crop-chem-docs/corpus/epa_ppls/100-1335.md

# Difenoconazole/Mefenoxam FS

- EPA Reg No: **100-1335**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Metalaxyl-M (0.27%); Difenoconazole (3.37%)
- Label accepted: 2009-05-21
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01335-20090521.pdf

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u.s. ENVIRONMENTAL PROTECTION AGENCY 
Office of Pesticide Programs 
Registration Division (7505P) 
Ariel Rios Building 
1200 Pennsylvania Ave., NW 
Washington, D.C. 20460 
NOTICE OF PESTICIDE: 
-L Registration 
Reregistration 
(under FIFRA, as amended) 
Name and Address of Registrant (include ZIP Code): 
Syngenta Crop Protection, Inc. 
P.O. Box 18300 
Greensboro, NC 27419 -Attn.: Patrick McCain 
EPA Reg. Number: Date ofissuance: 
100-1335 
HAY 2 1 2009 
Term ofissuance: Conditional 
Name of Pesticide Product: 
DifenoconazolelMefenoxam FS 
Not~; Changes in la~eling diffeiing< i~ substance from th~t accepted in connt!CtiQn with .this reglstratio~ ml:lSt b~ su~mitted' to and: a~cepted by t~e . ~ 
Registration DiviSion prior to use of the label in cOmmerce. Iri any correspOnderice on this product always refer to the above EPA registration number . 
. On the basis of information furnished by the registrant, the above named pesticide is hereby registered under the Federal Insecticide, Fungicide and 
Rodenticide Act. Registration is in no·way to be construed as an endorsement or recommendation of this product by the Agency. In order to protect 
health and the environment, the Administrator, on his motion, may at any time suspend or cancel the registration of a pesticide in accordance with the 
Act. The acceptance of any name in connection with the registration of a product under this Act is not to be construed as giving the registrant a right to 
exclusive use of the name or to its use if it has been covered by others. 
This product is conditionally registered in accordance with FIFRA sec. 3(c)(7)(A) provided that 
you: 
1. Submit and/or cite all data required for registration of your product under FIFRA Section 
3(c)(5) when the Agency requires all registrants of similar products to submit such data; and submit 
acceptable responses required for re-registration of your product under FIFRA Section 4. 
2. You must submit the following conditional data listed below, before the due date of 
07/1/2010: 
A. One year GLP storage stability (830.6317) and corrosion characteristics (830.6320) study 
on the product. It is requi~ed that the observations be made at 0,3,6,9, and 12 month intervals. 
The results must be submitted to the Agency in electronic and hard copy format. 
3. You must submit two copies of a final printed label within 30 days from the date of this 
notice which makes the following changes: 
A. On page 3 in the PPEsection, change "for washables" to "for washables exists." 
Signature of Approving Official: 
Tony Kish . 
Product Manager, Team 22 
Fungicide Branch 
Registration Division (7505P) 
EPA Form 8570-6 
Date: 
HAY 2 1 2009

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page 2 
EPA Reg. No. 100-1335 
B. On page 5, delete the Ag Use Requirements box because it is only needed for "at 
plant" applications of seed treatment products (i.e. where grower applies product to 
seed in planter box, hopper box or similar). "On-farm" treatment is considered' 
different than "at plant" treatment. 
If these conditions are not complied with, the registration will be subject to cancellation 
in accordance with FIFRA Section 6( e). Your release for shipment of the product constitutes 
acceptance of these conditions. 
A copy of the label stamped "Accepted with comments" is enclosed for your records.

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[MASTER - BOOKLET] 
Difenoconazole/Mefenoxam FS ™ . 
Fungicide 
. A seed treatment for control of diseases of wheat and barley. 
Active Ingredients: 
Difenoconazole* ....................................................................................................... 3.37% 
Mefenoxam** ........................................................................................................... 0.27.% 
Other Ingredients: 96.36% 
Total: 100.00% 
.. *CAS No. 119446-68~3 
**CAS Nos. 70630~17-0 and 69516-34-3 
Difenoconazole/Mefenoxam FS contains 0.31Ibs. difenoconazole and 0.025 lb. 
mefenoxam per gallon. 
KEEP OUT OF REACH OF CHILDREN. 
CAUTION 
See additional precautionary statements and'directions for use inside booklet. 
EPA Reg. No. 100-XXXX 
EPA Est. 
__ gallons 
Net Contents

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FIRST AID 
If swallowed • Call pOison control center or doctor immediately for treatment 
advice. 
• Have person sip a glass of water if able to swallow. 
• Do not induce vomiting unless told to do so by the poison control 
center or doctor. 
• Do not give anything by mouth to an unconscious person. 
If on skin or • Take off contaminated clothing. 
clothing • Rinse skin immediately with plenty of water for 15-20 minutes. 
• Cail a J~oison control center or doctor for treatment advice. 
If inhaled • Move person to fresh air. 
• If person is not breathing, call 911 or an ambulance, then give 
artificial respiration, preferably by mouth-to-mouth, if possible. 
• Call a poison control center or doctor for treatment advice. ' 
If in eyes .. Hold eye open and rinse slowly and gently with water for 15-20 
minutes. Remove contact lenses, if present, after the first 5 
minutes, then continue rinsing eye. 
• Call a poison control center or doctor for treatment advice. 
Have the product container or label with you when calling a poison control center or 
doctor, or going for treatment. 
HOT LINE NUMBER 
For 24 Hour Medical Emergency Assistance (Human or Animal) or 
Chemical Emergency Assistance (Spill, Leak, Fire, or Accident), 
Call 
1-800-888~8372 
PRECAUTIONARY STATEMENTS 
Hazards to Humans and Domestic Animals 
CAUTION 
Harmful if swallowed, absorbed through skin or inhaled. Avoid contact with skin, eyes, 
or clothing. Causes moderate eye irritation. Avoid breathing vapor or spray mist. 
Wash thoroughly with soap and water after handling and before eating, drinking, 
th~wing gum, or using tobacco. Remove and wash contaminated clothing before 
reuse.

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Personal Protective Equipment (PPE) 
Applicators and other handlers must wear: 
• Long-sleeved shirt and long pants 
• Shoes plus socks 
• Chemical-resistant gloves made of any waterproof material 
Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions 
for washables, use detergent and hot water. Keep and wash PPE separately from other 
laundry. 
Engineering Control Statements 
When handlE;lrs use closed systems or enclosed cabs in a manner that meets the 
requirements listed in the Worker Protection Standard (WPS) for agricultural pestiCides 
[40 CFR 170.240(d)(4-6)], the handler PPE requirements may be reduced or modified 
as specified in the WPS. 
User Safety Recommendations 
Users should: 
• Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. 
• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly 
and put on clean clothing. 
Environmental Hazards 
This product is toxic to fish and aquatic invertebrates. Do not apply directly to water, to 
areas where surface water is present, or to intertidal areas below the mean high water 
mark. Do not contaminate water when disposing of equipment wash waters or rinsate. 
If treated seed is spilled outdoors or in areas accessible to birds, promptly clean up or 
bury to prevent ingestion.

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CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY 
NonCE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not 
acceptable, return the product at once, unopened, and the purchase price will be 
refunded. 
The Directions for Use of this product must be followed carefully. It is impossible to 
eliminate all risks inherently associated with the use of this product. Crop injury, 
ineffectiveness, or other unintended consequences may result because of such factors 
as manner of use or application, weather or crop conditions, presence of other materials 
or other influencing factors in the use of the product, which are beyond the control of 
SYNGENTA CROP PROTECTION, Inc. or Seller. To the extent permitted by applicable 
law, Buyer and User agree to hold SYNGENTA and Seller harmless for any claims 
relating to such factors. 
SYNGENT A warrants that this product conforms to the chemical description on the label 
and is reasonably fit for the purposes stated in the Directions for Use, subjeCt to the 
inherent risks referred to above, when used in accordance with directions under normal 
use conditions. To the extent permitted by applicable law: (1) this warranty does not 
extend to the use of the product contrary to label instructions or under conditions not 
. reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and, (2) Buyer 
and User assume the risk of any such use. TO THE EXTENT PERMITTED BY 
APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY 
OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR 
IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL. 
To the extent permitted by applicable law, in no event shall SYNGENTA be liable for 
any incidental, consequential or special damages resulting from the use or handling of 
this product. TO THE EXTENT PERMITTED BY APPUCABLE LAW, THE 
EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LlABI.LITY 
OF SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES OR 
DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, 
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) 
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE 
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION 
OF SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT. 
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing Conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

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DIRECTIONS FOR USE 
It is a violation of Federal law to use this product in a manner inconsistent with its 
labeling. 
Do not apply this product in a way that will contact workers or other persons, either 
directly or through drift. Only protected handlers may be in the area during application. 
For any requirements specific to your State or Tribe, consult the agency responsible for 
pestiCide regulation. 
AGRICULTURAL USE REQUIREMENTS 
Use this product only in accordance with its labeling and with the Worker Protection 
Standard, 40 CFR part 170. This Standard contains requirements for the protection.of 
agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 
agricultural pestiCides. It contains requirements for training, decontamination, 
notification, and emergency assistance. It also contains specific instructions and 
exceptions pertaining to the statements on this label about personal protective 
equipment (PPE) and restricted-entry interval. The reqUirements in this box only apply 
to uses of this productthat are covered by the Worker Protection Standard. 
Do not enter or allow worker entry into treated areas during the restricted-entry 
interval (REI) of 48 hours. Exception: If the seed is treated with the product and the 
treated seed is soil-injected or soil-incorporated, the Worker Protection Standard, under 
certain circumstances, allows workers to enter the treated area if there will be no 
contact with anything that has been treated. 
For early entry to treated areas that is permitted underthe Worker Protection Standard 
and that involves contact with anything that has been treated, such as plants, soil, or 
water, wear: 
• Coveralls 
• Socks plus shoes 
• Chemical-resistant gloves made of any waterproof material 
FAILURE TO FOLLOW THE DIRECTIONS FOR USE AND PRECAUTIONS ON THIS 
LABEL MAY RESULT IN CROP INJURY, POOR DISEASE CONTROL, ANDIOR 
ILLEGAL RESIDUES.

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GENERAL INFORMATION 
Difenoconazole/Mefenoxam FS is a systemic seed dressing that controls or suppresses 
certain seed-borne, soil-borne, and early season foliar diseases of wheat and barley. It 
is a mixture of Dividend® and Apron XL®. Apron XL provides Pythium damping-off 
activity and Dividend provides activity on the remaining diseases claimed on this label. 
An EPA-approved coloring agent, Pigment Red 48, has been added to the formulation. 
Note: Mefenoxam is a systemic fungicide having a specific mode of action and could 
be subjectto development of insensitive strains of fungi. Development of insensitivity 
cannot be predicted. Therefore, Syngenta cannot assume liability for crop damage 
resulting from insensitive strains of fungi. Consult with your State Agricultural 
Experiment Station or Extension Service Specialist for guidance and ways to control any 
possible mefenoxam insensitive strains of fungi which may occur. 
MIXING PROCEDURES 
Difenoconazole/Mefenoxam FS is especially formulated for on-farm treatment using 
standard mechanical slurry- or mist-type seed treatment equipment which accurately 
meters and mixes a flowable seed treatment. The equipment must provide uniform 
coverage of Difenoconazole/Mefenoxam FS on the seed. Uneven seed coverage may 
not give the desired level of disease control. This product does not require the addition 
of water for application. Consult the manufacturer of the application equipment you plan 
to use for suitability for this application and for instructions on operation and calibration 
of the equipment. 
Tank Mixtures 
Confirm physical compatibility, seed safety, seed safety in stored seed, and biological 
efficacy before tank mixing with other seed treatment products. 
Follow the label directions for the most restrictive of label precautions and limitations. 
This product cannot be mixed with any product containing a label prohibition against 
such mixing. . 
RESTRICTIONS 
• Do not use for feed, food, or oil purposes. Store away from feeds and foodstuffs. 
• Green wheat forage may not be grazed until 55 days after planting .. 
• Green barley forage may not be grazed until 30 days after planting. 
• Do not plant any crop other than those on this label within 30 days tofields in which 
treated seeds were planted.

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SEED BAG LABEL REQUIREMENT 
Federal law requires that bags containing treated seeds shall be labeled with the 
following information: "This seed has been treated with the fungicides difenoconazole 
(CAS No. 119446-68-3) and mefenoxam (CAS Nos. 70630-17-0 and 69516-34-3). Do 
not use for feed, food, or oil purposes. Store away from feeds and foodstuffs. Green 
wheat forage may not be grazed until 55 days after planting. Green barley forage may 
not be grazed until 30 days after planting. Do not plant any crop other than those on 
this label within 30 days to fields in which treated seeds were planted." 
BARLEY 
Apply Difenoconazole/Mefenoxam FS to barley seed at the rates given in the following 
table: 
Rate/CWT Diseases Controlled Diseases Partially Controlled 1 
5 fl. oz. Barley Stripe Common Root Rot (Cochiliobolus spp.) 
General Seed Rots2 Fusarium Seed Scab 
Covered Smut Rhizoctonia Root Rot 
Pythium Damping Off 
10 fl. oz. Barley Stripe . Take-all 
General Seed Rots2 Common Root Rot (Cochilobolus spp.) 
Fusarium Seed Scab Fusarium Root Rot 
Covered Smut Fusarium Crown Rot 
Pythium Damping Off Rhizoctonia Root Rot 
1 Partial control can either mean erratic control from good to poor, or consistent control 
at a level below that is generally considered acceptable for commercial disease control. 
2General seed rots controlled include those caused by saprophytic organisms such as 
Penicillium spp. and Aspergillus spp. 
WHEAT 
Apply Difenoconazole/Mefenoxam FS to wheat seed at the rates given in the following 
table:

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Winter Wheat 
Fall Season Foliar Diseases Partially 
Rate/CWT Diseases Controlled Diseases Controlled 1 Controlled 2 
2.5 fl. oz.::> Common Bunt 
Loose Smut 
5 flo oz. Common Bunf Common Root Rot 
Dwarf Bunt (Cochliobolus spp.) 
Flag Smut Rhizoctonia Root Rot 
Seed-borne Septaria 
Loose Smut 
General Seed Rots4 
Fusarium Seed Scab 
Pythium Damping-Off 
10 flo oz. Common Bunf1 Fall Season Powdery Mildew Common Root Rot 
Dwarf Bunt F all Season Leaf Rust (Cochliobolus spp.) 
Loose Smut Fall Season Septaria Leaf Blotch Fusarium Root Rot 
Flag Smut Fusarium Crown Rot 
Seed-borne Septaria Take-All 
General Seed Rots4 Rhizoctonia Root Rot 
Fusarium Seed Scab 
Pythium Damping-Off 
1Difenoconazoie/Mefenoxam FS provides control of fall season powdery mildew, fall season leaf 
rust, and fall season Septaria leaf blotch in winter wheat for the first 6 weeks after planting. 
For full season control of these foliar diseases, use Tilt® fungicide according to label 
instructions. 
2Partial control can either mean erratic control from good to poor or consistent control at a level 
below that generally considered acceptable for commercial disease control. 
3Difenoconazoie/Mefenoxam FS controls both seed-borne and soil-borne common bunt. 
4General seed rots controlled include those caused by saprophytic organisms such as 
Penicillium spp. and Aspergillus spp. . 
5The 2.5 flo oz. rate should only be used in the following states: CA, CO, KS, MN, MO, MT, OK, 
NO, NE, SO, and TX.

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Spring Wheat 
Rate/CWT Diseases Controlled Diseases Partially_ Controlled4 
2.5-fl.oz.;J Common Bunt 
Loose Smut 
Fusarium Seed Scab 
5 flo oz. Common Bunt' Common Root Rot 
Seed-borne Septoria (Cochliobo/us spp.) 
Loose Smut Rhizoctonia Root Rot 
General Seed Rots2 
Fusarium Seed Scab 
pythium Damping-Off 
10 fl. oz. Common Bunt 1 
Take-All 
Loose Smut Common Root Rot 
Flag Smut (Coch/lobo/us spp.) 
Seed-borne Septoria Rhizoctonia Root Rot 
General Seed Rots2 
Fusarium Seed Scab 
Pythium Damping-Off 
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1Difenoconazoie/Mefenoxam FS controls both seed-borne and s~il-borne cO~-~·IO~bunt.-----------
2General seed rots controlled include those caused by saprophytic organisms, such as 
Penicillium spp. and Aspergillus spp. 
3The 2.5 flo oz. rate should only be used in the following states: CA, CO, KS, MO, NO, 
NE, OK, SO, MN, MT, and TX. 
4Partial ~ontrol can either mean erratic control from good to poor or consistent control at 
a level below that generally considered acceptable for commercial disease control. 
STORAGE AND DISPOSAL 
Do not contaminate water, food, or feed by storage or disposal. 
Pesticide Storage 
Keep container tightly closed when not in use. Store out of the reach of children. 
Spill Response 
For minor spills, leaks, etc., follow all precautions indicated on this label and clean up 
immediately. Take special care to avoid contamination of equipment and facilities 
during cleanup and disposal of wastes. In the event of a major spill, fire, or other 
emergency, call 1-800-888-8372, day or night. 
Pesticide Disposal

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Wastes resulting from the use of this product may be disposed of on site or at an 
approved waste disposal facility. 
Container Disposal 
. Non-refillable container. Do not reuse or refill this container. Offer for recycling if 
available. 
Residue Removal [capacities equal to or less than 5 gallons] 
Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: 
empty the remaining contents into application equipment or a mix tank and drain for 10 
seconds after the flow begins to drip. Fill the container % full with water and recap. 
Shake for 10 seconds .. P()ur rinsate into application equipment or a mix tank or store 
rinsate for later use or disposal. Drain for 10 seconds afterthe flow begins to drip . 
. Repeat this procedure two more times. 
For Bulk and Minibulk Containers: 
Triple rinse as follows: Empty the remaining contents into application equipment or a mix 
tank. Fill the container % full with water. Replace and tighten closures. Tip container on 
its side and roll it back and forth, ensuring at least one complete revolution, for 30 . 
seconds. Stand the container on its end and tip it back and forth several times. Turn the 
container over onto its other end and tip it back and forth several times. Empty the rinsate 
into application equipment or a mix tank or store rinsate for later use or disposal. Repeat· 
this procedure two more times. 
Container Disposal 
Refillable container. Refill this container with Difenoconazole/Mefenoxam FS only. Do 
not reuse this container for any other purpose. 
Residue Removal 
Cleaning the container before final disposal is the responsibility of the person disposing of 
the container. Cleaning before refilling is the responsibility of the refiller. 
After filling arid before transporting, check for leaks. Do not refill or transport damaged 
or leaking container. 
CONTAINER IS NOT SAFE FOR FOOD, FEED, OR DRINKING WATER.

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Apron XL®, DifeQ.oconazole/Mefenoxam FS TM, Dividend®, Tilt®, the Syngenta logo and 
the CP FRAME D are trademarks of a SYl1genta Group Company 
©200X Syngenta 
For non-emergency (e.g. current product information) call 
Syngenta Crop Protection at 1-800-334-9481. 
Manufactured for: 
Syngenta Crop Protection, Inc. 
P. O. Box 18300 
Greensboro, North Carolina 27419-8300 
Difenoconazole-Mefeno~am FS - bb - 10-23-0B 
0001 00-OXXXX.200B1 023.DIFEN-MEFEN-FS-1 OOB_pdf 
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