crop-chem-docs/corpus/epa_ppls/7969-434.md

# GMB151 PLANT-PARASITIC NEMATODE-PROTECTED SOYBEAN

- EPA Reg No: **7969-434**
- Registrant: BASF AGRICULTURAL SOLUTIONS US, LLC
- Signal word: Caution
- Active ingredients: Bacillus thuringiensis Cry14Ab-1 Crystal Protein as Expressed in Soy bean (0.016622%)
- Label accepted: 2026-08-17
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/007969-00434-20260817.pdf

---
August 17, 2026 
 
 
Andrew Olson. Ph.D. 
U.S. Regulatory Manager 
BASF Agricultural Solutions US LLC 
2 T.W. Alexander Drive 
Research Triangle Park, NC 27713 
 
Subject: Non-PRIA (Pesticide Registration Improvement Act) Amendment – Removal 
of the Registration Expiration Date, Updates to the Nematode Resistance 
Management Terms of Registration, and Addition of IPM Language to Product 
Label. 
Product Name: GMB151 Soybean 
EPA Registration Number: 7969-434 
EPA Receipt Date: July 28, 2026 
OPP Action Case Number: 00713372 
 
Dear Dr. Olson: 
 
The amendments referenced above and described below, submitted in connection with 
registration under Section 3(c)(5) of the Federal Insecticide, Fungicide, and Rodenticide Act 
(FIFRA), are acceptable. The updated terms and conditions are as follows: 
 
1. Submit/cite all data required for registration of your product under FIFRA section 3(c)(5) 
when the Agency requires all registrants of similar products to submit such data. 
 
2. The subject registration will be limited to Bacillus thuringiensis Cry14Ab-1 (vector pSZ8832) 
and the genetic material necessary for its production in GMB151 Soybean (OECD Unique 
Identifier: BCS-GM151-6). 
 
3. GMB151 Soybean may be combined through conventional breeding with other registered 
plant-incorporated protectants that are similarly approved for use in combination, through 
conventional breeding, with other registered plant-incorporated protectants to produce 
soybean varieties with combined pesticidal traits. 
 
4. BASF must submit the following data and/or information within the timeframe specified: 
 
a. Grower stewardship materials with respect to Heterodera glycines, soybean cyst 
nematodes, including educational materials and the technology use guide for the

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
product. These materials must be submitted within 90 days of the first commercial 
plantings of GMB151 Soybean. 
 
b. Baseline susceptibility data, sampling methods, and on-plant greenhouse bioassay 
methodology for detecting resistant populations. These methods and accompanying 
data must be submitted within one year of commercial plantings of GMB151 
Soybean. 
 
5. BASF must combine GMB151 Soybean (Cry14Ab-1) with soybean lines natively resistant to 
soybean cyst nematode, such as PI 88788. 
 
6. Resistance Management Program Elements. The required resistance management plan for 
GMB151 soybeans must have the following components: 
 
a. BASF must implement an Integrated Pest Management (IPM)-based stewardship 
program for GMB151 Soybean; 
 
b. Requirements for BASF to prepare and require GMB151 Soybean users to sign 
“grower agreements” which impose binding contractual obligations on the grower 
to comply with the RM requirements including best management practices for 
soybean cyst nematodes; 
 
c. Requirements for BASF to develop, implement, and report to EPA on programs to 
educate growers about resistance management practices as well as tools to evaluate 
growers' adoption of the measures recommended under the resistance 
management program; 
 
d. Requirements for BASF to develop, implement, and report to EPA on a resistance 
monitoring program for soybean cyst nematodes using sentinel plots and 
investigations of grower reports of unexpected damage; 
 
e. Requirements for BASF to develop, implement, and report to EPA on a resistance 
confirmation bioassay to determine whether there are statistically significant and 
biologically relevant changes in susceptibility to Cry14Ab-1 protein in soybean cyst 
nematodes; 
 
f. Requirements for BASF to develop, and if triggered, to implement a "remedial action 
plan" which would contain measures BASF would take in the event that any 
resistance was detected as well as to report on activity under the plan to EPA; 
 
g. Requirements for annual reports on or before the time frames specified in the 
Annual Reports section below.

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
7. Resistance Management Plan Requirements 
 
a. Integrated pest management (IPM) stewardship program 
 
BASF must implement a best management practice (BMP)-based stewardship 
program for GMB151 Soybean. This program will be designed to reduce selection 
pressure for soybean cyst nematode resistance and prolong trait durability. 
Implementation of the IPM strategy can include grower education initiatives and 
outreach to extension and consultant groups. Key components of the stewardship 
program include: 
 
x Non-host crop rotation after use of GMB151 Soybean; 
x Eliminate non-crop host plants during non-host crop rotation; 
x Monitoring for unexpected injury; 
x Sanitation and dispersal limitation measures. 
 
BASF must submit an annual report to the EPA documenting activities conducted 
under the IPM stewardship program. The report must include: 
 
x A third-party anonymous survey of grower practices an assessment of 
grower practices; 
x The level of IPM/BMP adoption by commercial growers of GMB151 Soybean 
growers in different regions of the country; and 
x A discussion of the potential impact of non-adoption of IPM/BMP measures. 
 
This report is due January 31
st, the following year of each growing season, beginning 
the first growing season of GMB151 Soybean commercial use. 
 
b. Grower Agreements 
 
1) Persons purchasing GMB151 Soybean must sign a grower agreement. The term 
“grower agreement” refers to any grower purchase contract, license agreement, 
or similar legal document. 
 
2) The grower agreement and/or specific stewardship documents referenced in the 
grower agreement must clearly set forth the terms of the current resistance 
management program. By signing the grower agreement, a grower must be 
contractually bound to comply with the requirements of the resistance 
management program. 
 
3) BASF must implement an approved system which is reasonably likely to assure 
that persons purchasing GMB151 Soybean will affirm annually that they are

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
contractually bound to comply with the requirements of the resistance 
management program. 
 
4) BASF must use a grower agreement for GMB151 Soybean. If BASF wishes to 
change any part of the grower agreement that would affect either the content of 
the resistance management program or the legal enforceability of the provisions 
of the agreement relating to the resistance management program, thirty days 
prior to implementing a proposed change, BASF must submit to EPA the text of 
such changes to ensure the agreement is consistent with the terms and 
conditions of this registration. 
 
5) BASF shall maintain records of all GMB151 Soybean grower agreements for a 
period of three years from December 31
st of the year in which the agreement 
was signed. 
 
6) BASF shall make available to the Agency upon request records of the number of 
units of GMB151 Soybean seed sold or shipped and not returned, and the 
number of such units that were sold to persons who have signed grower 
agreements for the previous growing season. BASF is required to submit reports 
within three months of the Agency’s request. 
 
7) BASF must allow a review of the grower agreements and grower agreement 
records by EPA or by a State pesticide regulatory agency if the State agency can 
demonstrate that confidential business information, including the names, 
personal information, and grower license number will be protected. 
 
c. Resistance Management Education Program 
 
BASF must implement the following resistance management education program: 
 
1) BASF must design and implement a comprehensive, ongoing resistance 
management education program designed to convey GMB151 Soybean users the 
importance of complying with the RM program. The program shall include 
information encouraging GMB151 Soybean users to pursue elements of the 
resistance management program relating to best management practices. The 
education program shall involve the use of multiple media, e.g. face-to-face 
meetings, mailing written materials, and electronic communications such as by 
internet or television commercials. The program shall involve at least one 
written communication annually to each GMB151 Soybean grower separate 
from the grower agreement. BASF shall coordinate its education program with 
educational efforts of other organizations, such as the Soybean Cyst Nematode 
Coalition, American Soybean Association, and state extension programs. 
Education presentations will target growers, university extension, consultants, 
internal sales and technical teams, and other appropriate audiences.

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
 
2) Annually, BASF shall revise, and expand as necessary, its education program to 
take into account the information collected through the best management 
practices survey required under section 7.a and from other sources. 
 
3) Within 90 days of request, BASF shall provide a report to EPA summarizing the 
activities it carried out under its education program for the prior year and its 
plans for its education program during the current year. 
 
d. Resistance Monitoring 
 
BASF must conduct an annual resistance monitoring program to assess the 
susceptibility of the soybean cyst nematode to the Cry14Ab-1 toxin. The resistance 
monitoring program must include sentinel plots for surveying for potential 
resistance and collection of information from growers about events that may 
indicate resistance. The Agency is imposing the following terms: 
 
1) BASF will monitor for resistance in soybean cyst nematodes by the following 
methods: 
 
a) Sentinel plots of GMB151 Soybean and comparative non-Bt soybean lines to 
monitor the abundance of soybean cyst nematodes in areas of expected high 
adoption and resistance risk. 
 
b) Investigations of grower, extension specialist or consultant reports of less 
than expected results or control failures of GMB151 Soybean. BASF will 
instruct its customers (growers and seed distributors) to contact them (e.g., 
via a toll-free customer service number) if incidents of unexpected levels of 
soybean cyst nematode damage occur. BASF must investigate all damage 
reports. See section 7.e “Remedial Action Plans” below. 
 
c) For both the sentinel plot and field damage report investigations, EPA 
defines “confirmed unexpected injury (UXI)” with the following triggers 
based on the number of cysts in 10 sampled plants: 
 
i. An average of 20 cysts per symptomatic plant prior to 60 days after 
planting; in case of sandy soils (>70% of sand) and/or alkaline soils (PH t 
7.5) the average of 30 cysts per symptomatic plant prior to 60 days after 
planting; 
ii. An average of 50 cysts per symptomatic plant up to 90 days after 
planting; in case of sandy soils (>70% of sand) and/or alkaline soils (PH t 
7.5) the average of 75 cysts per symptomatic plant prior to 90 days after 
planting;

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
iii. Any symptomatic plants documented after 90 days post-planting will be 
considered evidence as a confirmed UXI event; 
iv. BASF must resample the confirmed UXI field at or after harvest; 
v. BASF must implement remedial action measures in response to a 
confirmed UXI event – see section 7.e “Remedial Action Plans”. 
 
d) A confirmed UXI event will be considered “putatively resistant” if BASF 
samples the field again at or after harvest and collects 4000 eggs/100cm3 
soil. If this egg threshold is obtained, BASF will conduct an on-plant 
greenhouse bioassay to compare the putatively resistant population of 
soybean cyst nematode to a susceptible population. If a significant difference 
in survival of these two colonies is observed in GMB151 soybeans, then the 
population will be deemed “confirmed resistant.” 
 
i. For all cases of confirmed resistance, BASF must implement remedial 
action measures as required in section 7.e “Remedial Action Plans”. 
 
e) BASF is required submit the methodology for the on-plant greenhouse 
resistance confirmation bioassay within one year after commercialization of 
GMB151 Soybean. 
 
2) Once resistance is first confirmed in a field collection of SCN, it will be reported 
to the Agency. BASF will further investigate to 1) Determine if the observed 
effect is heritable; 2) Demonstrate that the increased survival is due to resistance 
to Cry14Ab-1; 3) Characterize the soil properties in which resistance developed; 
4) Determine the geographic extent of the resistance distribution; and 5) 
Determine the affected grower’s level of adherence to IPM best practices. BASF 
will report to the Agency on these findings and confer with the Agency regarding 
additional information needs. 
 
3) BASF must provide to EPA for review and approval any revisions to the soybean 
cyst nematode resistance monitoring plans prior to their implementation. 
 
4) A report on results of resistance monitoring and investigations of damage 
reports must be submitted to the Agency annually by September 30
th each year 
for soybean cyst nematode for the duration of this registration. Additionally, 
BASF will meet with the Agency by February 28
th of each year to discuss any 
damage incidents or resistance investigations from the previous year. 
 
e. Remedial Action Plans 
 
A specific remedial (mitigation) action plan for soybean cyst nematode is required 
for GMB151 Soybean for the purpose of containing resistance and perhaps 
eliminating resistance if it develops.

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
 
1) BASF must take the following actions for cases of confirmed UXI or confirmed 
resistance: 
 
a) For confirmed UXI or confirmed resistance cases, BASF must hold discussions 
with the relevant grower(s) and recommend the following best management 
practices: 
 
x Rotate to a non-host crop the season after GMB151 Soybean; 
x Eliminate non-crop host plants during the non-host crop rotation; 
x Mitigate against soil movement out of the UXI field through sanitation. 
 
b) For confirmed UXI or confirmed resistance cases, BASF must hold discussions 
with grower(s) of GMB151 Soybean within the county of the mitigation 
action area and recommend the following best management practices: 
 
x Rotate to non-host crop season after GMB151 Soybean; 
x Mitigate against soil movement from fields outside of the grower’s 
control (e.g., sanitation of shared equipment); 
x Monitor GMB151 for UXI, report to BASF if observed. 
 
c) After remediation, BASF must hold discussions with the relevant grower(s) 
and recommend the following best management practices: 
 
x Monitor GMB151 Soybean for UXI, report to BASF if observed; 
x Plant soybean with alternative genetic source (QTL) of host plant 
resistance if resistance confirmation finds virulence to QTL in UXI soybean 
crop; 
x Use nematocidal seed treatments in subsequent years. 
 
2) BASF must take the following measure for confirmed resistance cases: 
 
x BASF must cease sales of GMB151 Soybean to growers with fields 
exhibiting confirmed resistant populations of SCN as well as surrounding 
fields. 
x Affected customers and extension agents must be notified regarding 
confirmed resistance within 30 days; 
 
f. Reports for Sales, Grower Education, and Resistance Monitoring 
 
1) BASF must provide to EPA within 90 days of request:

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
a) Annual sales reported and summed by state (county level data will be made 
available by request); 
 
b) A report summarizing any substantive changes to the grower education 
program completed the previous year. 
 
2) A report on results of resistance monitoring and investigations of damage 
reports must be submitted to the Agency annually by September 30th each for 
the duration of this registration. BASF will also discuss any cases of putative 
resistance with the Agency prior to the subsequent field season by January 31
st. 
The report will contain information such as: 
 
a) Number of UXI reports and subsequently confirmed UXI cases in GMB151 
Soybean fields, including state and county information. 
 
b) Number of confirmed UXI cases that were assessed to have resistant 
populations of soybean cyst nematode. 
 
c) Detailed results and discussion of the resistance confirmation bioassay. 
 
3) A report must be submitted to EPA by September 30
th annually documented the 
results of the best management practice survey in section 7.e “Remedial Action 
Plans.” 
 
Please note that the record for this product currently contains the following acceptable 
Confidential Statement of Formula (CSF): 
 
x Basic CSF dated 3/31/2026 
 
Any CSFs other than that listed above are superseded/no longer valid. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes all 
previously accepted labeling. You must submit one (1) copy of the final printed labeling before 
you release this product for shipment with the new labeling. In accordance with 40 CFR § 
152.130(c), you may distribute or sell this product under the previously approved labeling for 
18 months from the date of this letter. After 18 months, you may only distribute or sell this 
product if it bears this new revised labeling or subsequently approved labeling. “To distribute or 
sell” is defined under FIFRA section 2(gg) and its implementing regulation at 40 § CFR 152.3. 
 
Should you wish to add/retain a reference to your company’s website on your label, then 
please be aware that the website becomes labeling under FIFRA and is subject to review by the 
U.S. Environmental Protection Agency (EPA). If the website is false or misleading, the product 
will be considered to be misbranded and sale or distribution of the product is unlawful under 
FIFRA section 12(a)(1)(E). 40 CFR § 156.10(a)(5) lists examples of statements EPA may consider

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EPA Registration No. 7969-434 
Action Case No. 00713372 
 
 
 
 
false or misleading. In addition, regardless of whether a website is referenced on your product’s 
label, claims made on the website may not substantially differ from those claims approved 
through the registration process. Therefore, should EPA find or if it is brought to our attention 
that a website contains statements or claims substantially differing from statements or claims 
made in connection with obtaining a FIFRA section 3 registration, the website will be referred 
to EPA’s Office of Enforcement and Compliance Assurance. 
 
Your release for shipment of this product constitutes acceptance of these terms. If these terms 
are not complied with, this registration will be subject to cancellation in accordance with FIFRA 
section 6. 
 
If you have any questions, please contact David Linz by email at linz.david@epa.gov or by 
phone at (513) 569-7538. 
 
Sincerely, 
 
 
 
Alan Reynolds, Product Manager 94 
Emerging Technologies Branch 
Biopesticides and Pollution 
 Prevention Division (7511M) 
Office of Pesticide Programs 
 
Enclosures: Product Label Stamped “Acceptable” 
Digitally signed by 
ALAN REYNOLDS 
Date: 2026.08.17 
15:51:29 -04'00'

Plant-Incorporated Protectant Label
GMB151
Plant-Parasitic Nematode-Protected Soybean
(OECD Unique Identifier BCS-GM151-6)
Active Ingredient:
Bacillus thuringiensis Cry14Ab-1 protein and the genetic material necessary for its production (vector 
pSZ8832) in GMB151 soybean (OECD ID BCS-GM151-6)……………………….……… < 0.016622%*
Inert Ingredient:
4-hydroxyphenyl pyruvate deoxygenate (HPPD-4) and the genetic material necessary for its production 
(vector pSZ8832) in GMB151 soybean (OECD ID BCS-GM151-6)…………..................... < 0.001271%*
*Maximum percent (wt/wt) of dry grain
KEEP OUT OF REACH OF CHILDREN
CAUTION
EPA Registration Number: 7969-434
EPA ESTABLISHMENT NUMBER: 7969-NC-1
NET CONTENTS:
BASF Agricultural Solutions US LLC
2 TW Alexander Drive
Research Triangle Park, NC 27713
08/17/2026
7969-434

DIRECTIONS FOR USE: 
 
It is a violation of federal law to use this product in a manner inconsistent with its labeling. 
 
GMB151 soybean may be combined through conventional breeding with other registered plant-
incorporated protectants that are similarly approved for use in combination, through conventional 
breeding, with other registered plant-incorporated protectants to produce soybean varieties with combined 
pesticidal traits. 
 
Soybean has been transformed to express Bacillus thuringiensis Cry14Ab-1 protein for the control of 
soybean cyst nematode (Heterodera glycines). 
 
There are no refuge requirements for planting GMB151 soybean.
 
 
 
INTEGRATED PEST MANAGEMENT: 
 
Best management practices are recommended when using Plant-Parasitic Nematode protection. Examples 
of appropriate BMPs include but are not limited to: 
x Non-host crop rotation after use of Cry14Ab-1 soybeans 
x Eliminate non-crop host plants during non-host crop rotation 
x Monitoring for unexpected injury 
x Sanitation and dispersal limitation measures