crop-chem-docs/corpus/epa_ppls/264-989.md

# TRIFLOXYSTROBIN FLOWABLE FUNGICIDE

- EPA Reg No: **264-989**
- Registrant: BAYER CROPSCIENCE, LLC
- Signal word: Caution
- Active ingredients: Trifloxystrobin (22%)
- Label accepted: 2023-05-11
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000264-00989-20230511.pdf

---
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
 
May 11, 2023 
 
Megan Mader 
Regulatory Affairs Manager, Fruits and Vegetables 
Bayer CropScience LP 
800 N. Lindbergh Blvd. 
St. Louis, MO 63167 
 
Subject: Registration Review Label Mitigation for Trifloxystrobin 
 Product Name: TRIFLOXYSTROBIN FLOWABLE FUNGICIDE 
 EPA Registration Number: 264-989 
 Application Date: July 12, 2022 
Decision Number: 555162 
 
Dear Megan Mader: 
 
The Agency, in accordance with the Federal Insecticide, Fungicide and Rodenticide Act 
(FIFRA), as amended, has completed reviewing all the information submitted with your 
application to support the Registration Review of the above referenced product in connection 
with the Trifloxystrobin Interim Decision, and has concluded that your submission is acceptable. 
The label referred to above, submitted in connection with registration under FIFRA, as amended, 
is acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be 
aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide 
Act and is subject to review by the Agency. If the website is false or misleading, the product 
would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 
CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, 
regardless of whether a website is referenced on your product’s label, claims made on the 
website may not substantially differ from those claims approved through the registration process. 
Therefore, should the Agency find or if it is brought to our attention that a website contains false 
or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes 
all previously accepted labeling. You must submit one copy of the final printed labeling 
before you release the product for shipment with the new labeling. In accordance with 40 
CFR 152.130(c), you may distribute or sell this product under the previously approved 
labeling for 12 months from the date of this letter. After 12 months, you may only 
distribute or sell this product if it bears this new revised labeling or subsequently 
approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its 
implementing regulation at 40 CFR 152.3.

Page 2 of 2 
EPA Reg. No. 264-989 
Decision No. 555162 
 
 
 
If you have any questions about this letter, please contact DeMariah Koger by phone at (202)-
566-2288, or via email at koger.demariah@epa.gov. 
 
 S i n c e r e l y , 
 
 
       Linda Arrington, Branch Chief 
 Risk Management and Implementation Branch 4 
 Pesticide Re-Evaluation Division 
 Office of Pesticide Programs
 
 
 
Enclosure

1
TRIFLOXYSTROBIN Flowable Fungicide
ACTIVE INGREDIENT:
Trifloxystrobin..................................................................................................................................................................22%
OTHER INGREDIENTS: ................................................................................................................................................78%
TOTAL 100%
Contains 2 pounds trifloxystrobin per gallon.
EPA Reg. No. 264-989 EPA Est. 
KEEP OUT OF REACH OF CHILDREN
CAUTION
For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1-800-334-7577
For PRODUCT USE Information Call 1-866-99BAYER (1-866-992-2937)
See [Back][Side] Panel for First Aid Instructions and [Leaflet][Booklet] for Complete Precautionary 
Statements and Directions for Use. (Note to reviewer : Location of additional precautionary statements, 
directions for use will vary between those listed, depending on container type/size.)
FIRST AID
IF IN EYES: x Hold eye open and rinse slowly and gently with water for 15-20 minutes.
x Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.
x Call a poison control center or doctor for treatment advice.
IF ON SKIN OR 
CLOTHING:
x Take off contaminated clothing.
x Rinse skin immediately with plenty of water for 15-20 minutes.
x Call a poison control center or doctor for treatment advice.
IF SWALLOWED: x Call a poison control center or doctor immediately for treatment advice.
x Have person sip a glass of water if able to swallow.
x Do not induce vomiting unless told to do so by a poison control center or doctor.
x Do not give anything by mouth to an unconscious person.
IF INHALED x Move person to fresh air.
x If person is not breathing, call 911 or an ambulance, th en give artificial respiration, preferably mouth-to -
mouth, if possible.
x Call a poison control center or doctor for further treatment advice.
In case of emergency call toll free the Bayer CropScience Emergency Response Telephone No. 1-800-334-7577.
Have the product label with you when calling a poison control center or doctor, or going for treatment.
TRIFLOXYSTROBIN GROUP 11 FUNGICIDE
May 11, 2023
264-989

2
 
PRECAUTIONARY STATEMENTS
CAUTION
HAZARDS TO HUMANS AND DOMESTIC ANIMALS
Causes moderate eye irritation. Harmful if absorbed through skin. Prolonged or frequently repeated skin contact may cause allergic 
reactions in some individuals. Avoid contact with eyes, skin, or clothing. Wash thoroughly with soap and water after handling.
PERSONAL PROTECTIVE EQUIPMENT (PPE)
Applicators and other handlers must wear:
x Long-sleeved shirt and long pants
x Socks plus shoes
x Waterproof gloves
x Protective eyewear
Engineering Controls: When handlers use closed systems in a manner that me ets the requirements listed in the Worker Protection 
Standard (WPS) for agricultural pesticides [40 CFR 170.607 (d)(e)(f) ], the handler PPE requirements may be reduced or modified as 
specified in the WPS.
USER SAFETY RECOMMENDATIONS
Users should: Wash hands before eating, drinking, chewing gum, using to bacco or using the toilet. Users should remove clothing 
immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing.
ENVIRONMENTAL HAZARDS
This pesticide is toxic to fish and aquatic invertebrates. Applying this product when rain is not predicted for the next 24 hours will 
help reduce potential risk to aquatic invertebrates by reducing pesticide runoff from the treatment area into water bodies. Do not 
apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not 
contaminate water when disposing of equipment washwaters. Drift or run-off from treated areas is hazardous to fish and aquatic 
organisms in water adjacent to treated areas. Treated seed exposed on the soil surface may be hazardous to wildlife. Cover or 
collect seeds spilled during loading.
DIRECTIONS FOR USE
It is a violation of Federal law to use this product in a manner inconsistent with its labeling.
Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may 
be in the area during application. Not for use on agricultural establishments in hopper-box, planter-box, slurry-box or other seed treatment 
applications at or immediately before planting. For any requirements specific to your State or Tribe, consult the agency respons ible for 
pesticide regulation.
STORAGE AND DISPOSAL
Do not contaminate water, food or feed by storage or disposal.
PESTICIDE STORAGE 
Store in a cool, dry place and in such a manner as to prevent cross contamination with other pesticides, fertilizers, food, and feed. Store 
in original container and out of the reach of children, preferably in a locked storage area.
Handle and open container in a manner as to prevent spillage. If container is leaking, invert to prevent leakage. If the container is 
leaking or material is spilled for any reason or cause, carefully dam up spilled material to prevent runoff. Refer to Precautionary 
Statements on label for hazards associated with the handling of this material. Do not walk through spilled material. Absorb spilled 
material with absorbing type compounds and dispose of as directed for pesticides below. In spill or leak incidents, keep unauthorized 
people away. You may contact the Bayer CropScience Emergency Response Team for decontamination procedures or any other 
assistance that may be necessary. The Bayer CropScience Emergency Response Telephone No. is 1-800-334-7577.
PESTICIDE DISPOSAL
Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility.
CONTAINER DISPOSAL
Rigid, Non-refillable containers small enough to shake (i.e., with capacities equal to or less than 5 gallons).
Non-refillable container. Do not reuse or refill this container. Offer for recycling, if available. Triple rinse or pressure rinse container (or 
equivalent) promptly after emptying.
Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow 
begins to drip. Fill the container ¼ full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix 
tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times.

3 
 
Pressure rinse as follows: Empty the remaining contents into application equipment or a mix tank and continue to drain for 10 seconds 
after the flow begins to drip. Hold container upside down over application equipment or mix tank or collect rinsate for later use or 
disposal. Insert pressure rinsing nozzle in the side of the container, and rinse at about 40 PSI for at least 30 seconds. Drain for 10 
seconds after the flow begins to drip. 
 
Once container is rinsed, offer for recycling if available, or puncture and dispose of in a sanitary landfill. 
 
Rigid Non-refillable containers that are too large to shake (i.e., with capacities greater than 5 gallons or 50 lbs) 
Non-refillable containers - Do not reuse or refill this container. After emptying product from container, either return container to Bayer 
CropScience per instructions from Bayer CropScience Customer Service Center (1-800-527-4781), or rinse and either recycle or 
dispose of the container as follows: 
 
Bottom Discharge IBC (e.g. – Schuetz Caged IBC or Snyder Square Stackable) 
Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. To pressure rinse the 
container before final disposal, empty the remaining contents from the IBC into application equipment or mix tank. Raise the bottom of 
the IBC by 1.5 inches on the side which is opposite of the bottom discharge valve to promote more complete product removal. 
Completely remove the top lid of the IBC. Use water pressurized to at least 40 PSI to rinse all interior portions. Continuously pump or 
drain rinsate into application equipment or rinsate collection system while pressure rinsing. Continue pressure rinsing for 2 minutes or 
until rinsate becomes clear. Replace the lid and close bottom valve. 
 
Top Discharge IBC, Drums, Kegs (e.g.– Snyder 120 Next Gen, Bonar B120, Drums, and Kegs). 
Triple rinsing the container before final disposal is the responsibility of the person disposing of the container. To triple rinse the 
container before final disposal, empty the remaining contents from this container into application equipment or mix tank. Fill the 
container at least 10 percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Rinse all interior 
surfaces. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this procedure two more times. 
 
Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill. 
 
Refillable Containers 
Refillable container. Refill this container with pesticide only. Do not reuse this container for any 
other purpose. After emptying product from container, either return container to Bayer CropScience per instructions from Bayer 
CropScience Customer Service Center (1-800-527-4781) or rinse and either recycle or dispose of the container as follows: 
 
Bottom Discharge IBC (e.g. – Schuetz Caged IBC or Snyder Square Stackable) 
Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. Cleaning before 
refilling is the responsibility of the refiller. To pressure rinse the container before final disposal, empty the remaining contents from the 
IBC into application equipment or mix tank. Raise the bottom of the IBC by 1.5 inches on the side which is opposite of the bottom 
discharge valve to promote more complete product removal. Completely remove the top lid of the IBC. Use water pressurized to at least 
40 PSI to rinse all interior portions. Continuously pump or drain rinsate into application equipment or rinsate collection system while 
pressure rinsing. Continue pressure rinsing for 2 minutes or until rinsate becomes clear. Replace the lid and close bottom valve. 
 
Top Discharge IBC, Drums, Kegs (e.g. – Snyder 120 Next Gen, Bonar B120, Drums, and Kegs). 
Triple rinsing the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling is 
the responsibility of the refiller. To triple rinse the containers before final disposal, empty the remaining contents from this container into 
application equipment or mix tank. Fill the container at least 10 percent full with water. Agitate vigorously or recirculate water with the 
pump for 2 minutes. Rinse all interior surfaces. Pour or pump rinsate into application equipment or rinsate collection system. Repeat 
this procedure two more times. 
 
Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill. 
 
Refillable Containers 
End users are authorized to remove tamper evident cables as required to remove the product from the container unless the container is 
equipped with one way valves and refilling or returning is planned. If this is the case, end users are not authorized to remove tamper 
evident cables, one way valves or clean container. See Container Disposal instructions under Storage and Disposal.

4 
 
LABELING OF TREATED SEED 
Seed commercially treated with TRIFLOXYSTROBIN Flowable Fungicide must be labeled in accordance with all applicable requirements 
of the Federal Seed Act. All bags containing treated seed must be labeled or tagged as follows: 
x This seed has been treated with trifloxystrobin. 
x Do not use for feed, food or oil processing. 
x Store away from feeds and other foodstuffs. 
x When opening this bag or loading/pouring the treated seed, wear a long-sleeved shirt, long pants, shoes, socks, and chemical 
resistant gloves. After the seeds have been planted, do not enter or allow worker entry into treated areas during the restricted entry 
interval of 12 hours. Exception: Once the seeds are planted in so il or other planting media, the Worker Protection Standard all ows 
workers to enter the treated area without restriction if there will be no worker contact with the treated seeds in the soil or planting 
media. 
 
FUNGICIDE RESISTANCE MANAGEMENT (FRAC) RECOMMENDATIONS 
For resistance management, please note that TRIFLOXYSTROBIN Fl owable Fungicide contains a Group 11 fungicide. Any fungal 
population may contain individuals naturally resistant to TRIFL OXYSTROBIN Flowable Fungicide and other Group 11 fungicides. A 
gradual or total loss of pest control may occur over time if thes e (fungicides) are used repeatedly in the same fields. Appropr iate 
resistance-management strategies should be followed. 
To delay fungicide resistance, take one or more of the following steps: 
x Adopt an integrated disease management program for fungicide use th at includes scouting, uses historical information related to 
pesticide use, and crop rotation, and which considers host plant resistance, impact of environmental conditions on disease 
development, disease thresholds, as well as cultural, biological and other chemical control practices. 
x Monitor treated fungal populations for resistance development. 
x Contact your local extension specialist or certified crop advi sor for any additional pesticide resistance-management and/or IPM 
recommendations for specific crops and pathogens. 
x For further information or to report suspected resistance contact Bayer CropScience at 1-866-99BAYER (1-866-992- 2937). You 
can also contact your pesticide distributor or university extension specialist to report resistance. 
 
GENERAL INFORMATION 
TRIFLOXYSTROBIN Flowable Fungicide provides seed and seedling protection against seedborne fungi, Alternaria spp., Aspergillus 
spp, Cladosporium spp., and Penicillium spp. causing seed decay and soilborne pathogens, Rhizoctonia solani and Fusarium spp. Apply 
as a seed treatment using standard slurry or mist-type seed treatment equipment. Uniform application of seed is necessary to en sure 
seed safety and best disease protection. Seed should be sound and well cured prior to treatment. Product should be diluted with sufficient 
water to ensure complete seed coverage. Consult a seed treatment specialist regarding slurry rates recommended for the crop to be 
treated with TRIFLOXYSTROBIN Flowable Fungicide. The length of control will vary depending on the rate used. 
 
USE RESTRICTION 
Do not use treated seed for food, feed, or oil processing. 
 
USE PRECAUTION 
When using formulations that do not contain dye (like this pr oduct), to comply with 40 CFR 153.155, all seed treated with an ec onomic 
poison must be colored to distinguish it and prevent subsequent inadvertent use as a food for man or feed for animals. 
Alfalfa: Apply at a product rate of 0.96 fl oz per 100 lbs of seed. 
Canola, cotton, Cucurbit vegetable group, Fruiting vegetable group, Field corn, Mustardseed, Rapeseed, Popcorn, Rice, Sorghum, Sugar 
beet, Wheat, Potato (seed-piece), Peanut, Turf grass, Conifer, and Ornamental flowers: Apply at a product rate of 0.32 – 0.64 fl.oz. per 
100 lbs. of seed. 
Soybean, Adzuki Bean, Asparagus Bean, Broad Bean (Succulent or Dry), Catjang Bean, Chinese Longbean, Field Bean, Guar Bean, 
Jackbean, Kidney Bean, Lablab Bean, Lima Bean (Succulent or Dry), Moth Bean, (Succulent or Dry), Mung Bean, Navy Bean, Pinto 
Bean, Rice Bean, Runner Bean, Snap Bean, Sword Bean, Tepary Bean, Urd Bean, Wax Bean, Yardlong Bean, Blackeyed Pea (Succulent 
or Dry), Chickpea, Cowpea (Succulent or Dry), Crowder Pea, Dwarf P ea, Edible-Pod Pea, English Pea, Field Pea, Garden Pea, Green 
Pea, Pigeon Pea (Succulent or Dry), Snow Pea, Southern Pea (Succ ulent or Dry), Sugar Snap Pea, Grain Lupin, Sweet Lupin, White 
Sweet Lupin, Lentil: Apply at a product rate of 0.32 fl. Oz. per 100 lbs. of seed. 
Sweet Corn: Apply at a product rate of 0.32 – 0.96 fl. Oz. per 100 lbs. of seed.

5 
 
Cotton For seed and seedling protection: apply Trifloxystrobin Flowable Fungicide as a seed treatment: 
 Application Rates* 
Number of cottonseed per 
pound 
fl oz per 100 pounds of 
seed mg ai/ seed fl oz/ 100,000 unit of seed 
3600 0.32 - 0.64 0.0063 - 0.0126 0.08 - 0.17 
4400 0.32 - 0.64 0.0051 - 0.0103 0.07 - 0.14 
5200 0.32 - 0.64 0.0044 - 0.0088 0.06 - 0.12 
6000 0.32 - 0.64 0.0038 - 0.0076 0.05 - 0.10 
* Do not apply more than 0.0013 lbs of active ingredient trifloxystrobin as a seed treatment per planted cotton 
acre 
 
Field 
Corn 
For seed and seedling protection: apply Trifloxystrobin Flowable Fungicide as a seed treatment: 
 Application Rates* 
Number of corn seed per 
pound 
fl oz per 100 pounds of 
seed mg ai/ seed fl oz/ 80,000 unit of seed 
1200 0.32 - 0.64 0.0189 - 0.0378 0.213 - 0.426 
1600 0.32 - 0.64 0.0142 - 0.0284 0.160 - 0.320 
2000 0.32 - 0.64 0.0114 - 0.0227 0.128 - 0.256 
2400 0.32 - 0.64 0.0095 - 0.0189 0.106 - 0.213 
 
Soybean For seed and seedling protection: apply Trifloxystrobin Flowable Fungicide as a seed treatment: 
 Application Rates* 
Number of soybean 
seed per pound 
fl oz per 100 pounds of 
seed mg ai/ seed fl oz / 140,000 unit of seed 
2000 0.32 0.0114 0.224 
2400 0.32 0.0095 0.187 
2800 0.32 0.0081 0.160 
3200 0.32 0.0071 0.140 
3600 0.32 0.0063 0.124 
* Do not apply more than 0.0027 lbs of active ingredient trifloxystrobin as a seed treatment per planted 
soybean acre 
 
ROTATIONAL CROP RESTRICTION 
Areas planted with treated seed may be replanted immediately with any crop for which a tolerance exists for trifloxystrobin. Do not plant 
any crop without trifloxystrobin tolerances until 30 days after planting trifloxystrobin treated seed.

6 
 
IMPORTANT: READ BEFORE USE 
Read the entire Directions for Use, Conditions, Disclaimer of Warranties and Limitations of Liability before using this product. If terms are 
not acceptable, return the unopened product container at once. 
By using this product, user or buyer accepts the following Conditions, disclaimer of Warranties and Limitations of Liability. 
Treatment of highly mechanically damaged seed, or seed of known lo w vigor and poor quality, may result in reduced germination a nd/or 
reduction of seed and seedling vigor. Treat and conduct germination tests on a small portion of seed before committing the tota l seed lot 
to a selected chemical treatment. Due to seed quality conditions beyond the control of Bayer CropScience, no claims are made to 
guarantee germination of carry-over seed. 
CONDITIONS: The directions for use of this product are believed to be adequate and must be followed carefully. However, it is impossible 
to eliminate all risks associated with the use of this product. Crop injury, ineffectiveness or other unintended consequences m ay result 
because of such factors as weather conditions, presence of other materials, or the manner of use or application, all of which are beyond 
the control of Bayer CropScience LP. All such risks shall be assumed by the user or buyer. 
DISCLAIMER OF WARRANTIES: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BAYER CROPSCIENCE LP MAKES NO 
OTHER WARRANTIES, EXPRESS OR IMPLIE D, OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR 
OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THIS LABEL. No agent of Bayer CropScience LP is authorized 
to make any warranties beyond those contained herein or to modi fy the warranties contained herein. TO THE EXTENT CONSISTENT 
WITH APPLICABLE LAW, BAYER CROPSCIENCE LP DISCLAIMS ANY LIABILITY WHATSOEVER FOR SPECIAL, INCIDENTAL OR 
CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 
LIMITATIONS OF LIABILITY: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER 
OR BUYER FOR ANY AND ALL LOSSES, INJURIES OR DAMAG ES RESULTING FROM THE USE OR HANDLING OF THIS 
PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHALL NOT 
EXCEED THE PURCHASE PRICE PAID, OR AT BAYER CROPSCIENCE’S ELECTION, THE REPLACEMENT OF PRODUCT. 
 
NET CONTENTS: 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Produced for 
 
Bayer CropScience LP 
800 N. Lindbergh Blvd. 
St. Louis, MO 63167 
1-866-99BAYER (1-866-992-2937) 
 
TRIFLOXYSTROBIN FLOWABLE FUNGICIDE (PENDING) 09/09/2019, 09/10/2019, 07/12/2022, 04/18/2023