crop-chem-docs/corpus/epa_ppls/100-1638.md

# A22353

- EPA Reg No: **100-1638**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Thiamethoxam (21.7%); Fludioxonil (1.08%); Metalaxyl-M (3.54%); Azoxystrobin (0.87%); Sedaxane (1.08%)
- Label accepted: 2026-08-12
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01638-20260812.pdf

---
August 12, 2026
Patsy Laird
Regulatory Manager, Seedcare
Syngenta Crop Protection, LLC
P.O. Box 18300
Greensboro, NC 27419
Patsy.laird@syngeta.com
Subject: Label Amendment - Registration Review Mitigation for Sedaxane
 Product Name: A22353
EPA Registration Number: 100-1638
 Application Date: February 13, 2026
Case Number: 684645
Dear Mrs. Patsy Laird:
The Agency, in accordance with the Federal Insecticide, Fungicide, and Rodenticide Act 
(FIFRA), as amended, has completed reviewing all the information submitted with your 
application to support the Registration Review of the above referenced product in 
connection with the Sedaxane Interim Decision, and has concluded that your submission 
is acceptable. The label referred to above, submitted in connection with registration under 
FIFRA, as amended, is acceptable.
Should you wish to add/retain a reference to the company’s website on your label, then 
please be aware that the website becomes labeling under the Federal Insecticide, 
Fungicide, and Rodenticide Act and is subject to review by the Agency. If the website is 
false or misleading, the product would be misbranded and unlawful to sell or distribute 
under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may 
consider false or misleading. In addition, regardless of whether a website is referenced on 
your product’s label, claims made on the website may not substantially differ from those 
claims approved through the registration process. Therefore, should the Agency find or if it 
is brought to our attention that a website contains false or misleading statements or 
claims substantially differing from the EPA approved registration, the website will be 
referred to the EPA’s Office of Enforcement and Compliance Assurance.

Page 2 of 2
EPA Reg. No. 100-1638
Decision No. 684645
A stamped copy of your labeling is enclosed for your records. This labeling 
supersedes all previously accepted labeling and must be used at your next label 
printing. You must submit one copy of the final printed labeling before you release 
the product for shipment with the new labeling. In accordance with 40 CFR 
152.130(c), you may distribute or sell this product under the previously approved 
labeling for 12 months from the date of this letter. After 12 months, you may only 
distribute or sell this product if it bears this new revised labeling or subsequently 
approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and 
its implementing regulation at 40 CFR 152.3.
If you have any questions about this letter, please contact Samantha Carter by phone at 
202-566-1179, or via email at carter.samantha@epa.gov. 
Sincerely,
Jaclyn Pyne, Team Leader
Risk Management and Implementation Branch 3
Pesticide Re-Evaluation Division
Office of Pesticide Programs
ENCLOSURE: Stamped label

A22353 
Page 1 
[MASTER]
THIAMETHOXAM GROUP 4A INSECTICIDE
MEFENOXAM GROUP 4 FUNGICIDE
SEDAXANE GROUP 7 FUNGICIDE
AZOXYSTROBIN GROUP 11 FUNGICIDE
FLUDIOXONIL GROUP 12 FUNGICIDE
A22353
Insecticide with Fungicides
A seed treatment product for protection against damage from listed early-season insect pests 
and diseases of soybean
Active Ingredients: 
Azoxystrobin1.............................................................................................................0.87%
Fludioxonil2 ................................................................................................................1.08%
Sedaxane3 .................................................................................................................1.08%
Mefenoxam4 ..............................................................................................................3.54%
Thiamethoxam5 .......................................................................................................21.70%
Other Ingredients: 71.73% 
Total: 100.00%
1CAS No. 131860-33-8 
2CAS No. 131341-86-1 
3CAS No. 874967-67-6 
4CAS No. 70630-17-0 and 69516-34-3 
5CAS No. 153719-23-4 
A22353 is a flowable concentrate for seed treatment containing 0.09 lb azoxystrobin, 0.11 lb 
fludioxonil, 0.11 lb sedaxane, 0.35 lb mefenoxam, and 2.14 lb thiamethoxam per gallon.
KEEP OUT OF REACH OF CHILDREN.
CAUTION
See additional precautionary statements and directions for use in booklet.
EPA Reg. No. 100-1638
EPA Est. No. XXXX
-----------------
Net Contents
[Batch Code: _____ ] (For nonrefillables only.)
08/12/2026
100-1638

A22353 
Page 2 
 
TABLE OF CONTENTS 
 
1.0 FIRST AID 
2.0 PRECAUTIONARY STATEMENTS 
2.1 Hazards to Humans and Domestic Animals 
2.2 Personal Protective Equipment (PPE) 
2.3 User Safety Requirements 
2.4 User Safety Recommendations 
2.5 Environmental Hazards 
2.5.1 Pollinator Precautions 
2.5.2 Groundwater Advisory 
2.6 Physical and Chemical Hazards 
DIRECTIONS FOR USE 
3.0 PRODUCT INFORMATION 
3.1 Insecticide Resistance Management 
3.2 Fungicide Resistance Management 
4.0 APPLICATION DIRECTIONS 
4.1 Tank Mixtures 
5.0 ROTATIONAL CROP RESTRICTIONS 
6.0 RESTRICTIONS 
7.0 SEED CONTAINER LABEL REQUIREMENTS 
7.1 Use of On-Farm Treated Seed (when treated seed are not for sale or distribution) 
7.2 Seed Treatment in Commercial Facilities or Seed Treatment on Farm (when treated seed 
are to be sold or distributed) – Seed Bag Labeling Requirements 
8.0 SEED TREATMENT DIRECTIONS 
8.1 Soybean 
8.2 Soybean Treatment for Protection Against Seed Storage Pests 
9.0 STORAGE AND DISPOSAL 
10.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY

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1.0 FIRST AID 
FIRST AID 
If swallowed x Call a poison control center or doctor immediately for treatment 
advice. 
x Have a person sip a glass of water if able to swallow. 
x Do not induce vomiting unless told to by a poison control center 
or doctor. 
x Do not give anything by mouth to an unconscious person. 
If on skin or 
clothing 
x Take off contaminated clothing. 
x Rinse skin immediately with plenty of water for 15-20 minutes. 
x Call a poison control center or doctor for treatment advice. 
Have the product container or label with you when calling a poison control center or 
doctor, or going for treatment. 
HOTLINE NUMBER 
For 24-Hour Medical Emergency Assistance (Human or Animal) 
Or Chemical Emergency Assistance (Spill, Leak, Fire or Accident), 
Call 
1-800-888-8372 
 
2.0 PRECAUTIONARY STATEMENTS 
2.1 Hazards to Humans and Domestic Animals 
CAUTION 
 
Harmful if swallowed or absorbed through skin. Avoid contact with skin, eyes or clothing. 
 
2.2 Personal Protective Equipment (PPE) 
Applicators and other handlers must wear: 
x Long-sleeved shirt and long pants 
x Chemical-resistant gloves: EDUULHUODPLQDWHEXW\OUXEEHU•PLOVQHRSUHQHUXEEHU
•PLOVQLWULOHUXEEHU•PLOVSRO\YLQ\OFKORULGH39&•PLOV, or Viton™ •PLOV 
x Shoes plus socks

A22353 
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2.3 User Safety Requirements 
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for 
washables exist, use detergent and hot water. Keep and wash PPE separately from other 
laundry. 
2.4 User Safety Recommendations 
Users should: 
x Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. 
x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly 
and put on clean clothing. 
x Remove PPE immediately after handling this product. Wash the outside of gloves 
before removing. As soon as possible, wash thoroughly and change into clean 
clothing. 
 
 
2.5 Environmental Hazards 
This pesticide is toxic to wildlife and freshwater and estuarine/marine fish and highly toxic to 
aquatic invertebrates. Do not contaminate water when disposing of equipment washwater or 
rinsate. Exposed treated seed may be hazardous to wildlife. 
 
2.5.1 Pollinator Precautions 
Thiamethoxam is highly toxic to bees exposed to direct treatment, and effects may be 
possible as a result of exposure to translocated residues in blooming crops. 
 
2.5.2 Groundwater Advisory 
Azoxystrobin can be persistent for several months or longer. Azoxystrobin and a degradate 
of azoxystrobin are known to leach through soil into groundwater under certain conditions as 
a result of label use. These chemicals may leach into groundwater if used in areas where 
soils are permeable, particularly where the water table is shallow, and may result in 
groundwater contamination. 
 
Mefenoxam is known to leach through soil into groundwater under certain conditions as a 
result of label use. This chemical may leach into groundwater if used in areas where soils 
are permeable, particularly where the water table is shallow, and may result in groundwater 
contamination.

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Fludioxonil has properties and characteristics associated with chemicals detected in 
groundwater. This chemical may leach into groundwater if used in areas where soils are 
permeable, particularly where the water table is shallow, and may result in groundwater 
contamination. 
 
Thiamethoxam has properties and characteristics associated with chemicals detected in 
groundwater. This chemical may leach into groundwater if used in areas where soils are 
permeable, particularly where the water table is shallow, and may result in groundwater 
contamination. 
 
2.6 Physical and Chemical Hazards 
Do not mix or allow to come in contact with an oxidizing agent, a hazardous chemical 
reaction may occur. 
 
DIRECTIONS FOR USE 
 
It is a violation of federal law to use this product in a manner inconsistent with its labeling. 
Use is only permitted in commercial seed treatment facilities. Use on-farm is not permitted. 
Do not use for at-plant applications (e.g. hopper box, planter box, etc.). This product is to be 
applied as a water-based slurry through standard liquid-type commercial seed treatment 
equipment. Seed treaters with atomizers or spinning discs are highly recommended for better 
product coverage on the seed. 
Do not apply this product in a way that will contact workers or other persons, either directly or 
through drift. Only protected handlers may be in the area during application. For any 
requirements specific to your State or Tribe, consult the agency responsible for pesticide 
regulation. 
Maximum usage when applying metalaxyl- and mefenoxam- containing products to the 
same crop within the same season: Do not apply more than the maximum yearly total 
application rate for the active ingredient as stated on the label of the product containing the 
lowest yearly total on that crop. 
FAILURE TO FOLLOW DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY 
RESULT IN CROP INJURY; POOR INSECT AND/OR DISEASE CONTROL; AND/OR 
ILLEGAL RESIDUES. 
Treatment of highly mechanically scarred or damaged seed or seed known to be of low vigor 
and poor quality may result in reduced germination and/or reduction of seed and seedling 
vigor. Therefore, it is recommended to treat a quantity of seed using equipment similar to 
that planned for treating the total seed lot. Then conduct germination tests with a portion of 
this treated seed before committing the total seed lot to a selected seed treatment.

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Due to seed quality, crop or variety sensitivity, and seed storage conditions beyond the 
control of Syngenta, no claims are made to guarantee the germination of seed or propagating 
material for any crop seed treated with A22353. 
 
3.0 PRODUCT INFORMATION 
A22353 is a broad-spectrum seed treatment for use only on soybean that consists of four 
fungicide active ingredients: azoxystrobin, fludioxonil, sedaxane, and mefenoxam, as well as 
one insecticide active ingredient: thiamethoxam. Each active ingredient has a different mode 
of action. This seed treatment is recommended for control of many listed important fungal 
plant diseases as well as listed early-season insect pests. 
 
Azoxystrobin fungicide is active against Rhizoctonia and Pythium species, seed-borne white 
mold (Sclerotinia sclerotiorum) as well as other listed seed-borne diseases causing decay, 
damping-off and seedling blight. 
 
Fludioxonil fungicide protects against damage from seed-borne and soil-borne disease 
caused by Fusarium and Rhizoctonia species leading to seed decay, damping-off, and 
seedling blight. This active ingredient also provides protection from seed-borne Diaporthe-
Phomopsis disease complex sometimes referred to as pod and stem blight (caused by 
Phomopsis longicolla and Diaporthe phaseolorum). Fludioxonil also suppresses seed-borne 
Sclerotinia. 
 
Sedaxane fungicide protects against damage from seed decay, seedling blight, and damping-
off caused by Rhizoctonia species. 
 
Mefenoxam fungicide provides protection against Pythium damping-off and early-season 
Phytophthora. 
 
Thiamethoxam protects against damage from listed insect pests. 
 
 
3.1 Insecticide Resistance Management 
 
 
 
A22353 contains thiamethoxam, a Group 4A insecticide. Thiamethoxam is a systemic 
insecticide belonging to the neonicotinoid class of chemistry which includes nicotinic 
acetylcholine receptor (nAChR) agonists. 
 
Insect populations may contain individuals naturally resistant to Group 4A insecticides and if 
used repeatedly in the same fields, then resistant members may eventually dominate the 
population. Because resistance development cannot be predicted, use sound resistance 
management strategies established for the crop and use area. 
 
THIAMETHOXAM GROUP 
4A INSECTICIDE

A22353 
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Base seed treatment on an integrated pest management program that includes field 
sanitation, historical information related to pesticide use, careful selection of pest-tolerant 
crop varieties, scouting, and management practices which optimize populations of natural 
enemies of insect pests such as within-field refuge (untreated areas). Sound management 
programs also consider cultural and biological control practices. 
 
In order to maintain susceptibility to these classes of chemistry: 
x Use products at their full, specified doses. 
x Use appropriate, well-maintained equipment. Use specified water volumes and apply at 
optimal temperatures in order to obtain optimal treatment. 
x When rate ranges are given, use the higher rate within the listed rate range when insect 
pressure is expected to be high. 
x Avoid using a single active ingredient or mode of action (same insecticide group) 
exclusively for season long control of insect species with more than one generation per 
crop season. 
x For insect species with successive or overlapping generations, use a treatment window 
approach. A treatment window is a period of time defined by the stage of crop 
development and the biology of the pests of concern. Within the treatment window, 
depending on the length of residual activity, single or consecutive applications may be 
made using seed, in-furrow, or foliar treatments unless otherwise excluded by product 
labels. Do not exceed the maximum amount of this insecticide’s mode of action allowed 
per growing season. 
x Following a treatment window of this insecticide’s mode of action, rotate to a treatment 
window of effective products with a different mode of action before making additional 
applications of this insecticide. 
 
If resistance to this product develops in your area, this product or other products with a 
similar mode of action may not provide adequate control. If poor performance cannot be 
attributed to improper application or weather conditions, a resistant strain of insect may be 
present. If you experience difficulty with control and resistance is a reasonable cause, 
immediately consult your local company representative or agricultural advisor for the best 
alternative method of control for the crop and use area. 
 
Syngenta encourages responsible product stewardship to ensure effective long term control 
of the insect pests on this label. 
 
For additional information on Insect Resistance Management: 
x Contact Syngenta representatives at 1-866-796-4368 
x Contact your local Cooperative Extension Service specialist, pest control advisor, or 
certified crop advisor 
x Visit the Insecticide Resistance Action Committee (IRAC) on the web at: 
http://www.irac-online.org

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3.2 Fungicide Resistance Management 
 
MEFENOXAM GROUP 4 FUNGICIDE 
SEDAXANE GROUP 7 FUNGICIDE 
AZOXYSTROBIN GROUP 11 FUNGICIDE 
FLUDIOXONIL GROUP 12 FUNGICIDE 
 
For resistance management, please note that A22353 contains Group 4 (mefenoxam), Group 
7 (sedaxane), Group 11 (azoxystrobin) and Group 12 (fludioxonil) fungicides. Any fungal 
population may contain individuals naturally resistant to A22353 and other Group 4, Group 7, 
Group 11 or Group 12 fungicides. A gradual or total loss of pest control may occur over time 
if these fungicides are used repeatedly in the same fields. Appropriate resistance-
management strategies should be followed. 
 
Mefenoxam belongs to the phenylamide class of chemistry, which interferes with fungal RNA 
synthesis. Sedaxane is a succinate dehydrogenase inhibitor (SDHI) and belongs to the 
carboxamide class of chemistry, which disrupts cellular respiration and energy generation. 
Azoxystrobin belongs to the strobilurin class of chemistry, which disrupts cellular respiration 
and energy generation. Fludioxonil belongs to the phenylpyrrole class of chemistry, which 
interferes with osmotic signal transduction. 
 
To delay fungicide resistance, take one or more of the following steps: 
x Rotate the use of A22353 or other Group 4, Group 7, Group 11 or Group 12 fungicides 
within a growing season sequence with different groups that control the same pathogens. 
x Use tank mixtures with a fungicide from a different group that is equally effective on the 
target pest when such use is permitted. Use at least the minimum application rate as 
labeled by the manufacturer. 
x Adopt an integrated disease management program for fungicide use that includes 
scouting, uses historical information related to pesticide use, and crop rotation, and which 
considers host plant resistance, impact of environmental conditions on disease 
development, disease thresholds, as well as cultural, biological and other chemical control 
practices. 
x Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage 
resistance. 
x Monitor treated fungal populations for resistance development. 
x Contact your local extension specialist or certified crop advisor for any additional pesticide 
resistance-management and/or IPM recommendations for specific crop and pathogens. 
For further information or to report suspected resistance, contact Syngenta at 1-866-
Syngent(a) (866-796-4368). You can also contact your pesticide distributor or university 
extension specialist to report resistance. 
 
Syngenta encourages responsible product stewardship to ensure effective long-tern control 
of the fungal disease.

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4.0 APPLICATION DIRECTIONS 
Important: Recirculate A22353 thoroughly before using. 
 
Follow the manufacturer’s application instructions for the seed treatment equipment being 
used. 
Apply A22353 as a water-based slurry through standard liquid-type commercial seed 
treatment equipment that provides uniform seed coverage. Seed treaters with atomizers or 
spinning discs are highly recommended for better product coverage on the seed. Uneven or 
incomplete seed coverage may not give the desired level of insect or disease control. The 
minimum slurry volume to achieve adequate coverage is 4.0 fluid ounces of liquid slurry per 
100 pounds of seed. More diluent may be required to obtain complete coverage. Thoroughly 
mix the specified amount of A22353 into the required amount of water or liquid inoculant for 
the slurry treater and dilution rate to be used. 
Continuous agitation or mixing of the slurry mixture is necessary to prevent settling out of the 
solution. Clean out any unused product from the treater after treating or maintain constant 
agitation if the leftover slurry will be maintained overnight. 
A22353 contains an EPA approved dye/colorant that imparts an unnatural color to the seed 
as required by 40 CFR 153.155 (c). 
Allow seed to dry before bagging. 
 
4.1 Tank Mixtures 
A22353 mixes easily with water and other water-based seed treatments manufactured by 
Syngenta and many other companies. When mixing with products from other manufacturers, 
test the compatibility prior to use by conducting a jar test: mix all intended seed treatments 
with a proportional amount of water to achieve the desired slurry mixture in a clear glass 
container. Mix well and allow mixture to sit for one hour. Remix and observe for 
incompatibility. 
Mixing A22353 with tank-mix partners: Add ½ of the required water to the mix tank and turn 
on the agitation. Mechanical agitation is preferred. If using wettable powders, add them first 
to clean water allowing them to completely disperse prior to adding A22353 or other products. 
Allow each tank-mix partner to completely disperse before adding the next product. Add the 
remaining amount of water and agitate. Maintain agitation until the entire slurry mixture has 
been used. 
It is the pesticide user’s responsibility to ensure that all products are registered for the 
intended use. Read and follow the applicable restrictions and limitations and directions for 
use on all product labels involved in tank mixing. Users must follow the most restrictive 
directions for use and precautionary statements of each product in the tank mixture.

A22353 
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5.0 ROTATIONAL CROP RESTRICTIONS 
x In the event of a crop failure or harvest of a crop grown from seed treated with A22353, 
the field may be replanted according to the following schedule: 
 
Plantback Interval Table 
Immediate Plantback Interval Minimum 30-Day Plantback Interval 
Canola 
Cereal Grains: Barley, Corn (Field, Pop, 
Seed, Sweet), Oats, Rye, Sorghum, 
Triticale, and Wheat 
Cotton 
Dried Shelled Pea and Bean Crop 
Subgroup 6C 
Oilseeds: Borage, Crambe, Flax Seed, 
and Mustard Seed 
Potato 
Soybean 
Sugarbeet 
 
Alfalfa 
Cereal Grains Crop Group 15 
Cucurbit Vegetables Crop Group 9 
Fruiting Vegetables Crop Group 8 
Head and Stem Brassica Crop Subgroup 5A 
Leafy Brassica Greens Crop Subgroup 5B 
Leafy Vegetables Crop Group 4 
Legume Vegetables (Succulent or Dried) 
Crop Group 6 
Mint: Peppermint and Spearmint 
Onion, Dry Bulb 
Peanut 
Root Vegetables Crop Subgroup 1A 
Safflower 
Strawberry 
Sunflower 
Tobacco 
Tuberous and Corm Vegetables Crop 
Subgroup 1D 
x For all other crops, the minimum plantback interval is 120 days from the date of planting 
seeds treated with A22353. A cover crop, other than the crops listed above, planted for 
erosion control or soil improvement may be planted sooner than the 120-day interval; 
however, the crop may not be grazed or harvested for food or feed.

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6.0 RESTRICTIONS 
x Only for use on listed crops. 
x For use only in commercial seed treatmen t facilities. Not for use on agricultural 
establishments in hopper-box, planter-box, slurry-box, or other seed-treatment 
applications at or immediately before planting. 
x Treated seed must be labeled in accordance with the requirements of the Federal Seed 
Act. 
x Do not use at a rate that will result in more than 0.266 lb thiamethoxam per Acre (120 
grams ai/A) per calendar year, regardless of type of application (seed treatment, soil, or 
foliar). Do not use at a rate that will result in more than 0.083 lb thiamethoxam per Acre 
(37.8 grams ai/A) per calendar year as a seed treatment application. 
x Do not apply more than 0.003 lb azoxystrobin per Acre (1.5 g ai/A) per calendar year as a 
seed treatment application. 
x Do not apply more than 0.004 lb fludioxonil per Acre (2.0 g ai/A) per calendar year as a 
seed treatment application. 
x Do not apply more than 0.004 lb sedaxane per Acre (2.0 g ai/A) per calendar year as a 
seed treatment application. 
x Do not apply more than 0.013 lb mefenoxam per Acre (5.7 g ai/A) per calendar year as a 
seed treatment application. 
x Maximum usage when applying metalaxyl and mefenoxam containing products to 
the same crop within the same season: Do not apply more than the maximum yearly 
total application rate for the active ingredient as stated on the label of the product 
containing the lowest yearly total on that crop. 
x Store treated seed away from food and feedstuffs. 
x Do not allow children, pets, or livestock to have access to treated seed. 
x Do not apply a neonicotinoid insecticide within 45 days of planting soybean seeds treated 
with this product.

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7.0 SEED CONTAINER LABEL REQUIREMENTS 
7.1 Use of On-Farm Treated Seed (when treated seed are not 
for sale or distribution) 
Treated seed sold or distributed for a use not permitted by the following labeling does not 
qualify as an exempted treated article under 40 CFR 152.25(a) and is therefore sale or 
distribution of an unregistered pesticide, pursuant to FIFRA section 12. 
 
x Store treated seed away from food and feedstuffs. 
x DO NOT allow children, pets, or livestock to have access to treated seed. 
x Treated seed are for planting purposes only. DO NOT use for food, feed, or oil purposes. 
DO NOT use treated seed for fuel or ethanol production purposes. 
x Wear long-sleeved shirt, long pants, shoe s, socks, and chemical-resistant gloves when 
handling treated seed. 
x DO NOT plant treated seed by broadcasting to the soil surface. Ensure that all planted 
seeds are thoroughly incorporated by the planter during planting. Additional incorporation 
may be required to thoroughly cover exposed seeds. 
x Treated seed exposed on the soil surface may be hazardous to wildlife. Cover or collect 
treated seed spilled during loading and planting (such as in row ends). 
x Treated seed must be planted into the soil at a depth greater than 1 inch. 
x Manage excess treated seed (e.g., spilled, u nused, or expired treated seed) by one or 
more of the following methods: 
o Collect excess treated seed for reuse for planting. 
o Bury excess treated seed (only allowed if totaling 1 pound or less) at least 30 feet 
away from bodies of water at a depth of 6 inches or double the planting depth, 
whichever is greater. 
o Dispose of excess treated seed by plac ing them in a landfill in accordance with 
applicable laws in your state. 
o Return excess treated seed to the supplier if permitted by the state. 
x DO NOT contaminate bodies of water when disposing of equipment wash water. 
x Advisory Dust-Reducing Technique: The use of seed flow lubricants or polymer 
coatings may help decrease the amount of dust released during planting. Follow the 
recommendations of the planter manufacturer regarding the use of seed flow lubricants.

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7.2 Seed Treatment in Commercial Facilities or Seed 
Treatment on Farm (when treated seed are to be sold or 
distributed) – Seed Bag Labeling Requirements 
The Federal Seed Act requires that containers of treated seed must be labeled with the 
following statements: 
x This seed has been treated with azoxystr obin, fludioxonil, sedaxane, and mefenoxam 
fungicides and thiamethoxam insecticide. 
x Do not use for food, feed, or oil purposes. 
 
The U.S. Environmental Protection Agency requires that bags containing treated seed shall 
be labeled with the following statements. Any seed treated with A22353 that is sold or 
distributed without these statements or that is sold or distributed for a use not permitted by 
the following labeling does not qualify as an exempted treated article under 40 CFR 
152.25(a) and is therefore sale or distribution of an unregistered pesticide, pursuant to FIFRA 
section 12(a)(1)(A). 
 
This seed has been treated with A22353 (EPA Reg No. 100-1638) containing azoxystrobin, 
fludioxonil, mefenoxam, thiamethoxam, and sedaxane. Any seed treated with A22353 that is 
sold or distributed for a use not permitted by the following labeling does not qualify as an 
exempted treated article under 40 CFR 152.25(a) and is therefore sale or distribution of an 
unregistered pesticide, pursuant to FIFRA section 12(a)(1)(A). 
 
x The contents of this bag are for planting purposes only. DO NOT use for food, feed, or oil 
purposes. DO NOT use for fuel or ethanol production purposes. 
x Store treated seed away from food and feedstuffs. 
x DO NOT allow children, pets, or livestock to have access to treated seed. 
x Wear long-sleeved shirt, long pants and chemical-resistant gloves when handling treated 
seed. 
x DO NOT plant treated seed by broadcasting to the soil surface. Ensure that all planted 
seeds are thoroughly incorporated by the planter during planting. Additional incorporation 
may be required to thoroughly cover exposed seeds. 
x Do not use at a rate that will result in more than 0.266 lb thiamethoxam per acre (120 
grams ai/A) per calendar year, regardless of type of application (seed treatment, soil, or 
foliar). Do not apply more than 0.083 lb thiamethoxam per acre (37.8 g ai/A), 0.003 lb 
azoxystrobin per acre (1.5 g ai/A), 0.004 lb fludioxonil per acre (2.0 g ai/A), 0.013 lb 
mefenoxam per acre (5.7 g ai/A), or 0.004 lb sedaxane per acre (2.0 g ai/A) per calendar 
year as a seed treatment application. 
x Soybean seeds treated with this product contain 0.076 mg of thiamethoxam/seed, 0.003 
mg of azoxystrobin/seed, 0.004 mg of fludioxonil/seed, 0.012 mg of mefenoxam/seed, and 
0.004 mg of sedaxane/seed. 
x Maximum usage when applying metalaxyl- and mefenoxam-containing products to 
the same crop within the same season: Do not apply more than the maximum yearly 
total application rate for the active ingredient as stated on the label of the product 
containing the lowest yearly total on that crop. 
x Do not apply a neonicotinoid insecticide within 45 days of planting soybean seeds treated 
with this product. 
x Treated seed must be planted into the soil at a depth greater than 1 inch.

A22353 
Page 14 
 
x Treated seed exposed on soil surface may be hazardous to wildlife. Cover or collect 
treated seed spilled during loading and planting (such as in row ends). 
x Manage excess treated seed (e.g., spilled, unused, or expired treated seed) by one or 
more of the following methods: 
o Collect excess treated seed for reuse for planting. 
o Bury excess treated seed (only allowed if totaling 1 pound or less) at least 30 feet 
away from bodies of water at a depth of 6 inches or double the planting depth, 
whichever is greater. 
o Dispose of excess treated seed by plac ing them in a landfill in accordance with 
applicable laws in your state. 
o Return excess treated seed to the supplier if permitted by the state. 
x Do not contaminate water bodies when disposing of planting equipment wash waters. 
x Dispose of seed packaging in accordance with local requirements. 
x Groundwater Advisory: Azoxystrobin, a degradate of azoxystrobin, and mefenoxam are 
known to leach through soil into groundwater under certain conditions as a result of label 
use. Fludioxonil and thiamethoxam have properties and characteristics associated with 
chemicals detected in groundwater. These chemicals may leach into groundwater if used 
in areas where soils are permeable, particularly where the water table is shallow. 
x Pollinator Precautions: Thiamethoxam is highly toxic to bees exposed to direct 
treatment, and effects may be possible as a result of exposure to translocated residues in 
blooming crops. 
x Advisory Dust-Reducing Technique: The use of seed flow lubricants or polymer 
coatings may help decrease the amount of dust released during planting. Follow the 
recommendations of the planter manufacturer regarding the use of seed flow lubricants.

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x In the event of a crop failure or harvest of a crop grown from seed treated with A22353, 
the field may be replanted according to the following schedule: 
Plantback Interval Table 
Immediate Plantback Interval Minimum 30-Day Plantback Interval 
Canola 
Cereal Grains: Barley, Corn (Field, Pop, 
Seed, Sweet), Oats, Rye, Sorghum, 
Triticale, and Wheat 
Cotton 
Dried Shelled Pea and Bean Crop 
Subgroup 6C 
Oilseeds: Borage, Crambe, Flax Seed, 
and Mustard Seed 
Potato 
Soybean 
Sugarbeet 
 
Alfalfa 
Cereal Grains Crop Group 15 
Cucurbit Vegetables Crop Group 9 
Fruiting Vegetables Crop Group 8 
Head and Stem Brassica Crop Subgroup 5A 
Leafy Brassica Greens Crop Subgroup 5B 
Leafy Vegetables Crop Group 4 
Legume Vegetables (Succulent or Dried) 
Crop Group 6 
Mint: Peppermint and Spearmint 
Onion, Dry Bulb 
Peanut 
Root Vegetables Crop Subgroup 1A 
Safflower 
Strawberry 
Sunflower 
Tobacco 
Tuberous and Corm Vegetables Crop 
Subgroup 1D 
x For all other crops, the minimum plantback interval is 120 days from the date of planting 
seeds treated with A22353. A cover crop, other than the crops listed above, planted for 
erosion control or soil improvement may be planted sooner than the 120-day interval; 
however, the crop may not be grazed or harvested for food or feed. 
x The maximum number of applications per season is 2. 
x [All seed bag tags must be legible and set in at least 8-point font size.]

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8.0 SEED TREATMENT DIRECTIONS 
8.1 Soybean 
 
Target Pests / Diseases 
Use Rate 
(fl oz/100 lb seeds) 
(fl oz/140,000 seeds unit) 
Use Rate 
(mg ai/seed)* Use Information 
 
Early-season Insect Pests 
 
Aphids, Bean leaf beetle, 
Grape colaspis, Leaf 
miners, Leaf hoppers, 
Mexican bean beetle, 
Seed corn maggot, Three-
cornered alfalfa hopper, 
Thrips, White grubs, and 
Wireworm 
 
 
Early-season Fungal 
Diseases 
 
Seed rot/pre-emergence 
damping-off, post-
emergence damping-off, 
and seedling blight caused 
by Fusarium, Pythium, and 
Rhizoctonia species 
 
Seedling root rot caused by 
Fusarium species 
 
Pod and stem blight caused 
by seed-borne Diaporthe-
Phomopsis species 
disease complex 
 
Early-season root rot and 
damping-off caused by 
Phytophthora 
 
Suppresses seed-borne 
Sclerotinia caused by 
Sclerotinia sclerotiorum 
 
3.0 fl oz 
/100 lb seeds 
 
 
 
1.4 fl oz 
/140,000 seeds unit 
TOTAL: 0.099 
 
Azoxystrobin: 0.003 
Fludioxonil: 0.004 
Sedaxane: 0.004 
Mefenoxam: 0.012 
Thiamethoxam: 0.076 
*The mg ai/seed rate 
provided is based on 
an average seed 
weight of 3,000 
soybeans/lb. 
If treating seed with 
a different average 
seed weight, 
recalculate the 
appropriate 
fl oz/100 lb seed 
rate. 
Resistance Management: 
x Refer to Section 3.1 and Section 3.2 
USE RESTRICTIONS 
x Refer to Section 6.0 for additional product use restrictions.

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8.2 Soybean Treatment for Protection Against Seed Storage Pests 
Target Pests 
Use Rate 
(fl oz/100 lb seed) 
(fl oz/140,000 seeds) 
Use Rate 
 (mg ai/seed) Use Information 
 
 
Seed Storage Pests 
Indian Meal Moth 
(Plodia interpunctella) 
Rice Weevil 
(Sitophilus oryza) 
Red Flour Beetle 
(Tribolium castaneum) 
Lesser Grain Borer 
(Rhizopertha dominica) 
3.0 fl oz 
/100 lb seeds 
 
1.4 fl oz 
/140,000 seeds unit 
TOTAL: 0.099 
 
Azoxystrobin: 0.003 
Fludioxonil: 0.004 
Sedaxane: 0.004 
Mefenoxam: 0.012 
Thiamethoxam: 0.076 
Provides protection against 
listed seed storage pests 
when applied prior to 
storage. 
 
If the seed to be treated has 
existing infestations of 
stored grain insects, 
fumigate the seed with a 
registered product approved 
for such use prior to treating 
with A22353 and bagging. 
 
Resistance Management: 
x Refer to Section 3.1 and Section 3.2 
USE RESTRICTIONS 
x Refer to Section 6.0 for additional product use restrictions. 
 
 
9.0 STORAGE AND DISPOSAL 
 
STORAGE AND DISPOSAL 
Do not contaminate water, food or feed by storage or disposal. 
Pesticide Storage 
 
Store in a cool, dry place. Storage for extended periods above 90°F is not recommended. 
Store in original containers only. Keep container closed when not in use. Do not store near 
food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical waste 
storage area until proper disposal can be made if product cannot be used according to the 
label. 
Pesticide Disposal 
Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or rinsate is 
a violation of Federal Law. If these wastes cannot be disposed of by use according to label 
instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous 
Waste Representative at the nearest EPA Regional Office for guidance. 
Container Handling (less than or equal to 5 gallons) 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents 
into application equipment or a mix tank and drain for 10 seconds after the flow begins to 
drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into

A22353 
Page 18 
 
application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 
seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for 
recycling if available or puncture and dispose of in a sanitary landfill, or by incineration, or by 
other procedures approved by state and local authorities. 
 
Container Handling (greater than 5 gallons) 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents 
into application equipment or a mix tank. Fill the container ¼ full with water. Replace and 
tighten closures. Tip container on its side and roll it back and forth, ensuring at least one 
complete revolution, for 30 seconds. Stand the container on its end and tip it back and forth 
several times. Turn the container over onto its other end and tip it back and forth several 
times. Empty the rinsate into application equipment or a mix tank or store rinsate for later 
use or disposal. Repeat this procedure two more times. Then offer for recycling if available 
or puncture and dispose of in a sanitary landfill, or by incineration, or by other procedures 
approved by state and local authorities. 
 
Container Handling (greater than 5 gallons) 
Refillable container. Refill this container with pesticide only. Do not reuse this container for 
any other purpose. Cleaning the container before final disposal is the responsibility of the 
person disposing of the container. Cleaning before refilling is the responsibility of the person 
refilling. To clean container before final disposal, empty the remaining contents from this 
container into application equipment or mix tank. Fill the container about 10 percent full with 
water. Agitate vigorously or recirculate water with the pump for 2 minutes. Pour or pump 
rinsate into application equipment or rinsate collection system. Repeat this rinsing procedure 
two more times. Then offer for recycling if available or puncture and dispose of in a sanitary 
landfill, or by incineration, or by other procedures approved by state and local authorities. 
 
CONTAINER IS NOT SAFE FOR FOOD, FEED, OR DRINKING WATER.

A22353 
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10.0 CONDITIONS OF SALE AND LIMITATION OF WARRANTY 
AND LIABILITY 
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not acceptable, 
return the product at once, unopened, and the purchase price will be refunded. 
The Directions for Use of this product must be followed carefully. It is impossible to eliminate 
all risks inherently associated with the use of this product. Crop injury, ineffectiveness or 
other unintended consequences may result because of such factors as manner of use or 
application, weather or crop conditions, presence of other materials or other influencing 
factors in the use of the product, which are beyond the control of SYNGENTA CROP 
PROTECTION, LLC or Seller. To the extent permitted by applicable law, Buyer and User 
agree to hold SYNGENTA and Seller harmless for any claims relating to such factors. 
 
SYNGENTA warrants that this product conforms to the chemical description on the label and 
is reasonably fit for the purposes stated in the Directions for Use, subject to the inherent risks 
referred to above, when used in accordance with directions under normal use conditions. To 
the extent permitted by applicable law: (1) this warranty does not extend to the use of the 
product contrary to label instructions, or under conditions not reasonably foreseeable to or 
beyond the control of Seller or SYNGENTA, and (2) Buyer and User assume the risk of any 
such use. TO THE EXTENT PERMITTED BY APPLICABLE LAW, SYNGENTA MAKES NO 
WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE 
NOR ANY OTHER EXPRESS OR IMPLIED WARRANTY EXCEPT AS WARRANTED BY 
THIS LABEL. 
 
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any 
incidental, consequential or special damages resulting from the use or handling of this 
product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE 
REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF SYNGENTA 
AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR DAMAGES 
(INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, CONTRACT, 
NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) RESULTING FROM THE 
USE OR HANDLING OF THIS PRODUCT, SHALL BE THE RETURN OF THE PURCHASE 
PRICE OF THE PRODUCT OR, AT THE ELECTION OF SYNGENTA OR SELLER, THE 
REPLACEMENT OF THE PRODUCT. 
 
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

A22353 
Page 20 
 
The ALLIANCE FRAME 
the SYNGENTA Logo, and the PURPOSE ICON 
are Trademarks of a Syngenta Group Company 
 
 
Viton™ is a trademark of The Chemours Company FC, LLC 
 
© 20XX Syngenta 
 
 
 
For non-emergency (e.g. current product information), call 
Syngenta Crop Protection at 1-866-796-4368. 
 
 
 
Manufactured for: 
Syngenta Crop Protection, LLC 
P.O. Box 18300 
Greensboro, North Carolina 27419-8300 
 
 
A22353 1638 MAS 0522 AMEND-B 0226 – CL – jeb – 06/26/2026 
000100-01638.20260216B.A22353-AMEND-0226-CL.pdf