crop-chem-docs/corpus/epa_ppls/7969-473.md

# Sphaerex Fungicide

- EPA Reg No: **7969-473**
- Registrant: BASF AGRICULTURAL SOLUTIONS US, LLC
- Signal word: Warning
- Active ingredients: Prothioconazole (18.19%); Metconazole (10.91%)
- Label accepted: 2022-02-25
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/007969-00473-20220225.pdf

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
Fast Track Label Acceptable v.20150320 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
February 25, 2022 
 
Rebecca Willis 
Product Registration Manager 
BASF Corporation, Agricultural Products 
P.O. Box 13528 
Research Triangle Park, NC 27709 
 
Subject: Label Amendment – Adding me-too uses for barley, oats, rye, and triticale; 
Incorporating Registration Review label mitigation for metconazole and 
prothioconazole. 
 Product Name: Sphaerex Fungicide 
 EPA Registration Number: 7969-473 
 Application Date: 4/20/2021 
 Decision Number: 580419 
 
Dear Rebecca Willis: 
 
The amended label referred to above, submitted in connection with registration under the Federal 
Insecticide, Fungicide and Rodenticide Act, as amended, is acceptable. This approval does not 
affect any conditions that were previously imposed on this registration. You continue to be 
subject to existing conditions on your registration and any deadlines connected with them. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes all 
previously accepted labeling. You must submit one copy of the final printed labeling before you 
release the product for shipment with the new labeling. In accordance with 40 CFR 152.130(c), 
you may distribute or sell this product under the previously approved labeling for 18 months 
from the date of this letter. After 18 months, you may only distribute or sell this product if it 
bears this new revised labeling or subsequently approved labeling. “To distribute or sell” is 
defined under FIFRA section 2(gg) and its implementing regulation at 40 CFR 152.3. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be 
aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide 
Act and is subject to review by the Agency. If the website is false or misleading, the product 
would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 
CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, 
regardless of whether a website is referenced on your product’s label, claims made on the 
website may not substantially differ from those claims approved through the registration process. 
Therefore, should the Agency find or if it is brought to our attention that a website contains false 
or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance.

Page 2 of 2 
EPA Reg. No. 7969-473 
Decision No. 580419 
 
Your release for shipment of the product constitutes acceptance of these conditions. If these 
conditions are not complied with, the registration will be subject to cancellation in accordance 
with FIFRA section 6. If you have any questions, please contact Stephanie Suarez by phone at 
202-566-2918, or via email at Suarez.Stephanie@epa.gov
 . 
 
 
Nathan Mellor, Product Manager 21 
Fungicide Branch 
Registration Division (7505P) 
Office of Pesticide Programs 
 
 
Enclosure

{Note to PM: Italicized text enclosed in “{ }” is information for the reviewer and not part of the label. 
[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.}
Metconazole Group 3 Fungicide
Prothioconazole Group 3 Fungicide
For disease control in wheat, barley, oats, rye, and triticale
Active Ingredients*:
metconazole: 5-[(4-chlorophenyl)methyl]-2,2-dimethyl-1- 
(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 .91%
prothioconazole: 2-[2-(1-chlorocyclopropyl)-3-(2-Chlorophenyl)-2- 
hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione . . . . . . . . . . . . . . . . . . . 18 .19%
Other Ingredients: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 .90%
Total: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .100 .00%
* SphaerexTM fungicide contains 0 .939 lb metconazole and 1 .565 lbs prothiconazole per gallon .
EPA Reg. No. 7969-473 EPA Est. No.
KEEP OUT OF REACH OF CHILDREN
WARNING/AVISO
Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en 
detalle . (If you do not understand this label, find someone to explain it to you in detail .)
See full label for complete First Aid, Precautionary Statements, Directions For Use, 
Conditions of Sale and Warranty, and state-specific crop and/or use site restrictions .
In case of an emergency endangering life or property involving this product, 
call day or night 1-800-832-HELP (4357).
Net Contents:
BASF Corporation 
26 Davis Drive, Research Triangle Park, NC 27709
02/25/2022
7969-473

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[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.}
Precautionary Statements
Hazards to Humans and Domestic Animals
WARNING. Causes substantial but temporary eye injury . 
Causes skin irritation . DO NOT get in eyes, on skin or on 
clothing . Wear appropriate protective eyewear (goggles, 
face shield, or safety glasses) . Harmful if swallowed or 
absorbed through skin . Harmful if inhaled . Avoid breathing 
vapor or spray mist . Wash thoroughly with soap and water 
after handling and before eating, drinking, chewing gum, 
using tobacco, or using the toilet . Wear long-sleeved shirt 
and long pants, shoes plus socks and appropriate 
 chemical-resistant/waterproof gloves . Remove and wash 
contaminated clothing before reuse .
Personal Protective Equipment (PPE)
Applicators and other handlers must wear:
• Protective eyewear
• Long-sleeved shirt and long pants
• Chemical-resistant gloves, including barrier laminate, 
butyl rubber, nitrile rubber, neoprene rubber, polyvinyl 
chloride, or viton
• Shoes plus socks
User Safety Requirements
Follow the manufacturer’s instructions for cleaning and 
maintaining PPE . If no such instructions for washables 
exist, use detergent and hot water . Keep and wash PPE 
separately from other laundry .
Engineering Controls
When handlers use closed systems, enclosed cabs, or air -
craft in a manner that meets the requirements listed in the 
Worker Protection Standard (WPS) for agricultural 
pesticides [40 CFR 170 .240 (d) (4-6)], the handler PPE 
requirements may be reduced or modified as specified in 
the WPS .
USER SAFETY RECOMMENDATIONS
Users should:
• Remove clothing/PPE immediately if pesticide gets 
inside . Then wash thoroughly and put on clean 
clothing .
• Remove clothing/PPE immediately after handling this 
product . Wash the outside of gloves before removing . 
As soon as possible, wash thoroughly and change into 
clean clothing .
Environmental Hazards
This pesticide is toxic to birds, mammals, fish, and aquatic 
invertebrates . Drift or runoff may be hazardous to aquatic 
organisms in water adjacent to treated areas .
DO NOT apply directly to water, or to areas where surface 
water is present, or to intertidal areas below the mean high 
water mark . DO NOT contaminate water when disposing 
of equipment washwater or rinsate .
This product may impact surface water quality because of 
runoff of rainwater . This is especially true for poorly drain-
ing soils and soils with shallow groundwater .
Groundwater Advisory
Degradates of prothioconazole are known to leach through 
soil into groundwater under certain conditions as a result 
of label use . These chemicals may leach into groundwater 
if used in areas where soils are permeable, particularly 
where the water table is shallow . 
FIRST AID
If in eyes
• Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes .
• Remove contact lenses, if present, after first 5 minutes; then continue rinsing .
• Call a poison control center for treatment advice .
If on skin
• Take off contaminated clothing .
• Rinse skin immediately with plenty of water for 15 to 20 minutes .
• Call a poison control center or doctor for treatment advice .
If swallowed
• Call a poison control center or doctor immediately for treatment advice .
• Have person sip a glass of water if able to swallow .
• DO NOT induce vomiting unless told to do so by a poison control center or doctor .
• DO NOT give anything by mouth to an unconscious person .
If inhaled
• Move person to fresh air .
• If person is not breathing, call 911 or an ambulance; then give artificial respiration, prefer-
ably mouth to mouth if possible .
• Call a poison control center or doctor for further treatment advice .
HOTLINE NUMBER
Have the product container or label with you when calling a poison control center or doctor or going for treatment . 
You may also contact BASF Corporation for emergency medical treatment information: 1-800-832-HELP (4357) .

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[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.}
Surface Water Advisory
This product may impact surface water quality due to run -
off of rain water . This product is classified as having a high 
potential for reaching surface water via runoff for several 
months or more after application . Poorly draining soils or 
soils with shallow water tables are more prone to produce 
runoff that contains this product . A level, well-maintained 
vegetative buffer strip between areas to which this product 
is applied and surface water features including ponds, 
streams, and springs will reduce the potential for contami -
nation of water from rainfall runoff . Runoff of this product 
will be reduced by avoiding applications when rainfall is 
forecast to occur within 48 hours .
Directions For Use
It is a violation of federal law to use this product in a man-
ner inconsistent with its labeling . This labeling must be in 
the user’s possession during application .
Read the entire label . Use strictly in accordance with pre-
cautionary statements and directions and with applicable 
state and federal regulations .
DO NOT apply this product in a way that will contact 
workers or other persons, either directly or through drift . 
Only protected handlers may be in the area during applica -
tion . For any requirements specific to your state or tribe, 
consult the agency responsible for pesticide regulation .
AGRICULTURAL USE REQUIREMENTS
Use this product only in accordance with its labeling and 
with the Worker Protection Standard, 40 CFR Part 170 . 
This standard contains requirements for the protection 
of agricultural workers on farms, forests, nurseries, and 
greenhouses, and handlers of agricultural pesticides . It 
contains requirements for training, decontamination, 
notification, and emergency assistance . It also contains 
specific instructions and exceptions pertaining to the 
statements on this label about personal protective 
equipment (PPE), restricted-entry interval, and notifica -
tion to workers . The requirements in this box only apply 
to uses of this product that are covered by the Worker 
Protection Standard .
DO NOT enter or allow worker entry into treated areas 
during the restricted-entry interval (REI) of 12 hours .
PPE required for early entry to treated areas that is per-
mitted under the Worker Protection Standard and that 
involves contact with anything that has been treated, 
including plants, soil, or water, is:
• Protective eyewear
• Coveralls
• Chemical-resistant gloves, made of any waterproof 
material (including nitrile, butyl, neoprene, and/or barri -
er laminate)
• Shoes plus socks
STORAGE AND DISPOSAL
DO NOT contaminate water, food, or feed by storage or 
disposal .
Pesticide Storage
Store in original containers only . Keep container closed 
when not in use . DO NOT store near food or feed .
DO NOT store below 10° F .
Pesticide Disposal
Pesticide wastes may be hazardous . Improper disposal 
of excess pesticide, spray mixture or rinsate is a violation 
of Federal Law . If these wastes cannot be disposed of 
by use according to label instructions, contact your 
State Pesticide or Environmental Control Agency, or the 
Hazardous Waste representatives at the nearest EPA 
Regional Office for guidance .
Container Handling
Nonrefillable Container. DO NOT reuse or refill this 
container . Triple rinse or pressure rinse container (or 
equivalent) promptly after emptying; then offer for recy -
cling, if available, or reconditioning, if appropriate, or 
puncture and dispose of in a sanitary landfill, or by incin -
eration, or by other procedures approved by state and 
local authorities .
Triple rinse containers small enough to shake 
(capacity ≤ 5 gallons) as follows: Empty the remain-
ing contents into application equipment or a mix tank 
and drain for 10 seconds after the flow begins to drip . Fill 
the container 1/4 full with water and recap . Shake for 
10 seconds . Pour rinsate into application equipment or a 
mix tank, or store rinsate for later use or disposal . Drain 
for 10 seconds after the flow begins to drip . Repeat this 
procedure two more times .
Triple rinse containers too large to shake 
 (capacity > 5 gallons) as follows: Empty the remain-
ing contents into application equipment or a mix tank . 
Fill the container 1/4 full with water . Replace and tighten 
closures . Tip container on its side and roll it back and 
forth, ensuring at least one complete revolution, for 
30 seconds . Stand the container on its end and tip it 
back and forth several times . Turn the container over 
onto its other end and tip it back and forth several times . 
Empty the rinsate into application equipment or a mix 
tank, or store rinsate for later use or disposal . Repeat 
this procedure two more times .
Pressure rinse as follows: Empty the remaining con-
tents into application equipment or mix tank and 
continue to drain for 10 seconds after the flow begins to 
drip . Hold container upside down over application 
equipment or mix tank, or collect rinsate for later use or 
disposal . Insert pressure rinsing nozzle in the side of the 
container and rinse at about 40 PSI for at least 30 sec -
onds . Drain for 10 seconds after the flow begins to drip .
(continued)

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STORAGE AND DISPOSAL (continued)
Container Handling (continued)
Refillable Container. Refill this container with pesticide 
only . DO NOT reuse this container for any other pur-
pose . Triple rinsing the container before final disposal is 
the responsibility of the person disposing of the contain -
er . Cleaning before refilling is the responsibility of the 
refiller .
Triple rinse as follows: To clean the container before 
final disposal, empty the remaining contents from this 
container into application equipment or mix tank . Fill the 
container about 10% full with water . Agitate vigorously or 
recirculate water with the pump for 2 minutes . Pour or 
pump rinsate into application equipment or rinsate col -
lection system . Repeat this rinsing procedure two more 
times .
When this container is empty, replace the cap and seal 
all openings that have been opened during use; return 
the container to the point of purchase or to a designated 
location . This container must only be refilled with a pesti-
cide product . Prior to refilling, inspect carefully for 
damage including cracks, punctures, abrasions, worn-
out threads and closure devices . Check for leaks after 
refilling and before transport . DO NOT transport if this 
container is damaged or leaking . If the container is dam-
aged, or leaking, or obsolete and not returned to the 
point of purchase or to a designated location, triple rinse 
emptied container and offer for recycling, if available, or 
dispose of container in compliance with state and local 
regulations .
In Case of Emergency
In case of large-scale spill of this product, call:
• CHEMTREC 1-800-424-9300
• BASF Corporation 1-800-832-HELP (4357)
In case of medical emergency regarding this product, call:
• Your local doctor for immediate treatment
• Your local poison control center (hospital)
• BASF Corporation 1-800-832-HELP (4357)
Steps to take if material is released or spilled:
• In case of spill on floor or paved surfaces, mop and 
remove to chemical waste storage area until proper dis-
posal can be made if product cannot be used according 
to label .
• Dike and contain the spill with inert material (sand, earth, 
etc .) and transfer liquid and solid diking material to sepa -
rate containers for disposal .
• Remove contaminated clothing and wash affected skin 
areas with soap and water .
• Wash clothing before reuse .
• Keep the spill out of all sewers and open bodies of water .
Product Information
SphaerexTM fungicide is a broad-spectrum fungicide 
containing the active ingredients metconazole and 
 prothioconazole for use in wheat, barley, oats, rye, and 
 triticale . For optimum disease control, apply Sphaerex in 
a regularly scheduled protective spray program and use in 
a rotation program with non-Group 3 fungicides .
Mode of Action
Metconazole and prothioconazole, the active ingredients in 
Sphaerex, inhibit the demethylation step of sterol biosyn-
thesis (DMI), which disrupts cell membrane synthesis and 
are classified by the Fungicide Resistance Action Commit -
tee (FRAC) as Group 3 fungicides .
Resistance Management
Sphaerex contains Group 3 fungicides . Any fungal 
 population may contain individuals naturally resistant to 
Sphaerex and other Group 3 fungicides . A gradual or 
total loss of pest control may occur over time if these fun-
gicides are used repeatedly in the same fields . Follow 
appropriate resistance management strategies .
To delay fungicide resistance, take one or more of 
the following steps:
• Rotate the use of Sphaerex or other Group 3 fungi-
cides within a growing season sequence with different 
groups that control the same pathogens .
• Use tank mixtures with fungicides from a different group 
that are equally effective on the target pest when such 
use is permitted . Use at least the minimum application 
rate as labeled by the manufacturer .
• Adopt an integrated disease management program for 
fungicide use that includes scouting, uses historical infor-
mation related to pesticide use, and crop rotation, and 
which considers host plant resistance, impact of environ -
mental conditions on disease development, disease 
thresholds, as well as cultural, biological and other 
chemical control practices .
• Where possible, make use of predictive disease models 
to effectively time fungicide applications . Note that using 
predictive models alone is not sufficient to manage 
resistance .
• Monitor treatment area for lack of biological efficacy that 
might indicate possible resistance development .
• Contact your local extension specialist or certified crop 
advisor for any additional pesticide resistance- 
management and/or Integrated Pest Management 
(IPM) guidance for specific crops and pathogens .
• For further information or to report suspected resistance, 
consult your local BASF representative, extension spe -
cialist, or certified crop advisor .

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[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.}
Application Instructions
• SphaerexTM fungicide can be applied by ground or air, 
and through field sprinkler irrigation (chemigation) systems .
• Application equipment, including injection systems, must 
be cleaned thoroughly before and after applying this 
product, particularly if a product with the potential to 
injure crops was used before application of Sphaerex . 
Flush system with clean water .
Use Rate Conversion
fl ozs 
product/acre
lbs 
metconazole/acre
lb 
prothioconazole/acre
4 0 .030 0 .049
5 0 .037 0 .061
5 .5 0 .041 0 .067
7 .3 0 .054 0 .089
14 .6 0 .107 0 .179
Ground Application
Thorough coverage of foliage and flowers is required for opti-
mum disease control . A nonionic surfactant at the lowest 
labeled rate may be used to improve spray coverage . Refer to 
the adjuvant product label for specific use directions . 
DO NOT use adjuvants that contain methylated seed oil, 
crop oil concentrate, or crop oil with emulsifier properties .
Aerial Application
Select spray nozzles, pumping pressure, and sprayer height 
to provide medium-to-fine spray droplets that penetrate 
throughout the crop canopy . Spray calibration must be con-
ducted to confirm spray droplet sizes . Continue to monitor 
spray application (including weather conditions) to assure 
proper droplet size and canopy penetration . For all aerial 
application volumes (gpa), a nonionic surfac tant at the lowest 
labeled rate may be used to improve spray coverage . Refer to 
the adjuvant product label for specific use directions . 
DO NOT use adjuvants that contain methylated seed oil, 
crop oil concentrate, or crop oil with emulsifier properties .
Spray Drift Advisories
THE APPLICATOR IS RESPONSIBLE FOR AVOIDING 
OFF-SITE SPRAY DRIFT . BE AWARE OF NEARBY NON- 
TARGET SITES AND ENVIRONMENTAL CONDITIONS .
Importance of Droplet Size
An effective way to reduce spray drift is to apply large drop-
lets . Use the largest droplets that provide target pest 
control . While applying larger droplets will reduce spray drift, 
the potential for drift will be greater if applications are made 
improperly or under unfavorable environmental conditions .
Controlling Droplet Size - Ground Boom
• Volume - Increasing the spray volume so that larger droplets 
are produced will reduce spray drift . Use the highest practical 
spray volume for the application . If a greater spray volume is 
needed, consider using a nozzle with a higher flow rate .
• Pressure - Use the lowest spray pressure recommend-
ed for the nozzle to produce the target spray volume and 
droplet size .
• Spray Nozzle - Use a spray nozzle that is designed for 
the intended application . Consider using nozzles 
designed to reduce drift .
Controlling Droplet Size - Aircraft
• Adjust Nozzles - Follow nozzle manufacturers’ recom-
mendations for setting up nozzles . Generally, to reduce 
fine droplets, nozzles should be oriented parallel with the 
airflow in flight .
Boom Height - Ground Boom
For ground equipment, the boom should remain level with 
the crop and have minimal bounce .
Release Height - Aircraft
Higher release heights increase the potential for spray drift .
Shielded Sprayers
Shielding the boom or individual nozzles can reduce spray 
drift . Consider using shielded sprayers . Verify that the 
shields are not interfering with the uniform deposition of 
the spray on the target area .
Boomless Ground Applications: Setting nozzles at the 
lowest effective height will help to reduce the potential for 
spray drift
Handheld Technology Applications: Take precautions 
to minimize spray drift .
Temperature and Humidity
When making applications in hot and dry conditions, use 
larger droplets to reduce effects of evaporation .
Temperature Inversions
Drift potential is high during a temperature inversion . Tempera-
ture inversions are characterized by increasing temperature 
with altitude and are common on nights with limited cloud 
cover and light to no wind . The presence of an inversion can 
be indicated by ground fog or by the movement of smoke 
from a ground source or an aircraft smoke generator . Smoke 
that layers and moves laterally in a concentrated cloud (under 
low wind conditions) indicates an inversion, while smoke that 
moves upward and rapidly dissipates indicates good vertical 
air mixing . Avoid applications during temperature inversions .
Wind
Drift potential generally increases with wind speed . Appli-
cators need to be familiar with local wind patterns and 
terrain that could affect spray drift .
Field Sprinkler Irrigation (Chemigation) 
Application
• Apply this product only through sprinkler irrigation sys -
tems including center pivot, lateral move, end tow, side 
(wheel) roll, traveler, big gun, solid set, or hand move

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irrigation systems . DO NOT apply this product through 
any other type of irrigation system .
• Add this product to the pesticide supply tank containing 
sufficient water to maintain a continuous flow by the injec-
tion equipment . In continuous moving systems, inject this 
product-water mixture continuously, applying the labeled 
rate per acre for that crop . DO NOT apply more than 
1/2 inch (13,577 gallons) per acre . In stationary or 
non-continuous moving systems, inject the product-water 
mixture in the last 15 to 30 minutes of each set, allowing 
enough time to apply the labeled rate per acre through the 
sprinkler heads . Crop injury, lack of effectiveness, or illegal 
pesticide residues in the crop can result from nonuniform 
distribution of treated water . Thorough coverage of foliage 
and flowers is required for optimum disease control . Main-
tain constant agitation throughout mixing and application .
• If you have questions about calibration, contact state 
extension service specialists, equipment manufacturers, 
or other experts .
• The system must contain a functional check valve, vacu -
um relief valve, and low pressure drain appropriately 
located on the irrigation pipeline to prevent water-source 
contamination from backflow .
• The pesticide injection pipeline must contain a functional, 
automatic, quick-closing check valve to prevent the flow 
of fluid back toward the injection pump .
• The pesticide injection pipeline must also contain a func -
tional, normally closed, solenoid-operated valve located 
on the intake side of the injection pump and connected 
to the system interlock to prevent fluid from being with-
drawn from the supply tank when the irrigation system is 
either automatically or manually shut down .
• The system must contain functional interlocking controls 
to automatically shut off the pesticide injection pump 
when the water pump motor stops .
• The irrigation line or water pump must include a function -
al pressure switch which will stop the water pump motor 
when the water pressure decreases to the point where 
pesticide distribution is adversely affected .
• Systems must use a metering pump, for example, a pos-
itive displacement injection pump (e .g . diaphragm pump), 
effectively designed and constructed of materials that are 
compatible with pesticides and capable of being fitted 
with a system interlock .
• Allow sufficient time for pesticide to be flushed through 
all lines and all nozzles before turning off irrigation water . 
A person knowledgeable of the chemigation system and 
responsible for its operation or under supervision of the 
responsible person, shall shut the system down and 
make necessary adjustments if needed .
• DO NOT connect an irrigation system used for pesticide 
application to a public water system unless the pesticide 
label-prescribed safety devices for public water systems 
are in place .
Specific Instructions for Public Water Systems
1 . Public water system means a system for the provision to 
the public of piped water for human consumption if such 
system has at least 15 service connections or regularly 
serves an average of at least 25 individuals daily at least 
60 days out of the year .
2 . Chemigation systems connected to public water sys-
tems must contain a functional, reduced-pressure zone, 
backflow preventer (RPZ) or the functional equivalent in 
the water supply line upstream from the point of pesti-
cide introduction . As an option to the RPZ, the water 
from the public water system must be discharged into a 
reservoir tank prior to pesticide introduction . There shall 
be a complete physical break (air gap) between the out-
let end of the fill pipe and the top or overflow rim of the 
reservoir tank of at least twice the inside diameter of the 
fill pipe .
3 . The pesticide injection pipeline must contain a function -
al, automatic, quick-closing check valve to prevent the 
flow of fluid back toward the injection pump .
4 . The pesticide injection pipeline must contain a function -
al, normally closed, solenoid-operated valve located on 
the intake side of the injection pump and connected to 
the system interlock to prevent fluid from being with-
drawn from the supply tank when the irrigation system is 
either automatically or manually shut down .
5 . The system must contain functional interlocking controls 
to automatically shut off the pesticide injection pump 
when the water pump motor stops, or in cases where 
there is no water pump, when the water pressure 
decreases to the point where pesticide distribution is 
adversely affected .
6 . Systems must use a metering pump, for example, a 
positive displacement injection pump (e .g ., diaphragm 
pump), effectively designed and constructed of materi-
als that are compatible with pesticides and capable of 
being fitted with a system interlock .
Tank Mixing Other Products and Additives
It is the pesticide user’s responsibility to ensure that all prod-
ucts are registered for the intended use . Read and follow 
the applicable restrictions and limitations and directions for 
use on all product labels involved in tank mixing . Users must 
follow the most restrictive directions for use and precaution-
ary statements of each product in the tank mixture .
SphaerexTM fungicide can be tank mixed with other 
 fungicides, insecticides, herbicides, liquid fertilizers, biolog -
ical control products, adjuvants, and additives . Always 
follow the most restrictive label use directions . See 
Table 1. Detailed Use Directions for additional 
information .
BASF has not tested all varieties and cultivars with all pos-
sible tank mix combinations and rates of additives or 
adjuvants . Local environmental conditions can also influ-
ence crop tolerance and may not match those under 
which BASF has conducted testing . Physical incompatibili-
ty, reduced disease control, or injury may result from 
mixing Sphaerex with other products .

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Rotational Crop Intervals
Barley, bushberry subgroup, canola, corn, cotton, dry 
beans and peas, oats, peanuts, rye, soybeans, sugar 
beets, triticale, and wheat may be planted as soon as 
practical after last application .
Brassica leafy vegetables and leafy vegetables, sorghum, 
sugarcane, sunflower, and tuberous and corm vegetables 
subgroup (potatoes) must not be planted within 30 days 
after the last application .
For all other crops, DO NOT plant sooner than 120 days 
after the last application .
Table 1. Detailed Use Directions
Target Disease
Product Use 
Rate per 
Application 
(fl ozs/A)
Maximum 
Number of 
Applications 
per Year
Maximum 
Product Rate 
per Year 
(fl ozs/A)
Minimum Time 
from Application 
to Harvest
(PHI) (days)
Black point (kernel blight or smudge)
Alternaria spp ., Cochliobolus sativus, 
Helminthosporium spp .
Powdery mildew
Erysiphe graminis
Rust
Puccinia spp .
Scald
Rynchosporium secalis
Septoria blotch, speckled leaf spot
Septoria spp .
Spot blotch
Cochliobolus sativus, 
Bipolaris sorokiniana
Stagonospora blotch
Parastagonospora nodorum
Tan spot (yellow leaf spot)
Pyrenophora spp .
4 .0 to 5 .0 
(early season)
5 .5 to 7 .3 
(flag leaf)
2 14 .6 30
Head scab (head blight)
Fusarium spp . 7 .3
Application Directions
- Under certain environmental conditions, when SphaerexTM fungicide is applied with emulsifiable concentrate (EC) 
formulated herbicides, bromoxynil contain products, insecticides, and/or fertilizers, phytotoxicity can occur . The pos-
sibility of phytotoxicity increases if applications are made under cool, wet, cloudy conditions that persist for several 
days following application . Lower gpa applications can increase the risk of phytotoxicity .
- Livestock may graze treated fields .
Foliar Applications
- When conditions favor disease or disease pressure is high, use the higher specified rate . For aerial applications, 
apply in a minimum of 2 gallons per acre (gpa) total spray volume . For ground applications, apply a minimum of 
5 gpa .
- Early Season: Apply when conditions favor disease development or disease pressure is high prior to flag leaf emer -
gence . When an early season application is used, a second application may be required to protect the flag leaf . Early 
season applications will not suppress or control head scab .
- Flag Leaf: To maximize yield, it is important to protect the flag leaf . For optimal disease control, begin applications 
prior to disease development or immediately after flag leaf emergence .
Head Scab Applications
- For best results, apply during early flowering using forward and reverse facing nozzles to ensure thorough coverage 
of the heads . For aerial applications, apply in a mini mum of 2 gpa total spray volume . For ground applications, apply 
a minimum of 10 gpa .
(continued)

8
{Note to PM: Italicized text enclosed in “{ }” is information for the reviewer and not part of the label. 
[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.}
Table 1. Detailed Use Directions (continued)
Use Restrictions
• The minimum retreatment interval (RTI) is 14 days after the first application .
• {Optional Text:} [DO NOT apply after Feekes Growth Stage 10 .5 .3 .]
• DO NOT apply SphaerexTM fungicide if the final spray solution contains fertilizer at a concentration more than 20% 
on a volume-to-volume (v/v) basis .
• DO NOT apply more than 7 .3 fl ozs (0 .054 lb metconazole plus 0 .089 lb prothioconazole) per application per acre .
• DO NOT make more than 2 applications of Sphaerex or other Group 3 fungicides per acre per year .
• DO NOT apply more than 14 .6 fl ozs (0 .107 lb metconazole plus 0 .179 lb prothioconazole) per acre per year .

9
{Note to PM: Italicized text enclosed in “{ }” is information for the reviewer and not part of the label. 
[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.}
© 2022 BASF Corporation
All rights reserved .
007969-00473 .20210420c .NVA 2021-04-629-0095
Supersedes: NVA 2020-04-629-0128
BASF Corporation
26 Davis Drive
Research Triangle Park, NC 27709
Sphaerex is a trademark of BASF.
Conditions of Sale and Warranty
The Directions For Use of this product reflect the 
 opinion of experts based on field use and tests . The 
 directions are believed to be reliable and must be 
followed carefully . However, it is impossible to eliminate 
all risks inherently associated with the use of this 
product . Crop injury, ineffectiveness or other unintended 
consequences may result because of such factors as 
weather conditions, presence of other materials, or use 
of the product in a manner inconsistent with its labeling, 
all of which are beyond the control of BASF 
CORPORATION (“BASF”) or the Seller . To the extent 
consistent with applicable law, all such risks shall be 
assumed by the Buyer .
BASF warrants that this product conforms to the 
chemical description on the label and is reasonably fit for 
the purposes referred to in the Directions For Use , 
subject to the inherent risks, referred to above .
TO THE EXTENT CONSISTENT WITH APPLICABLE 
LAW, BASF MAKES NO OTHER EXPRESS OR 
IMPLIED WARRANTY OF FITNESS OR 
 MERCHANTABILITY OR ANY OTHER EXPRESS OR 
IMPLIED WARRANTY.
TO THE EXTENT CONSISTENT WITH APPLICABLE 
LAW, BUYER’S EXCLUSIVE REMEDY AND BASF’S 
EXCLUSIVE LIABILITY, WHETHER IN CONTRACT, 
TORT, NEGLIGENCE, STRICT LIABILITY, OR 
 OTHERWISE, SHALL BE LIMITED TO REPAYMENT 
OF THE PURCHASE PRICE OF THE PRODUCT.
TO THE EXTENT CONSISTENT WITH APPLICABLE 
LAW, BASF AND THE SELLER DISCLAIM ANY 
 LIABILITY FOR CONSEQUENTIAL, EXEMPLARY, 
SPECIAL OR INDIRECT DAMAGES RESULTING 
FROM THE USE OR HANDLING OF THIS 
PRODUCT.
BASF and the Seller offer this product, and the Buyer 
and User accept it, subject to the foregoing Conditions 
of Sale and Warranty which may be varied only by 
 agreement in writing signed by a duly authorized 
representative of BASF . 1108

BASF Corporation 
26 Davis Drive, Research Triangle Park, NC 27709 
 
 
 
Supplemental Label 
 
For disease control in barley, oats, rye, and triticale 
This supplemental label expires February 16, 2025, and must not be used or distributed after this date. 
Active Ingredients*: 
metconazole: 5-[(4-chlorophenyl)methyl]-2,2-dimethyl-1- 
(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol ...................................................................................................... 10.91% 
prothioconazole: 2-[2-(1-chlorocyclopropyl)-3-(2-Chlorophenyl)-2- 
hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione .................................................................................... 18.19% 
Other Ingredients: .......................................................................................................................................... 70.90% 
Total: ............................................................................................................................................................... 100.00% 
* Sphaerex™ fungicide contains 0.939 lb metconazole and 1.565 lbs prothiconazole per gallon. 
 
EPA Reg. No. 7969-473 
WARNING/AVISO 
 
Directions For Use 
 It is a violation of federal law to use this product in a 
manner inconsistent with its labeling. 
 The supplemental labeling and the entire 
Sphaerex™ fungicide container label, EPA Reg. 
No. 7969-473, must be in possession of the user at 
the time of application. 
 Read the label affixed to the container for 
Sphaerex before applying. 
 Use of Sphaerex according to this labeling is subject 
to the use precautions and limitations imposed by the 
label affixed to the container for Sphaerex. 
Application Instructions 
Refer to Sphaerex container label for specific use 
directions, recommendations and restrictions in 
registered crops. 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Metconazole Group 3 Fungicide 
Prothioconazole Group 3 Fungicide 
02/25/2022
7969-473

2 
{Note to PM: Italicized text enclosed in “{ }” is information for the reviewer and not part of the label. 
[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.} 
Table 1. Detailed Use Directions 
 Target Disease 
Product Use 
Rate per 
Application 
(fl ozs/A) 
Maximum 
Number of 
Applications 
per Year 
Maximum 
Product Rate 
per Year 
(fl ozs/A) 
Minimum Time 
from Application 
to Harvest 
(PHI) (days) 
Black point (kernel blight or smudge) 
Alternaria spp., Cochliobolus sativus, 
Helminthosporium spp. 
Powdery mildew 
Erysiphe graminis 
Rust 
Puccinia spp. 
Scald 
Rynchosporium secalis 
Septoria blotch, speckled leaf spot 
Septoria spp. 
Spot blotch 
Cochliobolus sativus, 
Bipolaris sorokiniana 
Stagonospora blotch 
Parastagonospora nodorum 
Tan spot (yellow leaf spot) 
Pyrenophora spp. 
4.0 to 5.0 
(early season) 
5.5 to 7.3 
(flag leaf) 
2 14.6 30 
Head scab (head blight) 
Fusarium spp. 7.3 
Application Directions 
- Under certain environmental conditions, when Sphaerex™ fungicide is applied with emulsifiable concentrate 
(EC) formulated herbicides, bromoxynil contain products, insecticides, and/or fertilizers, phytotoxicity can occur. 
The possibility of phytotoxicity increases if applications are made under cool, wet, cloudy conditions that persist 
for several days following application. Lower gpa applications can increase the risk of phytotoxicity. 
- Livestock may graze treated fields. 
Foliar Applications 
- When conditions favor disease or disease pressure is high, use the higher specified rate. For aerial 
applications, apply in a minimum of 2 gallons per acre (gpa) total spray volume. For ground applications, 
apply a minimum of 5 gpa. 
- Early Season: Apply when conditions favor disease development or disease pressure is high prior to flag leaf 
emergence. When an early season application is used, a second application may be required to protect the flag 
leaf. Early season applications will not suppress or control head scab. 
- Flag Leaf: To maximize yield, it is important to protect the flag leaf. For optimal disease control, begin 
applications prior to disease development or immediately after flag leaf emergence. 
(continued)

3 
{Note to PM: Italicized text enclosed in “{ }” is information for the reviewer and not part of the label. 
[Bracketed information is optional text.] Text within brackets and separated by “/” denotes and/or options.} 
Table 1. Detailed Use Directions (continued) 
Head Scab Applications 
- For best results, apply at the beginning of flowering using forward and reverse facing nozzles at higher water 
volumes to ensure thorough coverage of the heads. For aerial applications, apply in a minimum of 2 gpa total spray 
volume. For ground applications, apply a minimum of 10 gpa. 
Use Restrictions 
 The minimum retreatment interval (RTI) is 14 days after the first application. 
 {Optional Text:} [DO NOT apply after Feekes Growth Stage 10.5.3.] 
 DO NOT apply Sphaerex™ fungicide if the final spray solution contains fertilizer at a concentration more than 
20% on a volume-to-volume (v/v) basis. 
 DO NOT apply more than 7.3 fl ozs (0.054 lb metconazole plus 0.089 lb prothioconazole) per application per acre. 
 DO NOT make more than 2 applications of Sphaerex or other Group 3 fungicides per acre per year. 
 DO NOT apply more than 14.6 fl ozs (0.107 lb metconazole plus 0.179 lb prothioconazole) per acre per year.

4 
Conditions of Sale and Warranty 
The Directions For Use of this product reflect the 
opinion of experts based on field use and tests. The 
directions are believed to be reliable and must be 
followed carefully. However, it is impossible to 
eliminate all risks inherently associated with the use 
of this product. Crop injury, ineffectiveness or other 
unintended consequences may result because of 
such factors as weather conditions, presence of 
other materials, or use of the product in a manner 
inconsistent with its labeling, all of which are beyond 
the control of BASF CORPORATION (“BASF”) or the 
Seller. To the extent consistent with applicable law, 
all such risks shall be assumed by the Buyer. 
BASF warrants that this product conforms to the 
chemical description on the label and is reasonably 
fit for the purposes referred to in the Directions For 
Use, subject to the inherent risks, referred to above. 
TO THE EXTENT CONSISTENT WITH 
APPLICABLE LAW, BASF MAKES NO OTHER 
EXPRESS OR IMPLIED WARRANTY OF FITNESS 
OR MERCHANTABILITY OR ANY OTHER 
EXPRESS OR IMPLIED WARRANTY. 
TO THE EXTENT CONSISTENT WITH 
APPLICABLE LAW, BUYER’S EXCLUSIVE 
REMEDY AND BASF’S EXCLUSIVE LIABILITY, 
WHETHER IN CONTRACT, TORT, NEGLIGENCE, 
STRICT LIABILITY, OR OTHERWISE, SHALL BE 
LIMITED TO REPAYMENT OF THE PURCHASE 
PRICE OF THE PRODUCT. 
TO THE EXTENT CONSISTENT WITH 
APPLICABLE LAW, BASF AND THE SELLER 
DISCLAIM ANY LIABILITY FOR 
CONSEQUENTIAL, EXEMPLARY, SPECIAL OR 
INDIRECT DAMAGES RESULTING FROM THE 
USE OR HANDLING OF THIS PRODUCT. 
BASF and the Seller offer this product, and the Buyer 
and User accept it, subject to the foregoing 
Conditions of Sale and Warranty which may be 
varied only by agreement in writing signed by a duly 
authorized representative of BASF. 
1108 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Sphaerex is a trademark of BASF.
 
© 2022 BASF Corporation 
All rights reserved. 
007969-00473.20211115c.NVA 2021-04-629-0214 
BASF Corporation 
26 Davis Drive 
Research Triangle Park, NC 27709