crop-chem-docs/corpus/epa_ppls/100-1588.md

# A21458B

- EPA Reg No: **100-1588**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Fludioxonil (0.37%); Metalaxyl-M (1.1%); Difenoconazole (3.53%); Sedaxane (0.74%)
- Label accepted: 2026-07-01
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01588-20260701.pdf

---
July 1, 2026
Patsy Laird
Regulatory Manager, Seedcare
Syngenta Crop Protection, LLC
P.O. Box 18300
Greensboro, NC 27419
Patsy.laird@syngeta.com
Subject: Label Amendment - Registration Review Mitigation for Sedaxane
 Product Name: A21458B
EPA Registration Number: 100-1588
 Application Date: February 13, 2026
Case Number: 685000
Dear Mrs. Patsy Laird:
The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act 
(FIFRA), as amended, has completed reviewing all the information submitted with your 
application to support the Registration Review of the above referenced product in 
connection with the Sedaxane Interim Decision, and has concluded that your submission 
is acceptable. The label referred to above, submitted in connection with registration under 
FIFRA, as amended, is acceptable.
please be aware that the website becomes labeling under the Federal Insecticide, 
Fungicide, and Rodenticide Act and is subject to review by the Agency. If the website is
false or misleading, the product would be misbranded and unlawful to sell or distribute 
under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may 
consider false or misleading. In addition, regardless of whether a website is referenced on 
claims approved through the registration process. Therefore, should the Agency find or if it 
is brought to our attention that a website contains false or misleading statements or 
claims substantially differing from the EPA approved registration, the website will be

Page 2 of 2
EPA Reg. No. 100-1588
Decision No. 685000
A stamped copy of your labeling is enclosed for your records. This labeling 
supersedes all previously accepted labeling and must be used at your next label 
printing. You must submit one copy of the final printed labeling before you release 
the product for shipment with the new labeling. In accordance with 40 CFR 
152.130(c), you may distribute or sell this product under the previously approved 
labeling for 12 months from the date of this letter. After 12 months, you may only 
distribute or sell this product if it bears this new revised labeling or subsequently 
defined under FIFRA section 2(gg) and 
its implementing regulation at 40 CFR 152.3.
If you have any questions about this letter, please contact Samantha Carter by phone at 
202-566-1179, or via email at carter.samantha@epa.gov. 
Sincerely,
Marianne Walters, Team Lead
Risk Management and Implementation Branch 3
Pesticide Re-Evaluation Division
Office of Pesticide Programs
ENCLOSURE: Stamped label

(Master label)
DIFENOCONAZOLE GROUP3 FUNGICIDE
MEFENOXAM GROUP 4 FUNGICIDE
SEDAXANE GROUP 7 FUNGICIDE
FLUDIOXONIL GROUP 12 FUNGICIDE
A21458B
Fungicide
A seed treatment product for protection against damage from listed diseases of 
rapeseed crop subgroup 20A and small grain cereals.
Active Ingredients:
Difenoconazole1.............................................................................. 3.53% 
Fludioxonil2...................................................................................... 0.37% 
Mefenoxam3.................................................................................... 1.10% 
Sedaxane4....................................................................................... 0.74% 
Other Ingredients: 94.26% 
Total: 100.00% 
1CAS No. 119446-68-3 
2CAS No. 131341-86-1 
3CAS No. 70630-17-0 and 69516-34-3 
4CAS No. 874967-67-6 
A21458B is a flowable concentrate for seed treatment containing 0.33 lb 
difenoconazole, 0.03 lb fludioxonil, 0.10 lb mefenoxam, and 0.07 lb sedaxane per
gallon. 
KEEP OUT OF REACH OF CHILDREN
CAUTION
See inside booklet for additional precautionary statements and complete directions for 
use.
EPA Reg. No. 100-1588
EPA Est. No.
Net Contents
July 1, 2026
100-1588

A21458B
Page 2
TABLE OF CONTENTS
1.0 FIRST AID
2.0 PRECAUTIONARY STATEMENTS
2.1 Hazards to Humans and Domestic Animals
2.2Personal Protective Equipment (PPE)
2.3 User Safety Requirements 
2.4 Engineering Controls 
2.5 User Safety Recommendations 
2.6 Environmental Hazards 
2.6.1 Groundwater Advisory
DIRECTIONS FOR USE
3.0 PRODUCT INFORMATION 
3.1 Resistance Management 
4.0 APPLICATION DIRECTIONS
4.1 Tank Mixtures 
5.0 ROTATIONAL CROP RESTRICTIONS 
6.0 SEED CONTAINER LABEL REQUIREMENTS
6.1 Use of On-Farm Treated Seed (when treated seed are not for sale or distribution)
6.2 Seed Treatment in Commercial Facilities or Seed Treatment on farm (when treated 
seed are to be sold or distributed) – Seed Bag Labeling Requirements 
7.0 SEED TREATMENT DIRECTIONS 
7.1 Rapeseed Crop Subgroup 20A 
7.2 Small Grain Cereals 
8.0 STORAGE AND DISPOSAL 
9.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY

A21458B
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1.0FIRST AID
FIRST AID
Have the product container or label with you when calling a poison control center or 
doctor, or going for treatment. 
HOTLINE NUMBER
For 24-Hour Medical Emergency Assistance (Human or Animal) or
Chemical Emergency Assistance (Spill, Leak, Fire, or Accident), 
Call
1-800-888-8372
2.0PRECAUTIONARY STATEMENTS
2.1 Hazards to Humans and Domestic Animals 
CAUTION 
2.2 Personal Protective Equipment (PPE) 
Applicators and other handlers must wear:
 
 Long-sleeved shirt and long pants 
 Chemical-resistant gloves made of b natural 
14 mils, nitrile rubber 14 mils, polyethylene, 
polyvinyl chloride (PVC) 14 mils, or Viton™ 
 Shoes plus socks 
 
2.3 User Safety Requirements 
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions 
for washables exist, use detergent and hot water. Keep and wash PPE separately from 
other laundry. 
 
2.4 Engineering Controls 
When handlers use closed systems in a manner that meets the requirements listed in 
the Worker Protection Standard (WPS) for agricultural pesticides (40 CFR 170.607 (d) 
and (e)), the handler PPE requirements may be reduced or modified as specified in the 
WPS.

A21458B
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2.5 User Safety Recommendations 
Users should: 
 Wash hands before eating, drinking, chewing gum, using tobacco or using the 
toilet.
 Remove clothing/PPE immediately if pesticide gets inside. Then wash 
thoroughly and put on clean clothing.
 Remove PPE immediately after handling this product. Wash the outside of 
gloves before removing. As soon as possible, wash thoroughly and change 
into clean clothing. Remove and wash contaminated clothing before reuse.
2.6 Environmental Hazards 
This pesticide is toxic to fish, aquatic invertebrates, oysters and shrimp. Do not 
contaminate bodies of water when disposing of equipment rinsate or washwaters. 
2.6.1 Groundwater Advisory 
Mefenoxam is known to leach through soil into groundwater under certain conditions as 
a result of label use. Fludioxonil has properties and characteristics associated with 
chemicals detected in groundwater. These chemicals may leach into groundwater if 
used in areas where soils are permeable, particularly where the water table is shallow.
DIRECTIONS FOR USE 
It is a violation of federal law to use this product in a manner inconsistent with its 
labeling. 
 
Use is permitted on-farm and in commercial seed treatment facilities. Do notuse for at-
plant applications (e.g. hopper box, planter box, etc.). This product is to be applied as a 
water-based slurry through standard slurry- or mist-type commercial seed treatment 
equipment. 
 
Do not apply this product in a way that will contact workers or other persons, either 
directly or through drift. Only protected handlers may be in the area during application. 
For any requirements specific to your State or Tribe, consult the agency responsible for 
pesticide regulation. 
 
Treatment of highly mechanically scarred or damaged seed or seed known to be of low 
vigor and poor quality may result in reduced germination and/or reduction of seed and 
seedling vigor. Treat a quantity of seed using equipment similar to that planned for 
treating the total seed lot. Then conduct germination tests with a portion of this treated 
seed before committing the total seed lot to a selected seed treatment.

A21458B
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Due to seed quality, crop or variety sensitivity, and seed storage conditions beyond the 
control of Syngenta, no claims are made to guarantee the germination of carry-over 
seed or propagating material for all crops when treated with A21458B.
 
Maximum usage when applying metalaxyl- and mefenoxam-containing products 
to the same crop within the same season: Do not apply more than the maximum 
yearly total application rate for the active ingredient as stated on the label of the product 
containing the lowest yearly total on that crop.
FAILURE TO FOLLOW THE DIRECTIONS FOR USE AND PRECAUTIONS ON THIS 
LABEL MAY RESULT IN CROP INJURY, POOR DISEASE CONTROL, AND/OR 
ILLEGAL RESIDUES. 
AGRICULTURAL USE REQUIREMENTS
Use this product only in accordance with its labeling and with the Worker Protection 
Standard, 40 CFR Part 170. This Standard contains requirements for the protection of 
agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 
agricultural pesticides. It contains requirements for training, decontamination, 
notification, and emergency assistance. It also contains specific instructions and 
exceptions pertaining to the statements on this label about personal protective 
equipment (PPE), notification to workers, and restricted-entry interval. The requirements 
in this box only apply to uses of this product that are covered by the Worker Protection 
Standard (WPS).
Do not enter or allow worker entry into treated areas during the restricted entry 
interval (REI) of 48 hours.Exception: If the seed is treated with the product and the 
treated seed is soil-injected or soil-incorporated, the Worker Protection Standard, under 
certain circumstances, allows workers to enter the treated area if there will be no 
contact with anything that has been treated. 
PPE required for early entry to treated areas that is permitted under the Worker 
Protection Standard and that involves contact with anything that has been treated, such 
as plants, soil, or water is:
 Coveralls 
 Chemical-resistant gloves made of b
14 m 14 mils, 
polyethylene, polyvinyl chloride (PVC) 14 mils 
Shoes plus socks

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3.0PRODUCT INFORMATION
A21458B is a broad-spectrum seed treatment fungicide containing four active 
ingredients: Difenoconazole, Fludioxonil, Mefenoxam and Sedaxane. A21458B protects 
against damage from listed seed-borne and seedling diseases of rapeseed crop 
subgroup 20A and small grain cereals. All these active ingredients have a different 
mode of action against fungal pathogens. 
 
Difenoconazole is active against Seed-borne Blackleg (Leptosphaeria maculans) on 
rapeseed crop subgroup 20A and several seed, seedling and certain foliar diseases 
including bunts and smuts on small grain cereals. 
 
Fludioxonil is active against Fusarium species and Rhizoctonia species in rapeseed 
crop subgroup 20A as well as Pink Snow Mold (Microdochium nivale or Monographella 
nivalis) and weakly pathogenic fungi such as Aspergillus and Penicillium species in 
small grain cereals. 
 
Mefenoxam is active against Pythium species causing damping-off and seed rot in 
rapeseed crop subgroup 20Aand small grain cereals. 
 
Sedaxane is active against seed decay, seedling blight and damping-off caused by 
Rhizoctonia species in rapeseed crop subgroup 20Aand loose smuts caused by 
Ustilago species in small grain cereals. 
 
 
3.1 Resistance Management 
DIFENOCONAZOLE GROUP3 FUNGICIDE 
MEFENOXAM GROUP 4 FUNGICIDE 
SEDAXANE GROUP 7 FUNGICIDE
FLUDIOXONIL GROUP 12 FUNGICIDE 
For resistance management, please note that A21458B contains Group 3/ 
difenoconazole, Group 4/mefenoxam, Group 7/sedaxane and Group 12/fludioxonil 
fungicides. Any fungal population may contain individuals naturally resistant to A21458B 
and other Group 3, Group 4, Group 7 or Group 12 fungicides. A gradual or total loss of 
pest control may occur over time if these fungicides are used repeatedly in the same 
fields. Appropriate resistance-management strategies should be followed.
Difenoconazole belongs to the triazole class of chemistry and is a demethylation 
inhibitor of sterol biosynthesis (DMI) which disrupts membrane synthesis of the fungal 
cell. Mefenoxam belongs to the phenylamide class of chemistry which interferes with 
fungal RNA synthesis. Sedaxane is a succinate dehydrogenase inhibitor (SDHI) and 
belongs to the carboxamide class of chemistry which disrupts cellular respiration and 
energy generation. Fludioxonil belongs to the phenylpyrrole class of chemistry which 
interferes with osmotic signal transduction.

A21458B
Page 7
To delay fungicide resistance, take one or more of the following steps:
Rotate the use of A21458B or other Group 3, Group 4, Group 7 or Group 12
fungicides within a growing season sequence with different groups that control the
same pathogens.
Use tank mixtures with fungicides from a different group that are equally effective on
the target pest when such use is permitted. Use at least the minimum application
rate as labeled by the manufacturer. 
Adopt an integrated disease management program for fungicide use that includes
scouting, uses historical information related to pesticide use, and crop rotation, and 
which considers host plant resistance, impact of environmental conditions on 
disease development, disease thresholds, as well as cultural, biological and other 
chemical control practices. 
 Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage 
resistance. 
 Monitor treated fungal populations for resistance development. 
 Contact your local extension specialist or certified crop advisor for any additional 
pesticide resistance-management and/or IPM recommendations for specific crop 
and pathogens.
 For further information or to report suspected resistance contact Syngenta at 1-866-
Syngent(a) (866-796-4368). You can also contact your pesticide distributor or 
university extension specialist to report resistance. 
 
Syngenta encourages responsible product stewardship to ensure effective long term 
control of the fungal diseases on this label. 
 
 
4.0 APPLICATION DIRECTIONS 
Important:Re-circulate A21458B thoroughly before using.
 
Follow the manufacturer’s application instructions for the seed treatment equipment 
being used. 
 
Apply A21458B as a water-based slurry through standard liquid-type seed treatment 
equipment that provides uniform seed coverage. Seed treaters with atomizers or 
spinning discs are highly recommended for better product coverage on the seed. The 
total application volume must be sufficient to provide the desired level of coverage. 
Dilution is typically done with water or liquid inoculants. Thoroughly mix the specified 
amount of A21458B into the required amount of water or liquid inoculant for the slurry 
treater and dilution rate to be used. Uneven or incomplete seed coverage may not give 
the desired level of disease control. 
 
Certain crops require addition of inoculants when the seed is treated or planted. 
A21458B is compatible with several liquid inoculant products. Consult the maker of the

A21458B
Page 8
inoculant product and a Syngenta representative for directions before applying 
A21458B with inoculants.
Continuous agitation or mixing of the slurry mixture is necessary to prevent settling out 
of the solution. Clean out any unused product from the treater after treating or maintain 
constant agitation if the leftover slurry will be maintained overnight. 
 
Required Dye Statement: Seed treated with this product must be visually identifiable 
from untreated seed by the use of an approved colorant or dye to prevent accidental 
use of treated seed as food for humans or feed for animals. Refer to 21 CFR, Part 2.25. 
Any colorant or dye added to treated seed must be cleared for use in accordance with 
40 CFR, Part 153.155(c). 
 
Allow seed to dry before bagging. 
 
Follow planter manufacturer’s specifications for use of talc or other hopper box additives 
at planting. Seed must be completely dry before adding to planter. 
 
4.1 Tank Mixtures 
A21458B mixes easily with water and other water-based seed treatments. When mixing 
with products from other manufacturers, test the compatibility prior to use by conducting 
a jar test: Mix all intended seed treatments with a proportional amount of water to 
achieve the desired slurry mixture in a clear glass container. Mix well and allow mixture 
to sit for one hour. Remix and observe for incompatibility.
Mixing A21458B with tank-mix partners: Add ½ of the required water to the mix tank and 
turn on the agitation. Mechanical agitation is preferred. If using wettable powders, add 
them first to clean water allowing them to completely disperse prior to adding A21458B
or other products. Allow each tank-mix partner to completely disperse before adding the 
next product. Add the remaining amount of water and agitate. Maintain agitation until 
the entire slurry mixture has been used.
It is the pesticide user’s responsibility to ensure that all products are registered for the 
intended use. Read and follow the applicable restrictions and limitations and directions 
for use on all product labels involved in tank-mixing. Users must follow the most 
restrictive directions for use and precautionary statements of each product in the tank 
mixture.

A21458B
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5.0 ROTATIONAL CROP RESTRICTIONS 
 In the event of crop failure or harvest of a crop grown from seed treated with 
A21458B, the field may be replanted immediately to the following crops:
Plantback Interval Table
Immediate Plantback
Cereals, Small Grain: Barley, Oats, Rye, Triticale, and Wheat
Cotton 
Dried Shelled Pea and Bean Crop Subgroup 6C
Potato 
Rapeseed (Including Canola) Crop Subgroup 20A
Soybean 
Sugarbeet 
Sweet Corn 
 For any other crops the minimum plantback interval is 30 days from the date the 
seeds treated with A21458B were planted.

A21458B
Page 10
6.0SEED CONTAINER LABEL REQUIREMENTS
6.1 Use of On-Farm Treated Seed (when treated seed are 
not for sale or distribution) 
Treated seed sold or distributed for a use not permitted by the following labeling does 
not qualify as an exempted treated article under 40 CFR 152.25(a) and is therefore sale 
or distribution of an unregistered pesticide, pursuant to FIFRA section 12. 
Store treated seed away from food and feedstuffs.
DO NOTallow children, pets, or livestock to have access to treated seed.
Treated seed are for planting purposes only. DO NOTuse for food, feed, or oil 
purposes. DO NOTuse treated seed for fuel or ethanol production purposes.
Wear long-sleeved shirt, long pants, shoes, socks, and chemical-resistant gloves 
when handling treated seed.
DO NOTplant treated seed by broadcasting to the soil surface. Ensure that all 
planted seeds are thoroughly incorporated by the planter during planting. Additional 
incorporation may be required to thoroughly cover exposed seeds.
Treated seed exposed on the soil surface may be hazardous to wildlife. Cover or 
collect treated seed spilled during loading and planting (such as in row ends).
Treated seed must be planted into the soil at a depth greater than ½ inch.
 Manage excess treated seed (e.g., spilled, unused, or expired treated seed) by one 
or more of the following methods: 
o Collect excess treated seed for reuse for planting. 
o Bury excess treated seed (only allowed if totaling 1 pound or less) at least 30 feet 
away from bodies of water at a depth of 6 inches or double the planting depth, 
whichever is greater. 
o Dispose of excess treated seed by placing them in a landfill in accordance with 
applicable laws in your state. 
o Return excess treated seed to the supplier if permitted by the state.
 DO NOTcontaminate bodies of water when disposing of equipment wash water. 
 Advisory Dust-Reducing Technique:The use of seed flow lubricants or polymer 
coatings may help decrease the amount of dust released during planting. Follow the 
recommendations of the planter manufacturer regarding the use of seed flow 
lubricants.

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6.2 Seed Treatment in Commercial Facilities or Seed 
Treatment on farm (when treated seed are to be sold or 
distributed) – Seed Bag Labeling Requirements 
The Federal Seed Act requires that containers of treated seed shall be labeled with the 
following statements:
 This seed has been treated with Difenoconazole, Fludioxonil, Mefenoxam and 
Sedaxane fungicides.
Do not use for food, feed, or oil purposes. 
The U.S. Environmental Protection Agency requires that bags containing treated seed 
shall be labeled with the following statements. Any seed treated with A21458B that is 
sold or distributed without these statements or that is sold or distributed for a use not 
permitted by the following labeling does not qualify as an exempted treated article under 
40 CFR 152.25(a) and is therefore sale or distribution of an unregistered pesticide, 
pursuant to FIFRA section 12(a)(1)(A).
This seed has been treated with A21458B (EPA Reg No. 100-1588) containing 
difenoconazole, fludioxonil, mefenoxam, and sedaxane. Any seed treated with A21458B 
that is sold or distributed for a use not permitted by the following labeling does not 
qualify as an exempted treated article under 40 CFR 152.25(a) and is therefore sale or 
distribution of an unregistered pesticide, pursuant to FIFRA section 12(a)(1)(A).
 The contents of this bag are for planting purposes only. DO NOT use for food, 
feed, or oil purposes. DO NOT use for fuel or ethanol production purposes. 
 Groundwater Advisory: Mefenoxam is known to leach through soil into 
groundwater under certain conditions as a result of label use. Fludioxonil has 
properties and characteristics associated with chemicals detected in 
groundwater. These chemicals may leach into groundwater if used in areas 
where soils are permeable, particularly where the water table is shallow.
 Store away from food and feedstuffs. 
 DO NOTallow children, pets, or livestock to have access to treated seed.
 Wear long-sleeved shirt, long pants and chemical-resistant gloves when handling 
treated seed.
 DO NOTplant treated seed by broadcasting to the soil surface. Ensure that all 
planted seeds are thoroughly incorporated by the planter during planting. 
Additional incorporation may be required to thoroughly cover exposed seeds. 
 Treated seed must be planted into the soil at a depth greater than ½ inch.
 Treated seed exposed on soil surface may be hazardous to wildlife. Cover or 
collect treated seed spilled during loading and planting (such as in row ends).
 Manage excess treated seed (e.g., spilled, unused, or expired treated seed) by 
one or more of the following methods:
o Collect excess treated seed for reuse for planting.

A21458B
Page 12
o Bury excess treated seed (only allowed if totaling 1 pound or less) at least 30 
feet away from bodies of water at a depth of 6 inches or double the planting 
depth, whichever is greater.
o Dispose of excess treated seed by placing them in a landfill in accordance 
with applicable laws in your state. 
o Return excess treated seed to the supplier if permitted by the state.
 Do not contaminate water bodies when disposing of planting equipment 
washwaters.
 Dispose of seed packaging in accordance with local requirements. 
 Maximum usage when applying metalaxyl- and mefenoxam-containing 
products to the same crop within the same season: DO NOT apply more 
than the maximum yearly total application rate for the active ingredient as stated 
on the label of the product containing the lowest yearly total on that crop. 
 Regardless of type of application (seed treatment, soil or foliar), DO NOT apply 
more than 0.46 lb ai/A (208.7 g ai/A) difenoconazole per calendar year. 
 For rapeseed crop subgroup 20A: DO NOT apply more than 0.0013 lb ai/A 
(0.59 g ai/A) of mefenoxam- or metalaxyl-containing products per year as a seed 
treatment. 
 For small grain cereals: DO NOT apply more than 0.097lb ai/A (44.0 g ai/A) of 
mefenoxam- or metalaxyl-containing products per year as a seed treatment. 
 Advisory Dust-Reducing Technique: The use of seed flow lubricants or 
polymer coatings may help decrease the amount of dust released during 
planting. Follow the recommendations of the planter manufacturer regarding the 
use of seed flow lubricants. 
 In the event of crop failure or harvest of a crop grown from seed treated with 
A21458B, the field may be replanted immediately to the following crops: 
Plantback Interval Table 
Immediate Plantback 
Cereals, Small Grain: Barley, Oats, Rye, Triticale, and Wheat 
Cotton 
Dried Shelled Pea and Bean Crop Subgroup 6C
Potato
Rapeseed (Including Canola) Crop Subgroup 20A
Soybean 
Sugarbeet 
Sweet Corn 
 
 For any other crops the minimum plantback interval is 30 days from the date the 
seeds treated with A21458B were planted.
 Cereal forage must not be grazed until 30 days after planting. 
 [All seed bag tags must be legible and set in at least 8-point font size.]

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7.0SEED TREATMENT DIRECTIONS
7.1 Rapeseed Crop Subgroup 20A 
Crops 
 
For Protection Against
the Following Diseases
Use Rate
(fl oz/100 
lb seed)
Use Rate
(g ai/100 kg seed) 
Borage 
Crambe 
Cuphea
Echium 
Flax seed
Gold of 
pleasure
Hare’s ear 
mustard 
Lesquerella 
Lunaria 
Meadowfoam 
Milkweed 
Mustard seed 
Oil radish 
Poppy seed 
Rapeseed 
(canola) 
Sesame 
Sweet rocket 
Cultivars, 
varieties, 
and/or hybrids 
of these 
Seed-borne Alternariaspecies
Seed-borne Blackleg 
(Leptosphaeria maculans) 
Seedling Disease Complex: 
Damping-off, Seedling Blight, 
Seed Rot, and Root Rot 
caused by Fusarium species, 
Pythium species, and 
Rhizoctonia species 
9.2 
Difenoconazole: 24 
Fludioxonil: 2.5 
Mefenoxam: 7.5 
Sedaxane: 5

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7.2 Small Grain Cereals 
Crop For Protection Against 
the Following Diseases
Use Rate
(fl oz/100 
lb seed) 
Use Rate
(g ai/100 kg seed)
Barley 
Oats 
Rye 
Triticale 
Wheat, Spring 
Wheat, Winter 
General Seed Rots1
Seedling Disease Complex: 
Damping-off, Seedling Blight,
Seed Rot, and Root Rot 
caused by Fusarium species, 
Pythiumspecies, and
Rhizoctonia species 
Bunts2: Common, Dwarf, and Karnal 
Pink Snow Mold (Microdochium 
nivale or Monographella nivalis)3
Seed-borne Septoria species 
Septoria Blotch4 
Smuts: Covered, False Loose, Flag, 
and Loose 
Diseases Suppressed5
Common Root Rot (Cochliobolus 
species) 
Crown and Foot Rot (Fusarium 
species) 
Take-All
4.6 – 9.2 
Difenoconazole: 
12 – 24
 
Fludioxonil: 
1.25 – 2.5 
 
Mefenoxam: 
3.75 – 7.5 
 
Sedaxane: 
2.5 - 5 
1Active on pathogens that cause general seed rots. These seed rots include those caused by saprophytic 
organisms such as Penicillium and Aspergillus species. 
2Provides protection against both seed- and soil-borne bunts (common, dwarf). 
3Provides protection against damage from pink snow mold (Microdochium nivale or Monographella 
nivalis) in Winter Wheat at the 9.2 fl oz/100 lb seed rate. For additional protection, tank mix with Maxim® 
4FS using up to 0.08 fl oz/100 lb seed of Maxim 4FS. A21458B will not provide protection against 
damage from pink snow mold if applied at rates less than 9.2 fl oz/100 lb seed. However, a tank mix with 
Maxim 4FS will provide protection against damage from pink snow mold at the rates listed below: 
 Vibrance ®Flexi at 5.7 fl oz/100 lb seed + Maxim 4FS at 0.03-0.107 fl oz/100 lb seed 
Vibrance Flexi at 4.6 fl oz/100 lb seed + Maxim 4FS at 0.04-0.117 fl oz/100 lb seed 
4Provides early-season foliar disease protection for up to 6 weeks after planting at the 9.2 fl oz/100 lb 
rate. For full-season protection, apply a foliar fungicide according to label directions. 
5Suppression means consistent protection at a level which is not optimal but is still of commercial benefit.

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8.0STORAGE AND DISPOSAL
STORAGE AND DISPOSAL
Do not contaminate water, food or feed by storage or disposal. 
Pesticide Storage 
Store in the original container and only in a cool, dry, secure place.
Pesticide Disposal
Wastes resulting from the use of this product must be disposed of on site or at an 
approved waste disposal facility. If these wastes cannot be disposed of by use 
according to label instructions, contact your State Pesticide or Environmental Control 
Agency or the Hazardous Waste Representative at the nearest EPA regional office for 
guidance.
Container Handling [less than or equal to 5 gallons]
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank and drain for 10 seconds after the flow 
begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal. 
Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more 
times. Then offer for recycling if available or puncture and dispose of in a sanitary 
landfill, or by incineration, or by other procedures approved by state and local 
authorities.
Container Handling [greater than 5 gallons –bulk] 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank. Fill the container ¼ full with water. 
Replace and tighten closures. Tip container on its side and roll it back and forth, 
ensuring at least one complete revolution, for 30 seconds. Stand the container on its 
end and tip it back and forth several times. Turn the container over onto its other end 
and tip it back and forth several times. Empty the rinsate into application equipment or a 
mix tank or store rinsate for later use or disposal. Repeat this procedure two more 
times. Then offer for recycling if available or puncture and dispose of in a sanitary 
landfill, or by incineration, or by other procedures approved by state and local 
authorities.

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Container Handling [greater than 5 gallons – bulk]
Refillable container.Refill this container with pesticide only. Do not reuse this 
container for any other purpose. Cleaning the container before final disposal is the 
responsibility of the person disposing of the container. Cleaning before refilling is the 
responsibility of the person refilling. To clean container before final disposal, empty the 
remaining contents from this container into application equipment or mix tank. Fill the 
container about 10 percent full with water. Agitate vigorously or recirculate water with 
the pump for 2 minutes. Pour or pump rinsate into application equipment or rinsate 
collection system. Repeat this rinsing procedure two more times. Then offer for 
recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, 
or by other procedures approved by state and local authorities.
For minor spills, leaks, etc., follow all precautions indicated on this label and clean up 
immediately. Take special care to avoid contamination of equipment and facilities during 
cleanup procedures and disposal of wastes.
CONTAINER IS NOT SAFE FOR FOOD, FEED, OR DRINKING WATER.

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9.0CONDITIONS OF SALE AND LIMITATION OF 
WARRANTY AND LIABILITY 
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not acceptable, 
return the product at once, unopened, and the purchase price will be refunded.
The Directions for Use of this product must be followed carefully. It is impossible to 
eliminate all risks inherently associated with the use of this product. Crop injury, 
ineffectiveness or other unintended consequences may result because of such factors as 
manner of use or application, weather or crop conditions, presence of other materials or 
other influencing factors in the use of the product, which are beyond the control of 
SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by applicable 
law, Buyer and User agree to hold SYNGENTA and Seller harmless for any claims 
relating to such factors.
SYNGENTA warrants that this product conforms to the chemical description on the label 
and is reasonably fit for the purposes stated in the Directions for Use, subject to the 
inherent risks referred to above, when used in accordance with directions under normal 
use conditions. To the extent permitted by applicable law: (1) this warranty does not 
extend to the use of the product contrary to label instructions, or under conditions not 
reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer 
and User assume the risk of any such use. TO THE EXTENT PERMITTED BY 
APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY 
OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR 
IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL. 
 
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any 
incidental, consequential or special damages resulting from the use or handling of this 
product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE 
REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF 
SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR 
DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, 
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) 
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE 
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION OF 
SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT. 
 
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

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Maxim®, Vibrance®, The ALLIANCE FRAME
the SYNGENTA Logo and the PURPOSE ICON
are Trademarks of a Syngenta Group Company 
Viton™ is a trademark of The Chemours Company FC, LLC 
© 20XX Syngenta 
 
For non-emergency (e.g., current product information), call 
Syngenta Crop Protection at 1-866-796-4368
Manufactured for:
Syngenta Crop Protection, LLC
P.O. Box 18300
Greensboro, North Carolina 27419-8300 
A21458B 1588 MAS 1022 AMEND-B 0226 – CL – jeb – 05/22/2026 
000100-01588.20260216B.A21458B_AMEND_FEB26-CL.pdf