crop-chem-docs/corpus/epa_ppls/100-1225.md

# QUADRIS XTRA FUNGICIDE

- EPA Reg No: **100-1225**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Azoxystrobin (18.2%); Cyproconazole (7.3%)
- Label accepted: 2022-04-07
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01225-20220407.pdf

---
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
 April 7, 2022 
 
Rebecca Haynie, Ph.D 
Regulatory Product Manager 
Syngenta Crop Protection, Inc. 
P.O. Box 18300 
Greensboro, NC 27419 
 
Subject: Registration Review Label Mitigation for Azoxystrobin and Cyproconazole 
 Product Name: QUADRIS XTRA FUNGICIDE 
 EPA Registration Number: 100-1225 
 Application Dates: 5/17/2019 and 12/18/2020 
Decision Numbers: 568969 and 577853 
 
Dear Rebecca Haynie: 
 
The Agency, in accordance with the Federal Insecticide, Fungicide and Rodenticide Act 
(FIFRA), as amended, has completed reviewing all the information submitted with your 
application to support the Registration Review of the above referenced product in connection 
with the Azoxystrobin and Cyproconazole Interim Decisions, and has concluded that your 
submission is acceptable. The label referred to above, submitted in connection with registration 
under FIFRA, as amended, is acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be 
aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide 
Act and is subject to review by the Agency. If the website is false or misleading, the product 
would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 
CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, 
regardless of whether a website is referenced on your product’s label, claims made on the 
website may not substantially differ from those claims approved through the registration process. 
Therefore, should the Agency find or if it is brought to our attention that a website contains false 
or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes 
all previously accepted labeling. You must submit one copy of the final printed labeling 
before you release the product for shipment with the new labeling. In accordance with 40 
CFR 152.130(c), you may distribute or sell this product under the previously approved 
labeling for 12 months from the date of this letter. After 12 months, you may only 
distribute or sell this product if it bears this new revised labeling or subsequently 
approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its 
implementing regulation at 40 CFR 152.3.

Page 2 of 2 
EPA Reg. No. 100-1225 
Decision No. 568969 and 577853 
 
If you have any questions about this letter, please contact Quinn Gavin by phone at 202-566-
2284, or via email at gavin.quinn@epa.gov. 
 
 Sincerely, 
 
 
 Linda Arrington, Branch Chief 
 Risk Management and Implementation Branch 4 
 Pesticide Re-Evaluation Division 
 Office of Pesticide Programs 
 
 
Enclosure

AZOXYSTROBIN GROUP 11 FUNGICIDE
CYPROCONAZOLE GROUP 3 FUNGICIDE
Quadris Xtra®
Fungicide
Broad-spectrum fungicide for control of plant diseases
Active Ingredients:
Azoxystrobin (CAS No. 131860-33-8) ......................................................18.2%
Cyproconazole (CAS No. 94361-06-5).......................................................7.3%
Other Ingredients: 74.5%
Total: 100.0%
Quadris Xtra is a 280SC formulation that contains 0.67 lb. a.i. cyproconazole 
and 1.67 lb. a.i. azoxystrobin per gallon.
KEEP OUT OF REACH OF CHILDREN.
CAUTION
See additional precautionary statements and directions for use inside booklet.
EPA Reg. No. 100-1225
EPA Est.
____ gallons
Net Contents
Apr 07, 2022
100-1225

Quadris Xtra
Page 2
FIRST AID
If swallowed y Call a poison control center or doctor immediately for treatment 
advice.
y Have person sip a glass of water if able to swallow.
y Do not induce vomiting unless told to do so by the poison control 
center or doctor.
y Do not give anything by mouth to an unconscious person.
If on skin or
clothing
y Take off contaminated clothing.
y Rinse skin immediately with plenty of water for 15-20 minutes.
y Call a poison control center or doctor for treatment advice.
If in eyes y Hold eye open and rinse slowly and gently with water for 15-20 
minutes.
y Remove contact lenses, if present, after the first 5 minutes, then 
continue rinsing eye.
y Call a poison control center or doctor for treatment advice.
If inhaled y Move person to fresh air
y If person is not breathing, call 911 or an ambulance, then give 
artificial respiration, preferably mouth to mouth, if possible.
y Call a poison control center or doctor for future treatment advice.
Have the product container or label with you when calling a poison control 
center or doctor, or going for treatment.
HOT LINE NUMBER
For 24-Hour Medical Emergency Assistance (Human or Animal) or
Chemical Emergency Assistance (Spill, Leak, Fire, or Accident),
Call
1-800-888-8372
PRECAUTIONARY STATEMENTS
Hazards to Humans and Domestic Animals
CAUTION
Harmful if swallowed, inhaled or absorbed through skin. Avoid contact with skin, eyes or 
clothing. Causes moderate eye irritation. Wash thoroughly with soap and water after 
handling and before eating, chewing gum, using tobacco or using the toilet. Remove and 
wash contaminated clothing before reuse.
Personal Protective Equipment (PPE)
Applicators and other handlers must wear:
x Long-sleeved shirt and long pants
x Waterproof gloves

Quadris Xtra
Page 3
x Shoes plus socks
User Safety Requirements
Follow the manufacturer’s instructions for cleaning/maintaining PPE. If no such 
instructions for washables exist, use detergent and hot water. Keep and wash PPE 
separately from other laundry.
Engineering Controls
When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets 
the requirements listed in the Worker Protection Standard (WPS) for agricultural 
pesticides (40 CFR 170.240(d)(4-6)), the handler PPE requirements may be reduced or 
modified as specified in the WPS. Human flagging is prohibited.
USER SAFETY RECOMMENDATIONS
Users should:
x Wash hands before eating, drinking, chewing gum, using tobacco or using the 
toilet.
x Remove clothing/PPE immediately if pesticide gets inside. Then wash 
thoroughly and put on clean clothing.
x Remove PPE immediately after handling this product. Wash the outside of 
gloves before removing. As soon as possible, wash thoroughly and change 
into clean clothin
g.
Environmental Hazards
Azoxystrobin is toxic to freshwater, estuarine/marine fish and aquatic invertebrates. 
Azoxystrobin can be persistent for several months or longer. For terrestrial uses do not 
apply directly to water, or to areas where surface water is present, or to intertidal areas 
below the mean high water mark. Drift and runoff may be hazardous to aquatic 
organisms in water adjacent to treated areas. Do not contaminate water when 
disposing of equipment wash-water or rinsate.
Ground Water Advisory
Azoxystrobin, a degradate of azoxystrobin and cyproconazole are known to leach 
through soil to ground water under certain conditions as a result of label use. This 
product may leach into ground water if used in areas where soils are permeable, 
particularly where the water table is shallow.

Quadris Xtra
Page 4
Surface Water Advisory
This product may impact surface water quality due to runoff of rain water. This is 
especially true for poorly draining soils and soils with shallow ground water. This 
product is classified as having a high potential for reaching surface water via runoff for 
several months or more after application. A level, well-maintained vegetative buffer 
strip between areas to which this product is applied and surface water features such as 
ponds, streams, and springs will reduce the potential loading of azoxystrobin and a 
degradate of azoxystrobin from runoff water and sediment. Runoff of this product will 
be reduced by avoiding applications when rainfall or irrigation is expected to occur 
within 48 hours.
Notify State and/or Federal authorities and Syngenta immediately if you observe any 
adverse environmental effects due to use of this product.
CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not 
acceptable, return the product at once, unopened, and the purchase price will be 
refunded.
The Directions for Use of this product must be followed carefully. It is impossible to 
eliminate all risks inherently associated with the use of this product. Crop injury, 
ineffectiveness or other unintended consequences may result because of such factors as
manner of use or application, weather or crop conditions, presence of other materials or 
other influencing factors in the use of the product, which are beyond the control of 
SYNGENTA CROP PROTECTION, LLC or Seller. To the extent permitted by applicable 
law, Buyer and User agree to hold SYNGENTA and Seller harmless for any claims 
relating to such factors.
SYNGENTA warrants that this product conforms to the chemical description on the label 
and is reasonably fit for the purposes stated in the Directions for Use, subject to the 
inherent risks referred to above, when used in accordance with directions under normal 
use conditions. To the extent permitted by applicable law: (1) this warranty does not 
extend to the use of this product contrary to label instructions or under conditions not 
reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and, (2) Buyer 
and User assume the risk of any such use. TO THE EXTENT PERMITTED BY 
APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY 
OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR 
IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL.
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for any 
incidental, consequential or special damages resulting from the use or handling of this

Quadris Xtra
Page 5
product. TO THE EXTENT PERMITTED BY APPLICABLE LAW, THE EXCLUSIVE 
REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY OF 
SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR 
DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, 
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) 
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE 
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION OF 
SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT.
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.
DIRECTIONS FOR USE
It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. 
FAILURE TO FOLLOW THE USE DIRECTIONS AND PRECAUTIONS ON THIS LABEL 
MAY RESULT IN PLANT INJURY OR POOR DISEASE CONTROL.
Do not apply this product in a way that will contact workers or other persons, either directly 
or through drift. Only protected handlers may be in the area during application. For any 
requirements specific to your State or Tribe, consult the agency responsible for pesticide 
regulation.
AGRICULTURAL USE REQUIREMENTS
Use this product only in accordance with its labeling and with the Worker Protection 
Standard, 40 CFR part 170. This Standard contains requirements for the protection 
of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 
agricultural pesticides. It contains requirements for training, decontamination, 
notification, and emergency assistance. It also contains specific instructions and 
exceptions pertaining to the statements on this label about personal protective 
equipment (PPE), notification to workers, and restricted-entry interval. The 
requirements in this box only apply to uses of this product that are covered by the 
Worker Protection Standard.
Do not enter or allow worker entry into treated areas during the restricted entry 
interval (REI) of 12 hours.
PPE required for early entry to treated areas that is permitted under the Worker 
Protection Standard and that involves contact with anything that has been treated, 
such as plants, soil or water is:
x Coveralls
x Waterproof 
gloves

Quadris Xtra
Page 6
x Shoes plus socks
USE INFORMATION
Quadris Xtra is a broad spectrum, preventative fungicide with systemic and curative 
properties recommended for the control of many important plant diseases. Quadris Xtra 
may be applied as a foliar spray in alternating spray programs or in tank mixes with other 
crop protection products. All applications must be made according to the use directions 
that follow. 
USE PRECAUTIONS
Do not use in nurseries, greenhouses or landscape plantings.
Under certain conditions conducive to extended infection periods, use another registered 
fungicide for additional applications if the maximum amount of product has been applied.
The active ingredient(s) in this product may have effects on federally listed threatened 
and endangered species or critical habitat in some counties. When using this product, 
you must follow the measures contained in the County Bulletin for the county in which 
you are applying the pesticide. To determine whether your County has a Bulletin consult
http://www.epa.gov/espp. Bulletins also may be available from local pesticide dealers, 
extension offices, or State pesticide agencies.
ROTATIONAL CROPS
Soybeans, corn, or wheat may be replanted immediately, if crop is lost. Cereal grains
other than wheat can be planted 180 days after last application. Cotton can be planted 
180 days after last application. All other crops (including leafy vegetables) can be planted 
270 days after last application. 
PHYTOTOXICITY
Quadris Xtra demonstrates some phytotoxic effects when mixed with products that are 
formulated as ECs. These effects are enhanced if applications are made under cool, 
cloudy conditions and these conditions remain for several days following application. In 
addition, adjuvants that contain some form of silicone can contribute to phytotoxicity. 
Under certain environmental conditions, tank mixes of Quadris Xtra plus herbicides and/or 
fertilizers may cause crop injury.
ATTENTION
Quadris Xtra is extremely phytotoxic to certain apple varieties.

Quadris Xtra
Page 7
AVOID SPRAY DRIFT. Extreme care must be used to prevent injury to apple trees (and 
apple fruit).
DO NOT spray Quadris Xtra where spray drift may reach apple trees.
DO NOT use spray equipment which has been previously used to apply Quadris Xtra to 
spray apple trees. Even trace amounts can cause unacceptable phytotoxicity to certain 
apple and crabapple varieties.
AVOIDING SPRAY DRIFT IS THE RESPONSIBILITY OF THE APPLICATOR.
INTEGRATED PEST (DISEASE) MANAGEMENT
Quadris Xtra should be integrated into an overall disease and pest management strategy 
whenever the use of a fungicide is required. Cultural practices known to reduce disease
development should be followed. The SPECIFIC USE DIRECTIONS section in this label 
identifies specific IPM recommendations for each crop. Consult your local agricultural 
authorities for additional IPM strategies established for your area. Quadris Xtra may be 
used in State Agricultural Extension advisory (disease forecasting) programs which 
recommend application timing based on environmental factors favorable for disease 
development. 
RESISTANCE MANAGEMENT
AZOXYSTROBIN GROUP
11 FUNGICIDE
CYPROCONAZOLE GROUP 3 FUNGICIDE
For resistance management, please note that Quadris Xtra contains both azoxystrobin, 
a strobilurin fungicide in Group 11 and cyproconazole, a triazole fungicide in Group 3. 
Any fungal population may contain individuals naturally resistant to either or both of the 
active ingredients in Quadris Xtra and other Group 11 or Group 3 fungicides. A gradual 
or total loss of pest control may occur over time if these fungicides are used repeatedly 
in the same fields. Appropriate resistance-management strategies should be followed.
Follow specific crop recommendations that limit the total number of sprays on a crop and 
the required alternations with fungicides from other resistance management groups. In 
situations requiring multiple sprays (more than two), develop season long spray programs 
for Group 11 (QoI) fungicides. The program should meet the goal of no more than 1/3 of 
the total sprays per season, when a Group 11 fungicide is used as a solo product, or 1/2 
the total sprays when a Group 11 fungicide is used in a mixture. Programs that include 
both solo Group 11 products and/or mixes containing Group 11 products should be no 
more than ½ the total sprays.

Quadris Xtra
Page 8
Quadris Xtra should not be alternated or tank mixed with any fungicide to which resistance 
has already developed. 
To delay fungicide resistance, take one or more of the following steps:
x Rotate the use of Quadris Xtra or other Group 11 and 3 fungicides within a growing 
season sequence with different groups that control the same pathogens.
x Use tank mixtures with fungicides from a different group that are equally effective on 
the target pest when such use is permitted. Use at least the minimum application rate 
as labeled by the manufacturer.
x Adopt an integrated disease management program for fungicide use that includes 
scouting, uses historical information related to pesticide use, and crop rotation, and 
which considers host plant resistance, impact of environmental conditions on disease 
development, disease thresholds, as well as cultural, biological and other chemical 
control practices.
x Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage 
resistance.
x Monitor treated fungal populations for resistance development.
x Contact your local extension specialist or certified crop advisor for any additional 
pesticide resistance-management and/or IPM recommendations for specific crops 
and pathogens.
x For further information or to report suspected resistance contact Syngenta Crop 
Protection at 1-866-796-4368. You can also contact your pesticide distributor or 
university extension specialist to report resistance.

Quadris Xtra
Page 9
SPRAY EQUIPMENT
Equip sprayers with nozzles that provide accurate and uniform application. Be certain 
that nozzles are the same size and uniformly spaced across the boom. Calibrate sprayer 
before use.
Use a pump with capacity to: (1) maintain at least 35-40 psi at nozzles, and (2) provide 
sufficient agitation in tank to keep mixture in suspension - this requires recirculation of 
10% of tank volume per minute. Use a jet agitator or liquid sparge tube for agitation. Do 
not air sparge.
Quadris Xtra is a suspoemulsion concentrate. It is suggested that screens be used to 
protect the pump and to prevent nozzles from clogging. Screens placed on suction side 
of pump should be 16-mesh or coarser. Do not place a screen in the recirculation line. 
Use 50-mesh or coarser screens between the pump and boom, and where required, at 
the nozzles. Check nozzle manufacturer’s recommendations.
For more information on spray equipment and calibration, consult sprayer manufacturers 
and state recommendations. For specific local directions and spray schedules, consult 
the current state and local agricultural recommendations.
SPRAYING/MIXING
Quadris Xtra may be applied with all types of spray equipment commonly used for making 
ground and aerial applications. Do not apply Quadris Xtra through any type of ultra low 
volume (ULV) spray system. Proper adjustments and calibration of spraying equipment 
to give good canopy penetration and coverage is essential for good disease control. 
Higher rates in the rate range and/or shorter spray intervals may be required under 
conditions of heavy infection pressure, highly susceptible varieties, or when 
environmental conditions conducive to disease exist.
For ground applications, apply Quadris Xtra in a minimum of 10 gallons of water volume 
for adequate coverage and canopy penetration. For aerial applications, apply Quadris 
Xtra according to local recommendations. 
Prepare no more spray mixture than is required for the immediate operation. Thoroughly 
clean spray equipment before using this product. Agitate the spray solution before and 
during application. Rinse spray tank thoroughly with clean water after each day’s use 
and dispose of pesticide rinsate by application to an already treated area.
Quadris Xtra Alone: Add 1/2 - 2/3 of the required amount of water to the spray of mixing 
tank, with the agitator running, add Quadris Xtra to the tank and continue agitation while 
adding the remainder of the water. Begin application of the spray solution after the

Quadris Xtra
Page 10
Quadris Xtra has completely dispersed into the mix water and maintain agitation until all 
of the mixture has been sprayed.
Quadris Xtra + Tank Mixtures: Do not combine Quadris Xtra in the spray tank with 
pesticides, surfactants, or fertilizers, unless compatibility charts or your own prior use has 
shown that the combination is physically compatible, effective, and non-injurious to the 
crop under your conditions of use. To determine physical compatibility of Quadris Xtra 
and other products, use a jar test. Using a quart jar, add the proportionate amounts of 
the products to 1 qt. of water. Add wettable powders and water-dispersible granular 
products first, then liquid flowables (suspoemulsions), and emulsifiable concentrates last. 
After thoroughly mixing, let stand for at least 5 minutes. If the combination remains mixed 
or can be remixed readily, it is physically compatible. Once compatibility has been 
proven, use the same procedure for adding required ingredients to the spray tank.
Add 1/2 - 2/3 of the required amount of water to the spray or mixing tank. With the agitator 
running, add the tank mix partner into the tank. Allow the material to completely dissolve 
and disperse into the mix water. Continue agitation while adding the remainder of the 
water and the Quadris Xtra to the spray tank. Allow the Quadris Xtra to completely 
disperse. Spray the mixture with the agitator running. 
Observe the most restrictive of the labeling limitations and precautions of all products 
used in tank mixtures.
SPRAY DRIFT MANAGEMENT
SPRAY DRIFT MANAGEMENT
Aerial Applications
x Do not release spray at a height greater than 10 ft. above the crop canopy, unless a 
greater application height is necessary for pilot safety.
x Applicators are required to select nozzles that deliver medium to coarse spray 
droplets in accordance with ASABE Standard S-572.1.
x Do not apply when wind speeds exceed 15 mph at the application site. If the 
windspeed is greater than 10 mph, the boom length must be 65% or less of the 
wingspan for fixed wing aircraft and 75% or less of the rotor diameter for helicopters. 
Otherwise, the boom length must be 75% or less of the wingspan for fixed-wing 
aircraft and 90% or less of the rotor diameter for helicopters.
x Applicators must use ½ swath displacement upwind at the downwind edge of the 
field.
x Do not apply during temperature inversions.
Ground Boom Applications

Quadris Xtra
Page 11
x User must only apply with the release height recommended by the manufacturer, but 
no more than 4 feet above the ground or crop canopy.
x Applicators are required to use a medium or coarser droplet size (ASABE S-572.1). 
x Do not apply when wind speeds exceed 15 miles per hour at the application site.
x Do not apply during temperature inversions.
SPRAY DRIFT ADVISORIES
x THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE SPRAY 
DRIFT.
x BE AWARE OF NEARBY NON-TARGET SITES AND ENVIRONMENTAL 
CONDITIONS.
IMPORTANCE OF DROPLET SIZE
The effective way to reduce spray drift is to apply large droplets. Use the largest
droplets that provide target pest control. While applying larger droplets will reduce spray 
drift, the potential for drift will be greater if applications are made improperly or under 
unfavorable environmental conditions. 
Controlling Droplet Size – Groundboom
x Volume - Increasing the spray volume so that larger droplets are produced will 
reduce spray drift. Use the highest practical spray volume for the application. If a 
greater spray volume is needed, consider using a nozzle with higher flow rate.
x Pressure - Use the lowest spray pressure recommended for the nozzle to
produce the target spray volume and droplet size.
x Nozzle Type - Use a spray nozzle that is designed for the intended application. 
Consider using nozzles designed to reduce drift.
Controlling Droplet Size – Aircraft
x Adjust Nozzles - Follow nozzle manufacturers recommendations for setting up 
nozzles. Generally, to reduce fine droplets, nozzles should be oriented parallel 
with the airflow in flight.
BOOM HEIGHT – Groundboom
x For ground equipment, the boom should remain level with the crop and have 
minimal bounce.
RELEASE HEIGHT – Aircraft
x Higher release heights increase the potential for spray drift.
SHIELDED SPRAYERS

Quadris Xtra
Page 12
x Shielding the boom or individual nozzles can reduce spray drift. Consider using 
shielded sprayers. Verify that the shields are not interfering with the uniform 
deposition of the spray on the target area.
TEMPERATURE AND HUMIDITY
x When making applications in hot and dry conditions, set up equipment to
produce larger droplets to reduce effects of evaporation.
TEMPERATURE INVERSIONS
x Drift potential is high during a temperature inversion. Temperature inversions are 
characterized by increasing temperature with altitude and are common on nights 
with limited cloud cover and light to no wind. Their presence of an inversion can 
be indicated by ground fog or by the movement of smoke from a ground source 
or an aircraft smoke generator. Smoke that layers and moves laterally in a 
concentrated cloud (under low wind conditions) indicates an inversion, while 
smoke that moves upward and rapidly dissipates indicates good vertical air 
mixing. Avoid applications during temperature inversions.
WIND
x Drift potential increases at wind speeds. AVOID APPLICATIONS DURING 
GUSTY WIND CONDITIONS.
x Applicator need to be familiar with local wind patterns and terrain that could affect 
spray drift.
APPLICATION INSTRUCTIONS
Apply Quadris Xtra at rates and timings as described in this label. Quadris Xtra may be 
applied by ground, by air, or via chemigation. Refer to crop section for specific directions.
Apply Quadris Xtra in a minimum of 10 GPA via ground application equipment and 2 GPA 
via aerial application equipment.
Directions for Use Through Sprinkler Chem igation Systems (apply Quadris Xtra 
only to crops for which chemigation is specified on this label):
Spray Preparation: Chemical tank and injector system should be thoroughly cleaned. 
Flush system with clean water.
Use Precautions for Sprinkler Irrigation Applications
Apply this product through sprinkler irrigation systems including center pivot, lateral move, 
end tow, side [wheel] roll, traveler, big gun, solid set, drip (trickle), or hand move irrigation

Quadris Xtra
Page 13
systems. Do not apply this product through any other type of irrigation system except as 
specified on this label.
Apply with center pivot or continuous-move equipment distributing 1/2 acre-inch or less 
during treatment. In general, use the least amount of water required for proper distribution 
and coverage. If stationary systems (solid set, handlines or wh eel lines other than 
continuous-move) are used, this product should be injected into no more than the last 20-
30 minutes of the set. Do not apply when winds are greater than 10-15 mph to avoid drift 
or wind skips. Do not apply when wind speed favors drift beyond the area intended for 
treatment. Plant injury, lack of effectiveness, or illegal pesticide residues in the crop can 
result from non-uniform treated water. Thorough coverage of foliage is required for good 
control. Good agitation should be maintained during the entire application period.
If you have questions about calibration you should contact State Extension Service 
specialist, equipment manufacturers or other experts.
The system must contain a functional check valve, vacuum relief valve, and low-pressure 
drain appropriately located on the irrigation pipeline to prevent water-source 
contamination from backflow.
The pesticide injection pipeline must contain a functional, automatic, quick-closing check 
valve to prevent the flow of fluid back toward the injection pump.
The pesticide injection pipeline must also contain a functional, normally closed, solenoid-
operated valve located on the intake side of the injection pump and connected to the 
system interlock to prevent fluid from bein g withdrawn from the supply tank when the 
irrigation system is either automatically or manually shut down.
The system must contain functional interlocki ng controls to automatically shut off the 
pesticide injection pump when the water pump motor stops.
The irrigation line or water pump must include a functional pressure switch which will stop 
the water pump motor when the water pressure decreases to the point where pesticide 
distribution is adversely affected.
Systems must use a metering pump, such as a positive displacement injection pump 
(e.g., diaphragm pump) effectively designed and constructed of materials that are 
compatible with pesticides and capable of being fitted with a system interlock.
Allow sufficient time for pesticide to be flushed through all lines and all nozzles before 
turning off irrigation water. A person k nowledgeable of the chemigation system and 
responsible for its operation, or under the supervision of the responsible person, shall 
shut the system down and make necessary adjustments should the need arise.

Quadris Xtra
Page 14
Do not connect an irrigation system (incl uding greenhouse systems) used for pesticide 
application to a public water system unless the pesticide label-prescribed safety devices 
for public water systems are in place.
Specific Instructions for Public Water Systems
1. Public water system means a system for the provision to the public of piped water 
for human consumption if such system ha s at least 15 service connections or 
regularly serves an average of at least 25 individuals daily at least 60 days out of 
the year.
2. Chemigation systems connected to public water systems must contain a functional, 
reduced-pressure zone (RPZ), back-flow preventer or the functional equivalent in 
the water supply line upstream from the point of pesticide introduction. As an 
option to the RPZ, the water from the public water system should be discharged 
into a reservoir tank prior to pesticide introduction. There shall be a complete 
physical break (air gap) between the outlet end of the fill pipe and the top or 
overflow rim of the reservoir tank of at least twice the inside diameter of the fill 
pipe.
3. The pesticide injection pipeline must contain a functional, automatic, quick-closing 
check valve to prevent the flow of fluid back toward the injection pump.
4. The pesticide injection pipeline must contain a functional, normally closed, solenoid-
operated valve located on the intake side of the injection pump and connected to the 
system interlock to prevent fluid from being withdrawn from the supply tank when 
the irrigation system is either automatically or manually shut down.
5. The system must contain functional interlocking controls to automatically shut off the 
pesticide injection pump when the water pump motor stops or in cases where there 
is no water pump, when the water pressure decreases to the point where pesticide 
distribution is adversely affected.
6. Systems must use a metering pump, such as a positive displacement injection pump 
(e.g., diaphragm pump) effectively designed and constructed of materials that are 
compatible with pesticides and capable of being fitted with a system interlock.
7. Do not apply when wind speed favors drift beyond the area intended for treatment.

Quadris Xtra
Page 15
SPECIFIC USE DIRECTIONS
Crop Target Diseases
Use Rate
fl. oz. 
product/A
Remarks
Cereals
Wheat 
Triticale
Early season 
suppression of:
Glume blotch
(Stagonospora 
nordorum)
Leaf blight
(Septoria tritici)
Powdery mildew
(Blumeria spp., 
Erysiphe spp.)
Tan spot
(Pyrenophora tritici-
repentis)
3.5 Apply Quadris Xtra in the spring at approximately 
Feekes Stage 5.
The minimum retreatment interval is 14 days.
Quadris Xtra may be applied by ground, air or 
chemigation. If applied by chemigation, the maximum 
amount of water should be 0.25 inches.
Control of Leaf 
Diseases:
Glume blotch
(Stagonospora 
nordorum)
Helminthosporium leaf 
blight
(Drechslera tritici-
repentis)
Leaf blight
(Septoria tritici)
Powdery mildew
(Blumeria spp., 
Erysiphe spp.)
Rust (stripe, leaf, and 
stem)
(Puccinia spp.)
Spot blotch
(Bipolaris sorokiniana)
Tan spot
(Pyrenophora tritici-
repentis)
5–6.8 Apply Quadris Xtra between Feekes Stage 8 and 
10.5.1. Protecting the flag leaf is important for 
maximizing the potential yield. 
The minimum retreatment interval is 14 days. 
Quadris Xtra may be applied up to 30 days prior to 
harvest. Quadris Xtra may be applied by ground, air 
or chemigation.
Resistance Management: No more than two foliar
applications of Quadris Xtra or other strobilurin
fungicides should be made per growing season. Do 
not alternate or tank mix with fungicides to which 
resistance has developed in the pathogen population.
Specific Use Restrictions:
(1) Do not apply more than 6.8 fl. oz./A of Quadris Xtra (0.036 lb. a.i./A cyproconazole and 0.089 lb. a.i./A 
azoxystrobin) per year.
(2) Do not apply more than 6.8 fl. oz/A (0.036 lb. a.i./A cyproconazole and 0.089 lb. a.i./A azoxystrobin) per single 
application.
(2) Do not harvest wheat within 30 days of application. 
(3) Do not harvest forage or hay within 21 days of application.
(4) Do not apply more than 0.036 lb. a.i./A/year cyproconazole containing products. 
(5) Do not apply more than 0.4 lb. a.i./A/year azoxystrobin containing products.

Quadris Xtra
Page 16
Crop Target Diseases
Use Rate
fl. oz. 
product/A
Remarks
Corn
Field
Seed
Eye spot
(Aureobasidium zeae)
Gray leafspot
(Cercospora zeae-
maydis)
Northern corn leaf blight
(Setosphaeria turcica)
Northern corn leaf spot
(Cochiliobolus 
carbonum)
Rusts (common and 
Southern)
(Puccinia spp.)
Southern corn leaf blight
(Cochliobolus 
heterostrophus)
[also known as
Helminthosporium leaf 
blights
(H. maydis, H. 
turcicum, H. 
carbonum)]
3.5–6.8 Apply Quadris Xtra when disease first appears. Use 
the low rate when disease pressure is low. Under 
heavy disease pressure or if conditions are favorable 
for disease, apply the high rate. A second application 
may be made 7–14 days later. A maximum of 6.8 
oz./A per season may be used.
Application Directions: Apply no more than 2 
applications of Quadris Xtra or any other Group 11 
fungicide per year. Quadris Xtra may be applied by 
ground, air or chemigation.
Resistance Management: No more than two foliar
applications of Quadris Xtra or other strobilurin 
fungicides should be made per growing season. Do 
not alternate or tank mix with fungicides to which 
resistance has developed in the pathogen population.
Specific Use Restrictions:
(1) Do not apply within 30 days of harvest. 
(2) Do not harvest silage within 21 days of an application. 
(3) Do not apply more than 6.8 fl. oz./A/year of Quadris Xtra. 
(4) Do not apply more than 0.036 lb. a.i. cyproconazole containing products/A/year. 
(5) Do not apply more than 2.0 lb. a.i. azoxystrobin containing products/A/year.

Quadris Xtra
Page 17
Crop Target Diseases
Use Rate
fl. oz. 
product/A
Remarks
Soybean Application Directions: Coverage and penetration 
are important for best results. Use sufficient water 
volume to provide thorough and uniform plant 
coverage. Applications may be made by ground, air 
or chemigation. Addition of an additive with 
spreading and penetrating qualities will enhance 
coverage and efficacy.
Resistance Management: No more than two foliar
applications of Quadris Xtra or other strobilurin
fungicides should be made per growing season. Do 
not alternate or tank mix with fungicides to which 
resistance has developed in the pathogen population.
Rust
(Phakopsora spp.)
4.0–6.8
For soybean rust: Apply 4–6.8 fl. oz./A. Repeat at 
14-28 day interval, if conditions persist for rust 
development. Lower use rates may require a shorter 
spray interval. Depending on the conditions, 
application timing should be at R1 (beginning 
flowering, approximately 50 days after planting) up to 
the R6 stage (seed development), but could be 
earlier. 
Aerial blight
(Rhizoctonia solani)
Alternaria leaf spot
(Alternaria spp.)
Anthracnose
(Colletotrichum 
truncatum)
Brown spot
(Septoria glycines)
Cercospora blight and 
leaf spot
(Cercospora kikuchii)
Frogeye leafspot
(Cercospora sojina)
Pod and Stem blight
(Diaporthe phaseolorum
5.0–6.8 For diseases other than soybean rust: Begin 
Quadris Xtra applications prior to disease 
development. Use the higher rates under conditions 
favorable for severe disease pressure, dense plant 
canopies, or when disease is present. Contact 
extension personnel for local economic thresholds 
and timings for specific diseases in your area. An 
adjuvant may be added at recommended rates to 
improve coverage. 
Specific Use Restrictions:
(1) Do not apply more than 13.6 fl.oz. Quadris Xtra/A/year.
(2) Do not apply within 30 days of harvest of soybeans (bean).
(3) Do not graze forage within 14 days of an application. 
(4) Do not apply more than 0.072 lb. a.i./A/year of cyproconazole containing products. 
(5) Do not apply more than 1.5 lb. a.i./A/year of azoxystrobin containing products.
(6) Do not use soybean forage or hay as livestock feed if making more than one application at 6.8 fl. oz. product/A.

Quadris Xtra
Page 18
Quadris Xtra Rate Conversion Table
fl. oz./A
lb. a.i./A 
Cyproconazole
lb. a.i./A 
Azoxystrobin
Treated acres 
per gallon 
product
3.5 0.018 0.046 36.6
4.0 0.021 0.052 32.0
5.0 0.026 0.066 25.6
6.5 0.034 0.085 19.7
6.8 0.036 0.089 18.8
13.6 0.072 0.178 N/A
STORAGE AND DISPOSAL
Do not contaminate water, food or feed by storage and disposal. 
Pesticide Storage
Store in original container only. Keep container closed when not in use. Do not store 
near food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical 
waste storage area until proper disposal can be made if product cannot be used according 
to the label.
Pesticide Disposal
Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray 
mixture, or rinsate is a violation of Federal Law. If these wastes cannot be disposed of 
by use according to label instructions, contact your State Pesticide or Environmental 
Control Agency, or the Hazardous Waste representative of the nearest EPA Regional 
Office for guidance.
Container Handling (equal to or less than 5 gallons)
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank and drain for 10 seconds after the flow 
begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal. 
Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. 
Then offer for recycling if available or puncture and dispose of in a sanitary landfill, by 
incineration, or Puncture and dispose of in a sanitary landfill or by incineration.

Quadris Xtra
Page 19
Container Handling (greater than 5 gallons)
Refillable container. Refill this container with pesticide only. Do not reuse the container 
for any other purpose. Cleaning the container before final disposal is the responsibility of 
the person disposing of the container. Cleaning before refilling is the responsibility of the 
person refilling. To clean cont ainer before final di sposal, empty the remaining contents 
from this container into application equipmen t or mix tank. Fill the container about 10 
percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. 
Pour or pump rinsate into application equipment or rinsate collection system. Repeat this 
rinsing procedure two more times. Then offer for recycling if available or puncture and 
dispose of in a sanitary landfill, or by incineration, or by other procedures allowed by state 
and local authorities.
CONTAINER IS NOT SAFE FOR FOOD, FEED OR DRINKING WATER.
Quadris Xtra®, the Syngenta logo, the ALLIANCE FRAME and the PURPOSE ICON
are trademarks of a Syngenta Group Company
©20XX Syngenta
For non-emergency (e.g. current product information), call
Syngenta Crop Protection at 1-800-334-9481.
Manufactured for:
Syngenta Crop Protection, LLC
P.O. Box 18300
Greensboro, North Carolina 27419-8300
QUADRIS XTRA 1225 MAS 1113 AMEND-C 1220-CL – ep – 2-25-21
000100-01225.20201218C.QUADRIS_XTRA-AMEND-1220-CL