crop-chem-docs/corpus/epa_ppls/100-1195.md

# APRONMAXX RFC

- EPA Reg No: **100-1195**
- Registrant: SYNGENTA CROP PROTECTION, LLC
- Signal word: Caution
- Active ingredients: Fludioxonil (2.31%); Metalaxyl-M (3.46%)
- Label accepted: 2019-07-19
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000100-01195-20190719.pdf

---
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
Reg Review Label Acceptable v.20151230 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
July 19, 2019 
 
Ricky Kyaw 
Regulatory Product Manager 
Syngenta CropScience LLC 
P.O. Box 18300 
Greensboro, NC 27419 
 
Subject: Registration Review Label Mitigation for Fludioxonil and Mefenoxam 
 Product Name: Apron MAXX® RFC 
 EPA Registration Number: 100-1195 
 Application Date: 7/31/2018; 2/1/2019 
Decision Number: 552855; 552856 
 
Dear Ricky Kyaw 
 
The Agency, in accordance with the Federal Insecticide, Fungicide and Rodenticide Act 
(FIFRA), as amended, has completed reviewing all of the information submitted with your 
application to support the Registration Review of the above referenced product in connection 
with the Fludioxonil and Mefenoxam Interim Decision, and has concluded that your submission 
is acceptable. The label referred to above, submitted in connection with registration under 
FIFRA, as amended, is acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be 
aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide 
Act and is subject to review by the Agency. If the website is false or misleading, the product 
would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 
CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, 
regardless of whether a website is referenced on your product’s label, claims made on the 
website may not substantially differ from those claims approved through the registration process. 
Therefore, should the Agency find or if it is brought to our attention that a website contains false 
or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance. 
 
A copy of your label stamped “Accepted” is enclosed. Products shipped after 12 months from the 
date of this amendment must bear the new revised label. Your release for shipment of the 
product bearing the amended label constitutes acceptance of these conditions. If these conditions 
are not complied with, the registration will be subject to cancellation in accordance with FIFRA 
section 6. 
 
If you have any questions about this letter, please contact Darius Stanton by phone at 703-347-
0433, or via email at last.first@epa.gov
.

Page 2 of 2 
EPA Reg. No. 100-1195 
Decision No. 552855; 552856 
 
 Sincerely, 
 
 
 
 Linda Arrington, Branch Chief 
 Risk Management and Implementation Branch 4 
 Pesticide Re-Evaluation Division 
 Office of Pesticide Programs 
 
Enclosure

(MASTER) 
MEFENOXAM GROUP 4 FUNGICIDE
FLUDIOXONIL GROUP 12 FUNGICIDE
ApronMAXX® RFC 
Fungicide 
Broad-spectrum seed treatment fungicide for protection against seed and seed-borne 
diseases. 
Active Ingredients: 
Fludioxonil:* ............................................................................................................ 2.31% 
Mefenoxam**: ......................................................................................................... 3.46% 
Other Ingredients: 94.23% 
Total: 100.00% 
 *CAS No. 131341-86-1 
**CAS Nos. 70630-17-0 and 69516-34-3 
Contains 0.21 pound active ingredient of fludioxonil and 0.31 pound active ingredient of 
mefenoxam per gallon. 
KEEP OUT OF REACH OF CHILDREN. 
CAUTION 
See additional precautionary statements and directions for use inside booklet. 
EPA Reg. No. 100-1195 
SCP 1195 
________gallons 
Net Contents 
Jul 19, 2019
100-1195

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FIRST AID 
If on skin or 
clothing 
x Take off contaminated clothing. 
x Rinse skin immediately with plenty of water for 15-20 minutes. 
x Call a poison control center or doctor for treatment advice. 
Have the product container or label with you when calling a poison control center or 
doctor, or going for treatment. 
HOT LINE NUMBER 
For 24 Hour Medical Emergency Assistance (Human or Animal) or 
Chemical Emergency Assistance (Spill, Leak, Fire, or Accident), 
Call 
1-800-888-8372
 
 
PRECAUTIONARY STATEMENTS 
 
Hazards to Humans and Domestic Animals 
 
CAUTION 
 
Harmful if absorbed through the skin. Avoid contact with skin, eyes, or clothing. Wash 
thoroughly with soap and water after handling. Prolonged or frequently repeated skin 
contact may cause allergic reactions in some individuals. 
 
Personal Protective Equipment (PPE) 
 
Applicators and other handlers must wear: 
x Long-sleeved shirt and long pants 
x Chemical-resistant gloves made of barrier laminate, butyl rubber > 14 mils, nitrile 
rubber > 14 mils, neoprene rubber > 14 mils, or polyvinyl chloride (PVC) > 14 mils or 
Viton® > 14 mils 
x Shoes plus socks 
 
Follow manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions 
for washables exist, use detergent and hot water. Keep and wash PPE separately from 
other laundry.

-3- 
Engineering Control Statements 
 
When handlers use closed systems in a manner that meets the requirements listed in 
the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-
6)], the handler PPE requirements may be reduced or modified as specified in the WPS. 
 
 
User Safety Recommendations 
 
Users should: 
 
x Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. 
x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly 
and put on clean clothing. 
x Remove PPE immediately after handling this product. Wash the outside of gloves 
before removing. As soon as possible, wash thoroughly and change into clean 
clothing. 
 
 
Environmental Hazards 
 
This pesticide is toxic to freshwater and estuarine/marine fish and aquatic invertebrates. 
Do not contaminate water when disposing of equipment washwater or rinsate. 
 
Groundwater Advisory Statement 
 
Mefenoxam is known to leach through soil into groundwater under certain conditions as 
a result of agricultural use. Use of this chemical in areas where soils are permeable, 
particularly where the water table is shallow, may result in groundwater contamination.

-4- 
CONDITIONS OF SALE AND LIMITATION OF WARRANTY AND LIABILITY 
 
NOTICE: Read the entire Directions for Use and Conditions of Sale and Limitation of 
Warranty and Liability before buying or using this product. If the terms are not 
acceptable, return the product at once, unopened, and the purchase price will be 
refunded. 
 
The Directions for Use of this product must be followed carefully. It is impossible to 
eliminate all risks inherently associated with the use of this product. Crop injury, 
ineffectiveness or other unintended consequences may result because of such factors 
as manner of use or application, weather or crop conditions, presence of other materials 
or other influencing factors in the use of the product, which are beyond the control of 
SYNGENTA CROP PROTECTION, LLC or Seller. To the extent consistent with 
applicable law, Buyer and User agree to hold Syngenta and Seller harmless for any 
claims relating to such factors. 
 
SYNGENTA warrants that this product conforms to the chemical description on the label 
and is reasonably fit for the purposes stated in the Directions for Use, subject to the 
inherent risks referred to above, when used in accordance with directions under normal 
use conditions. To the extent consistent with applicable law: (1) this warranty does not 
extend to the use of the product contrary to label instructions or under conditions not 
reasonably foreseeable to or beyond the control of Seller or SYNGENTA, and (2) Buyer 
and User assume the risk of any such use. TO THE EXTENT CONSISTENT WITH 
APPLICABLE LAW, SYNGENTA MAKES NO WARRANTIES OF MERCHANTABILITY 
OR OF FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR 
IMPLIED WARRANTY EXCEPT AS WARRANTED BY THIS LABEL. 
 
To the extent consistent with applicable law, in no event shall SYNGENTA be liable for 
any incidental, consequential or special damages resulting from the use or handling of 
this product. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE 
EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE EXCLUSIVE LIABILITY 
OF SYNGENTA AND SELLER FOR ANY AND ALL CLAIMS, LOSSES, INJURIES 
OR DAMAGES (INCLUDING CLAIMS BASED ON BREACH OF WARRANTY, 
CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE) 
RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, SHALL BE THE 
RETURN OF THE PURCHASE PRICE OF THE PRODUCT OR, AT THE ELECTION 
OF SYNGENTA OR SELLER, THE REPLACEMENT OF THE PRODUCT. 
 
SYNGENTA and Seller offer this product, and Buyer and User accept it, subject to the 
foregoing conditions of Sale and Limitation of Warranty and Liability, which may not be 
modified except by written agreement signed by a duly authorized representative of 
SYNGENTA.

-5- 
DIRECTIONS FOR USE 
 
It is a violation of Federal law to use this product in a manner inconsistent with its 
labeling. 
 
Do not apply this product in a way that will contact workers or other persons, either 
directly or through drift. Only protected handlers may be in the area during application. 
For any requirements specific to your State or Tribe, consult the agency responsible for 
pesticide regulation. 
 
Treatment of highly mechanically damaged seed, or seed of known low vigor and poor 
quality, may result in reduced germination and/or reduction of seed and seedling vigor. 
Treat and conduct germination test on a small portion of seed before committing the 
total seed lot to a selected chemical treatment. Due to seed-quality conditions beyond 
the control of Syngenta crop protection, no claims are made to guarantee germination of 
carry-over seed. 
 
Maximum usage when applying metalaxyl- and mefenoxam- containing products 
to the same crop within the same season: Do not apply more than the maximum 
yearly total application rate for the active ingredient as stated on the label of the product 
containing the lowest yearly total on that crop. 
 
AGRICULTURAL USE REQUIREMENTS 
 
Use this product only in accordance with its labeling and with the Worker Protection 
Standard, 40 CFR part 170. This Standard contains requirements for the protection of 
agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 
agricultural pesticides. It contains requirements for training, decontamination, and 
emergency assistance. It also contains specific instructions and exceptions pertaining 
to the statements on this label about personal protective equipment (PPE) and 
restricted-entry interval. The requirements in this box only apply to uses of this product 
that are covered by the Worker Protection Standard. 
 
Do not enter or allow worker entry into treated areas during the restricted-entry 
interval (REI) of 48 hours. Exception: If the seed is treated with the product and the 
treated seed is soil-injected or soil-incorporated, the Worker Protection Standard, under 
certain circumstances, allows workers to enter the treated area if there will be no 
contact with anything that has been treated. 
 
PPE required for early entry to treated areas that is permitted under the Worker 
Protection Standard and that involves contact with anything that has been treated, such 
as plants, soil, or water is: 
x Coveralls 
x Chemical-resistant gloves made of barrier laminate, butyl rubber > 14 mils, nitrile 
rubber > 14 mils, neoprene rubber > 14 mils, or polyvinyl chloride (PVC) > 14 
mils or Viton® > 14 mils 
x Shoes plus socks

-6- 
 
FAILURE TO FOLLOW THE DIRECTIONS FOR USE AND PRECAUTIONS ON THIS 
LABEL MAY RESULT IN CROP INJURY, POOR DISEASE CONTROL, OR ILLEGAL 
RESIDUES. 
 
GENERAL INFORMATION 
 
ApronMAXX RFC is a seed treatment fungicide that protects against damping-off and 
seed rots due to Pythium, Phytophthora, Fusarium, Rhizoctonia spp., and early season 
Phytophthora root rot. ApronMAXX RFC also suppresses seed-borne Sclerotinia and 
Phomopsis spp., particularly in soybeans. ApronMAXX RFC contains the active 
ingredient mefenoxam found in Apron XL® that provides protection against Pythium and 
early season Phytophthora root rot. ApronMAXX RFC also contains the active 
ingredient fludioxonil found in Maxim® that provides protection against the remaining 
diseases mentioned in this label. 
 
Resistance Management 
 
MEFENOXAM GROUP 4 FUNGICIDE
FLUDIOXONIL GROUP 12 FUNGICIDE
 
For resistance management, please note that Apron MAXX RFC contains Group 4/ 
mefenoxam and Group 12/fludioxonil fungicides. Any fungal population may contain 
individuals naturally resistant to Apron MAXX RFC and other Group 4 or Group 12 
fungicides. A gradual or total loss of pest control may occur over time if these fungicides 
are used repeatedly in the same fields. Appropriate resistance-management strategies 
should be followed. 
 
Mefenoxam belongs to the phenylamide class of chemistry which interferes with fungal 
RNA synthesis. Fludioxonil belongs to the phenylpyrrole class of chemistry which 
interferes with osmotic signal transduction. 
 
To delay fungicide resistance, take one or more of the following steps: 
x Rotate the use of Apron MAXX RFC or other Group 4 or Group 12 fungicides within 
a growing season sequence with different groups that control the same pathogens. 
x Use tank mixtures with fungicide from a different group that are equally effective on 
the target pest when such use is permitted. Use at least the minimum application 
rate as labeled by the manufacturer. 
x Adopt an integrated disease management program for fungicide use that includes 
scouting, uses historical information related to pesticide use, and crop rotation, and 
which considers host plant resistance, impact of environmental conditions on 
disease development, disease thresholds, as well as cultural, biological and other 
chemical control practices. 
x Where possible, make use of predictive disease models to effectively time fungicide 
applications. Note that using predictive models alone is not sufficient to manage 
resistance. 
x Monitor treated fungal populations for resistance development.

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x Contact your local extension specialist or certified crop advisor for any additional 
pesticide resistance-management and/or IPM recommendations for specific crop 
and pathogens. 
x For further information or to report suspected resistance contact Syngenta at 1-866-
Syngent(a) (866-796-4368). You can also contact your pesticide distributor or 
university extension specialist to report resistance. 
 
Make all applications according to the use directions that follow. If a rate range is 
specified, use higher rates of ApronMAXX RFC when the disease pressure is expected 
to be high. 
 
MIXING INSTRUCTIONS FOR SOYBEANS 
 
ApronMAXX RFC is especially formulated for on-farm or commercial treatment to be 
used with liquid rhizobia products, using standard mechanical slurry or mist-type seed 
treatment equipment which accurately measures and mixes a flowable seed treatment. 
The equipment must provide uniform coverage of ApronMAXX RFC on the seed. 
Uneven seed coverage may not give the desired level of disease control. ApronMAXX 
RFC must be diluted with either water or liquid inoculants prior to application to 
soybeans. Consult the manufacturer of the application equipment you plan to use for 
suitability for this application and for instructions on operation and calibration of the 
equipment. Do not mix ApronMAXX RFC fungicide with other pesticides unless 
sufficient compatibility, loading rates, and seed and crop safety factors are determined. 
Do not mix with any product that contains a prohibition on mixing. Follow the more 
restrictive labeling of any tank-mix partner. 
 
In a clean container large enough to contain the entire mixture add the desired amount 
of ApronMAXX RFC. Add half of the required water or liquid inoculant and mix 
thoroughly. Add the remaining amount of water or liquid inoculant and mix again. The 
slurry is ready for application to the soybeans. Mix as needed and do not store diluted 
mixture. 
 
Additional or continuous agitation or mixing of the slurry mixture may be necessary to 
prevent the ApronMAXX RFC from settling out of solution when using water or liquid 
inoculants. 
 
ApronMAXX RFC has been found to be compatible with some liquid inoculant products. 
ApronMAXX RFC may be mixed or applied sequentially with approved liquid inoculants. 
Consult the maker of the liquid inoculants and a Syngenta Crop Protection 
representative for directions before applying ApronMAXX RFC with liquid inoculants. 
 
Special Precaution: ApronMAXX RFC is specially formulated to be compatible with 
some liquid inoculants. If water is used to further dilute ApronMAXX RFC when 
rhizobia are present, use only nonchlorinated water. Chlorinated water will kill 
the live rhizobia contained in the inoculant.

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MIXING INSTRUCTIONS FOR OTHER LEGUMES 
 
Apply ApronMAXX RFC as a water based slurry utilizing standard slurry seed treatment 
equipment which provides uniform seed coverage. Uneven or incomplete seed 
coverage may not give the desired level of disease protection. Thoroughly mix the 
labeled amount of ApronMAXX RFC into the required amount of water for the slurry 
treater and dilution rate to be used. 
 
Follow the manufacturer application instructions for the seed treatment equipment being 
used. Maintain constant agitation of the slurry during the treatment. Allow seed to dry 
before bagging. 
 
CROP USE DIRECTIONS 
 
Note: Federal law requires that bags of treated seeds shall be labeled with the 
following information: “This seed has been treated with fludioxonil and mefenoxam 
fungicides. Do not use for food, feed or oil purposes. Store away from food and 
feedstuffs.” Treated seed bagged for later use must contain an EPA-approved dye or 
colorant that imparts an unnatural color to the seed. 
 
Soybean 
ApronMAXX RFC provides protection against damping-off and seed rots due to 
Pythium, Phytophthora, Fusarium, Rhizoctonia spp., and early season Phytophthora 
root rot. ApronMAXX RFC also suppresses seed-borne Sclerotinia and Phomopsis spp. 
For these soybean diseases, apply ApronMAXX RFC at the rate specified in the rate 
table, plus water at 3.5 fl oz per 100 lbs. seed. Alternatively, approved liquid rhizobia 
inoculants at rates specified by manufacturer to achieve proper total slurry volumes can 
be used. If the target fields have a history of high Phytophthora pressure, then use 
Apron XL as specified in the rate table. Read and follow all label directions for Apron 
XL use. 
 
Soybean use rate* 
ApronMAXX RFC** Additional Apron XL 
1.5 fl oz/100 lbs. seed** 
or 
0.005 fl oz/1,000 seed 
or 
0.7 fl oz/140,000 seed 
0.16-0.48 fl oz/100 lbs. seed 
or 
0.0005-0.0016 fl oz/1,000 seed 
or 
0.075-0.224 fl oz/140,000 seed 
0.0092 mg ai/seed 0.005-0.0170 mg ai/seed 
 *Based 3,000 seeds per pound. 
**Contains 3.75 g of mefenoxam and 2.5 g of fludioxonil/100 kg of seed. 
Legume Crops 
Bean (Lupinus spp.) 
 (grain lupin, sweet lupin, white lupin, white sweet lupin) 
Bean (Phaseolus spp.) 
 (field bean, kidney bean, lima bean, navy bean, pinto bean, runner bean, snap bean, 
tepary bean, wax bean)

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Bean (Vigna spp.) 
 (adzuki bean, asparagus bean, black-eyed pea, catjang, Chinese longbean, cowpea, 
Crowder pea, moth bean, mung bean, rice bean, southern pea, urd bean, yardlong 
bean) 
Broad bean (fava bean) 
Chickpea (garbanzo bean) 
Guar 
Jackbean 
Lablab bean (hyacinth bean) 
Lentil 
Pea (Pisum spp.) 
 (dwarf pea, edible-pod pea, English pea, field pea, garden pea, green pea, snow 
pea, sugar snap pea) 
Pigeon pea 
Sword bean 
 
ApronMAXX RFC provides protection against damping-off and seed rots due to 
Pythium, Phytophthora, Fusarium, Rhizoctonia spp., and early season Phytophthora 
root rot. Additional Apron XL may be necessary depending on the type of pathogen and 
the level of disease pressure. Use the table below to determine the appropriate use 
rate of ApronMAXX RFC and Apron XL, if needed. Read and follow all label directions 
for Apron XL use. 
 
 Use Rate 
(fl oz/100 lbs. seed) 
Pathogens ApronMAXX RFC Apron XL 
Pythium (low pressure), Fusarium and 
Rhizoctonia 
1.5 -- 
Pythium (high pressure), Fusarium and 
Rhizoctonia 
1.5 0.16 
Pythium (high pressure), Phytophthora, 
Fusarium and Rhizoctonia 
1.5 0.48

-10- 
STORAGE AND DISPOSAL 
 
Do not contaminate water, food or feed by storage or disposal. Open dumping is 
prohibited. 
 
Pesticide Storage 
 
Store in the original container only in a cool, dry, secure place. Keep container closed 
when not in use. Do not store near food or feed. In case of spill on floor or paved 
surfaces, mop and remove to chemical waste storage area until proper disposal can be 
made if product cannot be used according to the label. 
 
Pesticide Disposal 
 
Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray 
mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of 
by use according to label instructions, contact your State Pesticide or Environmental 
Control Agency, or the Hazardous Waste representative of the nearest EPA Regional 
Office for guidance. 
 
Container Handling 
 
Non-refillable container. Do not reuse or refill this container. Triple rinse container (or 
equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 
contents into application equipment or a mix tank. Fill the container ¼ full with water. 
Replace and tighten closures. Tip container on its side and roll it back and forth, 
ensuring at least one complete revolution, for 30 seconds. Stand the container on its 
end and tip it back and forth several times. Turn the container over onto its other end 
and tip it back and forth several times. Empty the rinsate into application equipment or 
a mix tank or store rinsate for later use or disposal. Repeat this procedure two more 
times. Then offer for recycling if available or puncture and dispose of in a sanitary 
landfill, by incineration, or by other procedures approved by state and local authorities. 
 
CONTAINER IS NOT SAFE FOR FOOD, FEED OR DRINKING WATER. 
 
 
ApronMAXX® RFC, Maxim®, Apron XL® the ALLIANCE FRAME, the Syngenta Logo 
and the PURPOSE ICON are Trademarks of a Syngenta Group Company 
 
©20XX Syngenta 
For non-emergency (e.g., current product information), call 
Syngenta Crop Protection at 1-800-334-9481. 
 
Manufactured for: 
Syngenta Crop Protection, LLC 
P.O. Box 18300 
Greensboro, North Carolina 27419-8300

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SCP 1195 
 
APRON MAXX RFC 1195 MAS 0310 AMEND JUN2018 mar draft – mar– 5/29/18 
000100-01195.20180529.APRON_MAXX_RFC.AMEND-JUN2018.PDF 
 
APRON MAXX RFC 1195 MAS 0310 AMEND JUN2018 mar draft-HI – mar– 5/29/18 
000100-01195.20180529.APRON_MAXX_RFC.AMEND-JUN2018-HI.PDF