Files
crop-chem-docs/corpus/epa_ppls/100-1527.md
T
claude 98842d1ed6
Image rebuild (skip scrape) / build (push) Successful in 1h46m17s
perf(epa_ppls): make the monthly refresh fit the runner's 3 h budget (#3)
Co-authored-by: claude <[email protected]>
2026-09-01 16:40:48 -04:00

788 lines
40 KiB
Markdown
Raw Blame History

This file contains ambiguous Unicode characters
This file contains Unicode characters that might be confused with other characters. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.
# CRUISER VIBRANCE QUATTRO
- EPA Reg No: **100-1527**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Thiamethoxam (5.75%); Fludioxonil (0.72%); Metalaxyl-M (0.86%); Difenoconazole (3.45%); Sedaxane (1.44%)
- Label accepted: 2026-06-23
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01527-20260623.pdf
---
June 23, 2026
Patsy Laird
Regulatory Manager, Seedcare
Syngenta Crop Protection, LLC
P.O. Box 18300
Greensboro, NC 27419
Subject: Label Amendment - Registration Review Mitigation for Sedaxane
Product Name: Cruiser® Vibrance® Quattro
EPA Registration Number: 100-1527
Application Date: February 13, 2026
Case Number: 684988
Dear Mrs. Patsy Laird:
The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA), as amended, has completed reviewing all the information submitted with your
application to support the Registration Review of the above referenced product in
connection with the Sedaxane Interim Decision, and has concluded that your submission
is acceptable. The label referred to above, submitted in connection with registration under
FIFRA, as amended, is acceptable.
Should you wish to add/retain a reference to the company’s website on your label, then
please be aware that the website becomes labeling under the Federal Insecticide,
Fungicide, and Rodenticide Act and is subject to review by the Agency. If the website is
false or misleading, the product would be misbranded and unlawful to sell or distribute
under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may
consider false or misleading. In addition, regardless of whether a website is referenced on
your product’s label, claims made on the website may not substantially differ from those
claims approved through the registration process. Therefore, should the Agency find or if it
is brought to our attention that a website contains false or misleading statements or
claims substantially differing from the EPA approved registration, the website will be
referred to the EPA’s Office of Enforcement and Compliance Assurance.
Page 2 of 2
EPA Reg. No. 100-1527
Decision No. 684988
A stamped copy of your labeling is enclosed for your records. This labeling
supersedes all previously accepted labeling and must be used at your next label
printing. You must submit one copy of the final printed labeling before you release
the product for shipment with the new labeling. In accordance with 40 CFR
152.130(c), you may distribute or sell this product under the previously approved
labeling for 12 months from the date of this letter. After 12 months, you may only
distribute or sell this product if it bears this new revised labeling or subsequently
approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and
its implementing regulation at 40 CFR 152.3.
If you have any questions about this letter, please contact Samantha Carter by phone at
202-566-1179, or via email at carter.samantha@epa.gov.
Sincerely,
Marianne Walters, Team Lead
Risk Management and Implementation Branch 3
Pesticide Re-Evaluation Division
Office of Pesticide Programs
ENCLOSURE: Stamped label
(Master Label)
THIAMETHOXAM GROUP4A INSECTICIDE
DIFENOCONAZOLE GROUP3 FUNGICIDE
MEFENOXAM GROUP4 FUNGICIDE
SEDAXANE GROUP 7 FUNGICIDE
FLUDIOXONIL GROUP12 FUNGICIDE
Cruiser®Vibrance®Quattro
A seed treatment product for protection against damage from certain insects and
diseases of small grain cereals.
Active Ingredient:
Thiamethoxam1. ...................................................................................................... 5.75%
Difenoconazole2: ..................................................................................................... 3.45%
Mefenoxam3: ........................................................................................................... 0.86%
Fludioxonil4: ............................................................................................................. 0.72%
Sedaxane5............................................................................................................... 1.44%
Other Ingredients: 87.78%
Total: 100.00%
1CAS No. 153719-23-4
2CAS No. 119446-68-3
3CAS Nos. 70630-17-0 and 69516-34-3
4CAS No. 131341-86-1
5CAS No. 874967-67-6
Cruiser Vibrance Quattro contains 0.51 lb. thiamethoxam, 0.31 lb. difenoconazole, 0.08
lb. mefenoxam, 0.06 lb. fludioxoniln and 0.13 lb. sedaxane per gallon.
KEEP OUT OF REACH OF CHILDREN.
CAUTION
See additional precautionary statements and directions for use in booklet [on label].
EPA Reg. No. 100-1527
EPA Est. No. XXXXX
Net Contents
6/23/2026
100-1527
-2-
FIRST AID
Have the product container with you when calling a poison control center or doctor, or
going for treatment.
HOTLINE NUMBER
For 24-Hour Medical Emergency Assistance (Human or Animal) or
Chemical Emergency Assistance (Spill, Leak, Fire, or Accident),
Call
1-800-888-8372
PRECAUTIONARY STATEMENTS
Personal Protective Equipment (PPE)
Mixers, loaders, applicators and other handlers must wear:
Long-sleeved shirt and long pants
Shoes plus socks
Chemical-resistant gloves made of polyvinyl chloride (PVC) , nitrile rubber
, butyl rubber , barrier laminate, neoprene rubber , natural
rubber , polyethylene, or Viton™
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions
for washables exist, use detergent and hot water. Keep and wash PPE separately from
other laundry.
Engineering Control Statements
When handlers use closed systems in a manner that meets the requirements listed in
the Worker Protection Standard (WPS) for agricultural pesticides (40 CFR 170.607 (d)
and (e)), the handler PPE requirements may be reduced or modified as specified in the
WPS.
User Safety Recommendations
Users should:
Wash hands before eating, drinking, chewing gum, using tobacco, or using the
toilet.
Remove clothing/PPE immediately if pesticides get inside. Then wash thoroughly
and put on clean clothing.
Remove PPE immediately after handling this product. Wash the outside of gloves
before removing. As soon as possible, wash thoroughly and change into clean
clothing.
-3-
Environmental Hazards
This product is toxic to wildlife, freshwater and estuarine/marine fish and highly toxic to
aquatic invertebrates. Runoff may be hazardous to aquatic organisms in neighboring
areas. Exposed treated seed may be hazardous to wildlife. Do not contaminate water
when disposing of equipment washwater or rinsate.
Pollinator Precautions
Thiamethoxam is highly toxic to bees, and effects are possible as a result of exposure
to translocated residues in blooming crops.
If treated seed is spilled outdoors or in areas accessible to birds, promptly clean up or
bury to prevent ingestion.
Groundwater Advisory
Mefenoxam is known to leach through soil into groundwater under certain conditions as
a result of agricultural use. Use of this chemical in areas where soils are permeable,
particularly where the water table is shallow, may result in groundwater contamination.
Thiamethoxam has properties and characteristics associated with chemicals detected in
groundwater. This chemical may leach into the groundwater if used in areas where
soils are permeable, particularly where the water table is shallow.
-4-
CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of
Warranty and Liability before buying or using this product. If the terms are not acceptable,
return the product at once, unopened, and the purchase price will be refunded.
The Directions for Use of this product must be followed carefully. It is impossible to
eliminate all risks inherently associated with the use of this product. Crop injury,
ineffectiveness or other unintended consequences may result because of such factors
as manner of use or application, weather or crop conditions, presence of other materials
or other influencing factors in the use of the product, which are beyond the control of
SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by
applicable law, Buyer and User agree to hold SYNGENTA and Seller harmless for any
claims relating to such factors.
SYNGENTA warrants that this product conforms to the chemical description on the label
and is reasonably fit for the purposes stated in the Directions for Use, subject to the
inherent risks referred to above, when used in accordance with directions under normal
use conditions. To the extent permitted by applicable law: (1) this warranty does not
extend to the use of the product contrary to label instructions or under conditions not
reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer
and User assume the risk of any such use. To the extent permitted by applicable law,
SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY OR OF FITNESS
FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED
WARRANTY EXCEPT AS WARRANTED BY THIS LABEL.
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any
incidental, consequential or special damages resulting from the use or handling of this
product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE
REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF
SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR
DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY,
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE)
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION OF
SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT.
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be
modified except by written agreement signed by a duly authorized representative of
SYNGENTA.
-5-
DIRECTIONS FOR USE
For commercial or on-farm use.
It is a violation of federal law to use this product in a manner inconsistent with its labeling.
Do not apply this product in a way that will contact workers or other persons, either directly
or through drift. Only protected handlers may be in the area during application. For any
requirements specific to your State or Tribe, consult the agency responsible for pesticide
regulation.
FAILURE TO FOLLOW DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY
RESULT IN CROP INJURY, POOR DISEASE CONTROL, AND/OR ILLEGAL
RESIDUES.
Treatment of highly mechanically scarred or damaged seed, or seed known to be of low
vigor and poor quality, except for the purpose of curative control of existing disease
pests, may result in reduced germination and/or reduction of seed and seedling vigor.
Treat using equipment similar to that planned for treating the total seed lot. Conduct
germination tests on a small portion of seed before committing the total seed lot to a
selected seed treatment. Due to seed quality and seed storage conditions beyond the
control of Syngenta, no claims are made to guarantee the germination of carry-over
treated seed.
Maximum usage when applying both metalaxyl- and mefenoxam-containing
products to the same crop within the same season: Do not apply more than the
maximum yearly total application rate for the active ingredient as stated on the label of
the product containing the lowest yearly total on that crop.
AGRICULTURAL USE REQUIREMENTS
Use this product only in accordance with its labeling and with the Worker Protection
Standard, 40 CFR part 170. This Standard contains requirements for the protection of
agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of
agricultural pesticides. It contains requirements for training, decontamination,
notification, and emergency assistance. It also contains specific instructions and
exceptions pertaining to the statements on this label about personal protective
equipment (PPE), notifications to workers, and restricted-entry interval. The
requirements in this box only apply to uses of this product that are covered by the
Worker Protection Standard.
Do not enter or allow worker entry into treated areas during the restricted-entry
interval (REI) of 48 hours.Exception: If the seed is treated with the product and the
treated seed is soil-injected or soil-incorporated, the Worker Protection Standard, under
certain circumstances, allows workers to enter the treated area if there will be no
contact with anything that has been treated.
-6-
PPE required for early entry to treated areas that is permitted under the Worker
Protection Standard and that involves contact with anything that has been treated, such
as plants, soil, or water is:
Coveralls
Chemical-resistant gloves made of polyvinyl chloride [PVC] , nitrile
rubber , butyl rubber , barrier laminate, neoprene rubber
mils, natural rubber , polyethylene, or Viton
Shoes plus socks
USE RESTRICTIONS
Do not use for food, feed, or oil purposes.
Store treated seed away from food and feedstuffs.
Wear long-sleeved shirt, long pants and chemical-resistant gloves when handling
treated seed.
Treated seed exposed on soil surface may be hazardous to wildlife. Cover or
collect treated seed spilled during loading and planting (such as in row ends).
Do not allow children, pets, or livestock to have access to treated seed.
Do not contaminate water bodies when disposing of planting equipment wash
waters.
Dispose of seed packaging in accordance with local requirements.
Treated seed must be planted into the soil at a depth greater than 0.5 inch.
For seed treated with Cruiser Vibrance Quattro, do not graze or feed livestock on
treated areas for 45 days after planting.
In the event of a crop failure or harvest of a crop grown from Cruiser Vibrance
Quattro treated seed, the field may be replanted immediately to canola, soybean,
barley, oat, rye triticale and wheat, sweet corn, and chickpea.
Alfalfa, Brassica (cole) leafy vegetables, buckwheat, corn (except sweet corn),
pearl millet, proso millet, popcorn, rice (dry-seeded), sorghum, teosinte, wild rice,
cotton, cucurbit vegetables, dry bulb onions, fruiting vegetables, leafy vegetables,
legume vegetables (except chickpea), mint (peppermint and spearmint), oil seed
crops (black mustard seed, borage seed, crambe seed, field mustard seed, flax
seed, Indian mustard seed, Indian rapeseed seed, peanuts, rapeseed seed, and
safflower seed), root vegetables, strawberry, sunflowers, tobacco, and tuberous
and corm vegetables may be planted 30 days from the date the Cruiser Vibrance
Quattro treated seed was planted.
For any other crop, the minimum plant back interval is 120 days from the date the
Cruiser Vibrance Quattro treated seed was planted. A cover crop other than the
crops listed above that is planted for erosion control or soil improvement may be
planted sooner than the 120-day interval; however, the crop may not be grazed
or harvested for food or feed.
Do not make any soil or foliar application of products containing thiamethoxam to
crops grown from seed treated with Cruiser Vibrance Quattro.
-7-
Do not use at a rate that will result in more than 0.05 lb thiamethoxam per acre
(22.7 grams ai/A) per year as a seed treatment application.
PRODUCT INFORMATION
Cruiser Vibrance Quattro is a seed treatment product containing one insecticide active
ingredient (thiamethoxam) and four fungicide active ingredients (difenoconazole,
mefenoxam, fludioxonil and sedaxane). Cruiser Vibrance Quattro seed treatment
protects against damage from certain early-season insects and certain seed- and soil-
borne diseases of cereal crops. Difenoconazole provides protection against several
seed, seedling and certain foliar disease including bunts and smuts. Mefenoxam
protects against damping-off caused by Pythium. Fludioxonil provides protection
against certain soil-borne and seed-borne diseases and is active against Fusarium,
Rhizoctonia, and weakly pathogenic fungi such as Aspergillus and Penicillium.
Sedaxane protects against Rhizoctonia and loose smuts (Ustilago).
Thiamethoxam is a systemic seed treatment insecticide belonging to the neoticotinoid
class of chemistry. Thiamethoxam in Cruiser Vibrance Quattro protects against aphids,
wireworm and European chafer.
Cruiser Vibrance Quattro may be applied in tank mixes, or sequentially with other EPA-
registered seed treatment pesticide products. If using Cruiser Vibrance Quattro in a tank
mixture with other seed treatment products, observe all directions for use, crops/sites,
use rates, dilution ratios, precautions, and limitations which appear on the tank-mix
partner label(s). Do not exceed any label dosage and follow the most restrictive label
precautions and limitations. This product must not be mixed with any product which
prohibits such mixing.
MIXING INSTRUCTIONS
Important:Always re-circulate Cruiser Vibrance Quattro thoroughly before using.
Apply Cruiser Vibrance Quattro as a water-based slurry utilizing standard slurry seed
treatment equipment which provides uniform seed coverage. Uneven or incomplete seed
coverage may not give the desired level of insect and disease control.
Consult the manufacturer of the application equipment you plan to employ for suitability
for this application and for instructions on operation and calibration of the equipment.
Follow the manufacturer application instructions for the seed treatment equipment being
used.
Continuous agitation or mixing of the slurry mixture is necessary to prevent settling out of
the solution.
-8-
Allow seed to dry before bagging.
Follow planter manufacturer specifications for use of talc or other hopper box additives at
planting. Seed must be completely dry before adding to planter.
Required Dye Statement: Seed treated with this product must be visually identifiable
from untreated seed by the use of an approved colorant or dye to prevent accidental use
of treated seed as food for humans or feed for animals. Refer to 21 CFR, Part 2.25. Any
colorant or dye added to treated seed must be cleared for use in accordance with 40
CFR, Part 153.155(c).
-9-
SEED BAG LABEL REQUIREMENTS
Use of On-Farm Treated Seed (when treated seed are not for sale or distribution)
Treated seed sold or distributed for a use not permitted by the following labeling does
not qualify as an exempted treated article under 40 CFR 152.25(a) and is therefore sale
or distribution of an unregistered pesticide, pursuant to FIFRA section 12.
Store treated seed away from food and feedstuffs.
DO NOTallow children, pets, or livestock to have access to treated seed.
Treated seed are for planting purposes only. DO NOT use for food, feed, or oil
purposes. DO NOT use treated seed for fuel or ethanol production purposes.
Wear long-sleeved shirt, long pants, shoes, socks, and chemical-resistant gloves
when handling treated seed.
DO NOT plant treated seed by broadcasting to the soil surface. Ensure that all
planted seeds are thoroughly incorporated by the planter during planting. Additional
incorporation may be required to thoroughly cover exposed seeds.
Treated seed exposed on the soil surface may be hazardous to wildlife. Cover or
collect treated seed spilled during loading and planting (such as in row ends).
Treated seed must be planted into the soil at a depth greater than 0.5 inch.
Manage excess treated seed (e.g., spilled, unused, or expired treated seed) by one
or more of the following methods:
o Collect excess treated seed for reuse for planting.
o Bury excess treated seed (only allowed if totaling 1 pound or less) at least 30 feet
away from bodies of water at a depth of 6 inches or double the planting depth,
whichever is greater.
o Dispose of excess treated seed by placing them in a landfill in accordance with
applicable laws in your state.
o Return excess treated seed to the supplier if permitted by the state.
DO NOTcontaminate bodies of water when disposing of equipment wash water.
Advisory Dust-Reducing Technique:The use of seed flow lubricants or polymer
coatings may help decrease the amount of dust released during planting. Follow the
recommendations of the planter manufacturer regarding the use of seed flow
lubricants.
-10-
Seed Treatment in Commercial Facilities or Seed Treatment on Farm (when
treated seed are to be sold or distributed) – Seed Bag Labeling Requirements
The Federal Seed Act requires that bags containing treated seed shall be labeled with
the following statements:
This seed has been treated with difenoconazole, fludioxonil ,mefenoxam, and
sedaxane fungicides and thiamethoxam insecticide.
Do not use for food, feed, or oil purposes.
The U.S. Environmental Protection Agency requires that bags containing treated seed
shall be labeled with the following statements. Any seed treated with Cruiser Vibrance
Quattro that is sold or distributed without these statements or that is sold or distributed
for a use not permitted by the following labeling does not qualify as an exempted treated
article under 40 CFR 152.25(a) and is therefore sale or distribution of an unregistered
pesticide, pursuant to FIFRA section 12(a)(1)(A).
This seed has been treated with Cruiser Vibrance Quattro (EPA Reg No. 100-1527)
containing difenoconazole, fludioxonil, mefenoxam, sedaxane, and thiamethoxam. Any
seed treated with Cruiser Vibrance Quattro that is sold or distributed for a use not
permitted by the following labeling does not qualify as an exempted treated article under
40 CFR 152.25(a) and is therefore sale or distribution of an unregistered pesticide,
pursuant to FIFRA section 12(a)(1)(A).
The contents of this bag are for planting purposes only. DO NOT use for food,
feed, or oil purposes. DO NOT use for fuel or ethanol production purposes.
Store treated seed away from food and feedstuffs.
DO NOT allow children, pets, or livestock to have access to treated seed.
DO NOT plant treated seed by broadcasting to the soil surface. Ensure that all
planted seed are thoroughly incorporated by the planter during planting.
Additional incorporation may be required to thoroughly cover exposed seed.
Wear long-sleeved shirt, long pants and chemical-resistant gloves when handling
treated seed.
Treated seed exposed on soil surface may be hazardous to wildlife. Cover or
collect treated seed spilled during loading and planting (such as in row ends).
Do not contaminate water bodies when disposing of planting equipment wash
waters.
Dispose of seed packaging in accordance with local requirements.
Treated seed must be planted into the soil at a depth greater than 0.5 inch.
Manage excess treated seed (e.g., spilled, unused, or expired treated seed) by
one or more of the following methods:
o Collect excess treated seed for reuse for planting.
o Bury excess treated seed (only allowed if totaling 1 pound or less) at least 30
feet away from bodies of water at a depth of 6 inches or double the planting
depth, whichever is greater.
o Dispose of excess treated seed by placing them in a landfill in accordance
with applicable laws in your state.
-11-
o Return excess treated seed to the supplier if permitted by the state.
For seed treated with Cruiser Vibrance Quattro, do not graze or feed livestock on
treated areas for 45 days after planting.
In the event of a crop failure or harvest of a crop grown from Cruiser Vibrance
Quattro treated seed, the field may be replanted immediately to canola, soybean,
barley, oat, rye triticale, wheat, sweet corn, and chickpea.
Alfalfa, Brassica(Cole) leafy vegetables, buckwheat, corn (except sweet corn),
pearl millet, Proso millet, popcorn, rice (dry-seeded), sorghum, teosinte, wild rice,
cotton, Cucurbit vegetables, dry bulb onions, fruiting vegetables, leafy
vegetables, Legume vegetables (except chickpea), mint (peppermint and
spearmint), oil seed crops (black mustard seed, borage seed, crambe seed, field
mustard seed, flax seed, Indian mustard seed, Indian rapeseed seed, peanuts,
rapeseed seed, and safflower seed), root vegetables, strawberry, sunflowers,
tobacco, and tuberous and corm vegetables may be planted 30 days from the
date the Cruiser Vibrance Quattro treated seed was planted.
For any other crop, the minimum plant back interval is 120 days from the date the
Cruiser Vibrance Quattro treated seed was planted. A cover crop other than the
crops listed above that is planted for erosion control or soil improvement may be
planted sooner than the 120-day interval; however, the crop may not be grazed
or harvested for food or feed.
Regardless of type of application (seed treatment, soil or foliar), do not apply
more than 0.46 lb/A (208.7 g ai/A) difenoconazole per calendar year.
Do not make any soil or foliar application of products containing thiamethoxam to
crops grown from seed treated with Cruiser Vibrance Quattro.
Do not apply more than 0.05 lb/A (22.7 g ai/A) thiamethoxam, 0.097 lb/A (44.0 g
ai/A) mefenoxam- or metalaxyl, or 0.016 lb ai/A (7.1 g ai/A) sedaxane per year as
a seed treatment application.
This seed has been treated with 0.008 mg ai thiamethoxam per seed assuming
an average seed size of 12,000 seeds per pound.
Pollinator Precaution: Thiamethoxam is highly toxic to bees, and effects are
possible as a result of exposure to translocated residues in blooming crops.
Groundwater Advisory: Mefenoxam is known to leach through soil into
groundwater under certain conditions as a result of agricultural use. Use of this
chemical in areas where soils are permeable, particularly where the water table
is shallow, may result in groundwater contamination. Thiamethoxam has
properties and characteristics associated with chemicals detected in
groundwater. This chemical may leach into the groundwater if used in areas
where soils are permeable, particularly where the water table is shallow.
Advisory Dust-Reducing Technique: The use of seed flow lubricants or
polymer coatings may help decrease the amount of dust released during
planting. Follow the recommendations of the planter manufacturer regarding the
use of seed flow lubricants.
[All seed bag tags must be legible and set in at least 8-point font size.]
-12-
CROP USE PRECAUTIONS
DIFENOCONAZOLE GROUP3 FUNGICIDE
MEFENOXAM GROUP4 FUNGICIDE
SEDAXANE GROUP 7 FUNGICIDE
FLUDIOXONIL GROUP12 FUNGICIDE
Fungicide Resistance Management
For resistance management, please note that Cruiser Vibrance Quattro contains Group
3/difenoconazole, Group 4/mefenoxam, Group 7/sedaxane, and Group 12/fludioxonil
fungicides. Any fungal population may contain individuals naturally resistant to Cruiser
Vibrance Quattro and other Group 3, Group 4, Group 7, or Group 12 fungicides. A
gradual or total loss of pest control may occur over time if these fungicides are used
repeatedly in the same fields. Appropriate resistance-management strategies should be
followed.
Difenoconazole belongs to the triazole class of chemistry and is a demethylation
inhibitor of sterol biosynthesis (DMI) which disrupts membrane synthesis of the fungal
cell. Mefenoxam belongs to the phenylamide class of chemistry which interferes with
fungal RNA synthesis. Sedaxane is a succinate dehydrogenase inhibitor (SDHI) and
belongs to the carboxamide class of chemistry which disrupts cellular respiration and
energy generation. Fludioxonil belongs to the phenylpyrrole class of chemistry which
interferes with osmotic signal transduction.
To delay fungicide resistance, take one or more of the following steps:
Rotate the use of Cruiser Vibrance Quattro or other Group 3, Group 4, Group 7,
or Group 12 fungicides within a growing season sequence with different groups
that control the same pathogens.
Use tank mixtures with fungicides from a different group that are equally effective
on the target pest when such use is permitted. Use at least the minimum
application rate as labeled by the manufacturer.
Adopt an integrated disease management program for fungicide use that
includes scouting, uses historical information related to pesticide use, and crop
rotation, and which considers host plant resistance, impact of environmental
conditions on disease development, disease thresholds, as well as cultural,
biological and other chemical control practices.
Where possible, make use of predictive disease models to effectively time
fungicide application. Note that using predictive models alone is not sufficient to
manage resistance.
Monitor treated fungal populations for resistance development.
-13-
Contact your local extension specialist or certified crop advisor for any additional
pesticide resistance-management and/or IPM recommendations for specific
crops and pathogens.
For further information or to report suspected resistance contact Syngenta at 1-
866-SYNGENT(A) (866-796-4368). You can also contact your pesticide
distributor or university extension specialist to report resistance.
Syngenta encourages responsible product stewardship to ensure effective long term
control of the fungal diseases on this label.
THIAMETHOXAM GROUP4A INSECTICIDE
Insecticide Resistance Management
For resistance management, note that Cruiser Vibrance Quattro contains a Group 4A
insecticide (thiamethoxam, belonging to the neonicotinoid class of chemistry). Any
insect population may contain individuals naturally resistant to Cruiser Vibrance Quattro
and other Group 4A insecticides. The resistant individuals may dominate the insect
population if these insecticides are used repeatedly in the same fields. Appropriate
resistance-management strategies should be followed.
To delay insecticide resistance, take the following steps:
Rotate the use of Cruiser Vibrance Quattro or other Group 4A insecticides within a
growing season, or among growing seasons, with different groups that control the
same pests.
Use tank mixtures with insecticides from a different group that are equally effective
on the target pest when such use is permitted. Do not rely on the same mixture
repeatedly for the same pest population. Consider any known cross-resistance
issues (for the targeted pests) between the individual components of a mixture. In
addition, consider the following recommendations provided by the Insecticide
Resistance Action Committee (IRAC):
o Individual insecticides selected for use in mixtures should be highly effective and
be applied at the rates at which they are individually registered for use against
the target species.
o Mixtures with components having the same IRAC mode of action classification
are not recommended for insect resistance management.
o When using mixtures, consider any known cross-resistance issues between the
individual components for the targeted pest(s).
o Mixtures become less effective if resistance is already developing to one or both
active ingredients, but they may still provide pest management benefits.
o The insect resistance management benefits of an insecticide mixture are greatest
if the two components have similar periods of residual insecticidal activity.
Mixtures of insecticides with unequal periods of residual insecticide activity may
offer an insect resistance management benefit only for the period where both
insecticides are active.
-14-
Adopt an integrated pest management program for insecticide use that includes
scouting, uses historical information related to pesticide use, crop rotation, record
keeping, and which considers cultural, biological and other chemical control
practices.
Monitor after application for unexpected target pest survival. If the level of survival
suggests the presence of resistance, consult with your local university specialist or
certified pest control advisor.
Contact your local extension specialist or certified crop advisors for any additional
pesticide resistance-management and/or IPM recommendations for the specific site and
pest problems in your area.
For additional information on Insect Resistance Management:
Contact your local extension specialist, certified crop advisor and/or product
manufacturer for additional insect resistance management recommendations.
Visit the Insecticide Resistance Action Committee (IRAC) on the web at:
http://www.irac-online.org/.
-15-
CROP USE DIRECTIONS
Crop Protection Against the following Insects Use Rate
Fluid Ounces per 100 lb
seed
Barley Aphids1
European Chafer
Wireworms1
5 fluid oz
Crop Protection Against the Following Diseases Use Rate
Fluid Ounces per 100 lb
seed
Barley General Seed Rots2
Seedling Blight, Root Rot, and Damping-Off
caused by seed- and soil-borne Fusarium . or
Rhizoctonia
Seedling Blight, Root Rot, and Damping-Off
caused by soil-borne Pythium
Seed-borne Septoria
Covered Smut
False Loose Smut
True Loose Smut
5 fluid oz
Crop Diseases Suppressed3 Use Rate
Fluid Ounces per 100 lb
seed
Barley Common Root Rot (Cochliobolus )
Fusarium Crown and Foot Rot
Take-All
5 fluid oz
Crop Protection Against the following Insects Use Rate
Fluid Ounces per 100 lb
seed
Oats Aphids1
European Chafer
Wireworms1
5 fluid oz
Crop Protection Against the Following Diseases Use Rate
Fluid Ounces per 100 lb
seed
Oats General Seed Rots2
Seedling Blight, Root Rot, and Damping-Off
caused by seed- and soil-borne Fusarium or
Rhizoctonia
Seedling Blight, Root Rot, and Damping-Off
caused by soil-borne Pythium
Seed-borne Septoria
Covered Smut
Loose Smut
5 fluid oz
Crop Diseases Suppressed3 Use Rate
-16-
Fluid Ounces per 100 lb
seed
Oats Common Root Rot (Cochliobolus) 5 fluid oz
Crop Protection Against the following Insects Use Rate
Fluid Ounces per 100 lb
seed
Rye Aphids1
European Chafer
Wireworms1
5 fluid oz
Crop Protection Against the Following Diseases Use Rate
Fluid Ounces per 100 lb
seed
Rye General Seed Rots2
Seedling Blight, Root Rot, and Damping-Off
caused by seed- and soil-borne Fusarium or
Rhizoctonia
Seedling Blight, Root Rot, and Damping-Off
caused by soil-borne Pythium
Seed-borne Septoria
Common Bunt4
Dwarf Bunt4
5 fluid oz
Crop Diseases Suppressed3 Use Rate
Fluid Ounces per 100 lb
seed
Rye Common Root Rot (Cochliobolus)
Fusarium Crown and Foot Rot
Take-All
5 fluid oz
Crop Protection Against the following Insects Use Rate
Fluid Ounces per 100 lb
seed
Winter Wheat Aphids1
European Chafer
Wireworms1
5 fluid oz
Crop Protection Against the Following Diseases Use Rate
Fluid Ounces per 100 lb
seed
Winter Wheat
and Triticale
General Seed Rots2
Seedling Blight, Root Rot, and Damping-Off
caused by seed- and soil-borne Fusarium or
Rhizoctonia
Seedling Blight, Root Rot, and Damping-Off
caused by soil-borne Pythium
Seed-borne Septoria
SeptoriaLeaf Blotch5
Common Bunt4
Flag Smut
Fusarium Seed Scab
5 fluid oz
-17-
Dwarf Bunt4
Karnal Bunt
Loose Smut
PythiumDamping Off
Crop Diseases Suppressed3 Use Rate
Fluid Ounces per 100 lb
seed
Winter Wheat
and Triticale
Common Root Rot (Cochliobolus)
Fusarium Crown and Foot and Root Rot
Take-All
5 fluid oz
Crop Protection Against the following Insects Use Rate
Fluid Ounces per 100 lb
seed
Spring Wheat Aphids1
European Chafer
Wireworms1
5 fluid oz
Crop Protection Against the Following Diseases Use Rate
Fluid Ounces per 100 lb
seed
Spring Wheat General Seed Rots2
Seedling Blight, Root Rot, and Damping-Off
caused by seed- and soil-borne Fusarium or
Rhizoctonia
Seedling Blight, Root Rot, and Damping-Off
caused by soil-borne Pythium
Seed-borne Septoria
Fusarium Seed Scab
Common Bunt4
Karnal Bunt
Loose Smut
Pythium Damping Off
5 fluid oz
Crop Diseases Suppressed3 Use Rate
Fluid Ounces per 100 lb
seed
Spring Wheat Common Root Rot (Cochliobolus )
Fusarium Crown and Foot and Root Rot
Take-All
5 fluid oz
1The 5 fluid oz/100 lbs rate of Cruiser Vibrance Quattro provides suppression of wireworm activity, aphids
and aphid vectored barley yellow dwarf virus. If pressure is moderate or high or control is required, apply
up to 0.8 fl. oz. additional Cruiser 5FS.
2Protection against general seed rots. This includes rots caused by Fusarium , Pythium , Rhizoctonia ,
Penicillium and Aspergillus .
3Suppression means consistent protection at a level which is not optimal but is still of commercial benefit.
4Protects against both seed- and soil-borne bunts (common, dwarf).
5Early season foliar disease protection for first 4 weeks after planting. For full season protection, apply a
foliar fungicide according to label directions.
-18-
STORAGE AND DISPOSAL
Do not contaminate water, food or feed by storage and disposal.
Pesticide Storage
Store in original containers only. Keep container closed when not in use. Do not store
near food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical
waste storage area until proper disposal can be made if product cannot be used according
to the label.
Pesticide Disposal
Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or
rinsate is a violation of Federal law. If these wastes cannot be disposed of by use
according to label instructions, contact your State Pesticide or Environmental Control
Agency, or the Hazardous Waste representative of the nearest EPA Regional Office for
guidance.
Container Handling [(less than 5 gallons)]
Non-refillable container. Do not reuse or refill this container. Offer for recycling if
available. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as
follows: Empty the remaining contents into application equipment or a mix tank and drain
for 10 seconds after the flow begins to drip. Fill the container ¼ full with water and recap.
Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store
rinsate for later use and disposal. Drain for 10 seconds after the flow beings to drip.
Repeat this procedure two more times. Then offer for recycling if available or puncture
and dispose of in a sanitary landfill, or by incineration, or by other procedures allowed by
state and local authorities.
Container Handling [(greater than 5 gallons)]
Non-refillable container. Do not reuse or refill this container. Offer for recycling if
available. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as
follows: Empty the remaining contents into application equipment or a mix tank. Fill the
container ¼ full with water. Replace and tighten closures. Tip container on its side and
roll it back and forth, ensuring at least one complete revolution, for 30 seconds. Stand
the container on its end and tip it back and forth several ties. Turn the container over
onto its other end and tip it back and forth several times. Empty the rinsate into application
equipment or a mix tank or store rinsate for later use or disposal. Repeat this procedure
two more times. Then offer for recycling if available or puncture and dispose of in a
sanitary landfill, or by incineration, or by other procedures allowed by state and local
authorities.
Container Handling [(greater than 5 gallons)]
Refillable container. Refill this container with pesticide only. Do not use this container
for any other purpose. Cleaning the container before final disposal is the responsibility of
the person disposing of the container. Cleaning before refilling is the responsibility of the
refiller. To clean container before final disposal, empty the remaining contents from this
-19-
container into application equipment or mix tank. Fill the container about 10 percent full
with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Pour or
pump rinsate into application equipment or rinsate collection system. Repeat this rinsing
procedure two more times. Then offer for recycling if available or puncture and dispose
of in a sanitary landfill, or by incineration, or by other procedures allowed by state and
local authorities.
CONTAINER IS NOT SAFE FOR FOOD, FEED OR DRINKING WATER.
Cruiser®, Vibrance®, the ALLIANCE FRAME, the SYNGENTA Logo and the PURPOSE
ICON are Trademarks of a Syngenta Group Company
Viton™ is a trademark of The Chemours Company FC, LLC
© 20XX Syngenta
For non-emergency (e.g., current product information) call
Syngenta Crop Protection at 1-866-796-4368.
Manufactured for:
Syngenta Crop Protection, LLC
P.O. Box 18300
Greensboro, North Carolina 27419-8300
Cruiser Vibrance Quattro 1527 MAS 0919 AMEND-B FEB2026-CL – jeb – 05/18/2026
000100-01527.20260216B.Cruiser Vibrance Quattro.AMEND.FEB2026-CL.PDF