
to the label. 
 
Pesticide Disposal 
Pesticide wastes are toxic. Improper dispos al of excess pesticide, spray mixture or 
rinsate is a violation of Federal Law. If these wastes cannot be disposed of by use 
according to label instructions, contact your State Pesticide or Environmental Control 
Agency, or the Hazardous Waste Representative at the nearest EPA Regional Office for 
guidance. 
 
Container Handling [less than or equal to 5 gallons] 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank and drain for 10 seconds after the flow 
begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal. 
Drain for 10 seconds after the flow beings to drip. Repeat this procedure two more times. 
Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by 
incineration, or by other procedures allowed by state and local authorities. 
 
Container Handling [greater than 5 gallons – mini-bulk] 
Non-refillable container. Do not reuse or refi ll this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank. Fill the container ¼ full with water. 
Replace and tighten closures. Tip container on its side and roll it back and forth, ensuring 
at least one complete revolution, for 30 seconds. Stand the container on its end and tip 
it back and forth several times. Turn the container over onto its other end and tip it back 
and forth several times. Empty the rinsate into application equipment or a mix tank or 
store rinsate for later use or disposal. Repeat this procedure two more times. Then offer 
for recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, 
or by other procedures allowed by state and local authorities.

A21185B 
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Container Handling [greater than 5 gallons – bulk] 
Refillable container. Ref ill this container with pesticide only. Do not use this container 
for any other purpose. Cleaning the container before final disposal is the responsibility of 
the person disposing of the container. Cleaning before refilling is the responsibility of the 
person refilling. To clean container before final disposal, empty the remaining contents 
from this container into application equipmen t or mix tank. Fill the container about 10 
percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. 
Pour or pump rinsate into application equipment or rinsate collection system. Repeat this 
rinsing procedure two more times. Then offe r for recycling if avai lable or puncture and 
dispose of in a sanitary landfill, or by incineration, or by other procedures allowed by state 
and local authorities. 
 
CONTAINER IS NOT SAFE FOR FOOD, FEED OR DRINKING WATER. 
 
 
Cruiser®, the ALLIANCE FRAME 
the SYNGENTA Logo and the PURPOSE ICON 
are Trademarks of a Syngenta Group Company 
 
Viton® trademark of E. I. du Pont de Nemours and Company 
 
©20XX Syngenta 
 
 
For non-emergency (e.g., current product information) call 
Syngenta Crop Protection at 1-800-334-9481. 
 
 
Manufactured for: 
Syngenta Crop Protection, LLC 
P.O. Box 18300 
Greensboro, North Carolina 27419-8300 
 
A21185B 1564 MAS 0216 AMEND-C 0618-CL – jeb – 10/01/2025 
000100-01564.20180625C.A21185B.AMEND.JUN2018-CL