crop-chem-docs/corpus/epa_ppls/100-913.md

# ENDEAVOR

- EPA Reg No: **100-913**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Pymetrozine (50%)
- Label accepted: 2026-02-04
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-00913-20260204.pdf

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February 4, 2026 
 
Victoria Kleczewski Ph.D. 
Regulatory Manager 
Syngenta Crop Protection, LLC 
P. O. Box 18300 
Greensboro, NC 27419 
 
Subject: Label Amendment - Registrati on Review Mitigation for Pymetrozine 
 Product Name: ENDEAVOR 
 EPA Registration Number: 100-913 
Case Number: 480478 
Application Dates: December 17, 2020 
 
Dear Victoria Kleczewski: 
 
The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), 
as amended, has completed reviewing all the information submitted with your application to 
support the Registration Review of the above referenced product in connection with the 
Pymetrozine Interim Decision, and has concluded that your submission is acceptable. The label 
referred to above, submitted in connection with registration under FIFRA, as amended, is 
acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please 
be aware that the website becomes labeling under the Federal Insecticide, Fungicide, and 
Rodenticide Act and is subject to review by the Agency. If the website is false or misleading, the 
product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 
40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In 
addition, regardless of whether a website is referenced on your product’s label, claims made on 
the website may not substantially differ from those claims approved through the registration 
process. Therefore, should the Agency find or if it is brought to our attention that a website 
contains false or misleading statements or claims substantially differing from the EPA approved 
registration, the website will be referred to the EPA’s Office of Enforcement and Compliance 
Assurance. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes 
all previously accepted labeling and must be used at your next label printing. You must 
submit one copy of the final printed labeling before you release the product for

Page 2 of 2 
EPA Reg. No. 100-913 
Case No. 480478 
 
shipment with the new labeling. In accordance with 40 CFR 152.130(c), you may 
distribute or sell this product under the previously approved labeling for 12 months 
from the date of this letter. After 12 months, you may only distribute or sell this 
product if it bears this new revised labeling or subsequently approved labeling. “To 
distribute or sell” is defined under FIFRA section 2(gg) and its implementing regulation 
at 40 CFR 152.3. 
 
If you have any questions about this letter, please contact Caleb Carr by phone at 202-566-
0635, or via email at carr.caleb@epa.gov. 
 
 S i n c e r e l y , 
 
 
Julie Javier, Team Leader 
Risk Mitigation and Implementation Branch 4 
Pesticide Re-Evaluation Division 
Office of Pesticide Programs 
 
ENCLOSURE: Stamped label

(Master) 
Endeavor®
Insecticide 
PYMETROZINE GROUP 9B INSECTICIDE
For control of listed insect pests on landscape and interiorscape ornamentals, field-
grown and container-grown ornamentals, Christmas trees, and non-bearing fruit and nut 
trees produced in greenhouses, nurseries, lath and shade houses, and other outdoor 
growing structures.
For control of listed insect pests on vegetable plants grown for sale to consumers and 
produced in greenhouses, nurseries, lath and shade houses, and other outdoor growing 
structures. 
Active Ingredient:
Pymetrozine* .............................................................................................. 50.0%
Other Ingredients: 50.0%
Total: 100.0%
* CAS No. 123312-89-0 
Endeavor is formulated as a water-dispersible granule.
KEEP OUT OF REACH OF CHILDREN.
CAUTION
See additional precautionary statements and directions for use in booklet.
EPA Reg. No. 100-913
EPA Est. 
Product of XXX
Formulated in XXX
SCP 913 MAS 
Net Weight
Feb 4, 2026
100-913

Endeavor 
2 
 
 
TABLE OF CONTENTS 
1.0 FIRST AID 
2.0 PRECAUTIONARY STATEMENTS 
2.1 Hazards to Humans and Domestic Animals 
2.2 Personal Protective Equipment 
2.2.1 User Safety Requirements 
2.2.2 Engineering Controls 
2.3 Environmental Hazards 
2.4 Physical or Chemical Hazards 
DIRECTIONS FOR USE 
3.0 PRODUCT INFORMATION 
3.0.1 Mode of Action 
3.0.2 Plant Safety 
3.1 Resistance Management 
3.1.1 Suitability for Integrated Pest Management Programs 
4.0 APPLICATION DIRECTIONS 
4.1 Methods of Application 
 4.1.1 Foliar Application 
 4.1.2 Drench Application to Soil Media 
4.2 Application Equipment 
4.3 Application Volume and Spray Coverage 
4.4 Mixing Directions 
4.4.1 Endeavor Alone 
4.4.2 Tank Mix Precautions 
4.4.3 Tank Mix Compatibility 
4.4.4 Endeavor in Tank Mixtures 
4.4.5 Spray Additives 
4.5 Application through Irrigation Systems (Chemigation) 
5.0 RESTRICTIONS AND PRECAUTIONS 
5.1 Use Restrictions 
 5.2 Spray Drift Management for Outdoor Applications 
6.0 APPLICATION DIRECTIONS - FOLIAR 
7.0 APPLICATION DIRECTIONS - DRENCH 
8.0 APPLICATION DIRECTIONS - FOLIAR - Vegetable Plants 
9.0 STORAGE AND DISPOSAL 
10.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY

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1.0 FIRST AID 
FIRST AID 
If in eyes x Hold eye open and rinse slowly and gently with water for 15–20 
minutes. 
x Remove contact lenses, if present, after the first 5 minutes, then 
continue rinsing eye. 
x Call a poison control center or doctor for treatment advice. 
If on skin or 
clothing 
x Take off contaminated clothing. 
x Rinse skin immediately with plenty of water for 15-20 minutes. 
x Call a poison control center or doctor for treatment advice. 
If inhaled x Move person to fresh air. 
x If person is not breathing, call 911 or an ambulance, then give 
artificial respiration, preferably by mouth-to-mouth, if possible. 
x Call a poison control center or doctor for further treatment 
advice. 
If swallowed x Call a poison control center or doctor immediately for treatment 
advice. 
x Have person sip a glass of water if able to swallow. 
x Do not induce vomiting unless told to do so by the poison 
control center or doctor. 
x Do not give anything by mouth to an unconscious person. 
Have the product container or label with you when calling a poison control center or 
doctor, or going for treatment. 
HOT LINE NUMBER 
For 24-Hour Medical Emergency Assistance (Human or Animal) or 
Chemical Emergency Assistance (Spill, Leak, Fire, or Accident), 
Call 
1-800-888-8372 
 
 
2.0 PRECAUTIONARY STATEMENTS 
 
2.1 Hazards to Humans and Domestic Animals 
 
CAUTION 
 
Causes moderate eye irritation. Harmful if absorbed through skin. Avoid contact with 
eyes, skin, or clothing. Wash thoroughly with soap and water after handling and before 
eating, drinking, chewing gum, using tobacco, or using the toilet.

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2.2 Personal Protective Equipment 
 
All applicators and other handlers must wear: 
x Long-sleeved shirt and long pants 
x Chemical-resistant gloves made of: barrier laminate, butyl rubber •PLOV, nitrile 
rubber •PLOV, neoprene rubber •PLOV, natural rubber •PLOV, 
polyethylene, polyvinylchloride (PVC) •PLOV or Viton® •PLOV. 
x Shoes plus socks 
 
In addition, mixers and loaders supporting chemigation applications must wear: 
x A minimum of a NIOSH-approved particulate filtering facepiece respirator with any N, R, 
or P filter; OR a NIOSH-approved elastomeric particulate respirator with any N, R, or P 
filter; OR a NIOSH-approved powered air purifying respirator with HE filters. 
 
2.2.1 User Safety Requirements 
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such 
instructions for washables exist, use detergent and hot water. Keep and wash PPE 
separately from other laundry. 
 
2.2.2 Engineering Controls 
 
When handlers use closed systems, enclosed cabs, or aircraft in a manner that 
meets the requirements listed in the Worker Protection Standard (WPS) for 
agricultural pesticides [40 CFR 170.240(d)(4-6)], the handler PPE requirements 
may be reduced or modified as specified in the WPS. 
 
User Safety Recommendations 
Users should: 
x Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. 
x Remove clothing immediately if pesticide gets inside. Then wash thoroughly and put 
on clean clothin
g. 
 
2.3 Environmental Hazards 
 
Do not apply directly to water, or to areas where surface water is present, or to intertidal 
areas below the mean high water mark. Do not contaminate water when cleaning 
equipment or disposing of equipment wash water. 
 
2.4 Physical or Chemical Hazards 
 
Do not use, pour, spill, or store near heat or open flame.

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DIRECTIONS FOR USE 
 
It is a violation of Federal Law to use this product in a manner inconsistent with its 
labeling. 
 
Do not apply this product in a way that will contact workers or other persons, either 
directly or through drift. Only protected handlers may be in the area during application. 
For any requirements specific to your State or Tribe, consult the agency responsible for 
pesticide regulation. 
 
FAILURE TO FOLLOW DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY 
RESULT IN CROP INJURY AND/OR POOR INSECT CONTROL. 
 
AGRICULTURAL USE REQUIREMENTS 
 
Use this product only in accordance with its labeling and with the Worker Protection 
Standard, 40 CFR part 170. This Standard contains requirements for the protection of 
agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 
agricultural pesticides. It contains requirements for training, decontamination, 
notification, and emergency assistance. It also contains specific instructions and 
exceptions pertaining to the statements on this label about personal protective 
equipment (PPE) and restricted-entry interval. The requirements in this box only apply 
to uses of this product that are covered by the Worker Protection Standard. 
 
Do not enter or allow worker entry into treated areas during the restricted entry 
interval (REI) of 12 hours. 
 
PPE required for early entry to treated areas that is permitted under the Worker 
Protection Standard and that involves contact with anything that has been treated, such 
as plants, soil, or water is: 
 
 • Long-sleeved shirt and long pants 
 • Chemical-resistant gloves made of: barrier laminate, butyl rubber •PLOV, nitrile 
rubber •PLOV, neoprene rubber •PLOV, natural rubber •PLOV, 
polyethylene, polyvinyl chloride (PVC) •PLOV or Viton •PLOV. 
 • Shoes plus socks
 
 
NON-AGRICULTURAL USE REQUIREMENTS 
 
The requirements in this box apply to uses of this product that are NOT within the scope 
of the Worker Protection Standard for agricultural pesticides (40 CFR Part 170). The 
WPS applies when this product is used to produce agricultural plants on farms, forests, 
nurseries, or greenhouses. 
 
Do not enter treated areas without protective clothin
g until sprays have dried.

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3.0 PRODUCT INFORMATION 
 
Endeavor is an insecticide that controls aphids and whiteflies on landscape 
ornamentals; field-grown ornamentals; container-grown ornamentals; non-bearing fruit 
and nut trees in nurseries; Christmas trees; ground covers; ornamental plants in 
greenhouses, lath houses and shade houses, and interiorscapes; and vegetable plants 
grown for sale to consumers and produced in greenhouses, nurseries, lath and shade 
houses, and other outdoor growing structures. 
 
3.0.1 MODE OF ACTION 
Endeavor has a mode of action that controls aphids and whiteflies by stopping their 
feeding activity. These insects stop feeding within hours, but remain on the plant for a 
short time (2-4 days). Endeavor has residual activity in the plant and will control aphids 
and whiteflies that move onto the plant after spraying. 
 
3.0.2 PLANT SAFETY 
Endeavor has been evaluated for phytotoxicity on many greenhouse, nursery, and 
ornamental plants. All plants tested under university research and commercial 
production conditions have not shown phytotoxicity at labeled rates of Endeavor. While 
many species and cultivars have been tested, a small group of each specie and cultivar 
should be evaluated for phytotoxicity two weeks prior to making applications to the 
entire crop. Foliar applications should not be made to poinsettias after bract formation. 
 
3.1 Resistance Management 
 
PYMETROZINE GROUP 9B INSECTICIDE 
For resistance management, Endeavor contains a Group 9B/pymetrozine insecticide. Any insect 
population may contain individuals naturally resistant to Endeavor and other Group 9B 
insecticides. The resistant individuals may domi nate the insect population if this group of 
insecticides are used repeatedly in the same areas. Appropriate resistance-management 
strategies should be followed. 
 
Other Insect Resistance Management (IRM) Practices 
To delay insecticide resistance, take the following steps: 
 
x Rotate the use of Endeavor or other Group 9B insecticides within a growing season, or 
among growing seasons, with different groups that control the same pests. 
x Use tank mixtures with insecticides from a different group that are equally effective on 
the target pest when such use is permitted. Do not rely on the same mixture repeatedly 
for the same pest population. Consider any known cross-resistance issues (for the 
targeted pests) between the individual components of a mixture. In addition, consider the 
following recommendations provided by the Insecticide Resistance Action Committee 
(IRAC): 
o Individual insecticides selected for use in mixtures should be highly effective and 
be applied at the rates at which they are individually registered for use against

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the target species. 
o Mixtures with components having the same IRAC mode of action classification 
are not recommended for insect resistance management. 
o When using mixtures, consider any known cross-resistance issues between the 
individual components for the targeted pest(s). 
o Mixtures become less effective if resistance is already developing to one or both 
active ingredients, but they may still provide pest management benefits. 
o The insect resistance management benefits of an insecticide mixture are greatest 
if the two components have similar periods of residual insecticidal activity. 
Mixtures of insecticides with unequal periods of residual insecticide activity may 
offer an insect resistance management benefit only for the period where both 
insecticides are active. 
x Adopt an integrated pest management program for insecticide use that includes 
scouting, uses historical information related to pesticide use, record keeping, and which 
considers cultural, biological and other chemical control practices. 
x Monitor after application for unexpected target pest survival. If the level of survival 
suggests the presence of resistance, consult with your local university specialist or 
certified pest control advisor. 
Contact your local Syngenta representative, retailer, or extension specialist for any additional 
pesticide resistance-management and/or IPM recommendations for the specific site and pest 
problems in your area.

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3.1.1 SUITABILITY FOR INTEGRATED PEST MANAGEMENT PROGRAMS 
 
Endeavor is suitable for Integrated Pest Management (IPM) programs as it has a low 
toxicity to beneficial insects (including honeybees and bumblebees) and mite 
populations. 
 
4.0 APPLICATION DIRECTIONS 
4.1 Methods of Application 
4.1.1 FOLIAR APPLICATION 
 
Foliar application rates are listed in Section 6.0. Apply Endeavor when pest 
populations are low to prevent the increase of that population to damaging levels. 
 
When making foliar applications to plants with hard-to-wet foliage, such as holly, ivy, or 
pine, the addition of a non-ionic or organosilicone-based surfactant to improve coverage 
is recommended. Follow product’s use directions and rate recommendations. If 
concentrate, mist-type or other low volume application equipment is used to apply 
Endeavor, apply the same amount of product per area as you would use if applying with 
higher application volumes. 
 
4.1.2 DRENCH APPLICATION TO SOIL MEDIA 
 
Endeavor can be applied to the growing media of containerized plants to control listed 
pests. Apply Endeavor when pest populations are low to prevent the increase of that 
population to damaging levels. Apply to moist soil media. Avoid leaching. For 
application to transplanted plugs and liners, do not apply drench to soil media until root 
growth has resumed. Excessive irrigation after application could reduce insect control. 
 
For drench applications, prepare a dilute drench solution by mixing Endeavor in water at 
the rate listed in Section 7.0. Apply drench solution to containers, flats, trays, benches 
or beds according to the application rates given in Section 7.0. Drench volume should 
be sufficient to thoroughly wet soil media without overflowing or leaching from the 
container. Irrigate during the next seven days following treatment to avoid leaching.

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4.2 Application Equipment 
x Use sprayer nozzles that provide accurate, uniform application to provide best 
control. 
x Calibrate sprayer to insure delivery of adequate spray volume per unit area. 
x To avoid spray drift, do not apply when co nditions favor drift beyond the target area. 
x Avoid spray overlap, as crop injury may occur. 
 
4.3 Application Volume and Spray Coverage 
x Use sufficient water to provide thorough, uniform coverage. 
 
4.4 Mixing Directions 
x Prepare no more spray mixture than is needed for the immediate operation. 
x Thoroughly clean spray equipment before using this product. 
x Vigorous agitation is necessary for proper dispersal of the product. 
x Maintain maximum agitation throughout the spraying operation. 
x Do not let the spray mixture stand overnight in the spray tank. 
x Flush the spray equipment thoroughly following each use and apply the rinsate to a 
previously treated area. 
 
4.4.1 Endeavor Alone 
1. Add ½ of the required amount of water to the mix tank. 
2. With the agitator running, add the Endeavor to the tank. 
3. Continue agitation while adding the remainder of the water. 
4. Begin application of the solution after the Endeavor has completely dispersed into 
the mix water. 
5. Maintain agitation until all of the mixture has been applied. 
 
4.4.2 Tank Mix Precautions 
x If using Endeavor in tank mixtures, all products in water-soluble packaging should be 
added to the tank before any other tank mix partner, including Endeavor. 
x Allow the water-soluble packaging to completely dissolve and the product(s) to 
completely disperse before adding any other tank mix partner to the tank. 
x It is the pesticide user’s responsibility to ensure that all products are 
registered for the intended use. Users must follow the most restrictive 
directions for use and precautionary statements of each product in the tank 
mixture. No label dosage rate should be exceeded. This product should not be 
mixed with any product which prohibits such mixing. Tank mixtures or other 
applications of products referenced on this label are permitted only in those states in 
which the referenced products are labeled. 
 
4.4.3 Tank Mix Compatibility 
Endeavor is compatible with most insecticide and fungicide products. However, the 
physical compatibility of Endeavor with tank mix partners should be tested before use. 
To determine the physical compatibility of Endeavor with other products, use a jar test.

Endeavor 
10 
 
 
 
Using a 1½ qt jar, add the proportionate amounts of the products to 1 qt of water. Add 
wettable powders and water-dispersible granular products first, then liquid flowables, 
and emulsifiable concentrates last. After thoroughly mixing, let stand for at least 5 
minutes. If the combination remains mixed or can be remixed readily, it is physically 
compatible. Once compatibility has been proven, use the same procedure for adding 
required ingredients to the spray tank. 
 
Compatibility Test: Since pesticides, adjuvants, and fertilizers can vary in quality, 
always check tank-mix compatibility with tank-mixed partners before each use. Be 
especially careful when using complete suspension or fluid fertilizers as carriers, as 
serious compatibility problems are more likely to occur with these products. Commercial 
application equipment may improve tank-mix compatibility in some instances. The 
following test assumes a spray volume of 25 gal/A. For other spray volumes, make 
appropriate changes in the components. Check tank-mix compatibility using this 
procedure: 
 
1. Add 1 pt of carrier (either the water or liquid fertilizer to be used in the spray 
operation) to each of two clear 1-qt jars with tight lids. 
 
2. To one of the jars, add ¼ tsp or 1.2 mL of a commercially available tank-mix 
compatibility agent approved for this use (¼ tsp is equivalent to 2 pt/100 gallons 
spray). Invert the jar, then shake or stir gently to ensure thorough mixing. 
 
3. To both jars, add the appropriate amount of each tank-mix partner. If more than one 
tank-mix partner is to be used, add them separately with dry formulations (wettable 
powders or water dispersible granules) first, followed by liquid flowables, capsule 
suspensions, emulsifiable concentrates and finally adjuvants. After each addition, 
invert the jar, shake or stir gently to thoroughly mix. The appropriate amount of 
each tank-mix partner for this test is as follows: 
 
Dry formulations: Add the tank-mix ingredients in their relative proportions, e.g., 
for each pound to be applied per acre, add 3/4 level tsp to each jar. 
 
Liquid formulations: Add the tank-mix ingredients in their relative proportions, 
e.g., for each pint to be applied per acre, add 0.5 tsp or 2.5 mL to each jar. 
 
4. After adding all ingredients, put lids on and tighten, then invert each jar 10 times to 
fully mix. Let the mixtures stand for 15-30 minutes and then assess by looking for 
separation, large flakes, precipitates, gels, heavy oily film on the jar, or other signs 
of incompatibility. Determine if a compatibility agent is needed in the spray mixture 
by comparing the two jars. If either mixture separates, but can be remixed readily, 
the mixture can be sprayed as long as good agitation is used. If the mixtures are 
incompatible, test the following methods of improving compatibility: (A) slurry dry 
formulations in water before addition, or (B) add the compatibility agent directly into

Endeavor 
11 
 
 
liquid formulations, before addition to the tank-mixture. If these procedures are 
followed but incompatibility is still observed, do not use the tank-mixture. 
 
4.4.4 Endeavor in Tank Mixtures 
1. If mixture is physically compatible, add ½ of the required amount of water to the mix 
tank. 
2. Start the agitator before adding any tank mix partners. 
3. Add products in this order: 
a. products packaged in water-soluble packaging 
b. wettable powders 
c. wettable granules (dry flowables) such as Endeavor 
d. liquid flowables 
e. liquids 
f. emulsifiable concentrates 
4. Always allow each tank mix partner to become fully dispersed before adding the next 
product. 
5. Provide sufficient agitation while adding the remainder of the water. 
6. Maintain agitation until all the mixture has been applied. 
 
4.4.5 Spray Additives 
x When an adjuvant is to be used with this product, the use of an adjuvant that meets 
the standards of the Council of Producers and Distributors of Agrotechnology 
(CPDA) adjuvant certification is recommended. 
x On hard-to-wet plants, add a nonionic or organosilicone-based surfactant to improve 
coverage. Follow product’s use directions and rate recommendations. 
 
4.5 Application through Irrigation Systems (Chemigation) 
 
4.5.1 CHEMIGATION 
Endeavor may be applied by injection into an irrigation system, either alone or in 
combination with other pesticides or chemicals that are registered for application 
through irrigation systems. Dilution ratios for Endeavor are normally 1:100 to 1:200 
depending on the system. 
 
Apply Endeavor to listed plants through micro-irrigation (individual spaghetti tube), drip 
irrigation, overhead irrigation, or motorized irrigation equipment. Apply Endeavor 
according to use directions and not according to the irrigation schedule unless the 
events coincide. In general, set the equipment to apply the minimum amount of water 
per acre. 
x Apply with center pivot or continuous-move equipment at a volume of ½ acre-inch 
or less during treatment. In general, use the least amount of water required for 
proper distribution and coverage. 
x If stationary systems are used, such as so lid set, hand lines or wheel lines other 
than continuous-move, this product should be injected into no more than the last 
20-30 minutes of the set.

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Specific Use Restrictions and Precautions for Chemigation (see also Section 5.0) 
x Do not apply through any type of irrigation system not listed on this label. 
x Do not make foliar applications when winds are greater than 10-15 mph to avoid 
drift or wind skips. 
x Do not connect an irrigation system, including greenhouse systems, used for 
pesticide application to a public water system, unless the pesticide label-prescribed 
safety devices for public water systems are in place (see Section 4.5.3 below). 
x Agitation must be maintained during the entire application period to ensure uniform 
chemigation. 
x For foliar applications, thorough coverage of foliage is required for best control. 
Crop injury or reduced effectiveness can result from non-uniform distribution. 
Excessive water may also reduce effectiveness. 
x Check with State and local regulatory agencies for potential use restrictions before 
applying any agricultural chemical through sprinkler irrigation equipment. 
 
A person knowledgeable of the chemigation system and responsible for its operation, or 
under the supervision of the responsible person, shall shut the system down and make 
adjustments when necessary. If you have questions about calibration, contact State 
Extension Service specialists, equipment manufacturers, or other experts. 
 
4.5.2 OPERATING INSTRUCTIONS FOR CHEMIGATION EQUIPMENT 
 
1. The system must contain a functional check-valve, vacuum relief valve, and low 
pressure drain appropriately located on the irrigation pipeline to prevent water-
source contamination from backflow. 
2. The pesticide injection pipeline must contain a functional, automatic, quick-closing 
check-valve to prevent the flow of fluid back toward the injection pump. 
3. The pesticide injection pipeline must also contain a functional, normally closed, 
solenoid-operated valve located on the intake side of the injection pump and 
connected to the system interlock to prevent fluid from being withdrawn from the 
supply tank when the irrigation system is either automatically or manually shut down. 
4. The system must contain functional interlo cking controls to automatically shut off the 
pesticide injection pump when the water pump motor stops. 
5. The irrigation line or water pump must in clude a functional pressure switch which will 
stop the water pump motor when the water pressure decreases to the point where 
pesticide distribution is adversely affected. 
6. Systems must use a metering pump, such as a positive displacement injection pump 
(e.g., diaphragm pump), effectively designed and constructed of materials that are 
compatible with pesticides and capable of being fitted with a system interlock. 
7. Do not apply when wind speed favors drift beyond the area intended.

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4.5.3 SPECIFIC INSTRUCTIONS FOR PUBLIC WATER SYSTEMS 
 
Public water system means a system for the provision to the public of piped water for 
human consumption if such system has at least 15 service connections or regularly 
serves an average of at least 25 individuals daily at least 60 days out of the year. 
 
1. Chemigation systems connected to public water systems must contain a functional, 
reduced-pressure zone, back-flow preventer (RPZ) or the functional equivalent in the 
water supply line upstream from the point of pesticide introduction. As an option to 
the RPZ, the water from the public water system should be discharged into a 
reservoir tank prior to pesticide introduction. There shall be a complete physical 
break (air gap) between the outlet end of the fill pipe and the top or overflow rim of 
the reservoir tank of at least twice the inside diameter of the fill pipe. 
2. The pesticide injection pipeline must contain a functional, automatic, quick-closing 
check valve to prevent the flow of fluid back toward the injection pump. 
3. The pesticide injection pipeline must contain a functional, normally closed, solenoid-
operated valve located on the intake side of the injection pump and connected to the 
system interlock to prevent fluid from being withdrawn from the supply tank when the 
irrigation system is either automatically or manually shut down. 
4. The system must contain functional interlo cking controls to automatically shut off the 
pesticide injection pump when the water pump motor stops, or in cases where there 
is no water pump, when the water pressure decreases to the point where pesticide 
distribution is adversely affected. 
5. Systems must use a metering pump, such as a positive displacement injection pump 
(e.g., diaphragm pump) effectively designed and constructed of materials that are 
compatible with pesticides and capable of being fitted with a system interlock. 
6. Do not apply when wind speed favors drift beyond the area intended for treatment. 
 
5.0 RESTRICTIONS AND PRECAUTIONS 
See Section 6.0 and Section 7.0 for use-specific restrictions and precautions. 
 
5.1 Use Restrictions 
x DO NOT apply aerially. 
x FOR PLANTS GROWN IN CONTAINERS: 
o DO NOT apply within 900 feet of any well where depth to groundwater is 
less than 30 feet; OR 
o If depth of the groundwater is less than 30 feet, a runoff and leaching 
management system is required. 
x FOR PLANTS GROWN IN GROUND: 
o DO NOT apply if: 
ƒ Soil contains greater than 60% sand AND 
ƒ Soil contains less than 3% organic matter AND 
ƒ Depth to groundwater is less than 30 feet

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14 
 
 
5.2 Spray Drift Management for Outdoor Applications 
Spray Drift Advisories 
THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE DRIFT. BE AWARE 
OF NEARBY NON-TARGET SITES AND ENVIRONMENTAL CONDITIONS
 
 
Importance of Droplet Size 
An effective way to reduce spray drift is to apply large droplets. Use the largest droplets 
that will provide target pest control. While applying larger droplets will reduce spray drift, 
the potential for drift will be greater if applications are made improperly or under 
unfavorable environmental conditions. 
 
 
Controlling Droplet Size – Ground Boom 
x Volume - Increasing the spray volume so that larger droplets are produced will 
reduce spray drift. Use the highest practical spray volume for the application. If a 
greater spray volume is needed, consider using a nozzle with a higher flow rate. 
x Pressure - Use the lowest spray pressure recommended for the nozzle to produce 
the target spray volume and droplet size. 
x Spray Nozzle - Use a spray nozzle that is designed for the intended application. 
Consider using nozzles designed to reduce drift. 
 
Boom Height – Ground Boom 
For ground equipment, the boom should remain level with the turf and have minimal 
bounce.
 
 
Shielded Sprayers 
Shielding the boom or individual nozzles can reduce spray drift. Consider using shielded 
sprayers. Verify that the shields are not interfering with the uniform deposition of the 
spray on the target area. 
 
 
Temperature and Humidity 
When making applications in hot and dry conditions, use larger droplets to reduce 
effects of evaporation. 
 
Temperature Inversions 
Drift potential is high during a temperature inversion. Temperature inversions are 
characterized by increasing temperature with altitude and are common on nights with 
limited cloud cover and light to no wind. The presence of an inversion can be indicated 
by ground fog or by the movement of smoke from a ground source or an aircraft smoke 
generator. Smoke that layers and moves laterally in a concentrated cloud (under low 
wind conditions) indicates an inversion, while smoke that moves upward and rapidly 
dissipates indicates good vertical air mixing. Avoid applications during temperature 
inversions. 
 
Wind 
Drift potential generally increases with wind speed. AVOID APPLICATIONS DURING 
GUSTY WIND CONDITIONS.

Endeavor 
15 
 
 
 
Handheld Technology Applications: 
Take precautions to minimize spray drift

Endeavor 
16 
 
 
6.0 APPLICATION DIRECTIONS - FOLIAR 
Ornamental Plants 
Breeding crops 
Bulb, corm and tuber crops 
(such as tulips, calla lilies) 
Evergreens, including conifers 
Flowering plants 
 
Flowering plants 
grown for seed 
production 
Foliage plants 
Ground covers 
Palms 
Perennial plants 
Pot and bedding plants 
Shrubs 
Trees, including non-bearing fruit 
and nut trees* 
Vines (non-bearing)* 
 
Target Pest Rate Application Timing Use Directions 
Whiteflies, 
including: 
Silverleaf whitefly 
 ( Bermisia 
argentifolii) 
 
Greenhouse Whitefly 
 (Trialeutrodes 
vaporariorum) 
 
Aphids including: 
Green Peach Aphid 
 (Myzus persica) 
 
Melon Aphid 
 (Aphis gossypii) 
2.5- 5.0 oz 
100 gal 
 
10 oz/A 
(maximum 
rate) 
Apply when target pests 
appear and conditions 
do not favor drift beyond 
the target area. 
 
Application interval: 
7-days - severe insect 
pressure 
 
14-days - normal 
insect pressure 
Apply by foliar spray or 
chemigation. Apply foliar 
spray mixture uniformly to 
all plant surfaces, 
particularly the stem and 
leaf undersides, to point of 
runoff. See Section 4.5 for 
additional chemigation 
instructions. 
 
On hard-to-wet plants, add 
a nonionic or 
organosilicone-based 
surfactant to improve 
coverage. Follow product’s 
use directions and rate 
recommendations. 
Precautions: 
x Avoid spray overlap that could cause phytotoxicity. 
x Applications should not be made to poinsettia after bract formation. 
USE RESTRICTIONS 
1) Refer to Section 5.1 for additional product use restrictions. 
2) Maximum Single Application Rate: 10 oz/A/application (0.31 lb ai/A of pymetrozine-
containing products) 
3) Minimum Application Interval: 7 days 
4) Maximum Annual Rate: 
a. Outdoor: 40 oz/A/year (1.25 lb ai/A /year of pymetrozine-containing products) 
b. Indoor: 100 oz/A/year (3.125 lb ai/A/y ear of pymetrozine-containing products) 
c. Do not apply more than 40 oz/A/year in CA (1.25 lb ai/A/year of pymetrozine-
containing products). 
5) Pre-Harvest Interval (PHI): NA 
*Non-bearing trees and vines are plants that will not bear edible fruit or nuts for one year after 
application.

Endeavor 
17 
 
 
7.0 APPLICATION DIRECTIONS - DRENCH 
 Ornamental Plants 
Breeding crops 
Bulb, corm and tuber crops 
(such as tulips, calla lilies) 
Evergreens, including conifers 
Flowering plants 
 
Flowering plants 
grown for seed 
production 
Foliage plants 
Ground covers 
Palms 
Perennial plants 
Pot and bedding plants 
Shrubs 
Trees, including non-bearing fruit and 
nut trees* 
Vines (non-bearing)* 
Target Pests Drench 
Solution 
Suggested Application 
Volumes** Use Directions 
Aphids 
Whiteflies
 
Silverleaf whitefly 
(Bermisia spp. – 
Biotype B & Q) 
Greenhouse Whitefly 
(Trialeurodes 
vaporariorum) 
 
 
5 oz per 100 
gallons 
 
 
Container 
Size 
(inches) 
Fl oz 
drench 
solution/ 
container 
4 3 
5 4 
6 4 
7 7 
8 10 
10 20-25 
 
For larger containers, apply 6 - 8 
fl oz of drench solution per 
gallon of soil media. 
 
For flats, trays, benches, or 
beds, apply sufficient amount of 
drench solution to adequately 
wet soil media without leaching. 
Apply by soil-
directed spray via 
ground application 
equipment or by 
chemigation. See 
Section 4.5 for 
additional 
chemigation 
instructions. 
 
Begin applications 
prior to or when 
pests first appear. 
 
Use higher listed 
rates when longer 
residual control is 
needed. 
 
**Adjust drench 
volume accordingly 
to ensure thorough 
wetting of the root 
zone without 
leaching product 
from the container. 
USE RESTRICTIONS 
1) Refer to Section 5.1 for additional product use restrictions. 
2) Maximum Single Application Rate: 10 oz/A/application (0.3125 lb ai/A of pymetrozine-
containing products) 
3) Minimum Application Interval: 7 days 
4) Maximum Annual Rate: 
a. Outdoor: 40 oz/A/year (1.25 lb ai/A/year of pymetrozine-containing products) 
b. Indoor: 100 oz/A/year (3.125 lb ai/A/year of pymetrozine-containing products) 
c. Do not apply more than 40 oz/A/year in CA (1.25 lb ai/A/year of pymetrozine-
containing products). 
5) Pre-Harvest Interval (PHI): NA

Endeavor 
18 
 
 
*Non-bearing trees and vines are plants that will not bear edible fruit or nuts for one year after 
application. 
 
 
8.0 APPLICATION DIRECTIONS - FOLIAR – Vegetable Plants 
 
Cole Crops 
 
Broccoli 
Broccoli raab 
Brussels sprouts 
Cabbage 
Cauliflower 
Cavalo broccolo 
 
Chinese broccoli 
Chinese cabbage (bok choy, 
napa) 
Chinese mustard cabbage 
Collards 
Kale 
Kohlrabi 
Mizuna 
Mustard greens 
Mustard spinach 
Rape greens 
Turnip greens 
Target Pests Application Rate Use Directions 
Aphids: 
Cabbage aphid 
Green peach aphid 
Turnip aphid 
Whiteflies (suppression) 
2.75 oz per A 
 
(0.31 oz per 5,000 sq ft) 
Apply by foliar spray or by 
chemigation. See Section 4.5 
for additional chemigation 
instructions. 
 
Apply when pests first appear, 
before populations build to 
damaging levels. 
 
Two applications on a 14-day 
interval may be needed to 
control persistent populations. 
 
Cucurbit Vegetables 
 
Chayote 
Chinese waxgourd 
Citron melon 
Cucumber 
 
 
Edible gourd 
Gherkin 
Momordica spp. 
Muskmelon 
 
Pumpkin 
Squash: 
summer, winter 
Watermelon 
Target Pests Application Rate Use Directions 
 
Aphids: 
Green peach aphid 
Melon aphid 
Whiteflies (suppression) 
 
 
2.75 oz per A 
 
(0.31 oz per 5,000 sq ft) 
 
Apply by foliar spray or by 
chemigation. See Section 4.5 
for additional chemigation 
instructions. 
 
Apply when pests first appear, 
before populations build to 
damaging levels.

Endeavor 
19 
 
 
Two applications on a 14-day 
interval may be needed to 
control persistent populations. 
 
Fruiting Vegetables 
 
Eggplant 
Ground cherry 
Pepino 
 
 
Peppers: bell, chili, cooking, 
pimento, and sweet 
Tomatillo 
 
Tomato 
Target Pests Application Rate Use Directions 
Aphids: 
Green peach aphid 
Potato aphid 
Whiteflies (suppression) 
2.75 oz per A 
 
(0.31 oz per 5,000 sq ft) 
Apply by foliar spray or by 
chemigation. See Section 4.5 
for additional chemigation 
instructions. 
 
Apply when pests first appear, 
before populations build to 
damaging levels. 
 
Two applications on a 14-day 
interval may be needed to 
control persistent populations. 
Leafy Vegetables 
Amaranth 
Arugula 
Cardoon 
Celery 
Celtuce 
Chervil 
Chinese celery 
Corn salad 
Dandelion 
Dock (sorrel) 
Edible-leaved 
chrysanthemum 
Endive (escarole) 
Fennel, Florence 
Garden/Upland cress 
Garden/Winter purslane 
Garland chr
ysanthemum 
Head lettuce 
Leaf lettuce 
Orach 
Parsley 
Radicchio 
Rhubarb 
Spinach 
Swiss chard 
Target Pests Application Rate Use Directions 
Aphids: 
Bean aphid 
Green peach aphid 
Lettuce aphid 
Potato aphid 
Red lettuce aphid 
Whiteflies 
2.75 oz per A 
 
(0.31 oz per 5,000 sq ft) 
Apply by foliar spray or by 
chemigation. See Section 4.5 
for additional chemigation 
instructions. 
 
Apply when pests first appear, 
before populations build to 
damaging levels. 
 
Two applications on a 14-day 
interval may be needed to 
control persistent populations. 
 
USE RESTRICTIONS

Endeavor 
20 
 
 
 
1. Refer to Section 5.1 for additional product use restrictions. 
2. Maximum Single Application Rate: 2.75 oz/A/application (0.086 lb ai/A of pymetrozine-
containing products) 
3. Maximum Rate Per Crop: 5.5 oz/A/crop (0.17 lb ai/A of pymetrozine-containing products) 
4. DO NOT make more than 2 applications per crop at the maximum single application rate 
5. Maximum Annual Rate: 
a. Outdoor: 40 oz/A/year (1.25 lb ai/A/year of pymetrozine-containing products) 
b. Indoor: 100 oz/A/year (3.125 lb ai/A/year of pymetrozine-containing products) 
c. Do not apply more than 40 oz/A/year in CA (1.25 lb ai/A/year of pymetrozine-
containing products) 
6. Apply only to vegetable plants grown for sale to consumers. 
7. Allow a minimum of 7 days (PHI) between last application and sale or shipping of 
vegetable plants intended for sale to consumers.

Endeavor 
21 
 
 
9.0 STORAGE AND DISPOSAL 
STORAGE AND DISPOSAL 
Do not contaminate water, food, or feed by storage or disposal. 
 
Pesticide Storage 
Store in original container, in a cool, dry place inaccessible to children and pets. 
Product is hydroscopic. Keep the container tightly closed. 
 
For minor spills, leaks, etc., follow all precautions indicated on this label and clean up 
immediately. Take special care to avoid contamination of equipment and facilities 
during cleanup procedures and disposal of wastes. 
 
Pesticide Disposal 
Pesticide wastes may be toxic. Improper disposal of unused pesticide, spray mixture, 
or rinse water is a violation of Federal Law. If these wastes cannot be used according 
to label instruction, contact your State Pesticide or Environmental Control Agency, or 
the Hazardous Waste representative at the nearest EPA Regional Office for guidance in 
proper disposal methods. 
 
Container Handling 
Non-refillable container. [(bags)] Do not reuse or refill this container. Completely 
empty bag into application equipment. Then offer for recycling if available or dispose of 
empty bag in a sanitary landfill, by incineration, or by other procedures approved by 
state and local authorities. 
 
 
Container Handling 
Non-refillable container. [(Plastic containers 50 pounds or less)] Do not reuse or refill 
this container. Triple rinse container (or equivalent) promptly after emptying. Triple 
Rinse as follows: Empty the remaining contents into application equipment or a mix 
tank. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate 
into application equipment or a mix tank or store rinsate for later use or disposal. Drain 
for 10 seconds after the flow begins to drip. Repeat this procedure two more times. 
Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by 
incineration. 
 
Container Handling 
Non-refillable container. [(Plastic containers larger than 50 pounds)] Do not reuse or 
refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple 
Rinse as follows: Empty the remaining contents into application equipment or a mix 
tank. Fill the container ¼ full with water. Replace and tighten closures. Tip container on 
its side and roll it back and forth, ensuring at least one complete revolution, for 30 
seconds. Stand the container on its end and tip it back and forth several times. Turn the 
container over onto its other end and tip it back and forth several times. Empty the 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal.

Endeavor 
22 
 
 
Repeat this procedure two more times. Then offer for recycling if available or puncture 
and dispose of in a sanitary landfill, or by incineration.

Endeavor 
23 
 
 
10.0 CONDITIONS OF SALE AND LIMITATION OF 
WARRANTY AND LIABILITY 
 
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not 
acceptable, return the product at once, unopened, and the purchase price will be 
refunded. 
 
The Directions for Use of this product must be followed carefully. It is impossible to 
eliminate all risks inherently associated with the use of this product. Crop injury, 
ineffectiveness or other unintended consequences may result because of such factors 
as manner of use or application, weather or crop conditions, presence of other materials 
or other influencing factors in the use of the product, which are beyond the control of 
SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by 
applicable law, Buyer and User agree to hold SYNGENTA and Seller harmless for any 
claims relating to such factors. 
 
SYNGENTA warrants that this product conforms to the chemical description on the label 
and is reasonably fit for the purposes stated in the Directions for Use, subject to the 
inherent risks referred to above, when used in accordance with directions under normal 
use conditions. To the extent permitted by applicable law: (1) this warranty does not 
extend to the use of the product contrary to label instructions, or under conditions not 
reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer 
and User assume the risk of any such use. TO THE EXTENT PERMITTED BY 
APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY 
OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR 
IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL. 
 
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for 
any incidental, consequential or special damages resulting from the use or handling of 
this product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE 
EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY 
OF SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES 
OR DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, 
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) 
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE 
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION 
OF SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT. 
 
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and of Liability, which may not 
be modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

Endeavor 
24 
 
 
Endeavor®, the ALLIANCE FRAME 
the SYNGENTA Logo and the PURPOSE ICON 
are Trademarks of a Syngenta Group Company 
 
Viton® is a trademark of E.I. DuPont de Nemours & Co. Inc. 
 
©20__ Syngenta 
 
For non-emergency (e.g. current product information), call 
Syngenta Crop Protection at 1-800-334-9481. 
 
Product of XXXXX 
 
Formulated in XXXX 
 
Manufactured for: 
Syngenta Crop Protection, LLC 
P.O. Box 18300 
Greensboro, North Carolina 27419-8300 
 
SCP 913 MAS 
 
Endeavor 913 MAS 1119 AMEND-C DEC2020-CL- jab-1/8/26 
000100-00913.20201217C.Endeavor.AMEND.1220-CL