crop-chem-docs/corpus/epa_ppls/228-728.md

# AZURE XTRA FUNGICIDE

- EPA Reg No: **228-728**
- Registrant: NUFARM AMERICAS, INC.
- Signal word: Caution
- Active ingredients: Azoxystrobin (18.2%); Cyproconazole (7.3%)
- Label accepted: 2022-02-02
- Source PDF: https://www3.epa.gov/pesticides/chem_search/ppls/000228-00728-20220202.pdf

---
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
 WASHINGTON, DC 20460 
 
 
 
OFFICE OF CHEMICAL SAFETY 
AND POLLUTION PREVENTION 
 February 2, 2022 
 
Danielle A. Larochelle 
Regulatory Manager 
Nufarm Americas, Inc. 
11901 S. Austin Avenue 
Alsip, IL 60803 
 
Subject: Registration Review Label Mitigation for Azoxystrobin and Cyproconazole 
 Product Name: Azure Xtra Fungicide 
 EPA Registration Number: 228-728 
 Application Dates: 7/5/2019; 1/6/2021 
Decision Numbers: 552860; 569426 
 
Dear Ms. Larochelle: 
 
The Agency, in accordance with the Federal Insecticide, Fungicide and Rodenticide Act 
(FIFRA), as amended, has completed reviewing all the information submitted with your 
application to support the Registration Review of the above referenced product in connection 
with the Azoxystrobin and Cyproconazole Interim Decisions, and has concluded that your 
submission is acceptable. The label referred to above, submitted in connection with registration 
under FIFRA, as amended, is acceptable. 
 
Should you wish to add/retain a reference to the company’s website on your label, then please be 
aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide 
Act and is subject to review by the Agency. If the website is false or misleading, the product 
would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 
CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, 
regardless of whether a website is referenced on your product’s label, claims made on the 
website may not substantially differ from those claims approved through the registration process. 
Therefore, should the Agency find or if it is brought to our attention that a website contains false 
or misleading statements or claims substantially differing from the EPA approved registration, 
the website will be referred to the EPA’s Office of Enforcement and Compliance. 
 
A stamped copy of your labeling is enclosed for your records. This labeling supersedes 
all previously accepted labeling. You must submit one copy of the final printed labeling 
before you release the product for shipment with the new labeling. In accordance with 40 
CFR 152.130(c), you may distribute or sell this product under the previously approved 
labeling for 12 months from the date of this letter. After 12 months, you may only 
distribute or sell this product if it bears this new revised labeling or subsequently 
approved labeling. “To distribute or sell” is defined under FIFRA section 2(gg) and its 
implementing regulation at 40 CFR 152.3.

Page 2 of 2 
EPA Reg. No. 228-728 
Decision No. 552860; 569426 
 
If you have any questions about this letter, please contact Jaclyn Pyne by phone at 202-566-
2326, or via email at pyne.jaclyn@epa.gov
. 
 
 Sincerely, 
 
 
 Linda Arrington, Branch Chief 
 Risk Management and Implementation Branch 4 
 Pesticide Re-Evaluation Division 
 Office of Pesticide Programs 
 
 
Enclosure

000228-00728.20210427.Reg Review Label
CYPROCONAZOLE GROUP 3 FUNGICIDE
AZOXYSTROBIN GROUP 11 FUNGICIDE
AZURE¥¥Xtra
Fungicide
Broad-spectrum fungicide for control of plant diseases
[ Alternate Brand Name: NUP-14035 Fungicide ]
ACTIVE INGREDIENTS
Azoxystrobin (CAS No. 131860-33-8)............................................................................................... 18.2%
Cyproconazole (CAS No. 94361-06-5) ............................................................................................... 7.3%
OTHER INGREDIENTS .................................................................................................................... 74.5%
TOTAL ........................................................................................................................................... 100.0%
Azure Xtra Fungicide is a 280SC formulation that contains 0.67 lb cyproconazole and 1.67 lb 
azoxystrobin per gallon
KEEP OUT OF REACH OF CHILDREN
CAUTION
See Label Booklet for [First Aid and] Precautionary Statements
For Chemical Spill, Leak, Fire, or Exposure, Call CHEMTREC (800) 424-9300 
For Medical Emergencies Only, Call (877) 325-1840
EPA Reg. No. 228-728
EPA Est. No. ___________
MANUFACTURED FOR
NUFARM AMERICAS INC.
11901 S. AUSTIN AVENUE
ALSIP, IL 60803
NET CONTENTS: Gallons ( Liters)
[Designation as “NONREFILLABLE” or “REFILLABLE” for containers > 5 GAL]
[Grow a Better Tomorrow]
[Nufarm Grow a Better Tomorrow]
Feb 02, 2022
228-728

Page 2 of 14 
 
FIRST AID 
IF SWALLOWED x Call a poison control center or doctor immediately for treatment advice. 
x Have person sip a glass of water if able to swallow. 
x Do not induce vomiting unless told to do so by the poison control center or doctor. 
x Do not give anything by mouth to an unconscious person. 
IF IN EYES x Hold eye open and rinse slowly and gently with water for 15-20 minutes. 
x Remove contact lenses, if present, after th e first 5 minutes, then continue rinsing 
eye. 
x Call a poison control center or doctor for treatment advice. 
IF ON SKIN OR 
CLOTHING 
x Take off contaminated clothing. 
x Rinse skin immediately with plenty of water for 15-20 minutes. 
x Call a poison control center or doctor for treatment advice. 
IF INHALED x Move person to fresh air 
x If person is not breathing, call 911 or an am bulance, then give artificial respiration, 
preferably mouth to mouth, if possible. 
x Call a poison control center or doctor for future treatment advice. 
HOTLINE NUMBER 
Have the product container or label with you when calling a poison control center or doctor, or going for 
treatment. You may also contact (877) 325-1840 for emergency medical treatment information. 
 
PRECAUTIONARY STATEMENTS 
HAZARDS TO HUMANS AND DOMESTIC ANIMALS 
CAUTION 
Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. 
PERSONAL PROTECTIVE EQUIPMENT (PPE) 
All handlers must wear: 
x Long-sleeved shirt and long pants 
x Waterproof gloves 
x Shoes plus socks 
In addition, mixers/loaders/applicators using mechanically pressurized handwands must wear: 
x A minimum of a NIOSH-approved particulate filtering fa cepiece respirator with any N, R or P filter; OR 
a NIOSH-approved elastomeric partic ulate respirator with any N, R or P filter; OR a NIOSH-approved 
powered air purifying respirator with HE filters. 
Human flagging is prohibited. 
Follow the manufacturer’s instructions for cleaning/maintaining PPE. If no such instructions for washables 
exist, use detergent and hot water. Keep and wash PPE separately from other laundry. 
Engineering Controls 
When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements 
listed in the Worker Protection Standard (WPS) for ag ricultural pesticides [40 CFR 170.240(d)(4-6)], the 
handler PPE requirements may be reduced or modified as specified in the WPS. 
Respirator fit testing, medical qualification, and training 
Using a program that conforms to OSHA's requirements (see 29 CFR Part 1910.134), employers must 
verify that any handler who uses a respirator is: 
• Fit-tested and fit-checked, 
• Trained, and 
• Examined by a qualified medical practitioner to ensure physical ability to safely wear the style of respirator 
to be worn. A qualified medical practitioner is a physi cian or other licensed health care professional who 
will evaluate the ability of a worker to wear a respirat or. The initial evaluation consists of a questionnaire 
that asks about medical conditions (such as a heart co ndition) that would be problematic for respirator 
use. If concerns are identified, then additional evaluations, such as a physical exam, might be necessary. 
The initial evaluation must be done before respir ator use begins. Handlers must be reexamined by a 
qualified medical practitioner if their health status or respirator style or use conditions change.

Page 3 of 14 
Upon request by local/state/federal /tribal enforcement personnel, employers must provide documentation 
demonstrating how they have complied with these requirements. 
 
USER SAFETY RECOMMENDATIONS 
Users should: 
x Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. 
x Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean 
clothing. 
x Remove PPE immediately after handling this product. Wash the outside of gloves before removing. 
As soon as possible, wash thoroughly and change into clean clothing. 
ENVIRONMENTAL HAZARDS 
Azoxystrobin is toxic to freshwater, estuarine/marine fi sh and aquatic invertebrates. Azoxystrobin can be 
persistent for several months or longer. 
For terrestrial uses: do not apply directly to water, or to areas where surface water is present, or to intertidal 
areas below the mean high water ma rk. Drift and runoff may be hazardous to aquatic organisms in water 
adjacent to treated areas. Do not contaminate water when disposing of equipment wash-water or rinsate. 
Ground Water Advisory 
Azoxystrobin, a degradate of azoxyst robin, and cyproconazole are known to leach through soil to ground 
water under certain conditions as a result of label use. This chemical may leach into ground water if used 
in areas where soils are permeable, particularly where the water table is shallow. 
Surface Water Advisory 
This product may impact surface water quality due to runoff of rain water. This is especially true for poorly 
draining soils and soils with shallow ground water. Th is product is classified as having a high potential for 
reaching surface water via runoff for several months or more after application. A level, well-maintained 
vegetative buffer strip between areas to which this product is applied and surface water features such as 
ponds, streams, and springs will reduce the pote ntial loading of azoxystrobin and a degradate of 
azoxystrobin from runoff water and sediment. Runo ff of this product will be reduced by avoiding 
applications when rainfall or irrigation is expected to occur within 48 hours. 
Notify state and/or federal authorit ies and Nufarm immediately if you observe any adverse environmental 
effects due to use of this product. 
DIRECTIONS FOR USE 
It is a violation of federal law to use this product in a manner inconsistent with its labeling. 
FAILURE TO FOLLOW THE USE DIRECTIONS AND PRECAUTIONS ON THIS LABEL MAY RESULT IN 
PLANT INJURY OR POOR DISEASE CONTROL. 
Do not apply this product in a way that will contact workers or other persons, either directly or through drift. 
Only protected handlers may be in the area during application. For any requirements specific to your state 
or tribe, consult the agency responsible for pesticide regulation. 
AGRICULTURAL USE REQUIREMENTS 
Use this product only in accordance with its labeling and with the Worker Prot ection Standard, 40 CFR 
Part 170. This Standard contains requirements for the protection of agricultural workers on farms, 
forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements 
for training, decontamination, notification, and em ergency assistance. It also contains specific 
instructions and exceptions pertaining to the stat ements on this label about personal protective 
equipment (
PPE), notification to workers, and restricted-entry interval. The requirements in this box only 
apply to uses of this product that are covered by the Worker Protection Standard. 
Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours. 
PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and 
that involves contact with anything that has been treated, such as plants, soil or water is: 
x Coveralls 
x Waterproof gloves 
x Shoes plus socks

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PRODUCT INFORMATION 
This product is a broad spectrum, preventative fu ngicide with systemic and curative properties 
recommended for the control of many important plant diseases. Applications may be made as foliar sprays 
in alternating spray programs or in tank mixes with ot her crop protection products. All applications must 
be made according to the use directions that follow. 
USE PRECAUTIONS 
Under certain conditions conducive to extended infect ion periods, use another registered fungicide for 
additional applications if the maximum amount of product has been applied. 
The active ingredients in this product may have ef fects on federally listed threatened and endangered 
species or critical habitat in some counties. Wh en using this product, you must follow the measures 
contained in the County Bulletin for the county in which you are applying the pesticide. To determine 
whether your County has a Bulletin consult http://128.104.224.199/espp_front/view.jsp. Bulletins also may 
be available from local pesticide dealers, extension offices, or state pesticide agencies. 
RESTRICTIONS 
Do not use in nurseries, greenhouses or landscape plantings. 
Rotational Crop Restrictions 
The following crops may be planted at the specified interval following application of this product. 
 
Crop Plantback Interval 
Soybean 
Corn 
Wheat 
0 Days 
Cereal grains other than wheat 
Cotton 
180 Days 
All other crops (including leafy vegetables 270 Days 
 
PHYTOTOXICITY 
This product is extremely phytotoxic to certain apple and crabapple varieties. 
AVOID SPRAY DRIFT. Extreme care must be used to prevent injury to apple and crabapple trees (and fruit). 
Refer to SPRAY DRIFT MANAGEMENT information below. 
Do not spray this product where spray drift may reach apple and crabapple trees. 
Do not spray apple and crabapple trees with spray equipment previously used to apply this product. Even 
trace amounts of this product may cause unacceptab le phytotoxicity to certain apple and crabapple 
varieties. 
This product demonstrates some phytotoxic effects when mixed with products that are formulated as ECs. 
These effects are enhanced if applications are made under cool, cloudy conditions and these conditions 
remain for several days following application. In addition, adjuvants that contain some form of silicone can 
contribute to phytotoxicity. Under certain environmental conditions, tank mixes of this product plus 
herbicides and/or fertilizers may cause crop injury.

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SPRAY DRIFT MANAGEMENT 
 
SPRAY DRIFT 
Aerial Applications 
x Do not release spray at a height greater than 10 feet above the ground or crop canopy, unless a 
greater application height is necessary for pilot safety. 
x Applicators are required to select nozzles that deliver medium to coarse spray droplets in 
accordance with ASABE Standard S-572.1. 
x Do not apply when wind speed exceeds 15 mph at the application site. If the windspeed is greater 
than 10 mph, the boom length must be 65% or less of the wingspan for fixed wing aircraft and 75% 
or less of the rotor diameter for helicopters. Otherwise, the boom length must be 75% or less of the 
wingspan for fixed-wing aircraft and 90% or less of the rotor diameter for helicopters. 
x Applicators must use ½ swath displacement upwind at the downwind edge of the field. 
x Do not apply during temperature inversions. 
Ground Boom Applications 
x User must only apply with the release height recommended by the manufacturer, but no more than 
4 feet above the ground or crop canopy. 
x Applicators are required to use a medium or coarser droplet size (ASABE S572.1). 
x Do not apply when wind speeds exceed 15 mph at the application site. 
x Do not apply during temperature inversions. 
SPRAY DRIFT ADVISORIES 
THE APPLICATOR IS RESPONSIBLE FOR AVOIDING OFF-SITE SPRAY DRIFT. 
BE AWARE OF NEARBY NON-TARGET SITES AND ENVIRONMENTAL CONDITIONS. 
IMPORTANCE OF DROPLET SIZE 
An effective way to reduce spray drift is to apply large droplets. Use the largest droplets that provide target 
pest control. While applying larger droplets will redu ce spray drift, the potential for drift will be greater if 
applications are made improperly or under unfavorable environmental conditions. 
Controlling Droplet Size – Ground Boom 
x Volume - Increasing the spray volume so that larger droplets are produced will reduce spray drift. Use 
the highest practical spray volume for the application. If a greater spray volume is needed, consider using 
a nozzle with a higher flow rate. 
x Pressure - Use the lowest spray pressure recommended for the nozzle to produce the target spray 
volume and droplet size. 
x Spray Nozzle - Use a spray nozzle that is designed for the intended application. Consider using nozzles 
designed to reduce drift. 
Controlling Droplet Size – Aircraft 
x Adjust Nozzles - Follow nozzle manufacturers ’ recommendations for settin g up nozzles. Generally, to 
reduce fine droplets, nozzles should be oriented parallel with the airflow in flight. 
BOOM HEIGHT – Ground Boom 
For ground equipment, the boom should remain level with the crop and have minimal bounce. 
RELEASE HEIGHT – Aircraft 
Higher release heights increase the potential for spray drift. 
SHIELDED SPRAYERS 
Shielding the boom or individual nozzles can reduce spray drift. Consider using shielded sprayers. Verify 
that the shields are not interfering with the uniform deposition of the spray on the target area. 
TEMPERATURE AND HUMIDITY 
When making applications in hot and dry conditions, use larger droplets to reduce effects of evaporation. 
TEMPERATURE INVERSIONS 
Drift potential is high during a temperature invers ion. Temperature inversions are characterized by 
increasing temperature with altitude and are common on nights with limited cloud cover and light to no wind. 
The presence of an inversion can be indicated by ground fog or by the movement of smoke from a ground 
source or an aircraft smoke generator. Smoke that layers and moves laterally in a concentrated cloud

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(under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates 
indicates good vertical air mixing. Avoid applications during temperature inversions. 
WIND 
Drift potential generally increases with wind speed. AVOID APPLICATIONS DURING GUSTY WIND 
CONDITIONS. 
Applicators need to be familiar with local wind patterns and terrain that could affect spray drift. 
RESISTANCE MANAGEMENT 
 
For resistance management, please note that AZURE ¥ XTRA Fungicide contains both a Group 3 
(cyproconazole) and Group 11 (azoxystrobin) fungicid e. Any fungal population may contain individuals 
naturally resistant to AZURE ¥ XTRA Fungicide and other Group 3 or Group 11 fungicides. A gradual or 
total loss of pest control may occur over time if th ese fungicides are used repe atedly in the same fields . 
Appropriate resistance-management strategies should be followed. 
The following steps may delay the development of fungicide resistance: 
 Rotate the use of this product or other Group 3 and 11 fungicides within a growing season sequence 
with different groups that control the same pathogens. 
 Use tank mixtures with fungicides from a different group that are effective on the target pest when such 
use is permitted. Use at least the minimum application rate as labeled by the manufacturer. 
 Adopt an integrated disease management program for fungicide use that includes scouting, uses 
historical information related to pesticide use , and crop rotation, and which considers host plant 
resistance, impact of environmental conditions on disease development, disease thresholds , as well as 
cultural, biological and other chemical control practices. 
 Where possible, make use of predictive disease models to effectively time fungicide applications . Note 
that using predictive models alone is not sufficient to manage resistance. 
 Monitor treated fungal populations for resistance development. 
 Contact your local extension specialist or certified crop advisor for any additi onal pesticide resistance 
management and/or IPM recommendations for specific crops and pathogens. 
 For further information or to report suspected resistance, contact Nufarm Americas Inc. at (855) 280-
6609. You can also contact your pesticide distribu tor or university extension specialist to report 
resistance. 
Follow crop specific recommendations that limit the total number of sprays on a crop and the required 
rotation with fungicides from other resistance management groups. In situations requiring multiple sprays 
(more than two), develop season long spray programs for Group 11 (QoI) fungicides. The program should 
meet the goal of no more than 1/3 of the total sprays per season, when a Group 11 fungicide is used as a 
solo product, or 1/2 the total sprays when a Group 11 fungicide is used in a mixture. Programs that include 
both solo Group 11 products and/or mixes containing Group 11 products should be no more than 1/2 the 
total sprays. 
Avoid rotating or tank mixing this product with any fungicide to which resistance has already developed. 
PRODUCT USE INSTRUCTIONS 
INTEGRATED PEST (DISEASE) MANAGEMENT 
Use this product as part of an integrated disease and pest management strategy whenever the use of a 
fungicide is needed. Follow cultural practices known to help reduce disease development. The CROP 
SPECIFIC USE DIRECTIONS section in this label identifies specif ic IPM recommendations for each crop. 
Consult your local agricultural authorities for additiona l IPM strategies established for your area. This 
product may be used in State Agricultural Extensio n advisory (disease forecasting) programs which 
recommend application timing based on environmental factors favorable for disease development. 
SPRAY EQUIPMENT 
Equip sprayers with nozzles that provide accurate and uniform application. Be certain that nozzles are the 
same size and uniformly spaced across the boom. Calibrate sprayer before use.

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Use a pump with capacity to: (1) maintain at least 35 -40 psi at nozzles, and (2) provide sufficient agitation 
in tank to keep mixture in suspension - this requires recirculation of 10% of tank volume per minute. Use a 
jet agitator or liquid sparge tube for agitation. Do not air sparge. 
This product is a suspoemulsion concentrate. It is suggested that screens be used to protect the pump and 
to prevent nozzles from clogging. Screens placed on suction side of pump should be 16-mesh or coarser. 
Do not place a screen in the recirculation line. Us e 50-mesh or coarser screens between the pump and 
boom, and where required, at the nozzles. Check nozzle manufacturer’s recommendations. 
For more information on spray equipment and cali bration, consult sprayer manufacturers and state 
recommendations. For specific local directions and spray schedules, consult the current state and local 
agricultural recommendations. 
SPRAYING/MIXING 
This product may be applied with all types of spra y equipment commonly used for ground and aerial 
applications. Do not apply this product through any type of ultra low volume (ULV) spray system. Proper 
adjustments and calibration of spraying equipment to give good canopy penetration and coverage is 
essential for good disease control. Higher rates in the rate range and/or shorter spray intervals may be 
required under conditions of heavy infection pressure, highly susceptible varieties, or when environmental 
conditions conducive to disease exist. 
For ground applications, apply this product in a mi nimum of 10 gallons of water volume for adequate 
coverage and canopy penetration. For aerial applications, follow local recommendations. 
Prepare no more spray mixture than is required for immediate use. Thoroughly clean spray equipment 
before using this product. Agitate the spray soluti on before and during application. Rinse spray tank 
thoroughly with clean water after each day’s use and dispose of pest icide rinsate by appli cation to an 
already treated area. 
AZURE XTRA Alone 
Add 1/2 - 2/3 of the required amount of water to a spra y or mixing tank. With the agitator running, add this 
product to the tank and continue agitation while adding the remainder of the water. Begin application of the 
spray solution after complete dispersion of the product into the mix water and maintain agitation until all of 
the mixture has been sprayed. 
Tank Mixtures of AZURE XTRA and Other Products 
Do not tank mix this product with pesticides, surfactants, or fertilizers, unless compatibility charts or your 
own prior use has shown that the combination is physical ly compatible, effective, and non-injurious to the 
crop under your conditions of use. 
Compatibility 
To determine physical compatibility of this product and other products, conduct a jar test. Using a quart jar, 
add proportionate amounts of the tank mix partners to 1 qt. of water. Add wettable powders and water-
dispersible granular products first, then liquid flow ables (suspoemulsions), and emulsifiable concentrates 
last. After thoroughly mixing, let stand for at least 5 minutes. If the combination remains mixed or can be 
remixed readily, it is physically compatible. Once compatibility has been proven, use the same procedure 
for adding required ingredients to the spray tank. 
Spray Solution Preparation 
Add 1/2 - 2/3 of the required amount of water to a spray or mixing tank. With the agitator running, add the 
tank mix partner into the tank. Allow the material to completely dissolve and disperse into the mix water. 
Continue agitation while adding the remainder of the wat er and this product to the spray tank. Allow the 
product to completely disperse. Spray the mixture with the agitator running. 
Observe the most restrictive of the labeling limitations and precautions of all products used in tank mixtures. 
APPLICATION INSTRUCTIONS 
Apply this product at rates and timings as described in this label. Apply by ground, by air, or via 
chemigation. Refer toCrop Specific Use Direction section of this label. 
Apply this product in a minimum of 10 GPA via ground application equipment and 2 GPA via aerial 
application equipment. 
Directions for Use Through Sprinkler Chemigation Systems (apply this product only to crops for 
which chemigation is specified on this label):

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Spray Preparation: Chemical tank and injector system should be thoroughly cleaned. Flush system with 
clean water. 
Use Precautions for Sprinkler Irrigation Applications 
Apply this product through sprinkler irrigation systems including center pivot, lateral move, end tow, side 
[wheel] roll, traveler, big gun, solid set, drip (trickle) , or hand move irrigation systems. Do not apply this 
product through any other type of irrigation system except as specified on this label. 
Apply with center pivot or continuous-move equipment di stributing 1/2 acre-inch or less during treatment. 
In general, use the least amount of water required for proper distribution and coverage. If stationary 
systems (solid set, handlines or wheel lines other than continuous-move) are used, this product should be 
injected into no more than the last 20-30 minutes of the set. Do not apply when winds are greater than 10-
15 mph to avoid drift or wind skips. Do not apply whe n wind speed favors drift beyond the area intended 
for treatment. Plant injury, lack of effectiveness, or illegal pesticide residues in the crop can result from 
non-uniform treated water. Thorough coverage of foliage is required for good control. Good agitation should 
be maintained during the entire application period. 
If you have questions about calibration you should co ntact State Extension Service specialist, equipment 
manufacturers or other experts. 
The system must contain a functional check valve, vacuum relief valve, and low-pressure drain 
appropriately located on the irrigation pipeline to prevent water-source contamination from backflow. 
The pesticide injection pipeline must contain a functional, automatic, quick-closing check valve to prevent 
the flow of fluid back toward the injection pump. 
The pesticide injection pipeline must also contain a functional, normally closed, solenoid-operated valve 
located on the intake side of the injection pump and connected to the system interlock to prevent fluid from 
being withdrawn from the supply tank when the irrigati on system is either automatically or manually shut 
down. 
The system must contain functional interlocking contro ls to automatically shut off the pesticide injection 
pump when the water pump motor stops. 
The irrigation line or water pump must include a functional pressure switch which will stop the water pump 
motor when the water pressure decreases to the point where pesticide distribution is adversely affected. 
Systems must use a metering pump, such as a positive displacement injection pump (e.g., diaphragm 
pump) effectively designed and constructed of materials that are compatible with pesticides and capable of 
being fitted with a system interlock. 
Allow sufficient time for pesticide to be flushed through all lines and all nozzles before turning off irrigation 
water. A person knowledgeable of the chemigation syst em and responsible for its operation, or under the 
supervision of the responsible person, shall shut the system down and make necessary adjustments should 
the need arise. 
Do not connect an irrigation system (including green house systems) used for pesticide application to a 
public water system unless the pesticide label-prescribed safety devices for public water systems are in 
place. 
 
Specific Instructions for Public Water Systems 
1. Public water system means a system for the provision to the public of piped water for human 
consumption if such system has at least 15 service connections or regularly serves an average of at 
least 25 individuals daily at least 60 days out of the year. 
2. Chemigation systems connected to public water syst ems must contain a functional, reduced-pressure 
zone, back-flow preventer (RPZ) or the functional eq uivalent in the water supply line upstream from 
the point of pesticide introduction. As an option to the RPZ, the water from the public water system 
should be discharged into a reservoir tank prior to pesticide introduction. There shall be a complete 
physical break (air gap) between the outlet end of the fill pipe and the top or overflow rim of the reservoir 
tank of at least twice the inside diameter of the fill pipe. 
3. The pesticide injection pipeline must contain a functional, automatic, quick-closing check valve to 
prevent the flow of fluid back toward the injection pump. 
4. The pesticide injection pipeline must contain a functional, normally closed, solenoid-operated valve 
located on the intake side of the injection pump and connected to the system interlock to prevent fluid

Page 9 of 14 
from being withdrawn from the supply tank when the irrigation system is either automatically or 
manually shut down. 
5. The system must contain functional interlocking cont rols to automatically shut off the pesticide injection 
pump when the water pump motor stops or in ca ses where there is no water pump, when the water 
pressure decreases to the point where pesticide distribution is adversely affected. 
6. Systems must use a metering pump , such as a positive displacement injection pump (e.g., diaphragm 
pump) effectively designed and co nstructed of materials that are compatible with pesticides and 
capable of being fitted with a system interlock. 
7. Do not apply when wind speed favors dri ft beyond the area intended for treatment.

Page 10 of 14 
CROP SPECIFIC USE DIRECTIONS 
 
Crop Target Diseases 
Use Rate 
fl oz product/A 
(ai/A) 
Remarks 
CEREALS 
WHEAT 
TRITICALE 
 
 
Early season 
suppression of: 
Glume blotch 
(Stagonospora 
nordorum) 
Leaf blight 
(Septoria tritici) 
Powdery mildew 
(Blumeria spp., 
Erysiphe spp.) 
Tan spot 
(Pyrenophora tritici-
repentis) 
3.5 
(0.018 lb 
cyproconazole) 
(0.046 lb 
azoxystrobin) 
Apply this product in the spring at 
approximately Feekes Stage 5. 
The minimum retreatment interval is 14 
days. Apply by ground, air, or 
chemigation. If applying by chemigation, 
use a maximum of 0.25 inch of water. 
Control of Leaf 
Diseases: 
Glume blotch 
(Stagonospora 
nordorum) 
Helminthosporium leaf 
blight 
(Drechslera tritici-
repentis) 
Leaf blight 
(Septoria tritici) 
Powdery mildew 
(Blumeria spp., 
Erysiphe spp.) 
Rust 
(stripe, leaf, and stem) 
(Puccinia spp.) 
Spot blotch 
(Bipolaris sorokiniana) 
Tan spot 
(Pyrenophora tritici-
repentis) 
5–6.8 
(0.026-0.036 lb 
cyproconazole) 
(0.065-0.089 lb 
azoxystrobin) 
 
Apply this product between Feekes 
Stage 8 and 10.5.1. Protecting the flag 
leaf is important for maximizing the 
potential yield. 
 
The minimum retreatment interval is 14 
days. Treat up to 30 days prior to 
harvest. Apply by ground, air, or 
chemigation. 
Resistance Management : Make no 
more than two foliar applications of this 
product or other Grpi[ 11 fungicides per 
growing season. Do not alternate or tank 
mix with fungicides to which resistance 
has developed in the pathogen 
population.
 
 
Specific Use Restrictions: 
(1) Do not apply more than 6.8 fl oz/A of this product per year. 
(2) Do not exceed the equivalent of 0.036 lb cyproconazole/A/year from any cyproconazole-containing 
products. 
(3) Do not exceed the equivalent of 0.4 lb azoxystrobin/A/year fr om any azoxystrobin- containing 
products. 
(4) Do not harvest wheat within 30 days of application. 
(5) Do not harvest forage or hay within 21 days of application.

Page 11 of 14 
Crop Target Diseases 
Use Rate 
fl oz product/A 
(ai/A) 
Remarks 
CORN 
FIELD 
SEED 
 
 
Eye spot 
(Aureobasidium zeae) 
Gray leafspot 
(Cercospora zeae-
maydis) 
Northern corn leaf blight 
(Setosphaeria turcica) 
Northern corn leaf spot 
(Cochliobolus 
carbonum) 
Rusts 
(common and 
Southern) 
(Puccinia spp.) 
Southern corn leaf blight 
(Cochliobolus 
heterostrophus) 
[also known as 
Helminthosporium leaf 
blights (H. maydis, 
H. turcicum, H. 
carbonum)] 
3.5–6.8 
(0.018-0.036 lb 
cyproconazole) 
(0.046-0.089 lb 
azoxystrobin) 
Apply this product when disease first 
appears. Use the low er rate when 
disease pressure is low. Under heavy 
disease
 pressure or if conditions are 
favorable for disease development, 
apply the high er rate. A sec ond 
application may be made 7 –14 days 
later. 
Application Directions : Apply by 
ground, air, or chemigation. 
Resistance Management : Make no 
more than two foliar applications of this 
product or other strobilurin Group 11 
fungicides per year. Do not alternate or 
tank mix with fungicides to which 
resistance has developed in the 
pathogen population.
 
Specific Use Restrictions: 
(1) Do not apply within 30 days of harvest. 
(2) Do not harvest silage within 21 days of an application. 
(3) Do not apply more than 6.8 fl oz/A/year of this product. 
(4) Do not exceed the equivalent of 0.036 lb cyproconazole/A/year from any cyproconazole-containing 
products. 
(5) Do not exceed the equivalent of 2.0 lb azoxystrobin/A/year fr om any azoxystrobin- containing 
products.

Page 12 of 14 
Crop Target Diseases 
Use Rate 
fl oz product/A 
(ai/A) 
Remarks 
SOYBEAN 
 
Rust 
(Phakopsora spp.) 
 
4.0–6.8 
(0.02-0.036 lb 
cyproconazole) 
(0.052-0.089 lb 
azoxystrobin) 
 
For soybean rust: Repeat applications 
at 14 - to 28-day intervals if conditions 
favorable for rust development persist. 
Lower use rates may require a shorter 
spray interval. Depending on the 
conditions, application timing should be 
at R1 (beginning flowering, 
approximately 50 days after planting) up 
to the R6 stage (seed development), but 
could be earlier. 
Aerial blight 
(Rhizoctonia solani) 
Alternaria leaf spot 
(Alternaria spp.) 
Anthracnose 
(Colletotrichum 
truncatum) 
Brown spot 
(Septoria glycines) 
Cercospora blight and 
leaf spot 
(Cercospora kikuchii) 
Frogeye leafspot 
(Cercospora sojina) 
Pod and Stem blight 
(Diaporthe 
phaseolorum 
5.0–6.8 
(0.026-0.036 lb 
cyproconazole) 
(0.065-0.089 lb 
azoxystrobin) 
 
For diseases other than soybean rust: 
Begin applications prior to disease 
development. Use the higher rates 
under conditions favorable for severe 
disease pressure, dense plant canopies, 
or when disease is present. Contact 
extension personnel for local economic 
thresholds and timings for specific 
diseases in your area. An adjuvant may 
be added at recommended rates to 
improve coverage. 
 
 
Application Directions: 
Coverage and penetration are important for best results. Use sufficient water volume to provide thorough 
and uniform plant coverage. Appl
y by ground, air or chemigation. Addition of an additive with spreading 
and penetrating qualities will enhance coverage and efficacy. 
Resistance Management: 
Make no more than two foliar applications of this product or other Group 11 fungicides per year. Do not 
alternate or tank mix with fungicides to which resistance has developed in the pathogen population. 
Specific Use Restrictions: 
(1) Do not apply more than 13.6 fl oz of this product/A/year. 
(2) Do not exceed the equivalent of 0.072 lb cyproconazole/A/year from any cyproconazole-containing 
products. 
(3) Do not exceed the equivalent of 1.5 lb azoxystrobin/A/year fr om any azoxystrobin- containing 
products. 
(4) Do not apply within 30 days of harvest of soybeans (bean). 
(5) Do not graze forage within 14 days of an application. 
(6) Do not use soybean forage or hay as livestock fe ed if making more than one application at 6.8 fl oz 
product/A.

Page 13 of 14 
RATE CONVERSION TABLE 
Product 
(fl oz/A) 
Cyproconazole 
(lb a.i./A) 
Azoxystrobin 
(lb a.i./A) 
Treated acres 
per gallon product 
3.5 0.018 0.046 36.6 
4.0 0.021 0.052 32.0 
5.0 0.026 0.065 25.6 
6.5 0.034 0.085 19.7 
6.8 0.036 0.089 18.8 
13.7 0.072 0.178 N/A 
 
 
STORAGE AND DISPOSAL 
Do not contaminate water, food, or feed by storage or disposal. 
STORAGE: Store in original container only. Keep container closed when not in use. Do not store near 
food or feed. In case of spill on floor or paved surfaces, mop and remove to chemical waste storage 
area until proper disposal can be made if product cannot be used according to the label. 
PESTICIDE DISP OSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess 
pesticide, spray mixture, or rinsate is a violation of federal law. If these wastes cannot be disposed of 
by use according to label instructions, contact yo ur State Pesticide or Environmental Control Agency, 
or the Hazardous Waste representative of the nearest EPA Regional Office for guidance. 
CONTAINER HANDLING: 
[Note to Reviewer: The following statement will be included on all Final Printed Labels bearing multiple 
Container Handling statements] “NOTE: This product is available in multiple containers. Refer to the 
Net Contents section of this product's labeling fo r the applicable “Nonrefillable” or “Refillable” 
designation. Follow the container handling instructions below that apply to your container type/size.” 
[Nonrefillable Containers 5 Gallons or Less] 
Nonrefillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) 
promptly after emptying. Triple rinse as follows: Empty the remaining contents into application 
equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container 1/4 full 
with water and recap. Shake for 10 seconds. Pour ri nsate into application equipment or a mix tank or 
store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this 
procedure two more times. Then offer for recycling or reconditioning, or puncture and dispose of in a 
sanitary landfill, or by other procedures approved by state and local authorities. Plastic containers are 
also disposable by incineration, or, if allowed by state and local authorities, by burning. If burned stay 
out of smoke. 
[Nonrefillable containers larger than 5 gallons] 
Nonrefillable container. Do not reuse or refill this container. Triple rinse or pressure rinse container (or 
equivalent) promptly af ter emptying. Triple rinse as follows: Empty the remaining contents into 
application equipment or a mix tank. Fill the container 1/4 full with water. Replace and tighten closures. 
Tip container on its side and roll it back and forth, ensuring at least one complete revolution, for 30 
seconds. Stand the container on its end and tip it back and forth several times. Turn the container over 
onto its other end and tip it back and forth several times. Empty the rinsate into application equipment 
or a mix tank or store rinsate for later use or disposal. Repeat this procedure two more times. Pressure 
rinse as follows: Empty the remaining contents into application equipment or a mix tank and continue 
to drain for 10 seconds after the flow begins to drip. Hold container upside down over application 
equipment or mix tank or collect rinsate for later use or disposal. Insert pressure -rinsing nozzle in the 
side of the container, and rinse at about 40 psi for at least 30 seconds. Drain for 10 seconds after the 
flow begins to drip. Then offer for recycling if available, or puncture and dispose of in a sanitary landfill, 
or by other procedures approved by state and local authorities. Plastic containers are also disposable 
by incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke.

Page 14 of 14 
[Refillable containers larger than 5 gallons] 
Refillable container. Refill this container with pest icide only. Do not reuse this container for any other 
purpose. Cleaning the container before final disposal is the responsibility of the person disposing of the 
container. Cleaning before refilling is the responsibility of the refiller. To clean the container before final 
disposal, empty the remaining contents from this co ntainer into application equipment or a mix tank. 
Fill the container about 10% full with water. Agitat e vigorously or recirculate water with the pump for 
two minutes. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this 
rinsing procedure two more times 
 
WARRANTY DISCLAIMER 
The directions for use of this product must be followed carefully. TO THE EXTENT CONSISTENT 
WITH APPLICABLE LAW, (1) THE GOODS DELIVERED TO YOU ARE FURNISHED “AS IS” BY 
MANUFACTURER OR SELLER AND (2) MANUFACTURER AND SELLER MAKE NO WARRANTIES, 
GUARANTEES, OR REPRESENTATIONS OF ANY KIND TO BUYER OR USER, EITHER EXPRESS OR 
IMPLIED, OR BY USAGE OF TRADE, STATUTORY OR OTHERWISE, WITH REGARD TO THE 
PRODUCT SOLD, INCLUDING, BUT NOT LIMI TED TO MERCHANTABILITY, FITNESS FOR A 
PARTICULAR PURPOSE, USE, OR ELIGIBILITY OF THE PRODUCT FOR ANY PARTICULAR TRADE 
USAGE. UNINTENDED CONSEQUENCES, INCLUDING BUT NOT LIMITED TO INEFFECTIVENESS, 
MAY RESULT BECAUSE OF SUCH FACTORS AS THE PRESENCE OR ABSENCE OF OTHER 
MATERIALS USED IN COMBINATION WITH THE GOODS, OR THE MANNER OF USE OR 
APPLICATION, INCLUDING WEATHER, ALL OF WHICH ARE BEYOND THE CONTROL OF 
MANUFACTURER OR SELLER AND ASSUMED BY BUYER OR USER. THIS WRITING CONTAINS ALL 
OF THE REPRESENTATIONS AND AGREEMENTS BETWEEN BUYER, MANUFACTURER AND 
SELLER, AND NO PERSON OR AGENT OF MANUFACTURER OR SELLER HAS ANY AUTHORITY TO 
MAKE ANY REPRESENTATION OR WARRANTY OR AGREEMENT RELATING IN ANY WAY TO THESE 
GOODS. 
LIMITATION OF LIABILITY 
TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, IN NO EVENT SHALL MANUFACTURER OR 
SELLER BE LIABLE FOR SPECIAL, INCIDENT AL, OR CONSEQUENTIAL DAMAGES, OR FOR 
DAMAGES IN THEIR NATURE OF PENALTIES RE LATING TO THE GOODS SOLD, INCLUDING USE, 
APPLICATION, HANDLING, AND DISPOSAL. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, 
MANUFACTURER OR SELLER SHALL NOT BE LIABLE TO BUYER OR USER BY WAY OF 
INDEMNIFICATION TO BUYER OR TO CUSTOMERS OF BUYER, IF ANY, OR FOR ANY DAMAGES OR 
SUMS OF MONEY, CLAIMS OR DEMANDS WHATSOEVER, RESULTING FROM OR BY REASON OF, 
OR RISING OUT OF THE MISUSE, OR FAILURE TO FOLLOW LABEL WARNINGS OR INSTRUCTIONS 
FOR USE, OF THE GOODS SOLD BY MANUFACTURER OR SELLER TO BUYER. ALL SUCH RISKS 
SHALL BE ASSUMED BY THE BUYER, USER, OR ITS CUSTOMERS. TO THE EXTENT CONSISTENT 
WITH APPLICABLE LAW, BUYER'S OR USER'S EXCLUSIVE REMEDY, AND MANUFACTURER'S OR 
SELLER'S TOTAL LIABILITY SHALL BE FOR DAMAGES NOT EXCEEDING THE COST OF THE 
PRODUCT. 
If you do not agree with or do not accept any of the directions for use, the warranty disclaimers, or 
limitations of liability, do not use the product and return it unopened to the Seller, and the purchase 
price will be refunded. 
 (RV042721) 
Azure is a trademark of Nufarm Americas Inc. 
All other trademarks that appear on this label which are not owned by Nufarm Americas Inc. or its 
subsidiaries are the property of their respective owners.