crop-chem-docs/corpus/epa_ppls/8033-122.md

# TOPSIN 4.5FL FUNGICIDE

- EPA Reg No: **8033-122**
- Registrant: NIPPON SODA CO., LTD.
- Signal word: Caution
- Active ingredients: Thiophanate-methyl (45%)
- Label accepted: 2020-04-30
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/008033-00122-20200430.pdf

---
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
PRIA Non-New-Use Label Acceptable v.20150320 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
April 30, 2020 
 
John Wrubel 
Regulatory Affairs Director 
Nippon Soda Co., Ltd. 
c/o Nisso America Inc. 
88 Pine Street, 14th Floor 
New York, NY 10005 
 
Subject: PRIA Label Amendment – Revising the directions for use for almonds, grapes, 
stone fruit and soybeans 
 Product Name: Topsin 4.5FL Fungicide 
 EPA Registration Number: 8033-122 
 Application Date: 8/29/2018 
 Decision Number: 543813 
 
Dear Mr. Wrubel: 
 
The amended label referred to above, submitted in connection with registration under the Federal 
Insecticide, Fungicide and Rodenticide Act, as amended, is acceptable. This approval does not 
affect any conditions that were previously imposed on this registration. You continue to be 
subject to existing conditions on your registration and any deadlines connected with them. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes all 
previously accepted labeling. You must submit one copy of the final printed labeling before you 
release the product for shipment with the new labeling. In accordance with 40 CFR 152.130(c), 
you may distribute or sell this product under the previously approved labeling for 18 months 
from the date of this letter. After 18 months, you may only distribute or sell this product if it 
bears this new revised labeling or subsequently approved labeling. “To distribute or sell” is 
defined under FIFRA section 2(gg) and its implementing regulation at 40 CFR 152.3. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be 
aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide 
Act and is subject to review by the Agency. If the website is false or misleading, the product 
would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 
CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, 
regardless of whether a website is referenced on your product’s label, claims made on the 
website may not substantially differ from those claims approved through the registration process. 
Therefore, should the Agency find or if it is brought to our attention that a website contains false 
or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance.

Page 2 of 2 
EPA Reg. No. 8033-122 
Decision No. 543813 
 
Your release for shipment of the product constitutes acceptance of these conditions. If these 
conditions are not complied with, the registration will be subject to cancellation in accordance 
with FIFRA section 6. If you have any questions, please contact Nathan Mellor by phone at 703-
347-8562, or via email at mellor.nathan@epa.gov. 
 
 
Shaja B. Joyner, Product Manager 20 
Fungicide-Herbicide Branch 
Registration Division 7505P 
 
 
 
 
Enclosure

1
Thiophanate-
methyl
GROUP 1 FUNGICIDE
TOPSIN® 4.5 FL
Fungicide
ACTIVE INGREDIENT:
Thiophanate-methyl (dimethyl[1,2-phenylene)-
bis(iminocarbonothioyl)]bis[carbamate])* . . . . . . . . . . . . . . . . . . . . . . . 45.0%
OTHER INGREDIENTS: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55.0%
TOTAL: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100.0%
Contains 4.5 pounds thiophanate-methyl per gallon.
*Also known as dimethyl 4,4’-o-phenylenebis[3-thioallophanate]
TOPSIN is a registered trademark of Nippon Soda Company, Ltd.
KEEP OUT OF REACH OF CHILDREN
CAUTION
FIRST AID
If inhaled:
x Move person to fresh air.
x If person is not breathing, call 911 or an ambulance, then give artificial respiration, 
preferably by mouth-to-mouth, if possible.
x Call a poison control center or doctor for further treatment advice.
If on skin or clothing:
x Take off contaminated clothing. 
x Rinse skin immediately with plenty of water for 15-20 minutes. 
x Call a poison control center or doctor for treatment advice. 
Have the product container or label with you when calling a poison control center or doctor or 
going for treatment. Contact the Rocky Mount ain Poison Control Center at 1-866-673-6671
for emergency medical treatment information.
EPA Reg. No.8033-122 EPA Est. No. 
NET CONTENTS: __________ Gallons Batch/Lot # ____________
Nippon Soda Co., Ltd.
c/o Nisso America Inc.
379 Thornall Street; 5th Floor
Edison, NJ 08837
04/30/2020
8033-122

2
PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS AND DOMESTIC ANIMALS
CAUTION: Harmful if absorbed through the skin or inhaled. Avoid contact with skin, eyes 
or clothing. Avoid breathing vapor or spray mist. Wash hands before eating, drinking, 
chewing gum, using tobacco products, or using the toilet.
PERSONAL PROTECTIVE EQUIPMENT (PPE)
Some materials that are chemical-resistant to this product are barrier laminate, butyl rubber 
•14 mils, nitrile rubber •14 mils, neoprene rubber •14 mils, natural rubber •14 mils,
polyethylene, polyvinyl chloride (PVC) •14 mils, and viton •14 mils.
Handlers mixing, loading, and applying the product as a dip must wear:
x Coveralls over long-sleeved shirt and long pants,
x Chemical-resistant gloves,
x Chemical-resistant footwear plus socks,
x Chemical-resistant apron.
All other mixers, loaders, and applicators must wear:
x Long-sleeved shirt and long pants,
x Shoes plus socks,
x Chemical-resistant gloves,
x Chemical-resistant apron for mixers, loaders, and other handlers exposed to the 
concentrate.
Seed treatment applicators and other seed treatment handlers must wear:
x Long-sleeved shirt and long pants,
x Shoes plus socks,
x Chemical-resistant gloves for all mixers and loaders and for applicators using hand-
held equipment,
x Chemical-resistant apron for mixers, loaders, and other handlers exposed to the 
concentrate.
Note: Persons involved in bagging treated seed, sewing or moving bags of treated seed, or 
cleaning up bagging areas or seed treatment equipment are pesticide handlers and must wear 
the PPE required on this label for pesticide handlers.
USER SAFETY REQUIREMENTS
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for 
washables exist, use detergent and hot water. Keep and wash PPE separately from other 
laundry. Discard clothing and other materials that have been drenched or heavily 
contaminated with this product’s concentrate. DO NOT reuse them.

3
ENGINEERING CONTROLS
When handlers use enclosed cabs in a manner that meets the requirements listed in the 
Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-6)], the 
handler PPE requirements may be reduced or modified as specified in the WPS.
USER SAFETY RECOMMENDATIONS
ƔUsers should remove clothing/PPE immediately if pesticide gets inside. Then wash 
thoroughly and put on clean clothing.
ƔUsers should remove PPE immediately after handling this product. Wash the outside of 
gloves before removing. As soon as possible, wash thoroughly and change into clean 
clothing.
ENVIRONMENTAL HAZARDS
DO NOT apply directly to water, or to areas where surface water is present or to intertidal 
areas below the mean high-water mark. Runoff from treated areas may be hazardous to 
aquatic organisms in neighboring areas. DO NOT contaminate water when disposing of 
equipment wash water.
DIRECTIONS FOR USE
SHAKE WELL BEFORE USING
It is a violation of Federal law to use this product in a manner inconsistent with its labeling.
DO NOT apply this product in a way that will contact workers or other persons, either 
directly or through drift. Only protected handlers may be in the area during application. For 
any requirements specific to your State or Tribe, consult the agency responsible for pesticide 
regulation.
DO NOT apply when wind speed favors drift beyond the area intended for treatment.
AGRICULTURAL USE REQUIREMENTS
Use this product only in accordance with its labeling and with the Worker Protection Standard, 
40 CFR part 170. This Standard contains requirements for the protection of agricultural 
workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. 
It contains requirements for training, decontamination, notification, and emergency assistance. 
It also contains specific instructions and exceptions pertaining to the statements on this label 
about personal protective equipment (PPE), and restricted-entry interval. The requirements in 
this box only apply to uses of this product that are covered by the Worker Protection Standard.
DO NOT enter or allow worker entry into treated areas during the restricted entry interval 
(REI).
Exemption: The Worker Protection Standard, under certain circumstances, allows workers to 
enter the treated area if there will be no contact with anything that has been treated.

4
DO NOT enter or allow workers entry into treated areas during the restricted-entry interval 
(REI). The REI for each crop is listed in the directions for use associated with that crop.
Exemption: If this product is applied by drenching or if treated seed is soil-injected or soil 
incorporated, the Worker Protection Standard, under certain circumstances, allows workers to 
enter the treated area if there will be no contact with anything that has been treated.
PPE required for early entry to treated areas that is permitted under the Worker Protection 
Standard and that involves contact with anything that has been treated, including plants, soil, 
or water, is:
x Coveralls over long-sleeved shirt and long pants,
x Chemical-resistant gloves made of any waterproof material,
x Chemical-resistant footwear plus socks,
x Chemical-resistant headgear for overhead exposures.
PRODUCT INFORMATION
Apply Topsin 4.5 FL with ground or aerial equipment, using sufficient volume of spray to 
provide thorough coverage. Continuous agitation is required to keep the material in 
suspension. 
Begin applications as disease is first observed or expected. Tank mixing with a protectant 
fungicide is directed for resistance management. Use the higher rate under conditions of 
severe disease pressure. Also, see local State Extension Service directions for application 
schedules. 
Aerial Applications. Use a minimum of 5 gall ons of spray volume per acre for row crops, 
and a minimum of 10 gallons of spray volume per acre for tree crops. 
Ground Applications. Use a minimum of 10 to 20 gallons of spray volume per acre for row 
crops. 
High Volume Dilute Applications. Use the Topsin 4.5 FL per acre use rate for concentrate 
spray application for tree crops (no more than 400 gallons on apples and pears; or 300 
gallons on stone fruit). When making dilute ground application, use Topsin 4.5 FL use rate 
per 100 gallons. Follow all crop specific application language on this label. 
Higher spray volumes will result in better coverage and better disease control. Lack of 
control when using below minimum spray volumes is solely at the risk of the applicator/user. 
This includes the use of electrostatic sprayers. 
Chemigation: Please see DIRECTIONS FOR USE THROUGH CHEMIGATION 
SYSTEMS for specific information. DO NOT apply through any irrigation system unless 
these instructions are followed.
Topsin 4.5 FL may be used for control of labeled diseases during the non-bearing years of 
new planting of tree fruit and tree nuts, and on nursery stock.

5
Plantback restrictions: DO NOT plant any crop not labeled for Topsin use within 30 days of 
last application. 
RESISTANCE MANAGEMENT: 
For resistance management, Topsin 4.5 FL contains a Group 1 fungicide. Any fungal 
population may contain individuals naturally resistant to Topsin 4.5 FL and other Group 1 
fungicides. A gradual or total loss of pest control may occur over time if these fungicides are 
used repeatedly in the same fields. Appropriate resistance-management strategies should be 
followed.
To delay fungicide resistance, take one or more of the following steps: 
• Rotate the use of Topsin 4.5 FL Fungicide or other Group 1 fungicides within a growing 
season sequence with different groups that control the same pathogens. 
• Use tank mixtures with fungicides from a different group that are equally effective on the 
target pest when such use is permitted. Use at least the minimum application rate as labeled 
by the manufacturer.
• Adopt an integrated disease management program for fungicide use that includes scouting,
uses historical information related to pesticide use, and crop rotation, and which considers 
host plant resistance, impact of environmental conditions on disease development, disease 
thresholds, as well as cultural, biological and other chemical control practices. 
• Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage resistance.
• Monitor treated fungal populations for resistance development. 
• Contact your local extension specialist or certified crop advisor for any additional pesticide 
resistance-management and/or IPM directions for specific crops and pathogens.
• For further information or to report suspected resistance contact Nippon Soda Co., Ltd. at 
212-490-0350. You can also contac t your pesticide distributor or university extension 
specialist to report resistance.
Mixing instructions:
SHAKE WELL BEFORE USING. Some settling may occur during prolonged periods of 
non-use. When high pH tank mixes exist, the interval between mixing and application 
should be minimized. The buffering of tank water to pH 6-7 prior to the addition of Topsin 
4.5 FL is directed. Add required amount of Topsin 4.5 FL to a partially filled tank (1/2 total 
volume), agitate by mechanical or hydraulic means, add tank mix product if used (see 
below), agitate again and then add remaining required amount of water.

6
Continuous agitation is directed to keep the material in proper suspension. For best results, 
use spray mixture the same day it is prepared.
Tank mixing instructions:
Topsin 4.5 FL may be tank-mixed with fungicides, insecticides and/or plant growth 
regulators that are approved for use on the intended crop. Consult the intended tank mix 
partner product label for appropriate application rates and use instructions. 
It is the pesticide user's responsibility to ensure that all products are registered for the 
intended use. Read and follow the applicable restrictions and limitations and directions for 
use on all product labels involved in tank mixing. Users must follow the most restrictive 
directions for use and precautionary statements of each product in the tank mixture.
Topsin 4.5 FL is compatible with most commonly used pesticides. If tank mixing with other 
materials, add products in the following order: wettable powders, dry flowables, liquid 
flowables, emulsifiable concentrates, and soluble materials including fertilizers. Tank mixes 
with highly alkaline pesticides, including Bordeaux mixture or lime sulfur are not advised.
No claim of compatibility with other pesticides is implied. It is directed to perform a 
Compatibility Jar Test to ensure tank mix product compatibility prior to use. See 
Compatibility Test section of this label for more information.
Compatibility Test for Mix Components
It is advised a Compatibility Jar Test be conducted for uncertainty of tank mix products. 
For 20 gallons per acre spray volume, use 3.3 cups of water from intended source. Add
components in the sequence indicated above in Mixing Instructions using 2 teaspoons for 
each pound or 1 teaspoon for each pint of specified label rate per acre. Tightly replace cap 
on the jar and invert 10 cycles between component additions.
When all tank mix products have been added to the jar and properly mixed, let sit for 15 
minutes. Evaluate the solution for uniformity and stability. The mixed spray solution 
should not have fine particles on the bottom, nor a thick texture, nor free oil on the surface. 
If tank mix partners are not compatible, test with the addition of a suitable compatibility 
agent. 
Mandatory Spray Drift Requirements
Aerial applications
ƔDO NOT release spray at a height greater than 10 ft above the vegetative canopy, unless a greater 
application height is necessary for pilot safety.
ƔFor all applications, applicators are required to use a medium or coarser spray droplet size 
(ASABE S572.1).
ƔThe boom length must not exceed 65% of the wingspan for airplanes or 75% of the rotor blade 
diameter for helicopters.
ƔApplicators must use ½ swath displacement upwind at the downwind edge of the field.

7
Mandatory Spray Drift Requirements continued
ƔNozzles must be oriented so the spray is direct toward the back of the aircraft.
ƔDO NOT apply when wind speeds exceed 10 miles per hour at the application site.
ƔDO NOT apply during temperature inversions.
Ground applications
ƔApply with the nozzle height recommended by the manufacturer, but not more than 3 feet above 
the ground or crop canopy.
ƔFor all applications, applicators are required to use a medium or coarser spray droplet size 
(ASABE S572.1).
ƔDO NOT apply when wind speeds exceed 10 miles per hour at the application site.
ƔDO NOT apply during temperature inversions.
Boom-less ground applications
ƔApplicators are required to use a medium or coarser spray droplet size (ASABE S572.1) for all 
applications.
ƔDO NOT apply when wind speeds exceed 10 miles per hour at the application site.
ƔDO NOT apply during temperature inversions.
o Spray Drift Advisories 
x THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE SPRAY 
DRIFT.
x BE AWARE OF NEARBY NON-TARGET SITES AND 
ENVIRONMENTAL CONDITIONS.
x IMPORTANCE OF DROPLET SIZE
An effective way to reduce spray drift is to apply large droplets. Use the 
largest droplets that provide target pest control. While applying larger droplets 
will reduce spray drift, the potential for drift will be greater if applications are 
made improperly or under unfavorable environmental conditions.
Controlling Droplet Size - Ground Boom 
ƒ Volume - Increasing the spray volume so that larger droplets are 
produced will reduce spray drift. Use the highest practical spray 
volume for the application. If a greater spray volume is needed, 
consider using a nozzle with a higher flow rate.
ƒ Pressure - Use the lowest spray pressure recommended for the nozzle 
to produce the target spray volume and droplet size.
ƒ Spray Nozzle - Use a spray nozzle that is designed for the intended 
application. Consider using nozzles designed to reduce drift.
Controlling Droplet Size - Aircraft

8
ƒ Adjust Nozzles - Follow nozzle manufacturers recommendations for 
setting up nozzles. Generally, to reduce fine droplets, nozzles should 
be oriented parallel with the airflow in flight.
x BOOM HEIGHT - Ground Boom
Use the lowest boom height that is compatible with the spray nozzles that will
provide uniform coverage. For ground equipment, the boom should remain 
level with the crop and have minimal bounce.
x RELEASE HEIGHT - Aircraft 
Higher release heights increase the potential for spray drift. When applying 
aerially to crops, DO NOT release spray at a height greater than 10 ft above 
the crop canopy, unless a greater application height is necessary for pilot 
safety.
x SHIELDED SPRAYERS
Shielding the boom or individual nozzles can reduce spray drift. Consider 
using shielded sprayers. Verify that the shields are not interfering with the 
uniform deposition of the spray on the target area.
x TEMPERATURE AND HUMIDITY 
When making applications in hot and dry conditions, use larger droplets to 
reduce effects of evaporation.
x TEMPERATURE INVERSIONS 
Drift potential is high during a temperature inversion. Temperature inversions 
are characterized by increasing temperature with altitude and are common on 
nights with limited cloud cover and light to no wind. The presence of an 
inversion can be indicated by ground fog or by the movement of smoke from a 
ground source or an aircraft smoke generator. Smoke that layers and moves 
laterally in a concentrated cloud (under low wind conditions) indicates an 
inversion, while smoke that moves upward and rapidly dissipates indicates 
good vertical air mixing. Avoid applications during temperature inversions. 
x WIND 
Drift potential generally increases with wind speed. AVOID APPLICATIONS 
DURING GUSTY WIND CONDITIONS.
Applicators need to be familiar with local wind patterns and terrain that could 
affect spray drift.
x Boom-less Ground Applications:
Setting nozzles at the lowest effective height will help to reduce the potential 
for spray drift.
x Handheld Technology Applications:
Take precautions to minimize spray drift.

9
Crop Specific Directions
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Almonds Brown Rot Blossom 
Blight (Monilinia)
Scab (Cladosporium)
Jacket Rot
(Monilinia,
Sclerotinia, Botrytis)
Leaf Blight
(Seimatosporium)
2 0–3 0
(0.7 –
1.05)
Apply as needed at 10 to 14-day 
intervals between pink bud and petal 
fall. Apply alone at pink bud for 
Brown Rot control. For all other 
applications, apply with a contact 
fungicide including Ziram 76DF (EPA 
Reg. No. 70506-173, ziram) or 
Manzate Pro-Stick (EPA Reg. No.
70506-234, mancozeb) for broad-
spectrum control and resistance 
management.
Restrictions:
-DO NOT apply more than 30.0 fl. 
oz./A (1.05 lb ai/A) per application.
-DO NOT apply more than 60.0 fl.
oz. of product (2.1 lbs a.i.)/A/year.
-The minimum retreatment interval is
ten (10) days. 
-DO NOT apply more than three (3)
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 3 days
Apples Apple Scab (Venturia)
Black Pox*
(Helminthosporium 
papulosum)
Flyspeck 
(Zygophiala)
Powdery Mildew 
(Podosphaera) 
Sooty Blotch
(Gloeodes) 
Black Rot 
(Botryosphaeria 
obtusa)
Brooks Fruit Spot 
15-20
(0.53 –
0.7)
(in CA 
use 30
(1.05))
3.75 – 5
(0.13 –
0.18)
Apply at 5- to 10-day intervals from
green tip through petal fall; continue 
at 7- to 14-day intervals in cover 
sprays. 
Restrictions:
-DO NOT apply more than 20.0 fl. 
oz./A (0.7 lb ai/A) per application.
-In California, DO NOT apply more 
than 30 fl. oz./A (1.05 lb ai/A) per 
application.
-DO NOT apply more than 80.0 fl.
oz. of product (2.8 lbs a.i.)/A/year.
-The minimum retreatment interval is
five (5) days.

10
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
(Mycosphaerella)
White Rot*
(Botryosphaeria 
dothidia)
*Not for use in California
-DO NOT apply more than five (5)
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 2 days
-PHI: 1 day
Pre-Harvest use to control Post-Harvest Diseases on Apples
Storage Rot
Blue Mold
(Penicillium 
expansum)
Gray Mold 
(Botrytis cinerea)
Bulls-Eye Rot 
(Neofabraea spp.)
15-20
(0.53 –
0.7)
3.75 - 5
(0.13 –
0.18)
Apply as a pre-harvest spray within 2 
weeks to 3 days of harvest.
Thorough coverage of the fruit is 
required. Application closer to 
harvest may provide better efficacy.
For resistance management, DO NOT
use a benzimidazole fungicide post-
harvest following Topsin 4.5 FL pre-
harvest application.
Application of a non-benzimidazole 
post-harvest fungicide will provide 
additional protection from post-
harvest diseases.
Restrictions:
-DO NOT apply more than 20.0 fl. 
oz./A (0.7 lb ai/A) per application.
-DO NOT apply more than 80.0 fl.
oz. of product (2.8 lbs a.i.)/A/year.
-The minimum retreatment interval is
five (5) days. 
-DO NOT apply more than five (5)
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 2 days
-PHI: 1 day
Beans, dry 
and succulent
White Mold 
(Sclerotinia)
30-40
(1.05 –
For one application: Apply when 
100% of plants have at least one open

11
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Including:
Lima bean
Snap bean
Kidney bean
Mung bean
Navy bean
Pinto bean
Wax bean
Broad bean
Fava bean
Asparagus bean
Blackeyed pea
Cowpea
Sweet lupine
White lupine
White Sweet
lupine
Grain lupine
Chick pea
Garbanzo bean
Gray Mold (Botrytis) 
Anthracnose
(Colletotrichum)
1.4)
OR
20-30
(0.7 –
1.05)
bloom or when conditions are 
favorable for disease development.
OR
For multiple applications: Make the 
first application when 10% to 30% of 
plants have at least one open bloom 
and follow with sequential 
applications on a 4 to 7-day interval. 
Apply prior to the development of 
disease for best results.
Restrictions:
-DO NOT apply more than 40.0 fl. 
oz./A (1.4 lb ai/A) per application.
-DO NOT apply more than 80.0 fl.
oz. of product (2.8 lbs a.i.)/A/year.
-The minimum retreatment interval is
four (4) days.
-DO NOT apply more than five (5)
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 1 day for 
succulent beans.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 3 days for dry
beans.
-PHI: California only, 14 days for 
succulent beans, 28 days for dry beans 
and lima beans.
-PHI: all other States, 14 days for 
succulent beans and lima beans, 28 
days for dry beans.

12
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Cucurbits:
Cantaloupe, 
Casaba, 
Cucumbers, 
Melons,
Pumpkins, 
Summer and 
Winter 
Squash, and 
Watermelons
Topsin 4.5FL can be used in a tank
mix with a protectant fungicide 
including Manzate Pro-Stick (EPA 
Reg. No. 70506-234, mancozeb),
Penncozeb (EPA Reg. No. 70506-185,
mancozeb), or Oranil 6L (EPA Reg.
No. 70506-262, chlorothalonil) for 
additional disease control and 
resistance management.
.
Restrictions:
-DO NOT apply more than 10 fl.oz. 
of product (0.35 lb a.i./A) per 
application.
-DO NOT apply more than 60 fl. oz. 
of product (2.1 lbs a.i.)/A/year from
any combination of application 
timings.
-The minimum retreatment interval is 
4 days.
-DO NOT make more than 5 
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 1 day.
-P H I : 1 d a y
Acremonium/
Cephalosporium 
Hypocotyl Rot
10
(0.35)
Apply in-furrow, on top of the seeds 
at planting. 
Restrictions:
DO NOT use less than 10 gallons of 
water per acre.
Anthracnose*
(Colletotrichum)
Gummy Stem Blight*
(Didymella)
Powdery Mildew
(Erysiphe, 
Sphaerotheca)
Begin applications when plants begin
to run or when disease first appears
and repeat at 7 to14 day intervals or as 
needed.
For Target Spot, use at 7-day intervals 
as needed.

13
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Target Spot*
(Corynespora)
*Not for use in
California
Belly Rots*
(Rhizoctonia,
Fusarium)
*Not for use in 
California
Apply in sufficient volume to allow 
runoff to the soil. Will not control 
Pythium or Phytophthora.
Suppression of Vine 
Decline 
(Monosporascus)
Charcoal Rot
(Macrophomina)
Apply through buried drip irrigation 
(chemigation) to the root zone. Apply 
at 14-day intervals, beginning at 
emergence and continuing to harvest.
Applications weekly or biweekly,
beginning 4 to 6 weeks prior to 
harvest will also offer suppression, but 
may not be as effective as a season-
long program. 
Garlic
(clove 
treatment)
Penicillium Clove Rot 20
(0.7)
Completely immerse garlic cloves in 
suspension for at least 5 minutes.
Continuously agitate the solution tank 
by hydraulic or mechanical means.
After treatment, remove cloves from 
solution and drain.
Dry cloves after treatment and prior to 
planting.
Onions*
Garlic
(In furrow)
*Not for use in
California
White Rot 
(Sclerotium 
cepivorum)
40
(1.4)
Broadcast
equivalent
Spray directly into the open furrow at 
the time of planting seed, sets or 
bulbs. 
Restrictions:
-Not for this use through any type of 
irrigation system.
-DO NOT apply more than 40 fl. oz.
(1.4 lbs a.i.) of product per 
application.
-DO NOT make for than one

14
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
application per year.
-DO NOT apply more than 40 fl. oz.
of product (1.4 lbs a.i.)/A/year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 3 days.
Peanuts
.
Early Leaf Spot 
(Cercospora)
Late Leaf Spot
(Cercosporidium)
Rust (Puccinia)
Limb Rot 
(Rhizoctonia)
Web Blotch
(Ascochyta)
10
(0.35)
Begin applications when disease first 
appears and repeat at 14-day intervals
as needed.
Restrictions:
-DO NOT apply more than 10 fl. oz.
(0.35 lbs a.i.) of product per 
application.
-DO NOT apply more than 40 fl. oz.
of product (1.4 lbs a.i.)/A/year.
-The minimum retreatment interval is 
14 days.
-DO NOT apply more than 4 
applications per year.
-Topsin 4.5FL should not be used 
alone. Use only in combination with a 
non-benzimidazole fungicide
including Manzate Pro-Stick (EPA 
Reg. No. 70506-234, mancozeb),
Penncozeb (EPA Reg. No. 70506-185,
mancozeb), or Oranil 6L (EPA Reg. 
No. 70506-262, chlorothalonil) 
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 1 day.
-PHI: 14 days
Pecans Brown Spot 
(Cercospora)
Downy Spot 
20
(0.7)
Begin applications when first leaves
are showing and repeat at 3- to 4-

15
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
(Mycosphaerella)
Liver Spot 
(Gnomonia)
Powdery Mildew 
(Microsphaera) 
Scab (Fusicladium)
Stem End Blight
(Botryosphaeria)
Zonate Leaf Spot 
(Cristulariella)
week intervals until shuck split. 
Restrictions:
-DO NOT apply after shuck split.
-DO NOT apply more than 20 fl. oz.
(0.7 lbs a.i.) of product per 
application.
-The minimum retreatment interval is 
21 days.
-DO NOT make more than three 
applications per year.
-DO NOT apply more than 60 fl. oz.
of product (2.1 lbs a.i.)/A/year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 3 days.
-PHI: 1 day
Pistachios Shoot Blight
(Botrytis, 
Botryosphaeria)
3 0–4 0
(1.05 –
1.4)
Apply at bloom. 
Apply in a minimum of 100 gallons
per acre by ground or 20 gallons per 
acre by air.
For aerial application, fly over every 
row or center. 
Restrictions:
-DO NOT apply more than 40.0 fl. 
oz./A (1.4 lb. a.i./A) per application.
-DO NOT apply more than 40.0 fl.
oz. of product (1.4 lbs a.i.)/A/year.
-DO NOT apply more than one (1) 
application per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 3 days.

16
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Potatoes White Mold
(Sclerotinia 
sclerotiorum)
20-30
(0.7 –
1.05)
Make the first application at row 
closure to full bloom of the primary 
flower clusters (prior to petal drop). 
Repeat the application within 7 to 14
days and at 7- to 14-day intervals if 
conditions for disease development 
are favorable. Thorough coverage of 
the flowers, stems, and branches is 
essential for disease control.
Use a minimum of 6 gallons of 
water/A for aerial application.
Apply prior to the development of 
disease for optimal results.
May be tank mixed with Manzate Pro-
Stick (EPA Reg. No. 70506-234,
mancozeb) or Penncozeb (EPA Reg. 
No. 70506-185, mancozeb) for early 
and late blight control.
Restrictions:
-DO NOT apply more than 30.0 fl.
oz./A (1.05 lb. a.i./A) per application.
-DO NOT apply more than 80.0 fl.
oz. of product (2.8 lbs a.i.)/A/year.
-The minimum retreatment interval is 
seven (7) days. 
-DO NOT apply more than four (4)
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 2 days.
-Pre-harvest interval: 21 days

17
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Soybeans Restrictions:
-DO NOT apply more than 40 fl. 
oz./A (1.4 lb. a.i./A) per for a single
application for white mold control
otherwise DO NOT apply more than 
20 fl. oz./A (0.7 lb. a.i./A) per for a 
single application.
-DO NOT apply more than 40 fl. oz. 
of product (1.4 lbs a.i.)/A/year.
-The minimum retreatment interval is 
seven (7) days.
-DO NOT apply more than two (2)
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 1 day.
-Pre-harvest interval: 21 days
-DO NOT graze or feed treated vines 
or hay to livestock.
Anthracnose
(Colletotrichum) 
Brown Spot (Septoria) 
Frogeye Leaf Spot 
(Cercospora) 
Pod and Stem Blight 
(Diaporthe,
Phomopsis)
Purple Seed Stain 
(Cercospora)
10-20
(0.35 –
0.7)
Apply from full bloom to when pods 
are 1/8'' to 1/4'' in length. Make a 
second application 14 to 21 days later. 
DO NOT make the second 
application later than 14 days after 
pods average 1/4'' in length or when 
beans form in the pod. Use the high 
rate under severe disease pressure. 
20
(0.7)
FOR SEED BEANS ONLY---For 
seed quality, make a single application 
when beans form in the pod.
White Mold
(Sclerotinia)
20 (0.7) for 
split 
application
OR
40 (1.4) for 
single 
For split applications, apply initial 
application of 20 fl. oz/A at early 
bloom R-1 stage). Follow with a
second application 7 to14 days later.
OR
For a single application, apply 40 fl.

18
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
application oz./A at early bloom (R-1 stage).
Thorough coverage of the flowers,
stems, and branches is essential for 
disease control.
Use a minimum of 5 gallons water/A 
by air.
Aerial Blight 
(suppression)
20
(0.7)
Make initial application when disease 
threatens and repeat 14 to 21 days
later if needed.
Stone Fruit Restrictions:
-DO NOT apply more than 30 fl. 
oz./A (1.05 lb. a.i./A) per application.
-DO NOT apply more than 80 fl. oz.
of product (2.8 lbs a.i.)/A/year.
-The minimum retreatment interval is
ten (10) days.
-DO NOT make more than four (4)
applications per year. 
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 2 days.
-Pre-harvest interval: 1 day
Apricots Brown Rot Blossom 
Blight
Fruit Brown Rot 
(Monilinia)
20-30
(0.7 –
1.05)
(in 
California
use 30
(1.05))
6.7-10
(0.24 –
0.35)
Apply at early bloom (red bud). Make 
a second application at full bloom.
If needed under severe disease 
pressure, apply additional sprays at 
10- to 14-day intervals between full 
bloom and final pre-harvest sprays.
Cherries
Sweet and
Sour
Brown Rot Blossom
Blight
European Brown Rot
Fruit Brown Rot
(Monilinia)
20-30
(0.7 –
1.05)
(in 
California
use 30
6.7-10
(0.24 –
0.35)
Apply at early bloom (early popcorn). 
Make a second application at full 
bloom. 
If needed under severe disease 
pressure, apply additional sprays at 
10- to 14-day intervals between full

19
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
(1.05)) bloom and final pre-harvest sprays.
Cherry Leaf Spot 
(Coccomyces)
22.5-30
(0.8 –
1.05)
7.5-10
(0.26 –
0.35)
Applications may be made at petal fall 
or before (when leaves first unfold) 
and at first, second, and third cover at 
10- to 14-day intervals and one spray
14 to 21 days after harvest.
Powdery Mildew
(Podosphaera, 
Sphaerotheca)
20-30
(0.7 –
1.05)
(in 
California
use 30
(1.05))
PLUS
22.5-30
(0.8 –
1.05)
6.7-10
(0.24 –
0.35)
PLUS
7.5-10
(0.26 –
0.35)
Apply at early bloom (early popcorn). 
Make a second application at full 
bloom. 
PLUS
Apply at shuck fall and first cover.
Nectarines Brown Rot Blossom 
Blight 
Fruit Brown Rot 
(Monilinia)
20-30
(0.7 –
1.05)
(in 
California
use 30
(1.05))
6.7-10
(0.24 –
0.35)
Apply at early bloom (pink bud). 
Make a second application at full 
bloom if conditions favor disease 
development. 
If needed under severe disease
pressure, apply additional sprays at 
10- to 14-day intervals between full 
bloom and final pre-harvest sprays.
Peaches Brown Rot Blossom 
Blight
Fruit Brown Rot 
(Monilinia)
20-30
(0.7 –
1.05)
(in 
California
use 30
(1.05))
6.7-10
(0.24 –
0.35)
Apply at early bloom (pink bud). 
Make a second application at full 
bloom if conditions favor disease 
development.
If needed under severe disease 
pressure, apply additional sprays at 
10- to 14-day intervals between full 
bloom and final pre-harvest sprays.
Peach Scab 
(Cladosporium)
20-30 (0.7 
– 1.05)
(in 
6.7-10
(0.24 –
0.35)
Apply at early bloom (pink bud).
Make a second application at full 
bloom if conditions favor disease

20
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
California
use 30
(1.05))
PLUS
22.5-30
(0.8 –
1.05)
PLUS
7.5-10
(0.26 –
0.35)
development. 
PLUS 
Apply at shuck split and at first cover 
sprays.
Plums and 
Prunes
Brown Rot Blossom 
Blight
Fruit Brown Rot 
(Monilinia)
20-30
(0.7 –
1.05)
(in 
California 
use 30
(1.05))
6.7-10
(0.24 –
0.35)
Apply at early bloom (green tip). 
Make a second application at full 
bloom.
If needed under severe disease 
pressure, apply additional sprays at 
10- to 14-day intervals between full 
bloom and final pre-harvest sprays.
Black Knot
(Dibotryon)
Apply at pre-bloom, petal fall, and at 
first, second, and third cover sprays at 
10- to 14-day intervals.
Leaf Spot 
(Coccomyces)
Applications may be made at petal 
fall, shuck split, and at first, second,
and third cover sprays at 10- to 14-day 
intervals and 1 spray 14 to 21 days
after harvest.
Strawberries Restrictions:
-DO NOT apply more than 20 fl. 
oz./A (0.7 lb. a.i./A) per application.
-DO NOT apply more than 80 fl. oz. 
of product (2.8 lbs a.i.)/A/year.
-The minimum retreatment interval is 
seven (7) days. 
-DO NOT apply more than 4 
applications per year.
-DO NOT enter or allow worker entry
into treated areas during the restricted
entry interval (REI) of 1 day.
-Pre-harvest interval: 1 day

21
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Crown Rot*
(Colletotrichum spp.)
Suppression only
*Not for use in 
California
15-20
(0.53 –
0.7)
Begin applications after establishment 
of the transplants and continue 
through first bloom at 10 to 14-day 
intervals. Use the high rate if the 
fields have a history of Colletotrichum 
crown rot and/or conditions are 
favorable for development of the 
disease. Will not control
Phytophthora species.
Fruit Rot (Botrytis)
Leaf Blight 
(Dendrophoma) 
Leaf Scorch 
(Diplocarpon)
Powdery Mildew
(Sphaerotheca)
Begin applications at early bloom and 
continue at 7- to 10-day intervals. Use 
the higher rate under conditions of
severe disease pressure. 
Charcoal Rot
(Macrophomina)
20
(0.7)
Apply through buried drip irrigation 
(chemigation) to the root zone. Apply 
at 14-day intervals beginning at 
transplant.
Sugar Beets Restrictions:
-DO NOT apply more than 20 fl. 
oz./A (0.7 lb. a.i./A) per application.
-DO NOT apply more than 60 fl. oz. 
of product (2.1 lbs a.i.)/A/year.
-The minimum retreatment interval is 
fourteen (14) days.
-DO NOT apply more than 3 
applications per year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 1 day.
-Pre-harvest interval: 21 days
Cercospora Leaf Spot 
(Cercospora)
10–20
(0.35 –
Apply when conditions become 
favorable for disease development

22
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
0.7) before the disease appears and follow 
with a non-benzimidazole fungicide 
within 14 days of application or as 
needed.
Topsin 4.5FL should be tank mixed 
with a protectant fungicide including
Manzate Pro-Stick (EPA Reg. No.
70506-234, mancozeb), Penncozeb
(EPA Reg. No. 70506-185, 
mancozeb) or Super Tin 4L (EPA 
Reg. No. 70506-212, triphenyltin 
hydroxide)when resistant strains of 
Cercospora are present in the field.
For areas east of the Rocky
Mountains: DO NOT make more 
than one application of Topsin 4.5FL 
per season for Cercospora Leaf Spot.
Powdery Mildew
(Erysiphe)
10–20
(0.35 –
0.7)
Apply as soon as disease symptoms 
appear and follow with a non-
benzimidazole fungicide at a 14-day 
interval or as needed.
Topsin 4.5FL can be tank-mixed with 
sulfur products including Microthiol
Disperss (EPA Reg. No. 70506-187,
sulfur) at 5 to 10 lbs/A for additional 
disease control and resistance 
management.

23
Crop Diseases Fl. Oz./
Acre (lb
a.i./A)
Fl. Oz./100
gal. (lb 
a.i./100 
gal.)
Application Instructions
Triticale and 
Fall-seeded 
Wheat
For this use 
in Idaho, 
Oregon, and 
Washington 
ONLY
Foot Rot,
Strawbreaker, 
Eye Spot
(Pseudocercosporella)
20
(0.7)
Apply in a single application by air or
ground after tillering but before stem 
elongation has begun. Use sufficient 
water to obtain thorough coverage.
Restrictions:
-DO NOT apply more than 20 fl. 
oz.of product (0.7 lb a.i./A) per 
application.
-DO NOT apply more than 20 fl. oz.
of product (0.7 lb a.i.)/A/year.
-DO NOT enter or allow worker entry 
into treated areas during the restricted
entry interval (REI) of 24 hours.
-DO NOT cut for hay within 90 days 
of application. 
-DO NOT allow livestock to graze in 
treated areas before harvest.
NOTE: Dilute sprays are not to exceed maximum rate per acre.

24
DIRECTIONS FOR USE 
In the Aid in Control of Certain Canker Diseases Following Pruning of Almonds, 
Apricots, Cherries, Nectarines, Peaches, Plums and Prunes.
To protect pruning cuts from canker diseases caused by fungal pathogens including 
Leucostoma persoonii (Cytospora), Calosphaeria pulchella, Lasiodiplodia theobromae, and 
Diaporthe neotheicola (Phomopsis) apply Topsin 4.5 FL fungicide in spray or paint-on to 
pruning wounds.
Spray: Apply Topsin 4.5 FL at 30 fl. oz. (1.05 lb a.i.) per acre in a minimum of 30 gallons 
alone, or a minimum of 50 gallons when tank mixed per acre, using power operated ground
application equipment or a backpack sprayer. If backpack sprayer is used, chemical-resistant
coveralls or a chemical-resistant coat must be worn. 
Paint-on: Apply Topsin 4.5 FL at 4.0 fl. oz. (0.14 lb a.i.) per 1gallon water (20 fl. oz (0.7 lb 
a.i.) per 5 gallons of water) as a paint to cut or pruned surfaces immediately after cutting and 
before rain, dew, fog and fungal spores come into contact with fresh wood. 
Results are improved by thorough coverage of pruning wounds and by pruning at a time 
when little or no rain is expected soon after treatment.
For improved management of canker diseases by fungal pathogens and for fungicide 
resistance management, it is directed to apply Topsin 4.5 FL in a tank-mix with Rally® 40
WSP (EPA Reg. No. 62719-410, myclobutanil) at 6 oz/acre for almonds, apricots, cherries, 
nectarines, peaches, plums and prunes and/or in the tank mix with other fungicides registered 
for canker disease management. Refer to the Rally 40 WSP (EPA Reg. No. 62719-410,
myclobutanil) Special 2(ee) Recommendation for further information on this use.
Protect pruning cuts as soon as possible especially if irrigation, rainfall or fog is expected. 
Application within 24 hours is highly advised. Applications after 24 hours are permitted, but 
disease control may be reduced. Assure thorough coverage of all cut wood surfaces. For 
these pathogens, multiple applications may be needed. Make additional applications at 
approximately two-week intervals, especially if irrigation, rainfall or high humidity 
conditions exist.
The addition of a labeled rate of a registered organo-silicone spray adjuvant may increase 
penetration of cut wood surfaces. It is the responsibility of the user to assure that the organo-
silicone spray adjuvant is safe to the crop under the existing conditions of use and label on 
the adjuvant container. Addition of a registered spray dye to the tank mix, and visual 
inspection of the pruning cuts after application, will help assure thorough coverage of 
susceptible tissue.

25
Specific Use Restrictions:
Crop Maximum Use Rate Per
Acre Per Year
REI
Almonds 60 fl. oz. (2.1 lbs ai)/A/Year 3 days
Apricots, Cherries, 
Nectarines, Peaches, Plums 
and Prunes
80 fl. oz. (2.8 lbs ai)/A/Year 2 days
DIRECTIONS FOR USE ON CONIFERS
(Not for this use in California)
CROP DISEASE RATE (Lb/A),
MINIMUM 
GALLONAGE
APPLICATION 
INSTRUCTIONS
Conifers 
(Pine)
Austrian
Red
Scots
Christmas
Trees
Tip Blight
(Diplodia)
20 fl. oz. (0.7 lb 
a.i.) per
100 gal./A Apply at bud break. 
Repeat 10 to 14 days later, 
just before needles emerge 
from sheath; repeat again 
10 to 14 days after needle 
emergence.
Restrictions:
-DO NOT apply more than 
60 fl. oz. of product (2.1 
lbs. a.i.)/A/year.
-The minimum retreatment 
interval is ten (10) days.
-DO NOT apply more than 
3 applications per year.
-DO NOT enter or allow 
worker entry into treated 
areas during the restricted 
entry interval (REI) of 12 
hours.
-DO NOT graze livestock 
in treated areas.

26
CROP DISEASE RATE (Lb/A),
MINIMUM 
GALLONAGE
APPLICATION 
INSTRUCTIONS
(Fir)
Douglas
Swiss Needle 
Cast
(Phaecryptopus)
Rhabdocline 
Needle Cast
20 fl. oz. (0.7 lb 
a.i.) per
50 gal./A
Apply initially in early 
May. Repeat at 4-week 
intervals.
Add a spreader/sticker to 
improve coverage.
Use minimum gallonage 
with mist-blower types of 
sprayers and higher 
gallonage with
conventional sprayers.
Restrictions:
-DO NOT apply more than 
100 fl. oz. of product (3.5 
lbs. a.i.)/A/year.
-The minimum retreatment 
interval is (28) days. 
-DO NOT apply more than 
5 applications per year.
Conifers
(seedling
treatment)
Longleaf
Brown Needle 
Blight (Scirrhia)
1.25 fl. oz.
product (0.044
lb a.i.) per 9.5
oz. dry 
Kaolinite clay 
for seedling 
roots
Wet seedling roots in clean 
water, then dip roots into
Topsin 4.5FL/Kaolinite 
mixture.
Loblolly
Longleaf
Slash
Fusarium and 
Rhizoctonia Root 
Rot
2.5 fl. oz.
product (0.088 
lb a.i.) per 50
oz. Kaolinite 
clay, plus 
enough water to 
make a slurry
Dip seedling roots with 
Topsin 4.5FL/Kaolinite 
slurry.
Restrictions for Seedling Treatment:
-DO NOT apply mixture to seedling foliage
-During treatment, avoid excessive drying of roots or exposure to temperatures greater than 
90 °F or less than 32 °F.
-DO NOT enter or allow workers to enter into treated areas during the restricted 
entry interval (REI) of 12 hours.
- Note: Topsin 4.5FL does not control Pythium or Phytophthora.

27
DIRECTIONS FOR USE THROUGH CHEMIGATION SYSTEMS
USE IN CALIFORNIA BY CHEMIGATION ONLY FOR BEANS, CUCURBITS 
(CANTALOPE, CASABA, CUCUMBERS, MELONS, PUMPKINS, SQUASH, 
WATERMELONS), PEANUTS, POTATOES, SOYBEANS, STRAWBERRIES, AND 
SUGAR BEETS.
PRODUCT INSTRUCTIONS
Apply this product only through sprinkler irrigation systems including center pivot, lateral 
move, end tow, side (wheel) roll, traveler, solid set or hand move; or drip (mini-micro 
sprinklers, strip tubing, trickle) irrigation systems. DO NOT apply this product through any 
other type of irrigation system.
Crop injury, lack of effectiveness, or illegal pesticide residues in the crop can result from 
nonuniform distribution of treated water.
If you have any questions about calibration, you should contact State Extension Service 
specialists, equipment manufacturers or other experts.
A person knowledgeable of the chemigation system and responsible for its operation, or
under the supervision of the responsible person, shall shut the system down and make 
necessary adjustments should the need arise.
DO NOT connect chemigation system (including greenhouse systems) used for pesticide 
irrigation to any public water system unless the pesticide label-prescribed safety devices for 
public water systems are in place. Public water system means a system for the provision of 
piped water for human consumption if such a system has at least 15 service connections or 
regularly serves an average of at least 25 individuals daily at least 60 days out of the year.
SYSTEM REQUIREMENTS
Chemigation systems connected to public water systems must contain a functional, reduced-
pressure zone, backflow preventer (RPZ) or the functional equivalent in the water supply line 
upstream from the point of pesticide introduction. As an option to the RPZ, the water from 
the public water system should be discharged into a reservoir tank prior to pesticide 
introduction. There shall be a complete physical break (air gap) between the outlet end of the 
fill pipe and the top or overflow rim of the reservoir tank of at least twice the inside diameter 
of the fill pipe.
Systems utilizing a pressurized water and pesticide injection system must meet the following 
requirements:
The system must contain a functional check valve, vacuum relief valve, and low pressure 
drain appropriately located on the irrigation pipeline to prevent water source contamination 
from backflow.
The pesticide injection pipeline must contain a functional, automatic, quick-closing check 
valve to prevent the flow of fluid back toward the injection pump. The pesticide injection

28
pipeline must also contain a functional, normally closed, solenoid-operated valve located on 
the intake side of the injection pump and connected to the system interlock to prevent fluid 
from being withdrawn from the supply tank when the irrigation system is either 
automatically or manually shut down.
The system must contain functional interlocking controls to automatically shut off the 
pesticide injection pump when the water pump motor stops.
The irrigation line or water pump must include a functional pressure switch which will stop
the water pump motor when the water pressure decreases to the point where pesticide 
distribution is adversely affected.
Systems must use a metering pump, including a positive displacement injection pump (e.g.,
diaphragm pump) effectively designed and constructed of materials that are compatible with 
pesticides and capable of being fitted with a system interlock.
APPLICATION INSTRUCTIONS
Observe the requirements in the System Requirements section above.
Apply Topsin 4.5FL only through systems containing anti-syphon and check valves designed 
to prevent water source contamination or overflow of the mix tank and containing 
interlocking controls between the metering device and the water pump to insure simultaneous 
shut-off.
Maintain a gentle continuous agitation in mix tank during mixing and application to assure a 
uniform suspension.
Greater accuracy in calibration and distribution will be achieved by injecting a larger volume 
of a more dilute suspension per unit time.
Application of more than directed quantities of irrigation water per acre may result in 
decreased product performance.
DO NOT apply when wind speed favors drift, when system connections or fittings leak, 
when nozzles do not provide uniform distribution or when lines containing the product 
cannot be flushed and must be dismantled and drained. In a center pivot system, block the 
nozzle set nearest the well/pivot/injection unit to prevent spray being applied to this area.
Where sprinkler distribution patterns do not overlap sufficiently, unacceptable disease 
control may result.
Allow sufficient time for pesticide to be flushed through all lines and all nozzles before 
turning off irrigation water.
Topsin 4.5FL may be applied in conjunction with chemically neutral liquid fertilizers. 
Application in conjunction with highly alkaline fertilizers, including aqueous ammonia, is

29
likely to cause a degradation of the pesticide, resulting in reduced performance and should be
avoided.
SPRAY PREPARATION: 
Remove scale, pesticide residues, and other foreign matter from the chemical tank and entire 
injector system. Flush with clean water. Prep are a suspension of Topsin 4.5FL in a mix tank. 
Fill the tank with ½ or ¾ the desired amount of water. Start mechanical or hydraulic
agitation. Slowly add the required amount of Topsin 4.5FL and then the remaining volume of 
water.
Sprinkler Irrigation
Observe all System Requirements and Application Instructions above.
Set sprinkler system to deliver a maximum of 0.4 inch of water per acre. Volumes of water 
higher than this may reduce efficacy. Start sprinkler and then uniformly inject the suspension 
of Topsin 4.5FL into the irrigation water line so as to deliver the desired rate per acre. The 
suspension of Topsin 4.5FL should be injected with a positive displacement pump into the 
main line ahead of a right angle turn to insure adequate mixing. When treatment with Topsin 
4.5FL has been completed, DO NOT irrigate the treated area for 24 to 48 hours to prevent 
washing the chemical off the crop.
DO NOT apply when wind speed favors drift beyond the area intended for treatment.
Where sprinkler distributed patterns do not overlap sufficiently, unacceptable disease control 
may result.
Check local restrictions and requirements regarding sprinkler irrigation applications, as they 
may vary from state to state.
Drip (Mini-Micro Sprinklers, Strip Tubing, Trickle) Irrigation 
Observe all System Requirements and Application Instructions above.
A pesticide supply tank is advised.
SEED TREATMENT USES
INSTRUCTIONS AND INFORMATION
NOTE: This product contains no colorant. The purchaser of this product is responsible for 
ensuring that all seed treated with this product are adequately colored with a suitable colorant 
to prevent its accidental use as food for man or feed for animals. Refer to 21CFR, Part 2.25. 
Any colorant added to treated seed must be cleared for use under 40CFR, Part 180.1001. 
Alternatively, use in combination with other colored seed treatment products may provide 
adequate coloration.

30
TOPSIN 4.5 FL is an effective fungicide for seed treatment that provides early season 
protection of seedlings against rhizoctonia. Seed should be sound and well-cured before 
treatment. 
DO NOT use TOPSIN 4.5 FL in combination with other seed treatment products unless 
compatibility has been verified. Read and follow carefully all label directions of each 
combination product. When using combinations of products, the most restrictive of label 
limitations and precautions must be followed.
Seed Treatment Equipment: TOPSIN 4.5 FL may be used both for commercial and for on-
farm application. It can be applied with mechanical, slurry, or mist-type seed treating
equipment, as long as the equipment can be calibrated to accurately and uniformly apply the 
product to seed without undue mechanical damage to the seed. Uniform application to seed 
is important for all seed treatment products. 
Treatment of mechanically damaged seed or seed of low vigor or poor quality may result in 
reduced germination. Treat and conduct germination tests on a small test sample of seed 
before using this product on commercial quantities. Due to seed quality and seed storage 
conditions beyond the control of Nippon Soda Co., Ltd. (Nisso), Nisso makes no claims or 
guarantees as to germination of carry-over seed.
Seed should be sound and well-cured before treatment. Refer to the label rates below. 
TOPSIN 4.5 FL is typically diluted with water and/or mixed with other products to attain an
appropriate slurry application volume (fl.oz/cwt slurry rates) to provide effective treating. 
The appropriate volume of slurry depends on crop, weather, type of treater and other factors 
and should be adjusted as per normal treating practices for the circumstances. Contact your 
local supplier or distributor representative for specific directions.
TO ENSURE UNIFORMITY, MIX PRODUCT WELL BEFORE USE.
TOPSIN 4.5 FL plus water and/or other treatments should be mixed thoroughly prior to 
treating seed. Recalibrate treati ng equipment to compensate for the required slurry rate to 
ensure all products are applied at the correct rate.

31
APPLICATION INSTRUCTIONS
Crop(s) Application Rate
WHEAT, TRITICALE
For early season control of seed decay (Fusarium, Rhizoctonia) 
and suppression of seedling blight (Fusarium, Rhizoctonia)
0.14 – 0.28 fl. oz/cwt
(0.005 – 0.01 lb ai/cwt)
SOYBEANS
NOTE: Seed may be treated on a fl.oz./seed unit (to deliver a 
target mg active ingredient/kernel) basis or and a per weight of 
seed basis, as shown.
For early season control of seed decay (Phomopsis, Fusarium, 
Rhizoctonia) and suppression of seedling blight (Fusarium, 
Rhizoctonia)
Per Seed Unit:
0.065-0.13 fl. oz./seed unit
(140,000 seeds) 
(0.002 – 0.005 lb a.i./seed
unit (140,00 seeds)
(applies 0.0075-0.015 mg 
ai/seed)
OR 
Per Seed Weight:
0.14 – 0.28 fl. oz./cwt
(0.005 – 0.01 lb a.i./cwt)
Crop(s) Application Rate
DRY BEANS and SNAP BEANS: 
For early season control of seed decay (Phomopsis, 
Rhizoctonia) and suppression of seedling blight (Fusarium, 
Rhizoctonia)
0.14 – 0.28 fl. oz./cwt
(0.005 – 0.01 lb a.i./cwt)
Use higher rates for higher levels of seedling blight protection.
TREATED SEED LABELING
THE FEDERAL SEED ACT REQUIRES THAT BAGS CONTAINING TREATED SEED 
MUST BE LABELED WITH THE FOLLOWING INFORMATION:
Ɣ"This bag contains seed treated with TOPSIN 4.5 FL Seed Treatment Fungicide 
containing thiophanate-methyl. DO NOT use for food, feed, or oil purposes. Store away 
from feed and food stuffs.”
LABELS FOR COMMERCIALLY TREATED SEED MUST ALSO INCLUDE THE 
FOLLOWING ENVIRONMENTAL HAZARDS STATEMENTS:

32
Ɣ“Exposed treated seed may be hazardous to birds and wildlife. Dispose of all excess 
treated seed and seed packaging or containers by burial away from bodies of water in 
accordance with any local requirements. Cover, incorporate, or collect treated seeds spilled 
during loading and planting. DO NOT contaminate bodies of water when disposing of 
planting equipment wash water.”
SEED TREATMENT RESTRICTIONS:
Ɣ“DO NOT allow children, pets or livestock to have access to treated seeds.”
Ɣ“DO NOT graze or feed livestock on treated areas for 45 days after planting.”
Ɣ³:HDUORQJSDQWVORQJ-sleeved shirt, shoes, socks and chemical-resistant gloves when 
opening this bag or loading/pouring the treated seed.”
Ɣ“After the seeds have been planted, DO NOT enter or allow worker entry into treated areas 
during the restricted-entry interval (REI) of 12 hours. Exception: If the treated seed is soil-
injected or soil-incorporated, the Worker Protection Standard, under certain circumstances, 
allows workers to enter the treated area if there will be no contact with anything that has been 
treated. PPE required for early entry to treated areas that is permitted under the Worker 
Protection Standard and that involves contact with anything that has been treated, including
plants, soil or water is: coveralls, chemical-resistant gloves made of any waterproof material, 
and chemical-resistant footwear.”
USE RESTRICTIONS
Care must be exercised in the handling of treated seed. Augers used for handling treated 
seed should not be used to move seed for feed, food or oil processing. DO NOT re-use bags 
from treated seed to handle food or feed products.
STORAGE AND DISPOSAL
DO NOT contaminate water, food, or feed by storage and disposal.
STORAGE: Store in the original container in a dry area. DO NOT store in a manner where 
cross-contamination with other pesticides, fertilizers, food or feed could occur. If spilled 
during storage or handling, absorb with sand or other inert material and dispose of absorbent 
in accordance with the Pesticide Disposal Instructions listed below.
PESTICIDE DISPOSAL: Pesticide wastes are toxic. Improper disposal of excess pesticide, 
spray mixture, or rinsate is a violation of Federal Law. If these wastes cannot be disposed of 
by use according to label instructions, contact your State Pesticide or Environmental Control 
Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for 
guidance.
CONTAINER HANDLING: Nonrefillable container. DO NOT reuse or refill this 
container.

33
)RUFRQWDLQHUV”5 gallons:
Clean container promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank and drain for 10 seconds after the flow 
begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal. 
Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times.
Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by 
incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of 
smoke. 
For containers > 5 gallons:
Clean container promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank. Fill the container ¼ full with water. 
Replace and tighten closures. Tip container on its side and roll it back and forth, ensuring at 
least one complete revolution, for 30 seconds. Stand the container on its end and tip it back 
and forth several times. Turn the container over onto its other end and tip it back and forth 
several times. Empty the rinsate into application equipment or a mix tank or store rinsate for 
later use or disposal. Repeat this procedure two more times. Then offer for recycling if 
available or puncture and dispose of in a sanitary landfill, or by incineration, or, if allowed by 
state and local authorities, by burning. If burned, stay out of smoke.
Refillable Containers:
Refillable container. Refill this container with pesticide only. DO NOT reuse this container 
for any other purpose. Cleaning the container before final disposal is the responsibility of the
person disposing the container. Cleaning before refilling is the responsibility of the refiller. 
To clean the container before final disposal, empty the remaining contents into application 
equipment or a mix tank. Fill the container about 10% full of water. Agitate vigorously or 
recirculate water with the pump for two minutes. Pour or pump water into application 
equipment of rinsate collection system. Repeat this rinsing procedure two more times.
IMPORTANT INFORMATION
READ BEFORE USING PRODUCT
CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of Warranty and 
Liability before buying or using this product. If the terms are not acceptable, return the product at 
once, unopened, and the purchase price will be refunded.
The Directions for Use of this product reflect the opinion of experts based on field use and tests, and 
must be followed carefully. It is impossible to eliminate all risks associated with the use of this 
product. Crop injury, ineffectiveness or other unintended consequences may result because of such 
factors as manner of use or application, weather or crop conditions, presence of other materials or 
other influencing factors in the use of the product, which are beyond the control of Nippon Soda Co., 
Ltd. or Seller. Handling, storage, and use of the product by Buyer or User are beyond the control of 
Nippon Soda Co., Ltd. and Seller.

34
All such risks shall be assumed by Buyer and User, and Buyer 
and User agree to hold Nippon Soda Co., Ltd. and Seller harmless for any claims relating to such 
factors.
TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, NIPPON SODA CO., LTD. AND
SELLER MAKE NO WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A 
PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED WARRANTY EXCEPT 
AS STATED ON THIS LABEL.
To the extent consistent with applicable law, Nippon Soda Co., Ltd. or Seller shall not be liable for 
any incidental, consequential or special damages resulting from the use or handling of this product 
and THE EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE 
LIABILITY OF NIPPON SODA CO., LTD. AND SELLER FOR ANY AND ALL CLAIMS, 
LOSSES, INJURIES OR DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF 
WARRANTY, CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR 
OTHERWISE) RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, 
SHALL BE THE RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE 
ELECTION OF NIPPON SODA CO., LTD. OR SELLER, THE REPLACEMENT OF THE 
PRODUCT. 
Treatment of seed, especially seed that is mechanically damaged or seed known to be of low vigor 
and poor quality, may result in reduced germination and/or reduction of seed and seedling vigor. 
Treat and conduct germination tests on a small test sample of seed before treating commercial 
quantities with a selected chemical treatment that includes this product. Due to seed quality and seed 
storage conditions beyond the control of Nippon Soda Co., Ltd. (Nisso), Nisso makes no claims or 
guarantees as to germination of carry-over seed.
Nippon Soda Co., Ltd. and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing conditions of sale and limitations of warranty and of liability, which may not be modified 
except by written agreement signed by the duly authorized representative of Nippon Soda Co., Ltd.

35
[Note to PM: This section is the T&O sublabel portion of the master label
Thiophanate-
methyl
GROUP 1 FUNGICIDE
TOPSIN® 4.5FL
Turf and Ornamental Fungicide
ACTIVE INGREDIENT:
Thiophanate-methyl (dimethyl[1,2-phenylene)-
bis(iminocarbonothioyl)]bis[carbamate])* . . . . . . . . . . . . . . . . . . . . . . . 45.0%
OTHER INGREDIENTS: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55.0%
TOTAL: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100.0%
Contains 4.5 pounds thiophanate-methyl per gallon.
*Also known as dimethyl 4,4’-o-phenylenebis[3-thioallophanate]
KEEP OUT OF REACH OF CHILDREN
CAUTION
FIRST AID
If inhaled:
x Move person to fresh air.
x If person is not breathing, call 911 or an ambulance, then give artificial respiration, 
preferably by mouth-to-mouth, if possible.
x Call a poison control center or doctor for further treatment advice.
If on skin or clothing:
x Take off contaminated clothing. 
x Rinse skin immediately with plenty of water for 15-20 minutes. 
x Call a poison control center or doctor for treatment advice. 
Have the product container or label with you when calling a poison control center or doctor or 
going for treatment. Contact the Rocky Mountain Poison Control Center at 1-866-673-6671
for emergency medical treatment information.
EPA Reg. No.8033-122 EPA Est. No.
NET CONTENTS: __________ Gallons Batch/Lot # ___________
Nippon Soda Co., Ltd.
c/o Nisso America Inc.
379 Thornall Street, 5th Floor
Edison, NJ 08837

36
PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS AND DOMESTIC ANIMALS
CAUTION: Harmful if absorbed through the skin or inhaled. Avoid contact with skin, eyes 
or clothing. Avoid breathing vapor or spray mist. Wash thoroughly with soap and water 
after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. 
Remove and wash contaminated clothing before reuse.
PERSONAL PROTECTIVE EQUIPMENT (PPE)
Some materials that are chemical-resistant to this product are nitrile and butyl rubber. If you 
want more options, follow the instructions for category C on an EPA chemical-resistance 
category selection chart.
Handlers mixing, loading, and applying the product as a dip (including application of product 
in Kaolinite clay to conifer seedling roots) must wear:
x Coveralls over long-sleeved shirt and long pants,
x Chemical-resistant gloves,
x Chemical-resistant footwear plus socks,
x Chemical-resistant apron.
All other mixers, loaders, and applicators must wear:
x Long-sleeved shirt and long pants,
x Shoes plus socks,
x Chemical-resistant gloves,
x Chemical-resistant apron for mixers, loaders, and other handlers exposed to the 
concentrate.
USER SAFETY REQUIREMENTS
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for 
washables exist, use detergent and hot water. Keep and wash PPE separately from other 
laundry. Discard clothing and other materials that have been drenched or heavily 
contaminated with this product’s concentrate. DO NOT reuse them.
ENGINEERING CONTROLS
When handlers use enclosed cabs in a manner that meets the requirements listed in the 
Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-6)], the 
handler PPE requirements may be reduced or modified as specified in the WPS.
USER SAFETY RECOMMENDATIONS
ƔUsers should remove clothing/PPE immediately if pesticide gets inside. Then wash
thoroughly and put on clean clothing.
ƔUsers should remove PPE immediately after handling this product. Wash the outside of 
gloves before removing. As soon as possible, wash thoroughly and change into clean 
clothing.

37
ENVIRONMENTAL HAZARDS
DO NOT apply directly to water, or to areas where surface water is present or to intertidal 
areas below the mean high-water mark. Runoff from treated areas may be hazardous to 
aquatic organisms in neighboring areas. DO NOT contaminate water when disposing of 
equipment wash water or rinsate.
DIRECTIONS FOR USE
SHAKE WELL BEFORE USING
It is a violation of Federal law to use this product in a manner inconsistent with its labeling.
DO NOT apply this product in a way that will contact workers or other persons, either 
directly or through drift. Only protected handlers may be in the area during application. For 
any requirements specific to your State or Tribe, consult the agency responsible for pesticide 
regulation.
DO NOT apply when wind speed favors drift beyond the area intended for treatment.
AGRICULTURAL USE REQUIREMENTS
Use this product only in accordance with its labeling and with the Worker Protection Standard, 
40 CFR part 170. This Standard contains requirements for the protection of agricultural 
workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. 
It contains requirements for training, decontamination, notification, and emergency assistance. 
It also contains specific instructions and exceptions pertaining to the statements on this label 
about personal protective equipment (PPE), and restricted-entry interval. The requirements in 
this box only apply to uses of this product that are covered by the Worker Protection Standard.
DO NOT enter or allow worker entry into treated areas during the restricted entry interval 
(REI).
Exemption: The Worker Protection Standard, under certain circumstances, allows workers to
enter the treated area if there will be no contact with anything that has been treated.
DO NOT enter or allow workers entry into treated areas during the restricted-entry interval 
(REI). The REI for each crop is listed in the directions for use associated with that crop.
Exemption: If this product is applied by dr enching, the Worker Protection Standard, under 
certain circumstances, allows workers to enter the treated area if there will be no contact with 
anything that has been treated.
PPE required for early entry to treated areas that is permitted under the Worker Protection
Standard and that involves contact with anything that has been treated, including plants, soil, 
or water, is:
x Coveralls over long-sleeved shirt and long pants,
x Chemical-resistant gloves made of any waterproof material,
x Chemical-resistant footwear plus socks,
x Chemical-resistant headgear for overhead exposures.

38
PRODUCT INFORMATION for Turf and Ornamental Uses
Topsin 4.5FL Turf and Ornamental Fungicide is a broad-spectrum fungicide exhibiting 
preventative, curative, and systemic properties. It is useful on a wide variety of turf and 
ornamental disease problems. Apply Topsin 4.5 FL Turf and Ornamental Fungicide with 
ground equipment, using sufficient volume of spray to provide thorough coverage. Use the 
higher rates under conditions of severe disease pressure. Also, see local State Extension 
Service directions for application schedules. 
Chemigation instructions follow Directions For Use. Read and follow these instructions 
carefully for this method of application.
Mixing instructions: SHAKE WELL BEFORE USING. Some settling may occur during 
prolonged periods of non-use. When high pH tank mixes exist, the interval between mixing
and application should be minimized. The buffering of tank water to pH 6-7 prior to the 
addition of Topsin 4.5 FL Turf and Ornamental Fungicide is directed. Add required amount 
of Topsin 4.5FL Turf and Ornamental Fungicide to partially filled tank (1/2 total volume), 
agitate by mechanical or hydraulic means, add tank mix product if used (see below), agitate 
again and then add remaining required amount of water.
Continuous agitation is directed to keep the material in proper suspension. For best results, 
use spray mixture the same day it is prepared.
Tank mixing instructions: Topsin 4.5 FL Turf and O rnamental Fungicide is compatible with 
most commonly used pesticides. If tank mixing with other materials, add products in the 
following order: wettable powders, dry flowables, liquid flowables, emulsifiable 
concentrates, and soluble materials including fertilizers. No claim of compatibility with 
other products is implied. DO NOT tank mix with copper-containing materials or with 
highly alkaline pesticides, including Bordeaux mixture or lime sulfur. Consult the intended 
tank mix partner product label for appropriate application rates and use instructions. Follow 
the label directions for the most restrictive of label precautions and limitations. This product 
may not be mixed with any product containing a label prohibition against such mixing. Read 
and observe the most restrictive precautionary statements and other information appearing on 
product labels used in mixtures. Topsin 4.5 FL Turf and Ornamental Fungicide may be 
applied in conjunction with chemically neutral liquid fertilizers. Application in conjunction 
with highly alkaline fertilizers, including aqueous ammonia, may cause a degradation of the 
pesticide, resulting in reduced performance and should be avoided.
NON-AGRICULTURAL USE REQUIREMENTS
The requirements in this box only apply to uses of this product that are NOT within the scope 
of the Worker Protection Standard for agricultural pesticides (40CFR Part 170). The WPS
applies when this product is used to produce agricultural plants on farms, forests, nurseries, or 
greenhouses.
DO NOT allow others to enter until s
prays have dried.

39
RESISTANCE MANAGEMENT: 
For resistance management, Topsin 4.5 FL Turf & Ornamental Fungicide contains a Group 1 
fungicide. Any fungal population may contain individuals naturally resistant to Topsin 4.5
FL Turf & Ornamental Fungicide and other Group 1 fungicides. A gradual or total loss of 
pest control may occur over time if these fungicides are used repeatedly in the same fields. 
Appropriate resistance-management strategies should be followed.
To delay fungicide resistance, take one or more of the following steps: 
• Rotate the use of Topsin 4.5 FL Turf & Ornamental Fungicide or other Group 1 fungicides 
within a growing season sequence with different groups that control the same pathogens.
• Use tank mixtures with fungicides from a different group that are equally effective on the 
target pest when such use is permitted. Use at least the minimum application rate as labeled 
by the manufacturer.
• Adopt an integrated disease management program for fungicide use that includes scouting, 
uses historical information related to pesticide use, and crop rotation, and which considers 
host plant resistance, impact of environmental conditions on disease development, disease 
thresholds, as well as cultural, biological and other chemical control practices. 
• Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage resistance.
• Monitor treated fungal populations for resistance development. 
• Contact your local extension specialist or certified crop advisor for any additional pesticide 
resistance-management and/or IPM directions for specific crops and pathogens.
• For further information or to report suspected resistance contact Nippon Soda Co., Ltd. at 
212-490-0350. You can also contact your pesticid e distributor or university extension 
specialist to report resistance.
TURF APPLICATION –Not for homeowner use. For use only by certified applicators 
or those under their immediate supervision. DO NOT apply with fixed wing or rotary 
aircraft. Not for use on turf being grown for sale or other commercial use as sod.
DO NOT enter or allow others to enter until sprays have dried.
For use on all fine turf applications including commercial and residential lawns, parks, 
athletic fields, golf course greens, tees, and fairways, and cemeteries, consisting of cool and 
warm season grasses including Bentgrass, Bluegrass, Bermudagrass, Fescue, Ryegrass, St. 
Augustinegrass, Zoysiagrass, or their mixtures. When used in accordance with the label, 
Topsin 4.5 FL Turf and Ornamental Fungicide is not phytotoxic to any of the above-
mentioned grasses. Topsin 4.5 FL Turf and Ornamental Fungicide has both preventive and

40
curative activity, and is to be used for the prevention and control of the diseases mentioned
below. 
Ground Application: Apply Topsin 4.5 FL Turf and Ornamental Fungicide with properly 
calibrated hand held, mechanical or motorized spray equipment or by chemigation through 
appropriate sprinkler irrigation systems. Spray uniformly over the area to be treated. Apply 
specified amounts in sufficient water to obtain thorough coverage of treatment area (2-4 gal.
of finished spray per 1,000 sq ft is suggested). When treating golf greens, always treat 
aprons and approaches. Use the highest specified rate under conditions of severe disease
pressure. For best results, apply after mowing or avoid mowing for at least twelve hours 
after application.
Lightly water the treatment area with one to two tenths inch of water to move the fungicide 
into active root zone. Excessive irrigation may move Topsin 4.5 FL Turf and Ornamental 
Fungicide below active root zone and reduce application effectiveness. Green design and 
drainage will influence irrigation practices. When tank mixing with contact action fungicides 
for foliar diseases, applications should be allowed to dry on leaf surfaces. Normal watering 
may proceed after sprays have dried.
Restrictions
x DO NOT graze animals on treated turf.
x DO NOT feed clippings to livestock or poultry. 
x DO NOT apply with fixed wing or rotary aircraft.
x Minimum retreatment interval on turf is 14 days.
x DO NOT enter or allow others to enter until sprays have dried.
Restrictions for use on residential or public turf (commercial and residential lawns, parks, 
athletic fields, cemeteries):
x DO NOT apply more than 1.8 fl. oz. product (0.06 lb a.i.)/1000 ft 2 in one 
application
x DO NOT apply more than 7.2 fl. oz. product (0.25 lb a.i.)/1000 ft2 per year
Restrictions for use on golf courses (tees, greens, apron):
x DO NOT apply more than 5.34 fl. oz. product (0.19 lb a.i.)/1000 ft2 in one 
application
x DO NOT apply more than 14.4 fl. oz. product (0.51 lb a.i.)/1000 ft2 to tees or 
greens per year
x DO NOT apply more than 3.6 fl. oz. product (0.13 lb a.i.)/1000 ft2 to fairways 
(except Florida) per year
x In Florida, DO NOT apply more than 1.8 fl. oz. product (0.06 lb a.i.)/1000 ft2
to fairways per year

41
Diseases Rate: fl. oz. pr oduct (lb a.i.)/1,000 sq. 
ft.
Application Instructions
Golf courses
Non Golf 
Course
Tees & 
Greens
Fairways 
**
*
Anthracnose: basal 
Colletotrichum graminicola
Anthracnose: foliar 
Colletotrichum graminicola
3.6 – 5.4
(0.13 –
0.19)
2–4
(0.07 –
0.14)
3.6
(0.13)
1.8
(0.06)
For prevention in historic areas of disease pressure, apply 
twice at 14-day intervals when soil temperature reaches 
60°F. For curative control, apply when disease first appears
and continue at 14-day intervals as needed. Rotations and/or 
tank mix combinations with chlorothalonil or triadimefon 
can be used.
Bermudagrass decline:
Gaeumannomyces graminis
var. graminis
Take-All-Patch: 
Gaeumannomyces graminis 
var. avenae
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
Apply in mid-July or when disease symptoms first appear 
and repeat at 14-day intervals for suppression. Use higher 
rates under most severe disease pressure. Follow proper
agronomic directions to maintain plant vigor.
Cool Season Brown Patch: 
Rhizoctonia cerealis
Necrotic Ring Spot: 
Leptosphaeria korrea
Spring Dead Spot: 
Leptosphaeria korrea
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
For prevention, apply in fall before turf has stopped all 
growth activity. Make second application in early spring 
when soil temperatures reach 55-60°F or when disease first 
appears. For curative action, apply when disease first 
appears in early spring and continue at 14-day intervals.
Coprinus Snow Mold: 
Coprinus psychromorbidus
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
Make 2 treatments at 21-day intervals in late fall to early 
winter, with the last application made just prior to first 
permanent snow cover.

42
Diseases Rate: fl. oz. pr oduct (lb a.i.)/1,000 sq. 
ft.
Application Instructions
Golf courses
Non Golf 
Course
Tees & 
Greens
Fairways 
**
*
Fusarium Blight: Fusarium 
roseum, F. triticum
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
Apply when disease first appears at 14-day intervals.
Dollar Spot: Moellerodiscus, 
Lanzia
Large Brown Patch: 
Rhizoctonia solani
Ascochyta Leaf Blight: 
Ascochyta
Copper Spot:
Gloeocercospora sorghi
Fusarium patch: Fusarium 
nivale
Red Thread: Corticum 
fuciforme
Zoysia Patch: Rhizoctonia 
solani
2 – 3.6
(0.07 –
0.13)
2 - 3.6
(0.07 –
0.13)
1.8
(0.06)
Apply when disease first appears and continue at 14-day 
intervals. Rotations and/or tank mix combinations with 
chlorothalonil, iprodione, or mancozeb can be used.
Gray Leaf Spot (Blast),: 
Pyricularia grisea
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
Make preventative application before expected period of 
disease development. Continue applications at 14 day 
intervals.
Leaf Spot: Drechlsera
Leaf, crown, and root 
diseases: Bipolaris, 
Curvularia, Exserohilum
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
Apply when disease first appears and make applications at 
14-day intervals as needed. Rotations and/or tank mix 
combinations with chlorothalonil, iprodione, or mancozeb 
are advised under severe conditions.

43
Diseases Rate: fl. oz. pr oduct (lb a.i.)/1,000 sq. 
ft.
Application Instructions
Golf courses
Non Golf 
Course
Tees & 
Greens
Fairways 
**
*
Pink Snow Mold: 
Michrodochium nivale
2 – 3.6
(0.07 –
0.13)
2 – 3.6
(0.07 –
0.13)
1.8
(0.06)
Apply in late fall to early winter before turf has stopped all
growth activity. A second application may be used in 
combination with chlorthalonil, or thiram at directed rates 
before snow cover or during spring thaw.
Rusts: Puccinia, Uromyces 3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
Make 2 applications at 14-day intervals when disease first 
appears. Rotations and/or tank mix combinations with 
chlorothalonil or mancozeb are directed.
Stripe Smut: Ustilago 
striiformis
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
Apply at 14-day intervals when disease first appears. For 
prevention, apply in spring and fall.
Summer Patch: Magnaporthe 
poae
3.6 – 5.4
(0.13 –
0.19)
3.6
(0.13)
1.8
(0.06)
For prevention, make 3 applications starting late April or 
early May using 21-day intervals. Rotations and/or tank mix 
combinations may be used as part of the three-application 
program. For suppression, apply at 14-day intervals when 
disease first appears.
* public turf (commercial and residential lawns, parks, athletic fields, cemeteries)
** In Florida, DO NOT apply more than 1.8 fl. oz. product (0.06 lb a.i.)/1000 ft2 per year to fairways

44
HORTICULTURAL APPLICATIONS
Nursery Greenhouse, Landscape & Interiorscape
Annual and Perennial Flowers, Bedding Plants, Foliage Plants, Ground Covers, plus 
Deciduous and Evergreen Trees and Shrubs
DO NOT apply this product in a way that will contact any person, pet, either directly or
through drift. Keep people and pets out of the area during application.
Homeowners: For use on ornamentals only. DO NOT apply to home orchards/fruit 
trees. DO NOT ALLOW PEOPLE OR PETS TO ENTER THE TREATED AREA 
UNTIL SPRAYS HAVE DRIED.
Certified applicators: DO NOT enter or allow others to enter until sprays have 
dried.
DO NOT use fruit, nuts, or sap from treated trees as food or feed.
Not for homeowner use in New York State.
Topsin 4.5 FL Turf and Ornamental Fungicide is a broad-spectrum systemic fungicide 
which controls a variety of foliar, stem, and root diseases on a wide range of 
commercially important plants. Topsin 4.5 FL Turf and Ornamental Fungicide is also 
effective as a pre-plant dip on cuttings and bulbs. For soil drench applications, best plant 
protection is achieved with preventative treatments repeated every 21-28 days. For foliar
applications, begin treatments when disease first appears, or during suspected periods of 
disease development. Make additional applications every 7-14 days or as otherwise 
instructed for the prevention or control of the listed diseases. Use of a wetting agent is 
directed for plants that have leaves that are difficult to wet properly. Use of a spreader-
sticker is advised to enhance product performance in wet weather conditions or during 
periods of overhead irrigation. Topsin 4.5 FL Turf and Ornamental Fungicide may be 
used to control listed diseases on “backyard” ornamental fruit and nut trees including
almond, apple, apricot, cherry, nectarine, peach, pecan, plum, and prune trees. Topsin 
4.5 FL Turf and Ornamental Fungicide may be applied as a ground application using 
hand held, mechanical or motorized spray equipment, or as a chemigation spray or 
through an applicable sprinkler irrigation system; or as an aerial application where 
applicable. See specific instructions below.
Note: The “Directions For Use” of this product reflect the cumulative inputs from both 
historical field use and product testing programs. However, it is impossible to test this 
product on all species and cultivars. A preliminary trial is suggested on a small scale 
before a full treatment is applied to any plant type not shown on this label but found in a 
similar use site with a listed disease problem. Wait 5-7 days after treatment to evaluate 
results. This product is not directed for use on Swedish Ivy (Nephrolepis exhaltata), 
Boston Fern (Plectranthus australis), and Easter Cactus (Hatiora gaertneri).

45
Some plants may occasionally show some sensitivity to Topsin 4.5 FL Turf and
Ornamental Fungicide applications, primarily as seedlings. Symptoms rarely affect 
marketability of the plants. Please check compatibility under your conditions on small 
groups of plants to see if there is any sensitivity.
Application Instructions: Apply material with properly calibrated hand held, mechanical
or motorized spray equipment or by chemigation thorough appropriate sprinkler 
irrigation, flood, or drip systems. Begin applications when disease first appears and 
repeat at 7-14 day intervals or as needed during the growing season. Use the shortest 
interval when conditions are unusually favorable for the development of disease. For 
hand held, mechanical, or motorized applications, mix 10 - 20 oz. of Topsin 4.5 FL Turf 
and Ornamental Fungicide per 100 gal. and apply as a full coverage spray to drip for the
prevention and control of the diseases listed below. Spray volume may range up to 400 
gallons of finished spray per acre depending upon plant species and plant growth stage. 
For applications through irrigation systems, refer to aerial use rates indicated in the foliar 
application chart. For small volume applications less than 100 gallons, divide the 
directed rate by 16 to get the number of teaspoons of Topsin 4.5 FL/gallon water.
Special Instructions For Proportional Injectors (e.g. Dosatron, Dosmatic, Anderson, and 
similar equipment): Determine the treatment rate as indicated below in the ground 
application column for crop and pathogen. Determine the injection ratio for the 
individual system to be used for application. For systems using a 1:100 ratio, measure 
and add the exact amount of directed material per 100 gallons to each gallon of water in a 
stock bucket or tank. For systems using a 1:200 ratio, multiply the directed amount per 
100 gallons by 2. For systems using a 1:50 ratio, divide the directed amount per 100 
gallons by 2. For systems using a 1:16 ratio, divide the directed amount per 100 gallons 
by 6. Greater accuracy in calibration and distribution will be achieved by injecting a
larger volume of a more dilute suspension per unit time. An injection ratio of 1:100 is 
directed for most greenhouse and nursery systems.
Note: Homeowners DO NOT apply more than 51.4 fl. oz. product (1.8 lb a.i.) per acre 
per single application (1.2 fl. oz. (0.04 lb a.i.) per 1000 sq. ft.).
For cut flowers DO NOT apply more than 14.2 fl. oz. Topsin 4.5 FL Turf and 
Ornamental Fungicide (0.5 lb a.i.) per acre per application.

46
FOLIAR APPLICATION
Diseases
Controlled
Rate
fl. oz. product (lb
a.i.)/100 gallons or 
per acre
Application Instructions
Anthracnose 10 – 20
(0.35 – 0.7)
Apply as buds break or at first sign of disease 
period. Repeat at 7-14 day intervals as needed 
during disease period.
Black Spot of Rose
Diplocarpon rosae
1 0–2 0
(0.35 – 0.7)
Apply in early summer or at first sign of 
disease. Repeat at 7-14 days as needed during 
disease period.
Brown Rot and Blight
Monilinia, Sclerotinia, 
Whetzellinia
1 0–2 0
(0.35 – 0.7)
Apply in late spring or at first sign of disease.
Repeat every 7-14 days as needed during 
disease period.
Fusicladium and 
Venturia Leaf Scabs 
on: Crabapple, 
Hawthorn, Pear, 
Mountain Ash, 
Pyracantha, etc.
1 0–2 0
(0.35 – 0.7)
Apply as buds break. Repeat every 7-14 days 
as needed during disease period. Effective 
control requires coverage during leaf expansion. 
Rotations and/or tank mix combinations with 
mancozeb, chlorothalonil or propiconazole can 
be utilized.
Leaf Spots and Blights 
caused by:
Ascochyta, Blumeriella, 
Botrytis, Cercospora, 
Coccomyces, 
Corynespora, 
Curvularia,
Didymellina, 
Entomosporium, 
Fabraea, Fusarium, 
Ramularia, 
Rhizoctonia, 
Marssonina, 
Mycosphaerella, 
Myrothecium, Phoma, 
Physalospora, 
Schizothyrium, 
Septoria, Sphaceloma
1 0–2 0
(0.35 – 0.7)
Apply when disease symptoms first appear.
Repeat every 7-14 days as needed during 
disease period. Rotations and/or tank mix 
combinations with mancozeb or chlorothalonil
can be utilized.
Ovulinia Blight 10 – 15
(0.35 – 0.53)
Apply as flowers open. Repeat every 7-14 days 
as needed during disease period.
Powdery Mildews 
Erysiphe, Microsphaera, 
Phyllactinia, 
Podosphaera, Oidium, 
Sphaerotheca
1 0–2 0
(0.35 – 0.7)
Apply when disease first appears and repeat 
every 7-14 days during disease period. 
Rotations and/or tank mix combinations with 
mancozeb or triadimefon can be utilized.

47
Diseases
Controlled
Rate
fl. oz. product (lb
a.i.)/100 gallons or
per acre
Application Instructions
Rust Diseases caused 
by: Puccinia,
Gymnosporangium, 
Uromyces
1 0–2 0
(0.35 – 0.7) 
Apply in late spring or when symptoms first 
appear. Repeat every 7-14 days as needed 
during disease period. Rotations and/or tank 
mix combinations with mancozeb or 
chlorathalonil are directed.
Tip Blight of Pine
Sphaeropsis sapinea, 
Diplodia pinea 
1 5–2 0
(0.53 – 0.7) 
Begin application in spring when new growth 
starts. Make a second application just before 
needles emerge from the sheath and a third 
application 14 days later. Thorough coverage 
is essential for optimal disease control.
Twig Blights, Cankers, 
and Diebacks 
Diaporthe, Kabatina, 
Phoma, Phompsis
1 5–2 0
(0.53 – 0.7) 
Apply when symptoms first appear. Repeat 
every 7-14 days as needed during disease 
period. 
SOIL DRENCH APPLICATION
Germination of seedlings of some species and cultivars planted in soil drenched with Topsin 4.5FL Turf 
and Ornamental Fungicide may be delayed slightly, but the plants typically recover, and will be 
protected from seedling root infection. Soil drenches on young plants may cause a slight chlorosis 
(yellowing) of lower leaves, but typically do not affect the upper foliage. Other plants may also show a 
temporary stunting. 
Diseases
Controlled
Rate 
Fl. Oz. product
(lb a.i.)/100 gal. App lication Instructions
Stem, Crown, and Root Rots
caused by: 
Botrytis, Cylindrocladium, 
Fusarium, Gliocladium, 
Myrothecium, Penicillium, 
Ramularia, Rhizoctonia, Sclerotinia
Black Root Rot:Thielaviopsis
1 0–2 0
(0.35 – 0.7) 
Apply as a drench or directed spray using hand held, 
mechanical, or motorized spray equipment, or as a 
chemigation drench or directed spray using applicable 
sprinkler irrigation systems, after seeding or sticking of
cuttings (7 oz.) or after transplanting (11-14 oz.) to 
propagation beds, containers, pots, trays, or nursery or 
landscape beds at a rate to thoroughly soak the growing 
media through the root zone. A guide is 0.25-3 pints of 
finished mixture per sq ft depending on the media type 
and depth (about 4 oz. per 4 inch pot or 8 oz. per 6 inch 
pot). Repeat every 21-28 days for adequate crop 
protection. Note: Topsin 4.5 FL Turf and Ornamental 
Fungicide does not control Pythium or Phytophthora. 
Tank mix combinations with metalaxyl, mefenoxam, 
etridiazole, fosetyl-Al or propamocarb are required for the 
control of Pythium and Phytophthora.

48
PLANT DIP APPLICATIONS
Diseases 
Controlled
Rate 
Fl. Oz. product
(lb a.i.)/100 gal. $SSOLFDWLRQInstructions
Plant or Cutting Diseases
caused by: Botrytis,
Cylindrocladium, Fusarium, 
Gliocladium, Myrothecium, 
Penicillium, Ramularia, 
Rhizoctonia, Sclerotinia, 
Thielaviopsis
1 0–2 0
0.35 – 0.7) 
Immerse plants or cuttings for 10-15 min. Remove 
and allow to drain. Note: Follow accepted hygiene 
practices to minimize the introduction and spread of 
water borne bacterial and water mold fungal diseases. 
Bulb, Corm, and Rhizome Rots
caused by: 
Botrytis, Cylindrocladium, 
Fusarium, Gliocladium, 
Myrothecium Penicillium, 
Ramularia, Rhizoctonia, 
Sclerotinia, Thielaviopsis
1 0–2 0
(0.35 – 0.7) 
Soak cleaned bulbs for 15-30 min in warm solution 
(80-85 qF). For storage disease prevention, treat 
bulbs preferably within 48 hours after digging. After 
treatment, dry well before storing. If bulbs are for 
forcing, treat bulbs that have been heat-cured. Note: 
Follow accepted hygiene practices to minimize the 
introduction and spread of water borne bacterial and 
water mold fungal diseases.
DIRECTIONS FOR USE THROUGH CHEMIGATION SYSTEMS
INSTRUCTIONS
Apply this product only through sprinkler irrigation systems including center pivot, 
lateral move, end tow, side (wheel) roll, traveler, solid set or hand move; or drip (mini-
micro sprinklers, strip tubing, trickle) irrigation systems. DO NOT apply this product 
through any other type of irrigation system.
Crop injury, lack of effectiveness, or illegal pesticide residues in the crop can result from 
nonuniform distribution of treated water.
If you have any questions about calibration, you should contact State Extension Service 
specialists, equipment manufacturers or other experts.
A person knowledgeable of the chemigation system and responsible for its operation, or 
under the supervision of the responsible person, shall shut the system down and make 
necessary adjustments should the need arise.
DO NOT connect chemigation system (including greenhouse systems) used for pesticide 
irrigation to any public water system unless the pesticide label-prescribed safety devices

49
for public water systems are in place. Public water system means a system for the 
provision of piped water for human consumption if such a system has at least 15 service 
connections or regularly serves an average of at least 25 individuals daily at least 60 days 
out of the year.
SYSTEM REQUIREMENTS
Chemigation systems connected to public water systems must contain a functional, 
reduced-pressure zone, backflow preventer (RPZ) or the functional equivalent in the 
water supply line upstream from the point of pesticide introduction. As an option to the 
RPZ, the water from the public water system should be discharged into a reservoir tank 
prior to pesticide introduction. There shall be a complete physical break (air gap) 
between the outlet end of the fill pipe and the top or overflow rim of the reservoir tank of
at least twice the inside diameter of the fill pipe.
Systems utilizing a pressurized water and pesticide injection system must meet the 
following requirements:
The system must contain a functional check valve, vacuum relief valve, and low pressure 
drain appropriately located on the irrigation pipeline to prevent water source 
contamination from backflow.
The pesticide injection pipeline must contain a functional, automatic, quick-closing check 
valve to prevent the flow of fluid back toward the injection pump. The pesticide injection 
pipeline must also contain a functional, normally closed, solenoid-operated valve located 
on the intake side of the injection pump and connected to the system interlock to prevent 
fluid from being withdrawn from the supply tank when the irrigation system is either 
automatically or manually shut down.
The system must contain functional interlocking controls to automatically shut off the 
pesticide injection pump when the water pump motor stops.
The irrigation line or water pump must include a functional pressure switch which will 
stop the water pump motor when the water pressure decreases to the point where 
pesticide distribution is adversely affected.
Systems must use a metering pump including a positive displacement injection pump 
(e.g., diaphragm pump) effectively designed and constructed of materials that are 
compatible with pesticides and capable of being fitted with a system interlock.
APPLICATION INSTRUCTIONS
Observe the requirements in the System Requirements section above.
Apply Topsin 4.5 FL Turf and Ornamental Fungicide only through systems containing 
anti-syphon and check valves designed to prevent water source contamination or 
overflow of the mix tank and containing interlocking controls between the metering

50
device and the water pump to insure simultaneous shut-off.
Maintain a gentle continuous agitation in mix tank during mixing and application to 
assure a uniform suspension.
Greater accuracy in calibration and distribution will be achieved by injecting a larger 
volume of a more dilute suspension per unit time.
Application of more than directed quantities of irrigation water per acre may result in 
decreased product performance.
DO NOT apply when wind speed favors drift, when system connections or fittings leak, 
when nozzles DO NOT provide uniform distribution or when lines containing the
product cannot be flushed and must be dismantled and drained. In a center pivot system, 
block the nozzle set nearest the well/pivot/injection unit to prevent spray being applied to
this area.
Where sprinkler distribution patterns 
do not overlap sufficiently, unacceptable disease 
control may result.
Allow sufficient time for pesticide to be flushed through all lines and all nozzles before 
turning off irrigation water.
Topsin 4.5 FL Turf and Ornamental Fungicide may be applied in conjunction with 
chemically neutral liquid fertilizers. Application in conjunction with highly alkaline 
fertilizers, including aqueous ammonia, is likely to cause a degradation of the pesticide, 
resulting in reduced performance and should be avoided.
SPRAY PREPARATION: 
Remove scale, pesticide residues, and other foreign matter from the chemical tank and 
entire injector system. Flush with clean water. Prepare a suspension of Topsin 4.5 FL
Turf and Ornamental Fungicide in a mix tank. Fill the tank with ½ or ¾ the desired 
amount of water. Start mechanical or hydraulic agitation. Slowly add the required amount 
of Topsin 4.5 FL Turf and Ornamental Fungicide and then the remaining volume of 
water.
Sprinkler Irrigation 
Observe all System Requirements and Application Instructions above.
Set sprinkler system to deliver a maximum of 0.4 inch of water per acre. Volumes of 
water higher than this may reduce efficacy. Start sprinkler and then uniformly inject the 
suspension of Topsin 4.5 FL Turf and Ornamental Fungicide into the irrigation water line 
so as to deliver the desired rate per acre. The suspension of Topsin 4.5 FL Turf and
Ornamental Fungicide should be injected with a positive displacement pump into the

51
main line ahead of a right angle turn to insure adequate mixing. When treatment with 
Topsin 4.5 FL Turf and Ornamental Fungicide has been completed, DO NOT irrigate the 
treated area for 24 to 48 hours to prevent washing the chemical off the crop.
DO NOT apply when wind speed favors drift beyond the area intended for treatment.
Where sprinkler distributed patterns do not overlap sufficiently, unacceptable disease 
control may result.
Check local restrictions and requirements regarding sprinkler irrigation applications, as 
they may vary from state to state.
Drip (Mini-Micro Sprinklers, Strip Tubing, Trickle) Irrigation 
Observe all System Requirements and Application Instructions above.
A pesticide supply tank is advised.
STORAGE AND DISPOSAL
DO NOT contaminate water, food, or feed by storage and disposal.
STORAGE: Store in the original container in a dry area. DO NOT store in a manner where
cross-contamination with other pesticides, fertilizers, food or feed could occur. If spilled 
during storage or handling, absorb with sand or other inert material and dispose of absorbent 
in accordance with the Pesticide Disposal Instructions listed below.
PESTICIDE DISPOSAL: Pesticide wastes are toxic. Improper disposal of excess pesticide, 
spray mixture, or rinsate is a violation of Federal Law. If these wastes cannot be disposed of 
by use according to label instructions, contact your State Pesticide or Environmental Control 
Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for 
guidance.
CONTAINER HANDLING: Nonrefillable container. DO NOT reuse or refill this 
container.
)RUFRQWDLQHUV”JDOORQV
Clean container promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank and drain for 10 seconds after the flow 
begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour 
rinsate into application equipment or a mix tank or store rinsate for later use or disposal. 
Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times.
Then offer for recycling if available or puncture and dispose of in a sanitary landfill, or by 
incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of 
smoke.

52
For containers > 5 gallons: 
Clean container promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank. Fill the container ¼ full with water. 
Replace and tighten closures. Tip container on its side and roll it back and forth, ensuring at 
least one complete revolution, for 30 seconds. Stand the container on its end and tip it back 
and forth several times. Turn the container over onto its other end and tip it back and forth 
several times. Empty the rinsate into application equipment or a mix tank or store rinsate for 
later use or disposal. Repeat this procedure two more times. Then offer for recycling if 
available or puncture and dispose of in a sanitary landfill, or by incineration, or, if allowed by 
state and local authorities, by burning. If burned, stay out of smoke. 
Refillable Containers:
Refillable container. Refill this container with pesticide only. DO NOT reuse this container 
for any other purpose. Cleaning the container before final disposal is the responsibility of the 
person disposing the container. Cleaning before refilling is the responsibility of the refiller. 
To clean the container before final disposal, empty the remaining contents into application 
equipment or a mix tank. Fill the container about 10% full of water. Agitate vigorously or 
recirculate water with the pump for two minutes. Pour or pump water into application 
equipment of rinsate collection system. Repeat this rinsing procedure two more times.
IMPORTANT INFORMATION
READ BEFORE USING PRODUCT
CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of Warranty 
and Liability before buying or using this product. If the terms are not acceptable, return the 
product at once, unopened, and the purchase price will be refunded. 
The Directions for Use of this product reflect the opinion of experts based on field use and tests, 
and must be followed carefully. It is impossible to eliminate all risks associated with the use of 
this product. Crop injury, ineffectiveness or other unintended consequences may result because 
of such factors as manner of use or application, weather or crop conditions, presence of other 
materials or other influencing factors in the use of the product, which are beyond the control of
Nippon Soda Co., Ltd. or Seller. Handling, storage, and use of the product by Buyer or User are 
beyond the control of Nippon Soda Co., Ltd. and Seller. All such risks shall be assumed by 
Buyer and User, and Buyer and User agree to hold Nippon Soda Co., Ltd. and Seller harmless for 
any claims relating to such factors.
TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, NIPPON SODA CO., LTD.
AND SELLER MAKE NO WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR
A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED WARRANTY 
EXCEPT AS STATED ON THIS LABEL.

53
To the extent consistent with applicable law, Ni ppon Soda Co., Ltd. or Seller shall not be liable 
for any incidental, consequential or special damages resulting from the use or handling of this 
product and THE EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE 
EXCLUSIVE LIABILITY OF NIPPON SODA CO., LTD. AND SELLER FOR ANY AND 
ALL CLAIMS, LOSSES, INJURIES OR DAMAGES (INCLUDING CLAIMS BASED ON 
BREACH OF WARRANTY, CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY 
OR OTHERWISE) RESULTING FROM THE USE OR HANDLING OF THIS 
PRODUCT, SHALL BE THE RETURN OF THE PURCHASE PRICE OF THE 
PRODUCT OR, AT THE ELECTION OF NIPPON SODA CO., LTD. OR SELLER, THE 
REPLACEMENT OF THE PRODUCT.
Nippon Soda Co., Ltd. and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing conditions of sale and limitations of warranty and of liability, which may not be 
modified except by written agreement signed by the duly authorized representative of Nippon 
Soda Co., Ltd.

Supplemental Label
TOPSIN® 4.5 FL Fungicide
For Use on Soybeans to Control White Mold
EPA Reg. No. 8033-122
This supplemental label expires on April 30, 2023
and must not be used or distributed after this date
DIRECTIONS FOR USE
It is a violation of Federal law to use this product in a manner inconsistent with its labeling.
Follow all applicable directions, restrictions and precautions on the federally-registered label.
This label must be in the possession of the user at the time of pesticide application. Read the label affixed to the container for
TOPSIN 4.5 FL Fungicide before applying. Use of TOPSIN 4.5 FL Fungicide according to this labeling is subject to the use 
precautions and limitations imposed by the label affixed to the container of TOPSIN 4.5 FL Fungicide.
Crop Disease Fl. oz./A
(lb a.i./A)
Application Instructions
Soybeans White mold
(Sclerotinia)
20 (0.7) for split 
application
OR
40 (1.4) for single 
application
For split applications, apply initial 
application of 20 fl. oz of product/A
(0.7 lb a.i./A) at early bloom (R-1
stage). Follow with a second 
application 7 to14 days later. 
OR
For a single application, apply 40 fl. 
oz. of product /A (1.4 lb a.i./A) at 
early bloom (R-1 stage).
Thorough coverage of the flowers, 
stems, and branches is essential for 
disease control.
Use a minimum of 5 gallons water/A 
b
y air.
Restrictions:
-DO NOT apply more than 40 fl. oz./A (1.4 lb. a.i./A) per for a single application for white mold control otherwise DO NOT
apply more than 20 fl. oz./A (0.7 lb. a.i./A) per for a single application.
-DO NOT apply more than 40 fl. oz. of product (1.4 lbs a.i.)/A/year.
-The minimum retreatment interval is seven (7) days. 
-DO NOT apply more than two (2) applications per year.
-DO NOT enter or allow worker entry into treated areas during the restricted entry interval (REI) of 1 day.
-Pre-harvest interval: 21 days
-DO NOT graze or feed treated vines or hay to livestock.
04/30/2020
8033-122