crop-chem-docs/corpus/epa_ppls/100-1638.md

# A22353

- EPA Reg No: **100-1638**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Thiamethoxam (21.7%); Fludioxonil (1.08%); Metalaxyl-M (3.54%); Azoxystrobin (0.87%); Sedaxane (1.08%)
- Label accepted: 2022-05-19
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01638-20220519.pdf

---
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
 May 19, 2022 
 
Ricky Kyaw 
Regulatory Product Manager 
Syngenta Crop Protection, Inc. 
PO Box 18300 
Greensboro, NC 27419 
 
Subject: Registration Review Label Mitigation for Azoxystrobin, Fludioxonil, Mefenoxam 
 Product Name: A22353 
 EPA Registration Number: 100-1638 
 Application Dates: 2/1/2019; 5/17/2019; 5/3/2022 
Decision Numbers: 584502; 584503; 584504 
 
Dear Mr. Kyaw: 
 
The Agency, in accordance with the Federal Insecticide, Fungicide and Rodenticide Act 
(FIFRA), as amended, has completed reviewing all the information submitted with your 
application to support the Registration Review of the above referenced product in connection 
with the Azoxystrobin, Fludioxonil, Mefenoxam Interim Decisions, and has concluded that your 
submission is acceptable. The label referred to above, submitted in connection with registration 
under FIFRA, as amended, is acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be 
aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide 
Act and is subject to review by the Agency. If the website is false or misleading, the product 
would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 
CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, 
regardless of whether a website is referenced on your product’s label, claims made on the 
website may not substantially differ from those claims approved through the registration process. 
Therefore, should the Agency find or if it is brought to our attention that a website contains false 
or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes 
all previously accepted labeling. You must submit one copy of the final printed labeling 
before you release the product for shipment with the new labeling. In accordance with 40 
CFR 152.130(c), you may distribute or sell this product under the previously approved 
labeling for 12 months from the date of this letter. After 12 months, you may only 
distribute or sell this product if it bears this new revised labeling or subsequently 
approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its 
implementing regulation at 40 CFR 152.3.

Page 2 of 2 
EPA Reg. No. 100-1638 
Decision No. 584502; 584503; 584504 
 
If you have any questions about this letter, please contact Darius Stanton by phone at 202-566-
2332, or via email at stanton.darius@epa.gov. 
 
 Sincerely, 
 
 
 Linda Arrington, Branch Chief 
 Risk Management and Implementation Branch 4 
 Pesticide Re-Evaluation Division 
 Office of Pesticide Programs 
 
Enclosure

A22353 
Page 1
[MASTER]
THIAMETHOXAM GROUP 4A INSECTICIDE
MEFENOXAM GROUP 4 FUNGICIDE
SEDAXANE GROUP 7 FUNGICIDE
AZOXYSTROBIN GROUP 11 FUNGICIDE
FLUDIOXONIL GROUP 12 FUNGICIDE
A22353
Insecticide with Fungicides
A seed treatment product for protection against damage from listed early-season insect pests 
and diseases of soybean
Active Ingredients:
Azoxystrobin1.............................................................................................................0.87%
Fludioxonil2 ................................................................................................................1.08%
Sedaxane3 .................................................................................................................1.08%
Mefenoxam4 ..............................................................................................................3.54%
Thiamethoxam5 .......................................................................................................21.70%
Other Ingredients: 71.73%
Total: 100.00%
1CAS No. 131860-33-8
2CAS No. 131341-86-1
3CAS No. 874967-67-6
4CAS No. 70630-17-0 and 69516-34-3
5CAS No. 153719-23-4
A22353 is a flowable concentrate for seed treatment containing 0.09 lb azoxystrobin, 0.11 lb 
fludioxonil, 0.11 lb sedaxane, 0.35 lb mefenoxam, and 2.14 lb thiamethoxam per gallon.
KEEP OUT OF REACH OF CHILDREN.
CAUTION
See additional precautionary statements and directions for use in booklet.
EPA Reg. No. 100-1638
EPA Est. No. XXXX
-----------------
Net Contents
[Batch Code: _____ ] (For nonrefillables only.)
May 19, 2022
100-1638

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TABLE OF CONTENTS
1.0 FIRST AID
2.0 PRECAUTIONARY STATEMENTS
2.1 Hazards to Humans and Domestic Animals
2.2 Personal Protective Equipment (PPE)
2.2.1 User Safety Requirements
2.2.2 User Safety Recommendations
2.3 Environmental Hazards
2.3.1 Pollinator Precautions
2.3.2 Groundwater Advisory
2.4 Physical and Chemical Hazards
3.0 PRODUCT INFORMATION
3.1 Insecticide Resistance Management
3.2 Fungicide Resistance Management
4.0 APPLICATION DIRECTIONS
4.1 Tank Mixtures
5.0 ROTATIONAL CROP RESTRICTIONS
6.0 RESTRICTIONS
7.0 SEED CONTAINER LABEL REQUIREMENTS
8.0 SEED TREATMENT DIRECTIONS
8.1 Soybean
8.2 Soybean Treatment for Protection Against Seed Storage Pests
9.0 STORAGE AND DISPOSAL
10.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY

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1.0 FIRST AID
FIRST AID
If swallowed xCall a poison control center or doctor immediately for treatment 
advice.
xHave a person sip a glass of water if able to swallow.
xDo not induce vomiting unless told to by a poison control center 
or doctor.
xDo not give anything by mouth to an unconscious person.
If on skin or 
clothing
xTake off contaminated clothing. 
xRinse skin immediately with plenty of water for 15-20 minutes. 
xCall a poison control center or doctor for treatment advice.
Have the product container or label with you when calling a poison control center or 
doctor, or going for treatment.
HOT LINE NUMBER
For 24-Hour Medical Emergency Assistance (Human or Animal)
Or Chemical Emergency Assistance (Spill, Leak, Fire or Accident),
Call
1-800-888-8372
2.0 PRECAUTIONARY STATEMENTS
2.1 Hazards to Humans and Domestic Animals
CAUTION
Harmful if swallowed or absorbed through skin. Avoid contact with skin, eyes or clothing. 
2.2 Personal Protective Equipment (PPE)
Applicators and other handlers must wear:
x Long-sleeved shirt and long pants
x Chemical-resistant gloves: EDUULHUODPLQDWHEXW\OUXEEHU•PLOVQHRSUHQHUXEEHU
•PLOVQLWULOHUXEEHU•PLOVSRO\YLQ\OFKORULGH39&•PLOV, or 9LWRQŠ•PLOV
x Shoes plus socks

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Page 4
2.2.1 User Safety Requirements
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for 
washables exist, use detergent and hot water. Keep and wash PPE separately from other 
laundry.
2.2.2 User Safety Recommendations
Users should:
x Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet.
x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly 
and put on clean clothing.
x Remove PPE immediately after handling this product. Wash the outside of gloves 
before removing. As soon as possible, wash thoroughly and change into clean 
clothing.
2.3 Environmental Hazards
This pesticide is toxic to wildlife and freshwater and estuarine/marine fish and highly toxic to 
aquatic invertebrates. Do not contaminate water when disposing of equipment washwater or 
rinsate. Exposed treated seed may be hazardous to wildlife.
2.3.1 Pollinator Precautions
Thiamethoxam is highly toxic to bees exposed to direct treatment, and effects may be 
possible as a result of exposure to translocated residues in blooming crops.
2.3.2 Groundwater Advisory
Azoxystrobin can be persistent for several months or longer. Azoxystrobin and a degradate 
of azoxystrobin are known to leach through soil into groundwater under certain conditions as 
a result of label use. These chemicals may leach into groundwater if used in areas where 
soils are permeable, particularly where the water table is shallow, and may result in 
groundwater contamination.
Mefenoxam is known to leach through soil into groundwater under certain conditions as a 
result of label use. This chemical may leach into groundwater if used in areas where soils 
are permeable, particularly where the water table is shallow, and may result in groundwater 
contamination.

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Fludioxonil has properties and characteristics associated with chemicals detected in 
groundwater. This chemical may leach into groundwater if used in areas where soils are 
permeable, particularly where the water table is shallow, and may result in groundwater 
contamination.
Thiamethoxam has properties and characteristics associated with chemicals detected in 
groundwater. This chemical may leach into groundwater if used in areas where soils are 
permeable, particularly where the water table is shallow, and may result in groundwater 
contamination.
2.4 Physical and Chemical Hazards
Do not mix or allow to come in contact with an oxidizing agent, a hazardous chemical 
reaction may occur.
DIRECTIONS FOR USE
It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.
Use is only permitted in commercial seed treatment facilities. Use on-farm is not permitted. 
Do not use for at-plant applications (e.g. hopper box, planter box, etc.). This product is to be 
applied as a water-based slurry through standard liquid-type commercial seed treatment 
equipment. Seed treaters with atomizers or spinning discs are highly recommended for better 
product coverage on the seed.
Do not apply this product in a way that will contact workers or other persons, either directly or 
through drift. Only protected handlers may be in the area during application. For any 
requirements specific to your State or Tribe, consult the agency responsible for pesticide 
regulation.
Maximum usage when applying metalaxyl- and mefenoxam- containing products to the 
same crop within the same season: Do not apply more than the maximum yearly total 
application rate for the active ingredient as stated on the label of the product containing the 
lowest yearly total on that crop.
FAILURE TO FOLLOW DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY 
RESULT IN CROP INJURY; POOR INSECT AND/OR DISEASE CONTROL; AND/OR 
ILLEGAL RESIDUES.
Treatment of highly mechanically scarred or damaged seed or seed known to be of low vigor 
and poor quality may result in reduced germination and/or reduction of seed and seedling

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vigor. Therefore, it is recommended to treat a quantity of seed using equipment similar to 
that planned for treating the total seed lot. Then conduct germination tests with a portion of 
this treated seed before committing the total seed lot to a selected seed treatment.
Due to seed quality, crop or variety sensitivity, and seed storage conditions beyond the 
control of Syngenta, no claims are made to guarantee the germination of seed or propagating 
material for any crop seed treated with A22353.
3.0 PRODUCT INFORMATION
A22353 is a broad-spectrum seed treatment for use only on soybean that consists of four 
fungicide active ingredients: azoxystrobin, fludioxonil, sedaxane, and mefenoxam, as well as 
one insecticide active ingredient: thiamethoxam. Each active ingredient has a different mode 
of action. This seed treatment is recommended for control of many listed important fungal 
plant diseases as well as listed early-season insect pests.
Azoxystrobin fungicide is active against Rhizoctonia and Pythium species, seed-borne white 
mold (Sclerotinia sclerotiorum) as well as other listed seed-borne diseases causing decay, 
damping-off and seedling blight.
Fludioxonil fungicide protects against damage from seed-borne and soil-borne disease 
caused by Fusarium and Rhizoctonia species leading to seed decay, damping-off, and 
seedling blight. This active ingredient also provides protection from seed-borne Diaporthe-
Phomopsis disease complex sometimes referred to as pod and stem blight (caused by 
Phomopsis longicolla and Diaporthe phaseolorum). Fludioxonil also suppresses seed-borne 
Sclerotinia.
Sedaxane fungicide protects against damage from seed decay, seedling blight, and damping-
off caused by Rhizoctonia species.
Mefenoxam fungicide provides protection against Pythium damping-off and early-season 
Phytophthora.
Thiamethoxam protects against damage from listed insect pests.
3.1 Insecticide Resistance Management
A22353 contains thiamethoxam, a Group 4A insecticide. Thiamethoxam is a systemic 
insecticide belonging to the neonicotinoid class of chemistry which includes nicotinic 
acetylcholine receptor (nAChR) agonists.
THIAMETHOXAM GROUP
4A INSECTICIDE

A22353 
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Insect populations may contain individuals naturally resistant to Group 4A insecticides and if 
used repeatedly in the same fields, then resistant members may eventually dominate the 
population. Because resistance development cannot be predicted, use sound resistance 
management strategies established for the crop and use area.
Base seed treatment on an integrated pest management program that includes field 
sanitation, historical information related to pesticide use, careful selection of pest-tolerant 
crop varieties, scouting, and management practices which optimize populations of natural 
enemies of insect pests such as within-field refuge (untreated areas). Sound management 
programs also consider cultural and biological control practices.
In order to maintain susceptibility to these classes of chemistry:
x Use products at their full, specified doses.
x Use appropriate, well-maintained equipment. Use specified water volumes and apply at 
optimal temperatures in order to obtain optimal treatment.
x When rate ranges are given, use the higher rate within the listed rate range when insect 
pressure is expected to be high.
x Avoid using a single active ingredient or mode of action (same insecticide group) 
exclusively for season long control of insect species with more than one generation per 
crop season.
x For insect species with successive or overlapping generations, use a treatment window 
approach. A treatment window is a period of time defined by the stage of crop 
development and the biology of the pests of concern. Within the treatment window, 
depending on the length of residual activity, single or consecutive applications may be 
made using seed, in-furrow, or foliar treatments unless otherwise excluded by product 
labels. Do not exceed the maximum amount of this insecticide’s mode of action allowed 
per growing season.
x Following a treatment window of this insecticide’s mode of action, rotate to a treatment 
window of effective products with a different mode of action before making additional 
applications of this insecticide.
If resistance to this product develops in your area, this product or other products with a 
similar mode of action may not provide adequate control. If poor performance cannot be 
attributed to improper application or weather conditions, a resistant strain of insect may be 
present. If you experience difficulty with control and resistance is a reasonable cause, 
immediately consult your local company representative or agricultural advisor for the best 
alternative method of control for the crop and use area.
Syngenta encourages responsible product stewardship to ensure effective long term control 
of the insect pests on this label.
For additional information on Insect Resistance Management:
x Contact Syngenta representatives at 1-800-334-9481
x Contact your local Cooperative Extension Service specialist, pest control advisor, or 
certified crop advisor

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x Visit the Insecticide Resistance Action Committee (IRAC) on the web at: 
http://www.irac-online.org
3.2 Fungicide Resistance Management
MEFENOXAM GROUP 4 FUNGICIDE
SEDAXANE GROUP 7 FUNGICIDE
AZOXYSTROBIN GROUP 11 FUNGICIDE
FLUDIOXONIL GROUP 12 FUNGICIDE
For resistance management, please note that A22353 contains Group 4/mefenoxam, Group 
7/sedaxane, Group 11/azoxystrobin and Group 12/fludioxonil fungicides. Any fungal 
population may contain individuals naturally resistant to A22353 and other Group 4, Group 7, 
Group 11 or Group 12 fungicides. A gradual or total loss of pest control may occur over time 
if these fungicides are used repeatedly in the same fields. Appropriate resistance-
management strategies should be followed.
Mefenoxam belongs to the phenylamide class of chemistry which interferes with fungal RNA 
synthesis. Sedaxane is a succinate dehydrogenase inhibitor (SDHI) and belongs to the 
carboxamide class of chemistry which disrupts cellular respiration and energy generation. 
Azoxystrobin belongs to the strobilurin class of chemistry which disrupts cellular respiration 
and energy generation. Fludioxonil belongs to the phenylpyrrole class of chemistry which 
interferes with osmotic signal transduction.
To delay fungicide resistance, take one or more of the following steps:
x Rotate the use of A22353 or other Group 4, Group 7, Group 11 or Group 12 fungicides 
within a growing season sequence with different groups that control the same pathogens.
x Use tank mixtures with fungicide from a different group that are equally effective on the 
target pest when such use is permitted. Use at least the minimum application rate as 
labeled by the manufacturer.
x Adopt an integrated disease management program for fungicide use that includes 
scouting, uses historical information related to pesticide use, and crop rotation, and which 
considers host plant resistance, impact of environmental conditions on disease 
development, disease thresholds, as well as cultural, biological and other chemical control 
practices.
x Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage 
resistance.
x Monitor treated fungal populations for resistance development.
x Contact your local extension specialist or certified crop advisor for any additional pesticide 
resistance-management and/or IPM recommendations for specific crop and pathogens.
For further information or to report suspected resistance contact Syngenta at 1-866-
Syngent(a) (866-796-4368). You can also contact your pesticide distributor or university 
extension specialist to report resistance.

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Use should be based on an IRM program that includes field sanitation, scouting, historical 
information related to pesticide use, and crop rotation. The IRM program should also 
consider cultural, biological, and other chemical control practices.
Syngenta encourages responsible product stewardship to ensure effective long term control 
of the fungal diseases on this label.
For additional information on Fungicide Resistance Management:
x Contact Syngenta representatives at 1-800-334-9481
x Contact your local extension specialist or certified crop advisor
x Visit the Fungicide Resistance Action Committee (FRAC) on the web at: 
http://www.frac.info
4.0 APPLICATION DIRECTIONS
Important: Recirculate A22353 thoroughly before using.
Follow the manufacturer’s application instructions for the seed treatment equipment being 
used.
Apply A22353 as a water-based slurry through standard liquid-type commercial seed 
treatment equipment that provides uniform seed coverage. Seed treaters with atomizers or 
spinning discs are highly recommended for better product coverage on the seed. Uneven or 
incomplete seed coverage may not give the desired level of insect or disease control. The 
minimum slurry volume to achieve adequate coverage is 4.0 fluid ounces of liquid slurry per 
100 pounds of seed. More diluent may be required to obtain complete coverage. Thoroughly 
mix the specified amount of A22353 into the required amount of water or liquid inoculant for 
the slurry treater and dilution rate to be used.
Continuous agitation or mixing of the slurry mixture is necessary to prevent settling out of the 
solution. Clean out any unused product from the treater after treating or maintain constant 
agitation if the leftover slurry will be maintained overnight.
x Allow seed to dry before bagging.
4.1 Tank Mixtures
A22353 mixes easily with water and other water-based seed treatments manufactured by 
Syngenta and many other companies. When mixing with products from other manufacturers, 
test the compatibility prior to use by conducting a jar test: mix all intended seed treatments 
with a proportional amount of water to achieve the desired slurry mixture in a clear glass 
container. Mix well and allow mixture to sit for one hour. Remix and observe for 
incompatibility.

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Mixing A22353 with tank-mix partners: Add ½ of the required water to the mix tank and turn 
on the agitation. Mechanical agitation is preferred. If using wettable powders, add them first 
to clean water allowing them to completely disperse prior to adding A22353 or other products. 
Allow each tank-mix partner to completely disperse before adding the next product. Add the 
remaining amount of water and agitate. Maintain agitation until the entire slurry mixture has 
been used.
It is the pesticide user’s responsibility to ensure that all products are registered for the 
intended use. Read and follow the applicable restrictions and limitations and directions for 
use on all product labels involved in tank mixing. Users must follow the most restrictive 
directions for use and precautionary statements of each product in the tank mixture.
5.0 ROTATIONAL CROP RESTRICTIONS
x In the event of a crop failure or harvest of a crop grown from seed treated with A22353,
the field may be replanted according to the following schedule:
Plantback Interval Table
Immediate Plantback Interval Minimum 30-Day Plantback Interval
Canola
Cereal Grains: Barley, Corn (Field, Pop, 
Seed, Sweet), Oats, Rye, Sorghum, 
Triticale, and Wheat
Cotton
Dried Shelled Pea and Bean Crop 
Subgroup 6C
Oilseeds: Borage, Crambe, Flax Seed, 
and Mustard Seed
Potato
Soybean
Sugarbeet
Alfalfa
Cereal Grains Crop Group 15
Cucurbit Vegetables Crop Group 9
Fruiting Vegetables Crop Group 8
Head and Stem Brassica Crop Subgroup 5A
Leafy Brassica Greens Crop Subgroup 5B
Leafy Vegetables Crop Group 4
Legume Vegetables (Succulent or Dried) 
Crop Group 6
Mint: Peppermint and Spearmint
Onion, Dry Bulb
Peanut
Root Vegetables Crop Subgroup 1A
Safflower
Strawberry
Sunflower
Tobacco
Tuberous and Corm Vegetables Crop 
Subgroup 1D

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x For all other crops, the minimum plantback interval is 120 days from the date of planting 
seeds treated with A22353. A cover crop, other than the crops listed above, planted for 
erosion control or soil improvement may be planted sooner than the 120 day interval; 
however, the crop may not be grazed or harvested for food or feed.
6.0 RESTRICTIONS
x Only for use on listed crops.
x For use only in commercial seed treatment facilities. Not for use on agricultural 
establishments in hopper-box, planter-box, slurry-box, or other seed-treatment 
applications at or immediately before planting.
x Treated seed must be labeled in accordance with the requirements of the Federal Seed 
Act.
x Do not use at a rate that will result in more than 0.266 lb thiamethoxam per Acre (120 
grams ai/A) per calendar year, regardless of type of application (seed treatment, soil, or 
foliar). Do not use at a rate that will result in more than 0.083 lb thiamethoxam per Acre 
(37.8 grams ai/A) per calendar year as a seed treatment application.
x Do not apply more than 0.003 lb azoxystrobin per Acre (1.5 g ai/A) per calendar year as a 
seed treatment application. 
x Do not apply more than 0.004 lb fludioxonil per Acre (2.0 g ai/A) per calendar year as a 
seed treatment application. 
x Do not apply more than 0.004 lb sedaxane per Acre (2.0 g ai/A) per calendar year as a 
seed treatment application.
x Do not apply more than 0.013 lb mefenoxam per Acre (5.7 g ai/A) per calendar year as a 
seed treatment application. 
x Maximum usage when applying metalaxyl and mefenoxam containing products to 
the same crop within the same season: Do not apply more than the maximum yearly 
total application rate for the active ingredient as stated on the label of the product 
containing the lowest yearly total on that crop.
x Store treated seed away from feeds and foodstuffs.
x Do not allow children, pets, or livestock to have access to treated seed.
x Do not apply a neonicotinoid insecticide within 45 days of planting soybean seeds treated 
with this product.
7.0 SEED CONTAINER LABEL REQUIREMENTS

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The Federal Seed Act requires that containers of treated seeds must be labeled with the 
following statements:
x This seed has been treated with azoxystrobin, fludioxonil, sedaxane, and mefenoxam 
fungicides and thiamethoxam insecticide.
x Do not use for feed, food, or oil purposes.
In addition, the following statements are required on containers of seeds treated with A22353:
x Groundwater Advisory: Azoxystrobin, a degradate of azoxystrobin, and mefenoxam are 
known to leach through soil into groundwater under certain conditions as a result of label 
use. Fludioxonil and thiamethoxam have properties and characteristics associated with 
chemicals detected in groundwater. These chemicals may leach into groundwater if used 
in areas where soils are permeable, particularly where the water table is shallow.
x Pollinator Precautions: Thiamethoxam is highly toxic to bees exposed to direct treatment, 
and effects may be possible as a result of exposure to translocated residues in blooming 
crops.
x Do not allow children, pets, or livestock to have access to treated seed.
x Store treated seed away from feeds and foodstuffs.
x Wear long-sleeved shirt, long pants and chemical resistant gloves when handling treated 
seed.
x Do not use at a rate that will result in more than 0.266 lb thiamethoxam per Acre (120 
grams ai/A) per calendar year, regardless of type of application (seed treatment, soil, or 
foliar). Do not use at a rate that will result in more than 0.083 lb thiamethoxam per Acre 
(37.8 grams ai/A) per calendar year as a seed treatment application. Do not apply more 
than 0.003 lb azoxystrobin per Acre (1.5 g ai/A) per calendar year as a seed treatment 
application. Do not apply more than 0.004 lb fludioxonil per Acre (2.0 g ai/A) per calendar 
year as a seed treatment application. Do not apply more than 0.013 lb mefenoxam per 
Acre (5.7 g ai/A) per calendar year as a seed treatment application. Do not apply more 
than 0.004 lb sedaxane per Acre (2.0 g ai/A) per calendar year as a seed treatment 
application. Soybean seeds treated with this product contain 0.076 mg of 
thiamethoxam/seed, 0.003 mg of azoxystrobin/seed, 0.004 mg of fludioxonil, 0.012 mg of 
mefenoxam/seed, and 0.004 mg of sedaxane/seed.
x Maximum usage when applying metalaxyl- and mefenoxam-containing products to 
the same crop within the same season: Do not apply more than the maximum yearly 
total application rate for the active ingredient as stated on the label of the product 
containing the lowest yearly total on that crop.
x Do not apply a neonicotinoid insecticide within 45 days of planting soybean seeds treated 
with this product.
x Treated seed must be planted into the soil at a depth greater than 1 inch.
x Treated seeds exposed on soil surface may be hazardous to wildlife. Cover or collect 
treated seeds spilled during loading and in areas such as row ends.
x Dispose of all excess treated seed. Leftover treated seed may be doublesown around the 
headland or buried away from water sources in accordance with local requirements.

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x Do not contaminate water bodies when disposing of planting equipment wash waters.
x Dispose of seed packaging in accordance with local requirements.
x Excess treated seed may be used for ethanol production only if (1) by-products are not 
used for livestock feed and (2) no measurable residues of pesticide remain in the ethanol 
by-products that are used in agronomic practice.

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x In the event of a crop failure or harvest of a crop grown from seed treated with A22353, 
the field may be replanted according to the following schedule:
Plantback Interval Table
Immediate Plantback Interval Minimum 30-Day Plantback Interval
Canola
Cereal Grains: Barley, Corn (Field, Pop, 
Seed, Sweet), Oats, Rye, Sorghum, 
Triticale, and Wheat
Cotton
Dried Shelled Pea and Bean Crop 
Subgroup 6C
Oilseeds: Borage, Crambe, Flax Seed, 
and Mustard Seed
Potato
Soybean
Sugarbeet
Alfalfa
Cereal Grains Crop Group 15
Cucurbit Vegetables Crop Group 9
Fruiting Vegetables Crop Group 8
Head and Stem Brassica Crop Subgroup 5A
Leafy Brassica Greens Crop Subgroup 5B
Leafy Vegetables Crop Group 4
Legume Vegetables (Succulent or Dried) 
Crop Group 6
Mint: Peppermint and Spearmint
Onion, Dry Bulb
Peanut
Root Vegetables Crop Subgroup 1A
Safflower
Strawberry
Sunflower
Tobacco
Tuberous and Corm Vegetables Crop 
Subgroup 1D
x For all other crops, the minimum plantback interval is 120 days from the date of planting 
seeds treated with A22353. A cover crop, other than the crops listed above, planted for 
erosion control or soil improvement may be planted sooner than the 120 day interval; 
however, the crop may not be grazed or harvested for food or feed.
x The maximum number of applications per season is 2.

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8.0 SEED TREATMENT DIRECTIONS
8.1 Soybean
Target Pests / Diseases
Use Rate
(fl oz/100 lb seeds)
(fl oz/140,000 seeds unit)
Use Rate
(mg ai/seed)* Use Information
Early-season Insect Pests
Aphids, Bean leaf beetle, 
Grape colaspis, Leaf 
miners, Leaf hoppers, 
Mexican bean beetle, 
Seed corn maggot, Three-
cornered alfalfa hopper, 
Thrips, White grubs, and 
Wireworm
Early-season Fungal 
Diseases
Seed rot/pre-emergence 
damping-off, post-
emergence damping-off, 
and seedling blight caused 
by Fusarium, Pythium, and 
Rhizoctonia species
Seedling root rot caused by 
Fusarium species
Pod and stem blight caused 
by seed-borne Diaporthe-
Phomopsis species 
disease complex
Early-season root rot and 
damping-off caused by 
Phytophthora
Suppresses seed-borne 
Sclerotinia caused by 
Sclerotinia sclerotiorum
3.0 fl oz
/100 lb seeds
1.4 fl oz
/140,000 seeds unit
TOTAL: 0.099
Azoxystrobin: 0.003
Fludioxonil: 0.004
Sedaxane: 0.004
Mefenoxam: 0.012
Thiamethoxam: 0.076
*The mg ai/seed rate 
provided is based on 
an average seed 
weight of 3,000 
soybeans/lb.
If treating seed with 
a different average 
seed weight, 
recalculate the 
appropriate 
fl oz/100 lb seed 
rate.
Resistance Management:
x Refer to Section 3.1 and Section 3.2
USE RESTRICTIONS
x Refer to Section 6.0 for additional product use restrictions.

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8.2 Soybean Treatment for Protection Against Seed Storage Pests
Target Pests
Use Rate
(fl oz/100 lb seed)
(fl oz/140,000 seeds)
Use Rate
(mg ai/seed) Use Information
Seed Storage Pests
Indian Meal Moth 
(Plodia interpunctella)
Rice Weevil 
(Sitophilus oryza)
Red Flour Beetle
(Tribolium castaneum)
Lesser Grain Borer
(Rhizopertha dominica)
3.0 fl oz 
/100 lb seeds
1.4 fl oz
/140,000 seeds unit
TOTAL: 0.099
Azoxystrobin: 0.003
Fludioxonil: 0.004
Sedaxane: 0.004
Mefenoxam: 0.012
Thiamethoxam: 0.076
Provides protection against 
listed seed storage pests 
when applied prior to 
storage.
If the seed to be treated has 
existing infestations of 
stored grain insects, 
fumigate the seed with a 
registered product approved 
for such use prior to treating 
with A22353 and bagging.
Resistance Management:
x Refer to Section 3.1 and Section 3.2
USE RESTRICTIONS
x Refer to Section 6.0 for additional product use restrictions.
9.0 STORAGE AND DISPOSAL
STORAGE AND DISPOSAL
Do not contaminate water, food or feed by storage or disposal. 
Pesticide Storage
Store in a cool, dry place. Storage for extended periods above 90°F is not recommended.
Store in original containers only. Keep container closed when not in use. Do not store near 
food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical waste 
storage area until proper disposal can be made if product cannot be used according to the 
label.
Pesticide Disposal
Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or rinsate is 
a violation of Federal Law. If these wastes cannot be disposed of by use according to label 
instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous 
Waste Representative at the nearest EPA Regional Office for guidance.
Container Handling (less than or equal to 5 gallons)
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents 
into application equipment or a mix tank and drain for 10 seconds after the flow begins to

A22353 
Page 17
drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into 
application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 
seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for 
recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by 
other procedures approved by state and local authorities.
Container Handling (greater than 5 gallons) 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents 
into application equipment or a mix tank. Fill the container ¼ full with water. Replace and 
tighten closures. Tip container on its side and roll it back and forth, ensuring at least one 
complete revolution, for 30 seconds. Stand the container on its end and tip it back and forth 
several times. Turn the container over onto its other end and tip it back and forth several 
times. Empty the rinsate into application equipment or a mix tank or store rinsate for later 
use or disposal. Repeat this procedure two more times. Then offer for recycling if available 
or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures 
approved by state and local authorities.
Container Handling (greater than 5 gallons) 
Refillable container. Refill this container with pesticide only. Do not reuse this container for 
any other purpose. Cleaning the container before final disposal is the responsibility of the 
person disposing of the container. Cleaning before refilling is the responsibility of the person 
refilling. To clean container before final disposal, empty the remaining contents from this 
container into application equipment or mix tank. Fill the container about 10 percent full with 
water. Agitate vigorously or recirculate water with the pump for 2 minutes. Pour or pump 
rinsate into application equipment or rinsate collection system. Repeat this rinsing procedure 
two more times. Then offer for recycling if available or puncture and dispose of in a sanitary 
landfill, or by incineration, or by other procedures approved by state and local authorities.
CONTAINER IS NOT SAFE FOR FOOD, FEED, OR DRINKING WATER.

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10.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY 
AND LIABILITY
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not acceptable, 
return the product at once, unopened, and the purchase price will be refunded.
The Directions for Use of this product must be followed carefully. It is impossible to eliminate 
all risks inherently associated with the use of this product. Crop injury, ineffectiveness or 
other unintended consequences may result because of such factors as manner of use or 
application, weather or crop conditions, presence of other materials or other influencing 
factors in the use of the product, which are beyond the control of SYNGENTA CROP 
PROTECTION, LLC or Seller. To the extent permitted by applicable law, Buyer and User 
agree to hold SYNGENTA and Seller harmless for any claims relating to such factors.
SYNGENTA warrants that this product conforms to the chemical description on the label and 
is reasonably fit for the purposes stated in the Directions for Use, subject to the inherent risks 
referred to above, when used in accordance with directions under normal use conditions. To 
the extent permitted by applicable law: (1) this warranty does not extend to the use of the 
product contrary to label instructions, or under conditions not reasonably foreseeable to or 
beyond the control of Seller or SYNGENTA, and (2) Buyer and User assume the risk of any 
such use. TO THE EXTENT PERMITTED BY APPLICABLE LAW, SYNGENTA MAKES NO 
WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE 
NOR ANY OTHER EXPRESS OR IMPLIED WARRANTY EXCEPT AS WARRANTED BY 
THIS LABEL.
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any 
incidental, consequential or special damages resulting from the use or handling of this 
product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE 
REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF SYNGENTA 
AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR DAMAGES 
(INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, CONTRACT, 
NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) RESULTING FROM THE 
USE OR HANDLING OF THIS PRODUCT, SHALL BE THE RETURN OF THE PURCHASE 
PRICE OF THE PRODUCT OR, AT THE ELECTION OF SYNGENTA OR SELLER, THE 
REPLACEMENT OF THE PRODUCT.
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

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Page 19
The ALLIANCE FRAME
the SYNGENTA Logo, and the PURPOSE ICON
are Trademarks of a Syngenta Group Company 
Viton® is a registered trademark of E.I. DuPont de Nemours & Company, Inc.
©20XX Syngenta
For non-emergency (e.g. current product information), call
Syngenta Crop Protection at 1-800-334-9481.
Manufactured for:
Syngenta Crop Protection, LLC
P.O. Box 18300
Greensboro, North Carolina 27419-8300
A22353 1638 MAS 0718 AMEND-B-MAY2019-CL – jeb – 04/18/2022
000100-01638.20190516B.A22353-AMEND-0519-CL.pdf