crop-chem-docs/corpus/epa_ppls/352-853.md

# LEADOFF

- EPA Reg No: **352-853**
- Registrant: CORTEVA AGRISCIENCE, LLC
- Signal word: Caution
- Active ingredients: Thifensulfuron (16.7%); Rimsulfuron (16.7%)
- Label accepted: 2025-07-01
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000352-00853-20250701.pdf

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1
July 1, 2025
Wes Marchione
US CP Regulatory Leader
Corteva Agriscience LLC
9330 Zionsville Road
Indianapolis, Indiana 46268
Subject: PRIA Label Amendment – Add INZEN grain sorghum to the uses adds winter 
canola to the Rotational Crop Interval table with a reduced plant back interval 
(PBI) of 4-months. 
Product Name: Leadoff
 EPA Registration Number: 352-853
Application Date: 03/25/2024 & 07/03/2024
 Case Number: 00559412 & 00619893
Dear Wes Marchione:
The amended label referred to above, submitted in connection with registration under the 
Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), as amended, is acceptable. This 
approval does not affect any conditions that were previously imposed on this registration. You 
continue to be subject to existing conditions on your registration and any deadlines connected 
with them.
A stamped copy of your labeling is enclosed for your records. This labeling supersedes all 
previously accepted labeling. You must submit one copy of the final printed labeling before you 
release the product for shipment with the new labeling. In accordance with 40 CFR 152.130(c), 
you may distribute or sell this product under the previously approved labeling for 18 months 
from the date of this letter. After 18 months, you may only distribute or sell this product if it 
bears this new revised labeling or subsequently approved labeling. “To distribute or sell” is 
defined under FIFRA section 2(gg) and its implementing regulation at 40 CFR 152.3. 
Should you wish to add/retain a reference to the company’s website on your label, then please 
be aware that the website becomes labeling under FIFRA and is subject to review by the 
Agency. If the website is false or misleading, the product would be misbranded and unlawful to 
sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) lists examples of 
statements EPA may consider false or misleading. In addition, regardless of whether a website 
is referenced on your product’s label, claims made on the website may not substantially differ

Page 2 of 2 
EPA Reg. No. 352-853
Case No. 00559412 & 00619893
from those claims approved through the registration process. Therefore, should the Agency find 
or if it is brought to our attention that a website contains false or misleading statements or 
claims substantially differing from the EPA approved registration, the website will be referred 
to the EPA’s Office of Enforcement and Compliance.
Your release for shipment of the product constitutes acceptance of these conditions. If these 
conditions are not complied with, the registration will be subject to cancellation in accordance 
with FIFRA section 6. 
If you have any questions, please contact Francisco Llarena-Arias at llarena-
arias.francisco@epa.gov.
Sincerely, 
 F r a n c i s c o L l a r e n a - A r i a s
Acting for Product Manager 24 
Fungicide and Herbicide Branch 
Registration Division (7505P) 
U.S. Environmental Protection Agency
Enclosure 
cerely, 
i Ll
 Ai

R6V / Leadoff / Amendment / 06-30-2025 Page 1 
(Bulk/Tote Base Label): 
RIMSULFURON GROUP 2 HERBICIDE 
THIFENSULFURON-METHYL GROUP 2 HERBICIDE 
Leadoff® 
[Alternate Brand Name: DuPont Leadoff®] 
HERBICIDE 
Water Dispersible Granules 
For preplant and preemergence weed control in field corn and for preplant weed control in cotton, 
peanuts, soybeans and Inzen grain sorghum. 
Active Ingredients By Weight 
Rimsulfuron 
N-((4,6-dimethoxypyrimidin-2-yl)aminocarbonyl)-3-(ethylsulfonyl)- 
2-pyridinesulfonamide 16.7% 
Thifensulfuron-methyl 
Methyl 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl) amino]carbonyl]amino]sulfonyl] 
-2-thiophenecarboxylate 16.7% 
Other Ingredients 66.6% 
TOTAL 100.0% 
Contains 0.334 lb active ingredient (0.167 lb of rimsulfuron and 0.167 lb of thifensulfuron-methyl) per lb of 
product. 
Keep Out of Reach of Children 
CAUTION 
Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. (If you do 
not understand this label, find someone to explain it to you in detail.) 
 Precautionary Statements
 Hazards to Humans and Domestic Animals 
CAUTION 
Causes moderate eye irritation Ɣ Harmful if absorbed through skin 
Avoid contact with eyes, skin, or clothing. Wash thoroughly with soap and water after handling and before 
eating, drinking, chewing gum, or using tobacco, or using the toilet. 
PERSONAL PROTECTIVE EQUIPMENT (PPE) 
Applicators and other handlers must wear: 
x Long-sleeve shirt and long pants 
x Chemical resistant gloves made of nitrile rubber, natural rubber, neoprene rubber, or butyl rubber. 
x Shoes plus socks 
Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables 
exist, use detergent and hot water. Keep and wash PPE separately from other laundry. 
Jul 01, 2025
352-853

R6V / Leadoff / Amendment / 06-30-2025 Page 2 
 
Engineering Control Statement: When handlers use closed systems, enclosed cabs, or aircraft in a 
manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural 
pesticides [40 CFR 170.240(d)(4-6)], the handler PPE requirements may be reduced or modified as 
specified in the WPS. 
 
Important: When reduced PPE is worn because a closed system is being used, handlers must be 
provided all PPE specified above for “Applicators and Other Handlers” and have such PPE immediately 
available for use in an emergency, including a spill or equipment breakdown. 
 
USER SAFETY RECOMMENDATIONS 
 
USERS SHOULD: 
x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on 
clean clothing. 
x Remove PPE immediately after handling this product. Wash the outside of gloves before 
removing. As soon as possible, wash thoroughly and change into clean clothing. 
 
STORAGE AND DISPOSAL 
 
DO NOT contaminate water, food, or feed by storage and disposal. 
 
PESTICIDE STORAGE: Store product in original container only. DO NOT contaminate water, other 
pesticides, fertilizer, food or feed in storage. Store in a cool, dry place. 
 
PESTICIDE DISPOSAL: DO NOT contaminate water, food, or feed by disposal. Waste resulting from 
the use of this product must be disposed of on site or at an approved waste disposal facility. 
 
CONTAINER HANDLING: Refer to the Net Contents section of this product’s labeling for the 
applicable “Nonrefillable Container” or “Refillable Container” designation. 
 
Nonrefillable Plastic and Metal Containers (Capacity Equal to or Less Than 50 Pounds): 
Nonrefillable container. DO NOT reuse or refill this container. Triple rinse container (or equivalent) 
promptly after emptying. Triple rinse as follows: Empty the remaining contents into application 
equipment or a mix tank. Fill the container 1/4 full with water and recap. Shake for 10 seconds. Pour 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 
seconds after the flow begins to drip. Repeat this procedure two more times. Then, for Plastic 
Containers, offer for recycling if available or puncture and dispose of in a sanitary landfill, or by 
incineration. DO NOT burn, unless allowed by state and local ordinances. For Metal Containers, offer 
for recycling if available or reconditioning if appropriate, or puncture and dispose of in a sanitary landfill, 
or by other procedures approved by state and local authorities. 
 
Nonrefillable Plastic and Metal Containers (Capacity Greater Than 50 Pounds): Nonrefillable 
container. DO NOT reuse or refill this container. Triple rinse container (or equivalent) promptly after 
emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix 
tank. Fill the container 1/4 full with water. Replace and tighten closures. Tip container on its side and 
roll it back and forth, ensuring at least one complete revolution, for 30 seconds. Stand the container on 
its end and tip it back and forth several times. Turn the container over onto its other end and tip it back 
and forth several times. Empty the rinsate into application equipment or a mix tank or store rinsate for 
later use or disposal. Repeat this procedure two more times. Then, for Plastic Containers, offer for 
recycling if available or puncture and dispose of in a sanitary landfill, or by incineration. DO NOT burn, 
unless allowed by state and local ordinances. For Metal Containers, offer for recycling if available or 
reconditioning if appropriate, or puncture and dispose of in a sanitary landfill, or by other procedures 
approved by state and local authorities. 
 
Nonrefillable Plastic and Metal Containers, e.
g., Intermediate Bulk Containers [IBC] (Size or

R6V / Leadoff / Amendment / 06-30-2025 Page 3 
 
Shape Too Large to be Tipped, Rolled or Turned Upside Down): Nonrefillable container. DO NOT 
reuse or refill this container. Clean container promptly after emptying the contents from this container 
into application equipment or mix tank and before final disposal using the following pressure rinsing 
procedure. Insert a lance fitted with a suitable tank cleaning nozzle into the container and ensure that 
the water spray thoroughly covers the top, bottom and all sides inside the container. The nozzle 
manufacturer generally provides instructions for the appropriate spray pressure, spray duration and/or 
spray volume. If the manufacturer’s instructions are not available, pressure rinse the container for at 
least 60 seconds using a minimum pressure of 30 PSI with a minimum rinse volume of 10% of the 
container volume. Drain, pour or pump rinsate into application equipment or rinsate collection system. 
Repeat this pressure rinsing procedure two more times. Then, for Plastic Containers, offer for recycling 
if available or puncture and dispose of in a sanitary landfill, or by incineration. For Metal Containers, 
offer for recycling if available or reconditioning if appropriate or puncture and dispose of in a sanitary 
landfill, or by other procedures approved by state and local authorities. 
 
Nonrefillable Paper or Plastic Bags, Fiber Sacks including Flexible Intermediate Bulk 
Containers (FIBC) or Fiber Drums With Liners: Nonrefillable container. DO NOT reuse or refill this 
container. Completely empty paper or plastic bag, fiber sack or drum liner by shaking and tapping sides 
and bottom to loosen clinging particles. Empty residue into application or manufacturing equipment. 
Then offer for recycling if available or dispose of empty paper or plastic bag, fiber sack or fiber drum 
and liner in a sanitary landfill, or by incineration. DO NOT burn, unless allowed by state and local 
ordinances. 
 
Refillable Fiber Drums With Liners: Refillable container (fiber drum only). Refilling Fiber Drum: 
Refill this fiber drum with Leadoff
® containing rimsulfuron and thifensulfuron-methyl only. DO NOT 
reuse this fiber drum for any other purpose. Cleaning before refilling is the responsibility of the refiller. 
Completely empty liner by shaking and tapping sides and bottom to loosen clinging particles. Empty 
residue into application or manufacturing equipment. Disposing of Fiber Drum and/or Liner: DO NOT 
reuse this fiber drum for any other purpose other than refilling (see preceding). Cleaning the container 
(liner and/or fiber drum) before final disposal is the responsibility of the person disposing of the 
container. Offer the liner for recycling if available or dispose of liner in a sanitary landfill, or by 
incineration. DO NOT burn, unless allowed by state and local ordinances. If drum is contaminated and 
cannot be reused, dispose of it in the manner required for its liner. To clean the fiber drum before final 
disposal, completely empty the fiber drum by shaking and tapping sides and bottom to loosen clinging 
particles. Empty residue into application or manufacturing equipment. Then offer the fiber drum for 
recycling if available or dispose of in a sanitary landfill, or by incineration. DO NOT burn, unless 
allowed by state and local ordinances. 
 
All Other Refillable Containers: Refillable container. Refilling Container: Refill this container with 
Leadoff containing rimsulfuron and thifensulfuron-methyl only. DO NOT reuse this container for any 
other purpose. Cleaning before refilling is the responsibility of the refiller. Prior to refilling, inspect 
carefully for damage including cracks, punctures, abrasions, worn out threads and closure devices. If 
damage is found, DO NOT use the container, contact Corteva Agriscience at the number below for 
instructions. Check for leaks after refilling and before transporting. If leaks are found, do reuse or 
transport container, contact Corteva Agriscience at the number below for instructions. Disposing of 
Container: DO NOT reuse this container for any other purpose other than refilling (see preceding). 
Cleaning the container before final disposal is the responsibility of the person disposing of the 
container. To clean the container before final disposal, use the following pressure rinsing procedure. 
Insert a lance fitted with a suitable tank cleaning nozzle into the container and ensure that the water 
spray thoroughly covers the top, bottom and all sides inside the container. The nozzle manufacturer 
generally provides instructions for the appropriate spray pressure, spray duration and/or spray volume. 
If the manufacturer’s instructions are not available, pressure rinse the container for at least 60 seconds 
using a minimum pressure of 30 PSI with a minimum rinse volume of 10% of the container volume. 
Drain, pour or pump rinsate into application equipment or rinsate collection system. Repeat this 
pressure rinsing procedure two more times. Then, for Plastic Containers, offer for recycling if available 
or puncture and dispose of in a sanitary landfill, or by incineration. DO NOT burn, unless allowed by 
state and local ordinances. For Metal Containers, offer for rec
ycling if available or reconditioning if

R6V / Leadoff / Amendment / 06-30-2025 Page 4 
 
appropriate or puncture and dispose of in a sanitary landfill, or by other procedures approved by state 
and local authorities. 
 
DO NOT transport if this container is damaged or leaking. If the container is damaged, leaking or 
obsolete, or in the event of a major spill, fire or other emergency, contact Corteva Agriscience at 1-800-
992-5994, day or night. 
 
Refer to inside of label booklet for additional precautionary information including First Aid and 
Directions for Use. 
 
Notice: Read the entire label. Use only according to label directions. Before using this product, read 
Warranty Disclaimer, Inherent Risks of Use and Limitation of Remedies at end of label booklet. If 
terms are unacceptable, return at once unopened. 
 
In case of emergency endangering health or the environment involving this product, call: 1-800-992-5994 
 
Agricultural Chemical: DO NOT ship or store with food, feeds, drugs, or clothing. 
 
EPA REG. NO. 352-853 EPA Est. No._____ 
 
™
®Trademarks of Corteva Agriscience and its affiliated companies 
 
For product information call: 1-800-258-3033 
 
Produced for 
Corteva Agriscience LLC 
9330 Zionsville Road 
Indianapolis, IN 46268 
 
 
NET WEIGHT_________

R6V / Leadoff / Amendment / 06-30-2025 Page 5 
 
(Booklet Cover / Small Container Label): 
RIMSULFURON GROUP 2 HERBICIDE 
THIFENSULFURON-METHYL GROUP 2 HERBICIDE 
Leadoff® 
[Alternate Brand Name: DuPont Leadoff®] 
 
HERBICIDE 
 
Water Dispersible Granules 
 
For preplant and preemergence weed control in field corn and for preplant weed control in cotton, 
peanuts, soybeans and Inzen grain sorghum. 
 
Active Ingredients By Weight 
Rimsulfuron 
N-((4,6-dimethoxypyrimidin-2-yl)aminocarbonyl)-3-(ethylsulfonyl)- 
2-pyridinesulfonamide 16.7% 
Thifensulfuron-methyl 
Methyl 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl) amino]carbonyl]amino]sulfonyl] 
-2-thiophenecarbox
ylate 16.7% 
Other Ingredients 66.6% 
TOTAL 100.0% 
 
Contains 0.334 lb active ingredient (0.167 lb of rimsulfuron and 0.167 lb of thifensulfuron-methyl) per lb of 
product. 
 
Keep Out of Reach of Children 
CAUTION 
 
Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. (If you DO 
NOT understand this label, find someone to explain it to you in detail.) 
 
Refer to inside of label booklet for additional precautionary information including First Aid and 
Directions for Use. 
 
Notice: Read the entire label. Use only according to label directions. Before using this product, read 
Warranty Disclaimer, Inherent Risks of Use and Limitation of Remedies at end of label booklet. If 
terms are unacceptable, return at once unopened. 
 
In case of emergency endangering health or the environment involving this product, call: 1-800-992-5994 
 
Agricultural Chemical: DO NOT ship or store with food, feeds, drugs, or clothing. 
 
EPA REG. NO. 352-853 EPA Est. No._____ 
 
™
®Trademarks of Corteva Agriscience and its affiliated companies 
 
For product information call: 1-800-258-3033 
 
Produced for 
Corteva Agriscience LLC 
9330 Zionsville Road 
Indianapolis, IN 46268 
NET WEIGHT__________

R6V / Leadoff / Amendment / 06-30-2025 Page 6 
 
FIRST AID 
 
IF IN EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact 
lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or 
doctor for treatment advice. 
 
IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediately with plenty of 
water for 15-20 minutes. Call a poison control center or doctor for treatment advice. 
 
IF SWALLOWED: Call a poison control center or doctor immediately for treatment advice. Have 
person sip a glass of water if able to swallow. DO NOT induce vomiting unless told to by a poison 
control center or doctor. DO NOT give anything by mouth to an unconscious person. 
 
Have the product container or label with you when calling a poison control center or doctor, or going for 
treatment. You may also contact 1-800-992-5994 for emergency medical treatment information. 
 
 
 Precautionary Statements 
 Hazards to Humans and Domestic Animals 
CAUTION 
 
Causes moderate eye irritation Ɣ Harmful if absorbed through skin 
 
Avoid contact with eyes, skin, or clothing. Wash thoroughly with soap and water after handling and before 
eating, drinking, chewing gum, or using tobacco, or using the toilet. 
 
PERSONAL PROTECTIVE EQUIPMENT (PPE) 
 
Applicators and other handlers must wear: 
x Long-sleeve shirt and long pants 
x Chemical resistant gloves made of nitrile rubber, natural rubber, neoprene rubber, or butyl rubber. 
x Shoes plus socks 
 
Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables 
exist, use detergent and hot water. Keep and wash PPE separately from other laundry. 
 
Engineering Control Statement: When handlers use closed systems, enclosed cabs, or aircraft in a 
manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural 
pesticides [40 CFR 170.240(d)(4-6)], the handler PPE requirements may be reduced or modified as 
specified in the WPS. 
 
Important: When reduced PPE is worn because a closed system is being used, handlers must be 
provided all PPE specified above for “Applicators and Other Handlers” and have such PPE immediately 
available for use in an emergency, including a spill or equipment breakdown. 
 
USER SAFETY RECOMMENDATIONS 
 
USERS SHOULD: 
x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on 
clean clothing. 
x Remove PPE immediately after handling this product. Wash the outside of gloves before 
removing. As soon as possible, wash thoroughly and change into clean clothing.

R6V / Leadoff / Amendment / 06-30-2025 Page 7 
 
ENVIRONMENTAL HAZARDS 
 
DO NOT apply directly to water, or to areas where surface water is present, or to intertidal areas below 
the mean high water mark. DO NOT contaminate water when disposing of equipment washwaters or 
rinsate. 
 
Groundwater Advisory 
This product is known to leach through soil into groundwater under certain conditions as a result of label 
use. This product may leach into groundwater if used in areas where soils are permeable, particularly 
where the water table is shallow. 
 
Surface Water Advisory 
This product may impact surface water quality due to runoff of rainwater. This is especially true for poorly 
draining soils and soils with shallow ground water. This product is classified as having high potential for 
reaching surface water via runoff for several months or more after application. A level, well-maintained 
vegetative buffer strip between areas to which this product is applied and surface water features including 
ponds, streams, and springs will reduce the potential loading of this product from runoff water and 
sediment. Runoff of this product will be greatly reduced by avoiding applications when rainfall or irrigation 
is expected to occur within 48 hours. 
 
Windblown Soil Particles Advisory 
This product has the potential to move off-site due to wind erosion. Soils that are subject to wind erosion 
usually have a high silt and/or fine to very fine sand fractions and low organic matter content. Other 
factors which can affect the movement of windblown soil include the intensity and direction of prevailing 
winds, vegetative cover, site slope, rainfall, and drainage patterns. Avoid applying this product if 
prevailing local conditions may be expected to result in off-site movement. 
 
Non-target Organism Advisory 
This product is toxic to plants and may adversely impact the forage and habitat of non-target organisms, 
including pollinators, in areas adjacent to the treated area. Protect the forage and habitat of non-target 
organisms by minimizing spray drift. For further guidance and instructions on how to minimize spray drift, 
refer to the Spray Drift Management section of this label. 
 
Directions for Use 
It is a violation of Federal law to use this product in a manner inconsistent with its labeling. 
 
DO NOT apply this product in a way that will contact workers or other persons, either directly or through 
drift. Only protected handlers may be in the area during application. For any requirements specific to your 
State or Tribe, consult the agency in your State responsible for pesticide regulation. 
 
Leadoff herbicide must be used only in accordance with the directions for use on this label, or as 
otherwise permitted by FIFRA. Always read the entire label, including the Limitation of Warranty and 
Liability. 
 
AGRICULTURAL USE REQUIREMENTS 
 
Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR 
part 170. This Standard contains requirements for the protection of agricultural workers on farms, 
forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements 
for training, decontamination, notification, and emergency assistance. It also contains specific 
instructions and exceptions pertaining to the statements on this label about personal protective 
equipment (PPE) and restricted-entry interval. The requirements in this box only apply to uses of this 
product that are covered by the Worker Protection Standard. 
 
DO NOT enter or allow worker entr
y into treated areas during the restricted entry interval (REI) of 4

R6V / Leadoff / Amendment / 06-30-2025 Page 8 
 
hours. 
 
PPE required for early entry to treated areas that is permitted under the Worker Protection Standard 
and that involves contact with anything that has been treated, including plants, soil, or water, is: 
x Coveralls 
x Chemical resistant gloves made of nitrile rubber, natural rubber, neoprene rubber, or butyl 
rubber. 
x Shoes plus socks 
 
STORAGE AND DISPOSAL 
 
DO NOT contaminate water, food, or feed by storage and disposal. 
 
PESTICIDE STORAGE: Store product in original container only. DO NOT contaminate water, other 
pesticides, fertilizer, food or feed in storage. Store in a cool, dry place. 
 
PESTICIDE DISPOSAL: DO NOT contaminate water, food, or feed by disposal. Waste resulting from 
the use of this product must be disposed of on site or at an approved waste disposal facility. 
 
CONTAINER HANDLING: Refer to the Net Contents section of this product’s labeling for the 
applicable “Nonrefillable Container” or “Refillable Container” designation. 
 
Nonrefillable Plastic and Metal Containers (Capacity Equal to or Less Than 50 Pounds): 
Nonrefillable container. DO NOT reuse or refill this container. Triple rinse container (or equivalent) 
promptly after emptying. Triple rinse as follows: Empty the remaining contents into application 
equipment or a mix tank. Fill the container 1/4 full with water and recap. Shake for 10 seconds. Pour 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 
seconds after the flow begins to drip. Repeat this procedure two more times. Then, for Plastic 
Containers, offer for recycling if available or puncture and dispose of in a sanitary landfill, or by 
incineration. DO NOT burn, unless allowed by state and local ordinances. For Metal Containers, offer 
for recycling if available or reconditioning if appropriate, or puncture and dispose of in a sanitary landfill, 
or by other procedures approved by state and local authorities. 
 
Nonrefillable Plastic and Metal Containers (Capacity Greater Than 50 Pounds): Nonrefillable 
container. DO NOT reuse or refill this container. Triple rinse container (or equivalent) promptly after 
emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix 
tank. Fill the container 1/4 full with water. Replace and tighten closures. Tip container on its side and 
roll it back and forth, ensuring at least one complete revolution, for 30 seconds. Stand the container on 
its end and tip it back and forth several times. Turn the container over onto its other end and tip it back 
and forth several times. Empty the rinsate into application equipment or a mix tank or store rinsate for 
later use or disposal. Repeat this procedure two more times. Then, for Plastic Containers, offer for 
recycling if available or puncture and dispose of in a sanitary landfill, or by incineration. DO NOT burn, 
unless allowed by state and local ordinances. For Metal Containers, offer for recycling if available or 
reconditioning if appropriate, or puncture and dispose of in a sanitary landfill, or by other procedures 
approved by state and local authorities. 
 
Nonrefillable Plastic and Metal Containers, e.g., Intermediate Bulk Containers [IBC] (Size or 
Shape Too Large to be Tipped, Rolled or Turned Upside Down): Nonrefillable container. DO NOT 
reuse or refill this container. Clean container promptly after emptying the contents from this container 
into application equipment or mix tank and before final disposal using the following pressure rinsing 
procedure. Insert a lance fitted with a suitable tank cleaning nozzle into the container and ensure that 
the water spray thoroughly covers the top, bottom and all sides inside the container. The nozzle 
manufacturer generally provides instructions for the appropriate spray pressure, spray duration and/or 
spray volume. If the manufacturer’s instructions are not available, pressure rinse the container for at 
least 60 seconds usin
g a minimum pressure of 30 PSI with a minimum rinse volume of 10% of the

R6V / Leadoff / Amendment / 06-30-2025 Page 9 
 
container volume. Drain, pour or pump rinsate into application equipment or rinsate collection system. 
Repeat this pressure rinsing procedure two more times. Then, for Plastic Containers, offer for recycling 
if available or puncture and dispose of in a sanitary landfill, or by incineration. For Metal Containers, 
offer for recycling if available or reconditioning if appropriate or puncture and dispose of in a sanitary 
landfill, or by other procedures approved by state and local authorities. 
 
Nonrefillable Paper or Plastic Bags, Fiber Sacks including Flexible Intermediate Bulk 
Containers (FIBC) or Fiber Drums With Liners: Nonrefillable container. DO NOT reuse or refill this 
container. Completely empty paper or plastic bag, fiber sack or drum liner by shaking and tapping sides 
and bottom to loosen clinging particles. Empty residue into application or manufacturing equipment. 
Then offer for recycling if available or dispose of empty paper or plastic bag, fiber sack or fiber drum 
and liner in a sanitary landfill, or by incineration. DO NOT burn, unless allowed by state and local 
ordinances. 
 
Refillable Fiber Drums With Liners: Refillable container (fiber drum only). Refilling Fiber Drum: 
Refill this fiber drum with Leadoff containing rimsulfuron and thifensulfuron-methyl only. DO NOT reuse 
this fiber drum for any other purpose. Cleaning before refilling is the responsibility of the refiller. 
Completely empty liner by shaking and tapping sides and bottom to loosen clinging particles. Empty 
residue into application or manufacturing equipment. Disposing of Fiber Drum and/or Liner: DO NOT 
reuse this fiber drum for any other purpose other than refilling (see preceding). Cleaning the container 
(liner and/or fiber drum) before final disposal is the responsibility of the person disposing of the 
container. Offer the liner for recycling if available or dispose of liner in a sanitary landfill, or by 
incineration. DO NOT burn, unless allowed by state and local ordinances. If drum is contaminated and 
cannot be reused, dispose of it in the manner required for its liner. To clean the fiber drum before final 
disposal, completely empty the fiber drum by shaking and tapping sides and bottom to loosen clinging 
particles. Empty residue into application or manufacturing equipment. Then offer the fiber drum for 
recycling if available or dispose of in a sanitary landfill, or by incineration. DO NOT burn, unless 
allowed by state and local ordinances. 
 
All Other Refillable Containers: Refillable container. Refilling Container: Refill this container with 
Leadoff containing rimsulfuron and thifensulfuron-methyl only. DO NOT reuse this container for any 
other purpose. Cleaning before refilling is the responsibility of the refiller. Prior to refilling, inspect 
carefully for damage including cracks, punctures, abrasions, worn out threads and closure devices. If 
damage is found, DO NOT use the container, contact Corteva Agriscience at the number below for 
instructions. Check for leaks after refilling and before transporting. If leaks are found, do reuse or 
transport container, contact Corteva Agriscience at the number below for instructions. Disposing of 
Container: DO NOT reuse this container for any other purpose other than refilling (see preceding). 
Cleaning the container before final disposal is the responsibility of the person disposing of the 
container. To clean the container before final disposal, use the following pressure rinsing procedure. 
Insert a lance fitted with a suitable tank cleaning nozzle into the container and ensure that the water 
spray thoroughly covers the top, bottom and all sides inside the container. The nozzle manufacturer 
generally provides instructions for the appropriate spray pressure, spray duration and/or spray volume. 
If the manufacturer’s instructions are not available, pressure rinse the container for at least 60 seconds 
using a minimum pressure of 30 PSI with a minimum rinse volume of 10% of the container volume. 
Drain, pour or pump rinsate into application equipment or rinsate collection system. Repeat this 
pressure rinsing procedure two more times. Then, for Plastic Containers, offer for recycling if available 
or puncture and dispose of in a sanitary landfill, or by incineration. DO NOT burn, unless allowed by 
state and local ordinances. For Metal Containers, offer for recycling if available or reconditioning if 
appropriate or puncture and dispose of in a sanitary landfill, or by other procedures approved by state 
and local authorities. 
 
DO NOT transport if this container is damaged or leaking. If the container is damaged, leaking or 
obsolete, or in the event of a major spill, fire or other emergency, contact Corteva Agriscience at 1-800-
992-5994, da
y or night.

R6V / Leadoff / Amendment / 06-30-2025 Page 10 
 
PRODUCT INFORMATION 
 
Leadoff herbicide is a water soluble granule containing 33.4% active ingredient by weight. Leadoff is a 
selective herbicide for burndown and residual control of certain annual grass and broadleaf weeds when 
applied preplant or preemergence to field corn. It may also be applied 30 days or more preplant to cotton 
or soybeans and 45 days or more preplant to peanuts for winter vegetation management. Residual weed 
control is dependent on rainfall or sprinkler irrigation for herbicide activation. 
Leadoff herbicide may be applied in tank mixtures with other herbicides labeled for use in the intended 
crop. However, in the case of tank mixes with other herbicides, the most restrictive label must be 
followed. 
 
Leadoff is absorbed through the roots and leaf tissue of plants, rapidly inhibiting the growth of susceptible 
weeds. Rainfall or sprinkler irrigation is needed to move Leadoff into the soil. Susceptible weeds will 
generally not emerge from preemergence application. In some cases, susceptible weeds may germinate 
and emerge a few days after application, but growth then ceases and leaves become chlorotic three to 
five days after emergence. Death of leaf tissue and growing point will follow in some species, while others 
will remain green but stunted and noncompetitive. 
 
The herbicidal action of Leadoff may be less effective on weeds stressed from adverse environmental 
conditions (including extreme temperatures or moisture), abnormal soil conditions, or cultural practices.

R6V / Leadoff / Amendment / 06-30-2025 Page 11 
 
Rate Summary for Leadoff 
 
Rate of Leadoff Pounds of Active Ingredient 
Rimsulfuron 
Pounds of Active Ingredient 
Thifensulfuron - methyl 
1.5 oz 0.016 lb ai 0.016 lb ai 
2.0 oz 0.021 lb ai 0.021 lb ai 
2.7 oz 0.028 lb ai 0.028 lb ai 
 
RESTRICTIONS 
 
CROPS 
Maximum 
Oz of Product/ 
Acre/ Single 
Application 
Maximum 
Lb AI/ 
Acre/Single 
Application 
Maximum 
Number of 
Applications 
per 
Year 
Maximum 
Oz of Product 
/Acre/Year 
Maximum 
Lb AI/A 
per 
Year 
Corn, Field 2.7 oz 0.028 lb ai 
rimsulfuron + 
0.028 lb ai 
thifensulfuron-
methyl 
1 2.7 oz 0.028 lb ai 
rimsulfuron + 
0.028 lb ai 
thifensulfuron-
methyl 
Cotton, 
Soybean 
2.0 oz 0.021 lb ai 
rimsulfuron + 
0.021 lb ai 
thifensulfuron-
methyl 
1 2.0 oz 0.021 lb ai 
rimsulfuron + 
0.021 lb ai 
thifensulfuron-
methyl 
Peanuts 1.5 oz 0.016 lb ai 
rimsulfuron + 
0.016 lb ai 
thifensulfuron-
methyl lb ai 
1 1.5 oz 0.016 lb ai 
rimsulfuron + 
0.016 lb ai 
thifensulfuron-
methyl lb ai 
Inzen grain 
sorghum 
Preplant 1.5 to 
2.7 oz 
0.016 lb ai 
rimsulfuron + 
0.016 lb ai 
thifensulfuron-
methyl lb ai to 
0.028 lb ai 
rimsulfuron + 
0.028 lb ai 
thifensulfuron-
methyl 
1 2.7 0.016 lb ai 
rimsulfuron + 
0.016 lb ai 
thifensulfuron-
methyl lb ai to 
0.028 lb ai 
rimsulfuron + 
0.028 lb ai 
thifensulfuron-
methyl 
 
DO NOT plant cotton or soybeans less than 30 days following an application of 1.5 ounces per acre of 
Leadoff or less than 60 days following an application of >1.5 to 2.0 ounces per acre of Leadoff. 
 
DO NOT plant field corn less than 30 days following an application of Leadoff in the states of Florida east 
of US 231 and Georgia. 
 
DO NOT plant peanuts less than 45 days following an application of Leadoff. 
 
DO NOT apply the organophosphate insecticide terbufos within 30 days of a preplant or preemerge 
application of Leadoff except in the states of Alabama, Florida and Georgia in which case DO NOT apply 
the organophosphate insecticide terbufos within 45 days of a preplant or preemerge application of 
Leadoff since crop injury may result. 
 
DO NOT apply more than a total of 0.0625 lb active ingredient rimsulfuron and 0.0469 lb thifensulfuron-
methyl per acre per year to field corn or soybeans from all sources. In field corn this includes 
combinations of preplant and preemergence applications, as well as rimsulfuron and/or thifensulfuron-

R6V / Leadoff / Amendment / 06-30-2025 Page 12 
 
methyl from postemergence application(s). In soybeans this includes the preplant application of Leadoff. 
 
DO NOT apply more than a total of 0.5 oz (0.03125 lb) active ingredient rimsulfuron and 0.75 oz (0.047 
lb) thifensulfuron-methyl per acre per year to cotton or peanuts from all sources. This includes the 
preplant application of Leadoff. 
 
DO NOT apply to coarse textured soils (sand, loamy sand or sandy loam) with less than 1% organic 
matter. 
 
DO NOT apply during a temperature inversion, when winds are gusty, or when conditions favor poor 
coverage and/or off target spray movement. 
 
DO NOT apply postemergence to any crop. 
 
DO NOT graze, feed forage, grain or fodder (stover) from treated areas to livestock within 30 days of 
Leadoff application. 
 
DO NOT apply Leadoff or drain or flush application equipment on or near desirable trees or other plants, or 
on areas where their roots may extend, or in locations where the chemical may be washed or moved into 
contact with their roots. 
 
DO NOT use on lawns, walks, driveways, or tennis courts. 
 
DO NOT contaminate any body of water. 
 
PRECAUTIONS 
 
Allow at least 3 weeks between preemergence applications of Leadoff and postemergence applications of 
rimsulfuron containing products. 
 
Leadoff may interact with certain insecticides applied to soybean, peanuts, cotton, or corn. Crop response 
varies with field crop, insecticide used, insecticide application method, and soil type. 
 
Leadoff may be applied to crops previously treated with nonorganophosphate (OP) soil insecticides 
regardless of soil type. 
 
Preplant/Preemergence applications of Leadoff to corn where an application of chlorpyrifos, or phorate is 
planned may cause unacceptable crop injury, especially on soils of less than 4% organic matter. 
 
Crop injury may occur following an application of Leadoff if there is a prolonged period of cold weather 
and/or in conjunction with wet soils. 
 
Bedding flat ground or rebuilding beds in fields treated with Leadoff may increase the potential of crop 
response due to an increased concentration of herbicide in the planting-seed zone. 
 
Prevent drift or spray to desirable plants. 
 
Thoroughly clean application equipment immediately after use. It is advised to flush the sprayer system 
and recharge with clean water when there are extended periods between Leadoff applications. See 
Sprayer Cleanup section of this label for instructions. 
 
WEED RESISTANCE MANAGEMENT 
 
Leadoff, which contains the active ingredients rimsulfuron and thifensulfuron-methyl, is a Group 2 
herbicide based on the mode of action classification system of the Weed Science Society of America.

R6V / Leadoff / Amendment / 06-30-2025 Page 13 
 
Proactively implementing diversified weed control strategies to minimize selection for weed populations 
resistant to one or more herbicides is a best practice. A diversified weed management program may 
include the use of multiple herbicides with different sites of action and overlapping weed spectrum with or 
without tillage operations and/or other cultural practices. Research has demonstrated that using the 
labeled rate and directions for use is important to delay the selection for resistance. 
 
The continued effectiveness of this product depends on the successful implementation of a weed 
resistance management program. 
 
To aid in the prevention of developing weeds resistant to this product, users should: 
x Scout fields before application to ensure herbicides and rates will be appropriate for the weed species 
and weed sizes present. 
x Start with a clean field, using either a burndown herbicide application or tillage. 
x Control weeds early when they are relatively small (less than 4 inches). 
x Apply full rates of Leadoff herbicide for the most difficult to control weed in the field at the specified 
time (correct weed size) to minimize weed escapes. 
x Scout fields after application to detect weed escapes or shifts in control of weed species. 
x Control weed escapes before they reproduce by seed or proliferate vegetatively. 
x Report any incidence of non-performance of this product against a particular weed to your company 
representative, local retailer, or county extension agent. 
x Contact your company representative, crop advisor, or extension agent to find out if suspected 
resistant weeds to this MOA have been found in your region. If resistant biotypes of target weeds 
have been reported, use the application rates of this product specified for your local conditions. Tank 
mix products so that there are multiple effective sites of actions for each target weed. 
x If resistance is suspected, treat weed escapes with an herbicide having a site of action other than 
Group 2 and/or use nonchemical methods to remove escapes, as practical, with the goal of 
preventing further seed production. 
x Suspected herbicide-resistant weeds may be identified by these indicators: 
x Failure to control a weed species normally controlled by the herbicide at the dose applied, 
x especially if control is achieved on adjacent weeds; 
x A spreading patch of non-controlled plants of a particular weed species; and 
x Surviving plants mixed with controlled individuals of the same species. 
 
Additionally, users should follow as many of the following herbicide resistance management practices as 
is practical: 
x Use a broad spectrum soil-applied herbicide with other sites of action as a foundation in a weed 
control program. 
x Utilize sequential applications of herbicides with alternative sites of action. 
x Rotate the use of this product with non-Group 2 herbicides. 
x Avoid making more than two applications of Leadoff and any other Group 2 herbicides within a single 
growing season unless mixed with an herbicide with a different site of action with an overlapping 
spectrum for the difficult-to-control weeds. 
x Incorporate non-chemical weed control practices, including mechanical cultivation, crop rotation, 
cover crops and weed-free crop seeds, as part of an integrated weed control program. 
x Use good agronomic principles that enhance crop development and crop competitiveness. 
x Thoroughly clean plant residues from equipment before leaving fields suspected to contain resistant 
weeds. 
x Manage weeds in and around fields, during and after harvest to reduce weed seed production. 
 
INTEGRATED PEST MANAGEMENT 
 
This product may be used as part of an Integrated Pest Management (IPM) program that can include 
biological, cultural, and genetic practices aimed at preventing economic pest damage. IPM principles and 
practices include field scouting or other detection methods, correct target pest identification, population

R6V / Leadoff / Amendment / 06-30-2025 Page 14 
 
monitoring, and treating when target pest populations reach locally determined action thresholds. Consult 
your state cooperative extension service, professional consultants or other qualified authorities to 
determine appropriate action treatment threshold levels for treating specific pest/crop systems in your 
area. 
 
MANDATORY SPRAY DRIFT MANAGEMENT 
 
Ground Boom Applications: 
x Apply with the nozzle height recommended by the manufacturer, but no more than 3 feet above the 
ground or crop canopy unless making a rangeland application, in which case applicators may apply 
with a nozzle height no more than 4 feet above the ground. 
x For applications prior to the emergence of crops and target weeds, applicators are required to use 
a Coarse or coarser droplet size (ASABE S572.1). 
x For all other applications, applicators are required to use a Medium or coarser droplet size (ASABE 
S572.1). 
x DO NOT apply when wind speeds exceed 10 miles per hour at the application site. 
x DO NOT apply during temperature inversions. 
 
Aerial Applications: 
x DO NOT release spray at a height greater than 10 feet above the vegetative canopy, unless a 
greater application height is necessary for pilot safety. 
x For applications prior to the emergence of crops and target weeds, applicators are required to use 
a Coarse or coarser droplet size (ASABE S572.1). 
x For all other applications, applicators are required to use a Medium or coarser droplet size (ASABE 
S572.1). 
x The boom length must not exceed 65% of the wingspan for airplanes or 75% of the rotor blade 
diameter for helicopters. 
x Applicators must use one-half swath displacement upwind at the downwind edge of the field. 
x Nozzles must be oriented so the spray is directed toward the back of the aircraft. 
x DO NOT apply when wind speeds exceed 10 miles per hour at the application site. 
x DO NOT apply during temperature inversions. 
 
Boom-less Ground Applications: 
x Applicators are required to use a Medium or coarser droplet size (ASABE S572.1) for all 
applications. 
x DO NOT apply when wind speeds exceed 10 miles per hour at the application site. 
 
SPRAY DRIFT MANAGEMENT ADVISORIES 
 
THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE SPRAY DRIFT. 
 
BE AWARE OF NEARBY NON-TARGET SITES AND ENVIRONMENTAL CONDITIONS. 
 
IMPORTANCE OF DROPLET SIZE 
 
An effective way to reduce spray drift is to apply large droplets. Use the largest droplets that provide 
target pest control. While applying larger droplets will reduce spray drift, the potential for drift will be 
greater if applications are made improperly or under unfavorable environmental conditions. 
 
Controlling Droplet Size – Ground Boom 
x Volume - Increasing the spray volume so that larger droplets are produced will reduce spray drift. 
Use the highest practical spray volume for the application. If a greater spray volume is needed, 
consider using a nozzle with a higher flow rate.

R6V / Leadoff / Amendment / 06-30-2025 Page 15 
 
x Pressure - Use the lowest spray pressure recommended for the nozzle to produce the target spray 
volume and droplet size. 
x Spray Nozzle - Use a spray nozzle that is designed for the intended application. Consider using 
nozzles designed to reduce drift. 
 
Controlling Droplet Size – Aircraft 
x Adjust Nozzles - Follow nozzle manufacturers recommendations for setting up nozzles. Generally, to 
reduce fine droplets, nozzles should be oriented parallel with the airflow in flight. 
 
BOOM HEIGHT – Ground Boom 
Use the lowest boom height that is compatible with the spray nozzles that will provide uniform coverage. 
For ground equipment, the boom should remain level with the crop and have minimal bounce. 
 
RELEASE HEIGHT – Aircraft 
Higher release heights increase the potential for spray drift. When applying aerially to crops, DO NOT 
release spray at a height greater than 10 ft above the crop canopy, unless a greater application height is 
necessary for pilot safety. 
 
Boom-less Ground Applications: 
x Setting nozzles at the lowest effective height will help to reduce the potential for spray drift. 
 
Handheld Technology Applications: 
x Take precautions to minimize spray drift. 
 
SHIELDED SPRAYERS 
Shielding the boom or individual nozzles can reduce spray drift. Consider using shielded sprayers. Verify 
that the shields are not interfering with the uniform deposition of the spray on the target area. 
 
TEMPERATURE AND HUMIDITY 
When making applications in hot and dry conditions, use larger droplets to reduce effects of evaporation. 
 
TEMPERATURE INVERSIONS 
Drift potential is high during a temperature inversion. Temperature inversions are characterized by 
increasing temperature with altitude and are common on nights with limited cloud cover and light to no 
wind. The presence of an inversion can be indicated by ground fog or by the movement of smoke from a 
ground source or an aircraft smoke generator. Smoke that layers and moves laterally in a concentrated 
cloud (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly 
dissipates indicates good vertical air mixing. Avoid applications during temperature inversions. 
 
WIND 
Drift potential generally increases with wind speed. AVOID APPLICATIONS DURING GUSTY WIND 
CONDITIONS. 
x Applicators need to be familiar with local wind patterns and terrain that could affect spray drift. 
 
DRIFT CONTROL ADDITIVIES 
Using product compatible drift control additives can reduce drift potential. When a drift control additive is 
used, read and carefully observe cautionary statements and all other information on the additive’s label. If 
using an additive that increases viscosity, ensure that the nozzles and other application equipment will 
function properly with a viscous spray solution. Preferred drift control additives have been certified by the 
Council of Producers & Distributors of Agrotechnology (CPDA).

R6V / Leadoff / Amendment / 06-30-2025 Page 16 
 
APPLICATION INFORMATION 
 
Field Corn - Preplant-Preemergence 
 
Rate 
 
Apply a single application of Leadoff at 1.5 - 2.7 ounces per acre. 
 
Apply the lower use rate of 1.5 oz per acre for most applications based on weed pressure. Consult 
technical bulletins for additional application rates. See cumulative rimsulfuron rate limitations noted in this 
label. 
 
Not all field corn varieties have been tested; nor does Corteva Agriscience have access to all seed 
company data. Consequently, To the extent consistent with applicable law, Corteva Agriscience is not 
responsible for any crop injury arising from the use of Leadoff on field corn. When tank mixing check the 
tank mix partner label for crop tolerances and instructions for use. In addition, consult with your local 
company sales representative for any additional information relative to potential corn hybrid sensitivity to 
Leadoff. 
 
Timing to Crop 
 
Leadoff may be applied preplant after fall harvest through early spring, up to planting, whenever the 
ground is not frozen, to control emerged weeds and to provide limited residual control of early-emerging 
spring weeds. 
 
Additionally, Leadoff may be applied any time after planting, but before corn emergence. 
 
DO NOT apply postemergence to corn. 
 
In the states of Florida east of US 231, and Georgia, apply Leadoff at least 30 days prior to planting. 
 
Control of emerged weeds will require the addition of spray adjuvants as noted in this label. 
 
Sequential Application 
 
Leadoff may be used in a sequential herbicide program for corn. Apply Leadoff for burndown and residual 
weed control, followed by a post, in-crop application of herbicide. Allow at least 3 weeks between 
preemergence applications of Leadoff and postemergence applications of rimsulfuron containing 
products,. Refer to the appropriate product label for use restrictions, application information, rotational 
crop intervals, and cautionary statements prior to application. 
 
Additional Control of Grasses and Broadleaves 
 
Leadoff may be tank mixed with preplant/preemergence grass and broadleaf herbicides including atrazine 
to provide added residual activity or burndown activity on emerged weeds. Sequential applications may 
also be made following preplant applications of Leadoff. Consult tank mix partner labeling for rate and 
soil-type restrictions. 
 
Cotton or Soybeans - Preplant Only 
 
Rate 
 
Apply a single application of Leadoff at 1.5 ounces per acre 30 days prior to planting. 
 
Apply a single application of Leadoff at > 1.5 to 2.0 ounces per acre 60 days prior to planting.

R6V / Leadoff / Amendment / 06-30-2025 Page 17 
 
 
Apply a single application of Leadoff at 1.5 - 2.7 ounces per acre 0 days or more prior to planting 
soybeans with BOLT® technology. 
 
Refer to Rotational Crop Intervals for additional rotational interval information. 
 
Timing to Crop 
 
Leadoff may be applied preplant after fall harvest through early spring 30 days or more prior to planting if 
using 1.5 ounces per acre or 60 days or more prior to planting if using >1.5 - 2.0 ounces per acre 
whenever the ground is not frozen, to control emerged weeds and to provide limited residual control of 
early-emerging spring weeds. 
 
Additional Information - Soybeans: 
 
Soybeans can be planted per the label guidelines following a Leadoff application provided any one of the 
following conditions is met: 
 
x The soybean variety has a high degree of crop tolerance to ALS inhibiting and/or sulfonylurea 
herbicides. Consult seed provider for confirmation. 
x Soil has not been excessively cold and wet at time of planting early season soybeans. DO NOT plant 
soybeans to poorly drained soils under cool and excessively wet conditions. Soil temperature must be 
>50° F and the soil temperature must be trending warmer, which is conducive to good early soybean 
growth. 
x Field soil with pH 6.5 or less. Refer to "The Importance of Soil pH" for additional information. 
 
If none of these conditions are met, extend soybean recrop interval to 10 months. 
 
Sequential Application - Soybeans 
 
Leadoff may be used in a sequential herbicide program in soybeans. Apply Leadoff for burndown and 
residual weed control 30 days or more prior to planting, followed by an appropriate application of 
herbicides. Refer to the product labels for use restrictions, application information, rotational crop 
intervals, and cautionary statements prior to application. 
 
Additional Control of Grasses and Broadleaves 
 
Leadoff may be tank mixed with herbicides registered for cotton or soybeans. Refer to the product labels 
for use restrictions, application information, rotational crop intervals, and cautionary statements prior to 
application. It is the pesticide user's responsibility to ensure that all products are registered for the 
intended use. Read and follow the applicable restrictions and limitation and directions for use on all 
product labels involved in tank mixing. Users must follow the most restrictive directions for use and 
precautionary statements of each product in the tank mixture. 
 
Peanuts - Preplant Only 
 
Rate 
 
Apply a single application of Leadoff at 1.5 ounces per acre. 
 
Refer to Rotational Crop Intervals for additional rotational interval information. 
 
Timing to Crop 
 
Leadoff may be applied preplant after fall harvest through early spring 45 days or more prior to planting

R6V / Leadoff / Amendment / 06-30-2025 Page 18 
 
peanuts whenever the ground is not frozen, to control emerged weeds and to provide limited residual 
control of early-emerging spring weeds. 
 
Additional Control of Grasses and Broadleaves 
 
Leadoff may be tank mixed with preplant herbicides registered for peanuts. Refer to the product labels for 
use restrictions, application information, rotational crop intervals, and cautionary statements prior to 
application. 
 
It is the pesticide user's responsibility to ensure that all products are registered for the intended use. Read 
and follow the applicable restrictions and limitation and directions for use on all product labels involved in 
tank mixing. Users must follow the most restrictive directions for use and precautionary statements of 
each product in the tank mixture. 
 
Inzen Grain Sorghum - Preplant 
 
Rate 
Apply Leadoff at 1.5 - 2.7 ounces per acre up to 14 days prior to planting grain sorghum containing the 
Inzen trait. Do not use Leadoff on grain sorghum that does not contain the Inzen™ trait as severe injury 
or death will occur. 
 
Corteva Agriscience specifies a use rate of 1.5 oz per acre for most applications. Consult Corteva 
Agriscience technical bulletins for additional application rates. See cumulative rimsulfuron rate limitations 
noted in this label. 
 
Not all Inzen sorghum hybrids have been tested; nor does Corteva Agriscience have access to all seed 
company data. Consequently, Corteva Agriscience is not responsible for any crop injury arising from the 
use of Leadoff on Inzen grain sorghum. When tank mixing, check the tank mix partner label for tolerances 
and instructions for use. In addition, consult with your local Corteva Agriscience representative or the 
Corteva Agriscience Label Web Site (http://corteva.com/) for any additional supplemental labeling 
information relative to potential Inzen sorghum hybrid sensitivity to Leadoff. 
 
Timing to Crop 
Leadoff may be applied preplant after fall harvest through early spring, up to 14 days prior to planting, 
whenever the ground is not frozen, to control emerged weeds and to provide limited residual control of 
early-emerging spring weeds. In the states of Florida east of US 231, and Georgia, apply Leadoff at least 
30 days prior to planting. Control of emerged weeds will require the addition of spray adjuvants as noted 
in this label. Sequential Application Leadoff may be used in a sequential herbicide program for Inzen 
grain sorghum. Apply Leadoff for burndown and residual weed control, followed by a post, in-crop 
application of Zest WDG (Reg. No. 352-560) for control of many annual grass weeds. Refer to the Zest 
WDG (352-560) product label for use restrictions, application information, rotational crop guidelines, and 
cautionary statements prior to application. 
 
Additional Control of Grasses and Broadleaves 
Leadoff may be tank mixed with labeled preplant grass and broadleaf herbicides such as atrazine, to 
provide added residual activity or burndown activity on emerged weeds. Sequential applications of Zest 
WDG (352-560) for postemergence grass control may also be made following preplant applications of 
Leadoff. Consult tank mix partner labeling for rate and soil-type restrictions. 
 
SPRAY ADJUVANTS 
 
For control of emerged weeds, application of Leadoff must contain an appropriate adjuvant. If applied in 
tank mix combination with a glyphosate or glufosinate herbicide that contains a built-in adjuvant system, 
no additional surfactant needs to be added. Consult local fact sheets, technical bulletins, and service 
policies prior to using other adjuvant systems. Products must contain only EPA-exempt ingredients.

R6V / Leadoff / Amendment / 06-30-2025 Page 19 
 
Use Restriction: DO NOT use with spray additives that alter the pH of the spray solution below 5.0 or 
above 9.0 as rapid product degradation can occur. Spray solutions of pH 6.0 – 8.0 allow for optimum 
stability of Leadoff. 
 
Petroleum Crop Oil Concentrate (COC) or Modified Seed Oil (MSO) 
 
x Apply at 1% v/v (1 gallon per 100 gallons spray solution) or 2% under arid conditions. 
 
x MSO adjuvants may be used at 0.5% v/v (0.5 gallon per 100 gallons spray solution) if specifically 
noted on adjuvant product labeling. 
 
x Oil adjuvants must contain at least 80% high quality, petroleum (mineral) or modified vegetable seed 
oil with at least 15% surfactant emulsifiers. 
 
Nonionic Surfactant (NIS) 
 
x Apply at 0.25% v/v (1 qt per 100 gal spray solution). 
x Surfactant products must contain at least 60% nonionic surfactant with a hydrophilic/lipophilic balance 
(HLB) greater than 12. 
 
Ammonium Nitrogen Fertilizer 
 
In addition to a spray adjuvant, an ammonium nitrogen fertilizer may be used. 
 
x Use 2 qt/acre of a high-quality urea ammonium nitrate (UAN) including 28%N or 32%N, or 2 lb/acre of 
a spray-grade ammonium sulfate (AMS). 
 
Special Adjuvant Types 
 
x Combination adjuvant products may be used at doses that provide the required amount of NIS and 
ammonium nitrogen fertilizer. Consult product literature for use rates and restrictions. 
 
TANK MIXTURES 
 
Tank Mix Compatibility Testing 
 
Perform a jar test prior to tank mixing to ensure compatibility of Leadoff and other pesticides. Use a clear 
quart jar with lid and mix the tank mix ingredients in their relative proportions. Invert the jar containing the 
mixture several times and observe the mixture for approximately 1/2 hour. If the mixture balls-ups, forms 
flakes, sludge, gel, oily film or layers, or other precipitates, it is not compatible and the tank mix 
combination must not be used. 
 
WEEDS CONTROLLED/SUPPRESSED 
 
Leadoff may be tank mixed with glyphosate (including ABUNDIT® Edge), paraquat, glufosinate, 
saflufenacil, 2,4-D LVE, and dicamba herbicides for improved control of the below emerged weed species 
when applied preplant or preemergence. For application methods and other use specifications; use the 
most restrictive label directions for the intended combination. 
 
Broadleaf & Grass Weeds 
Burndown 
Leadoff Alone 
Burndown Leadoff tank mixed with 
glyphosate + 2,4-D or dicamba 
Residual 
Leadoff Alone 
Alfalfa, volunteer C C NC 
Barley, volunteer C C S 
Barnyardgrass C C C 
Bluegrass, annual C C C 
Buckwheat, common C C NC

R6V / Leadoff / Amendment / 06-30-2025 Page 20 
 
C= Control 
S= Suppression 
NC = No Control 
1 = <1/2” 
2 = Must add 2,4-D LVE or dicamba for control 
3 = ALS Sensitive 
4 = Resistant biotypes are known to occur 
 
Mixing Instructions 
 
Fertilizer Carrier Instructions 
 
Leadoff may be dissolved in water and added to liquid fertilizer for preemergence application. When using 
Buttercup, smallflower C C NC 
Carpetweed NC C S 
Canada thistle S C NC 
Chamomile, false NC C C 
Chickweed (common, mouseear) C C NC 
Cocklebur S C S 
Crabgrass C 1 C S 
Cupgrass, woolly (1”) C C NC 
Curly Dock C C NC 
Dandelion (6” diameter) C C NC 
Evening primrose, cutleaf C 2 C NC 
Field pennycress C C NC 
Filaree, redstem NC C C 
Foxtail (bristly, giant, green, yellow) C C C 
Geranium, Carolina C C NC 
Groundsel, common C C NC 
Henbit C C C 
Knotweed, prostrate C C NC 
Jimsonweed NC C S 
Johnsongrass, seedling S C NC 
Kochia C 3 C C3 
Lambsquarters, common C C C 
Marestail (Horseweed) S C C3 
Millet, wild proso S C NC 
Morningglory, ivyleaf S C S 
Mustard (birdsrape, black) C C C 
Mustard, wild C C NC 
Nightshade, hairy S C S 
Nightshade, black NC C S 
Palmer amaranth NC C4 S 4 
Panicum, fall C C S 
Pigweed (prostrate, redroot, smooth) C 4 C C 
Purslane, common S C C 
Quackgrass S C NC 
Ragweed, common S C S 
Russian thistle, seedling NC C S 
Ryegrass, Italian S 4 C S4 
Sandbur (field, longspine) NC C NC 
Shattercane (4”) C C NC 
Shepherd’s purse C C NC 
Signalgrass, broadleaf S C C 
Smartweed, Pennsylvania C C S 
Smartweed, Ladysthumb C C NC 
Stinkgrass S C NC 
Velvetleaf C C S 
Wallflower, bushy C C NC 
Wheat, volunteer C C C 
Wild buckwheat NC C NC 
Wild oat S C S 
Wild radish C C NC 
Yellow nutsedge S C NC

R6V / Leadoff / Amendment / 06-30-2025 Page 21 
 
liquid fertilizer as the carrier, always dissolve Leadoff in clean water before adding to fertilizer solutions. 
Add the Leadoff solution to the final complete liquid fertilizer mixture – DO NOT add Leadoff during the 
fertilizer mixing process. 
 
Always use good agitation while adding the dissolved Leadoff solution to liquid fertilizers and maintain 
good agitation until sprayed. When using liquid fertilizer as the carrier, conduct a compatibility test with all 
components prior to mixing. 
 
DO NOT use with spray additives or liquid fertilizer carriers that alter the pH of the spray solution below 
pH 5.0 or above pH 9.0 as rapid product degradation can occur. Spray solutions of pH 6.0 - 8.0 allow for 
optimum stability of Leadoff. 
 
Water Carrier Instructions 
 
1. Fill the tank 1/3 to 1/2 full of clean water only. 
2. While agitating, add the required amount of Leadoff. 
3. Continue agitation until the Leadoff is fully dissolved, at least 5 minutes. When the water temperature 
is 40
o F or less, it is important to allow agitation and mixing to occur for the full 5 minutes to ensure 
the product is completely dissolved. 
4. Once the Leadoff is fully dissolved, maintain agitation and continue filling tank with water. Leadoff 
must be thoroughly mixed and dissolved with water before adding any other materials including water 
conditioners or other additives. 
5. As the tank is filling, add tank mix partners (if desired) in the proper mixing order. 
6. Maintain agitation throughout mixing and application. If the mixture is not continuously agitated, 
settling of spray components could occur. If settling occurs, thoroughly re-agitate before using. 
7. At the end of the day, or for extended periods of time between Leadoff applications, it is advised to 
flush boom hoses and lines of spray solution and recharge with clean water. This will aid in proper 
sprayer cleanout when concluding Leadoff applications before moving on to spray other 
products/crops. 
8. Apply Leadoff spray mixture within 48 hours of mixing to avoid product degradation. 
 
If the selected companion herbicide has a ground or surface water advisory, consider this advisory when 
using the companion herbicide. 
 
Ground Application 
 
Use a minimum of 15 gallons of water per acre (GPA) to ensure thorough coverage of the weeds and the 
best performance. Use a minimum of 10 GPA for light, scattered stands of weeds. 
 
Heavy crop residues may reduce burndown control of emerged weeds if residues impede spray 
coverage. Higher spray volumes and pressures can improve burndown control in heavy crop residue 
situations. 
 
Refer to SPRAY DRIFT MANAGEMENT section. 
 
Aerial Application 
 
Use nozzle types and arrangements that will provide optimum spray distribution and maximum coverage 
at a minimum of 5 GPA. 
 
Refer to SPRAY DRIFT MANAGEMENT section.

R6V / Leadoff / Amendment / 06-30-2025 Page 22 
 
ROTATIONAL CROP INTERVALS 
 
The following rotational intervals must be observed: 
 
1.5 OZ/A MAXIMUM USE RATE OF LEADOFF 
Rotation Crop Interval 
(months) 
Corn, field Anytime 
Soybeans with BOLT® Technology Anytime 
Potatoes 1 
Cotton * 1 
Soybeans * 1 
Tomato 1 
Cereals, Winter 3 
Cereals, Spring 9 
Alfalfa 10 
Spring Canola 10 
Corn, pop, seed or sweet 10 
Cucumber 10 
Flax 10 
Peanuts 1.5 
Peas 10 
Rice 10 
Red Clover 10 
Sorghum 10 
Sorghum (Inzen grain) 0.5 
Snap beans, dry beans 10 
Sunflower 10 
Sugarbeets 10 
Sugarcane 4† 
Sweet potatoes/yams** 1.5 
Tobacco 1.5 
Crops Not Listed 18 
Winter canola, winter carinata, winter camelina, and winter 
cress*** 4 
 
* In the states of Illinois, Oklahoma and Texas west of I-35 (not including the counties containing I-35) the rotational interv al to 
cotton and soybeans is 10 months. In the state of Virginia, the soybean rotational interval is 2 months. In the state of Missou ri, 
excluding the bootheel, the soybean rotational interval south of I-70 is 2 months and north of I-70 is 10 months. Sulfonylurea 
resistant soybean rotational interval is one month. Refer to Additional Information - Soybeans page 5. 
 
** On soils with pH 6.5 or less. 
*** Winter canola, winter carinata, winter camelina, and winter cress can be planted in AL, AR, IL, IN, KY, MO, MS, and TN as a 
second crop (double crop) a minimum of 4 months after application. If drought conditions are present after application, some st and 
loss may occur. 
 
† Only for the state of Louisiana. Recrop to sugarcane in all other states is 18 months. 
 
GREATER THAN 1.5 OZ/A UP TO 2.7 OZ/A MAXIMUM USE RATE OF LEADOFF 
 
Rotation Crop Interval (months) 
Corn, field Anytime 
Soybeans with BOLT® Technology Anytime 
Potatoes 1 
Tomato 1 
Sulfonylurea Resistant Soybean 1 
Cereals, Winter 4 
Cereals, Spring 9 
Corn pop, seed or sweet 10

R6V / Leadoff / Amendment / 06-30-2025 Page 23 
 
Cotton†* 10 
Cucumber 10 
Flax 10 
Sorghum (Inzen grain) 0.5 
Soybeans * 10 
Snap beans, dry beans 10 
Sunflower 10 
Crops Not Listed 18 
 
† The rotation interval must be extended to 18 months if drought conditions prevail after application and before the rotational crop is 
planted unless sprinkler irrigation has been applied and totals greater than 15" during the growing season. 
 
* If a maximum use rate of 2.0 oz/A is used the rotational interval is 2 months except in the states of Illinois, Missouri excluding the 
bootheel, Oklahoma, Texas or Virginia. 
 
SPRAYER PREPARATION/CLEANUP 
 
The spray equipment must be cleaned before Leadoff is sprayed. Follow the cleanup procedures 
specified on the labels of the previously applied products. 
When spraying or mixing equipment will be used over an extended period to apply multiple loads of 
Leadoff, partially fill the tank with fresh water at the end of each day of spraying, flush the boom and 
hoses, and allow to sit overnight. 
 
To avoid subsequent injury to desirable crops, thoroughly clean all mixing and spray equipment 
immediately following applications of Leadoff as follows: 
 
1. Empty the tank and drain the sump completely. 
2. Spray the tank walls with clean water using a minimum volume of 10% of the tank volume. Circulate 
the water through the lines, including all bypass lines, for at least two minutes. Flush the boom well 
and empty the sprayer. Completely drain the sump. 
3. Repeat step 2. 
4. Remove the nozzles, screens, and the end caps of sprayer booms and clean separately in a bucket 
containing water. 
 
The rinsate solution may be applied back to the crop(s) listed on this label. DO NOT exceed the maximum 
labeled use rate. If cleaners are used, consult the cleaner label for rinsate disposal instructions. If no 
instructions are given, dispose of the rinsate on site or at an approved waste disposal facility. 
 
Notes: 
 
1. Always start with a clean spray tank, hoses, boom and nozzles. Ensure boom sections between end 
nozzles and the end of the boom are clean of deposits (It is advised to remove end caps and visually 
inspect). If needed, thoroughly flush rinse water through the boom sections with the end caps 
removed to ensure booms are clean and free of any residue or deposits. 
2. Steam-cleaning aerial spray tank is advised to facilitate the removal of any caked deposits. 
3. When Leadoff is tank mixed with other pesticides, all cleanout procedures for each product must be 
examined and the most rigorous procedure must be followed. 
4. Follow any pre-cleanout guidelines advised on other product labels. 
 
THE IMPORTANCE OF SOIL PH 
 
Soil pH varies greatly, even within the same field. For example, variations as much as 2 pH units are 
common. Composite soil samples taken across an entire field, including those samples taken for soil 
fertility recommendations, may not detect areas of high pH. Sub-sampling is advised for areas likely to 
have pH values higher than the field average. The following is a non-inclusive list of potential high pH 
areas where subsampling is advised.

R6V / Leadoff / Amendment / 06-30-2025 Page 24 
 
x Where different soil types are evident within a field, sample soil types separately. 
x Where conditions vary within a field, sample areas separately, including areas bordered by limestone 
gravel roads, river bottoms subject to flooding, low areas in hardpan soils where evaporative ponds 
may occur, eroded hillsides, along drain tile lines, and areas where drainage ditch spoil has been 
spread. 
x Where lime has not been deeply incorporated, soil may exhibit significantly higher pH values in the 
upper 3 inches of soil. Composite soil samples taken at a 6-8 inch depth may not reflect the elevated 
pH near the surface. In these cases, shallow sampling of the upper 3 inches is advised. 
 
Determine soil pH by laboratory analysis using a 1:1 soil:water suspension. 
 
 
 Terms and Conditions of Use 
If terms of the following Warranty Disclaimer, Inherent Risks of Use, and Limitation of Remedies are not 
acceptable, return unopened package at once to the seller for a full refund of purchase price paid. To the 
extent consistent with applicable law, use by the buyer or any other user constitutes acceptance of the 
terms under Warranty Disclaimer, Inherent Risks of Use and Limitations of Remedies. 
 
 Warranty Disclaimer 
Corteva Agriscience warrants that this product conforms to the chemical description on the label and is 
reasonably fit for the purposes stated on the label when used in strict accordance with the directions for 
use, subject to the inherent risks set forth below. To the extent consistent with applicable law, Corteva 
Agriscience MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY OF MERCHANTABILITY OR 
FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER EXPRESS OR IMPLIED WARRANTY. 
 
 Inherent Risks of Use 
It is impossible to eliminate all risks associated with use of this product. Plant injury, lack of performance, 
or other unintended consequences may result because of such factors as use of the product contrary to 
label instructions (including conditions noted on the label, such as unfavorable temperatures, soil 
conditions, etc.), abnormal conditions (such as excessive rainfall, drought, tornadoes, hurricanes), 
presence of other materials, the manner of application or other factors, all of which are beyond the control 
of Corteva Agriscience or the seller. To the extent consistent with applicable law, Corteva Agriscience will 
not be responsible for losses or damages resulting from the use of this product in any manner not 
specifically directed by Corteva Agriscience. To the extent consistent with applicable law, all such risks 
associated with non-directed use shall be assumed by buyer and/or user. 
 
 Limitation of Remedies 
To the extent consistent with applicable law, the exclusive remedy for losses or damages resulting from 
this product (including claims based on contract, negligence, tort, strict liability, or other legal theories), 
shall be limited to, at Corteva Agriscience’s election, one of the following: 
 
1. Refund of purchase price paid by buyer or user for product bought, or 
2. Replacement of product used. 
 
To the extent consistent with applicable law, Corteva Agriscience shall not be liable for losses or 
damages resulting from handling or use of this product unless Corteva Agriscience is promptly notified of 
such loss or damage in writing. To the extent consistent with applicable law, in no case shall Corteva 
Agriscience be liable for consequential, incidental or special damages or losses. 
 
The terms of the Warranty Disclaimer, Inherent Risks of Use, and Limitation of Remedies cannot be 
varied by any written or verbal statements or agreements. No employee or sales agent of Corteva 
Agriscience or the seller is authorized to vary or exceed the terms of the Warranty Disclaimer or this 
Limitation of Remedies in any manner.

R6V / Leadoff / Amendment / 06-30-2025 Page 25 
 
For product information call: 1-800-258-3033 
 
Produced for 
Corteva Agriscience LLC 
9330 Zionsville Road 
Indianapolis, IN 46268 
 
™
®Trademarks of Corteva Agriscience and its affiliated companies 
 
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